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Endothelins in cardiovascular biology and therapeutics.

Dhaun N, Webb DJ.

Nat Rev Cardiol. 2019 Mar 13. doi: 10.1038/s41569-019-0176-3. [Epub ahead of print] Review.


A novel role for myeloid endothelin-B receptors in hypertension.

Czopek A, Moorhouse R, Guyonnet L, Farrah T, Lenoir O, Owen E, van Bragt J, Costello HM, Menolascina F, Baudrie V, Webb DJ, Kluth DC, Bailey MA, Tharaux PL, Dhaun N.

Eur Heart J. 2019 Mar 1;40(9):768-784. doi: 10.1093/eurheartj/ehy881.


Low-dimensional nano-patterned surface fabricated by direct-write UV-chemically induced geometric inscription technique.

Allsop T, Neal R, Kundrat V, Wang C, Mou C, Culverhouse P, Ania-Castanon JD, Kalli K, Webb DJ.

Opt Lett. 2019 Jan 15;44(2):195-198. doi: 10.1364/OL.44.000195.


Impaired pressure natriuresis and non-dipping blood pressure in rats with early type 1 diabetes mellitus.

Culshaw GJ, Costello HM, Binnie D, Stewart KR, Czopek A, Dhaun N, Hadoke PWF, Webb DJ, Bailey MA.

J Physiol. 2019 Feb;597(3):767-780. doi: 10.1113/JP277332. Epub 2018 Dec 23.


Ultrasensitive Graphene Optoelectronic Probes for Recording Electrical Activities of Individual Synapses.

Wang R, Shi M, Brewer B, Yang L, Zhang Y, Webb DJ, Li D, Xu YQ.

Nano Lett. 2018 Aug 6. doi: 10.1021/acs.nanolett.8b02298. [Epub ahead of print]


Attending a social event and consuming alcohol is associated with changes in serum microRNA: a before and after study in healthy adults.

Ten Berg PW, Shaffer J, Vliegenthart ADB, McCrae J, Sharkey N, Webb DJ, Dear JW.

Biomarkers. 2018 Dec;23(8):781-786. doi: 10.1080/1354750X.2018.1499128. Epub 2018 Aug 23.


Long-term adverse effects of paracetamol - a review.

McCrae JC, Morrison EE, MacIntyre IM, Dear JW, Webb DJ.

Br J Clin Pharmacol. 2018 Oct;84(10):2218-2230. doi: 10.1111/bcp.13656. Epub 2018 Jul 20. Review.


Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.

Williams B, MacDonald TM, Morant SV, Webb DJ, Sever P, McInnes GT, Ford I, Cruickshank JK, Caulfield MJ, Padmanabhan S, Mackenzie IS, Salsbury J, Brown MJ; British Hypertension Society programme of Prevention And Treatment of Hypertension With Algorithm based Therapy (PATHWAY) Study Group.

Lancet Diabetes Endocrinol. 2018 Jun;6(6):464-475. doi: 10.1016/S2213-8587(18)30071-8. Epub 2018 Apr 11. Erratum in: Lancet Diabetes Endocrinol. 2018 Aug;6(8):e16.


Real-time chest-wall-motion tracking by a single optical fibre grating: a prospective method for ventilator triggering.

Ivanović MD, Petrovic J, Savić A, Gligorić G, Miletić M, Vukčević M, Bojović B, Hadžievski L, Allsop T, Webb DJ.

Physiol Meas. 2018 Apr 26;39(4):045009. doi: 10.1088/1361-6579/aab7ac.


Gabapentin and pregabalin: do the benefits outweigh the harms?

Morrison EE, Sandilands EA, Webb DJ.

J R Coll Physicians Edinb. 2017 Dec;47(4):310-313. doi: 10.4997/JRCPE.2017.402.


Novel thermal annealing methodology for permanent tuning polymer optical fiber Bragg gratings to longer wavelengths.

Pospori A, Marques CAF, Sagias G, Lamela-Rivera H, Webb DJ.

Opt Express. 2018 Jan 22;26(2):1411-1421. doi: 10.1364/OE.26.001411.


α5β1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration.

Diggins NL, Kang H, Weaver A, Webb DJ.

J Cell Sci. 2018 Mar 6;131(5). pii: jcs207019. doi: 10.1242/jcs.207019.


Endothelin antagonism reduces circulating galectin-3 in patients with proteinuric chronic kidney disease.

Farrah TE, Anand A, Miller-Hodges E, Mills NL, Webb DJ, Dhaun N.

Kidney Int. 2018 Jan;93(1):270. doi: 10.1016/j.kint.2017.10.009. No abstract available.


Carbodiimides as catalysts for the reduction of a cadmium hydride complex.

Webb DJ, Fitchett CM, Lein M, Fulton JR.

Chem Commun (Camb). 2018 Jan 16;54(5):460-462. doi: 10.1039/c7cc08393a. Epub 2017 Dec 7.


Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial.

MacDonald TM, Williams B, Webb DJ, Morant S, Caulfield M, Cruickshank JK, Ford I, Sever P, Mackenzie IS, Padmanabhan S, McCann GP, Salsbury J, McInnes G, Brown MJ; British Hypertension Society Programme of Prevention And Treatment of Hypertension With Algorithm‐based Therapy (PATHWAY).

J Am Heart Assoc. 2017 Nov 18;6(11). pii: e006986. doi: 10.1161/JAHA.117.006986.


Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part II: Role in disease conditions: a joint consensus statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors and the Japanese Society of Hypertension.

Rossi GP, Seccia TM, Barton M, Danser AHJ, de Leeuw PW, Dhaun N, Rizzoni D, Rossignol P, Ruilope LM, van den Meiracker AH, Ito S, Hasebe N, Webb DJ.

J Hypertens. 2018 Mar;36(3):462-471. doi: 10.1097/HJH.0000000000001600.


Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part I: General mechanisms: a joint consensus statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors and The Japanese Society of Hypertension.

Rossi GP, Seccia TM, Barton M, Danser AHJ, de Leeuw PW, Dhaun N, Rizzoni D, Rossignol P, Ruilope LM, van den Meiracker AH, Ito S, Hasebe N, Webb DJ.

J Hypertens. 2018 Mar;36(3):451-461. doi: 10.1097/HJH.0000000000001599.


Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin.

Erdogan B, Ao M, White LM, Means AL, Brewer BM, Yang L, Washington MK, Shi C, Franco OE, Weaver AM, Hayward SW, Li D, Webb DJ.

J Cell Biol. 2017 Nov 6;216(11):3799-3816. doi: 10.1083/jcb.201704053. Epub 2017 Oct 11.


Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model.

Vliegenthart ADB, Wei C, Buckley C, Berends C, de Potter CMJ, Schneemann S, Del Pozo J, Tucker C, Mullins JJ, Webb DJ, Dear JW.

Toxicol Sci. 2017 Oct 1;159(2):380-391. doi: 10.1093/toxsci/kfx144.


A randomized, multicenter, open-label, blinded end point trial comparing the effects of spironolactone to chlorthalidone on left ventricular mass in patients with early-stage chronic kidney disease: Rationale and design of the SPIRO-CKD trial.

Hayer MK, Edwards NC, Slinn G, Moody WE, Steeds RP, Ferro CJ, Price AM, Andujar C, Dutton M, Webster R, Webb DJ, Semple S, MacIntyre I, Melville V, Wilkinson IB, Hiemstra TF, Wheeler DC, Herrey A, Grant M, Mehta S, Ives N, Townend JN.

Am Heart J. 2017 Sep;191:37-46. doi: 10.1016/j.ahj.2017.05.008. Epub 2017 May 24.


Longitudinal Assessment of the Effect of Atrasentan on Thoracic Bioimpedance in Diabetic Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial.

Webb DJ, Coll B, Heerspink HJL, Andress D, Pritchett Y, Brennan JJ, Houser M, Correa-Rotter R, Kohan D, Makino H, Perkovic V, Remuzzi G, Tobe SW, Toto R, Busch R, Pergola P, Parving HH, de Zeeuw D.

Drugs R D. 2017 Sep;17(3):441-448. doi: 10.1007/s40268-017-0201-0.


A call to incorporate systems theory and human factors into the existing investigation of harm in clinical research involving healthcare products.

Edwards BD, Bégaud B, Daemen E, Dokas I, Fishbein JM, Greenberg HE, Hochberg A, Le Louet H, Lyngvig J, Mogles N, Owen K, Prendergast C, Rejzek M, Trantza S, Webb DJ, Whalen M, Whiteley S.

Br J Clin Pharmacol. 2017 Nov;83(11):2339-2342. doi: 10.1111/bcp.13353. Epub 2017 Jul 19.


APPL1 is a multifunctional endosomal signaling adaptor protein.

Diggins NL, Webb DJ.

Biochem Soc Trans. 2017 Jun 15;45(3):771-779. doi: 10.1042/BST20160191. Review.


Cardiovascular disease biomarkers are associated with declining renal function in type 2 diabetes.

Jenks SJ, Conway BR, McLachlan S, Teoh WL, Williamson RM, Webb DJ, Welsh P, Sattar N, Strachan MWJ, Price JF.

Diabetologia. 2017 Aug;60(8):1400-1408. doi: 10.1007/s00125-017-4297-0. Epub 2017 May 20.


First-in-Man Demonstration of Direct Endothelin-Mediated Natriuresis and Diuresis.

Hunter RW, Moorhouse R, Farrah TE, MacIntyre IM, Asai T, Gallacher PJ, Kerr D, Melville V, Czopek A, Morrison EE, Ivy JR, Dear JW, Bailey MA, Goddard J, Webb DJ, Dhaun N.

Hypertension. 2017 Jul;70(1):192-200. doi: 10.1161/HYPERTENSIONAHA.116.08832. Epub 2017 May 15.


Prescribing Safety Assessment 2016: Delivery of a national prescribing assessment to 7343 UK final-year medical students.

Maxwell SRJ, Coleman JJ, Bollington L, Taylor C, Webb DJ.

Br J Clin Pharmacol. 2017 Oct;83(10):2249-2258. doi: 10.1111/bcp.13319. Epub 2017 Jun 13.


Polymer optical fiber Bragg grating inscription with a single UV laser pulse.

Pospori A, Marques CAF, Bang O, Webb DJ, André P.

Opt Express. 2017 Apr 17;25(8):9028-9038. doi: 10.1364/OE.25.009028.


Fast Bragg Grating Inscription in PMMA Polymer Optical Fibres: Impact of Thermal Pre-Treatment of Preforms.

Marques CAF, Pospori A, Demirci G, Çetinkaya O, Gawdzik B, Antunes P, Bang O, Mergo P, André P, Webb DJ.

Sensors (Basel). 2017 Apr 18;17(4). pii: E891. doi: 10.3390/s17040891.


Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial.

Snowdon VK, Lachlan NJ, Hoy AM, Hadoke PW, Semple SI, Patel D, Mungall W, Kendall TJ, Thomson A, Lennen RJ, Jansen MA, Moran CM, Pellicoro A, Ramachandran P, Shaw I, Aucott RL, Severin T, Saini R, Pak J, Yates D, Dongre N, Duffield JS, Webb DJ, Iredale JP, Hayes PC, Fallowfield JA.

PLoS Med. 2017 Feb 28;14(2):e1002248. doi: 10.1371/journal.pmed.1002248. eCollection 2017 Feb.


Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis.

Erdogan B, Webb DJ.

Biochem Soc Trans. 2017 Feb 8;45(1):229-236. doi: 10.1042/BST20160387. Review.


Real-time kinetic binding studies at attomolar concentrations in solution phase using a single-stage opto-biosensing platform based upon infrared surface plasmons.

Allsop T, Mou C, Neal R, Mariani S, Nagel D, Tombelli S, Poole A, Kalli K, Hine A, Webb DJ, Culverhouse P, Mascini M, Minunni M, Bennion I.

Opt Express. 2017 Jan 9;25(1):39-58. doi: 10.1364/OE.25.000039.


Smooth Muscle Endothelin B Receptors Regulate Blood Pressure but Not Vascular Function or Neointimal Remodeling.

Miller E, Czopek A, Duthie KM, Kirkby NS, van de Putte EE, Christen S, Kimmitt RA, Moorhouse R, Castellan RF, Kotelevtsev YV, Kuc RE, Davenport AP, Dhaun N, Webb DJ, Hadoke PW.

Hypertension. 2017 Feb;69(2):275-285. doi: 10.1161/HYPERTENSIONAHA.115.07031. Epub 2016 Dec 27.


Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit.

Brown JA, Codreanu SG, Shi M, Sherrod SD, Markov DA, Neely MD, Britt CM, Hoilett OS, Reiserer RS, Samson PC, McCawley LJ, Webb DJ, Bowman AB, McLean JA, Wikswo JP.

J Neuroinflammation. 2016 Dec 12;13(1):306.


Chorioretinal thinning in chronic kidney disease links to inflammation and endothelial dysfunction.

Balmforth C, van Bragt JJ, Ruijs T, Cameron JR, Kimmitt R, Moorhouse R, Czopek A, Hu MK, Gallacher PJ, Dear JW, Borooah S, MacIntyre IM, Pearson TM, Willox L, Talwar D, Tafflet M, Roubeix C, Sennlaub F, Chandran S, Dhillon B, Webb DJ, Dhaun N.

JCI Insight. 2016 Dec 8;1(20):e89173. doi: 10.1172/jci.insight.89173.


Biomechanics of cell reorientation in a three-dimensional matrix under compression.

Yang L, Carrington LJ, Erdogan B, Ao M, Brewer BM, Webb DJ, Li D.

Exp Cell Res. 2017 Jan 1;350(1):253-266. doi: 10.1016/j.yexcr.2016.12.002. Epub 2016 Dec 2.


Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells.

Oosthuyzen W, Scullion KM, Ivy JR, Morrison EE, Hunter RW, Starkey Lewis PJ, O'Duibhir E, Street JM, Caporali A, Gregory CD, Forbes SJ, Webb DJ, Bailey MA, Dear JW.

J Am Soc Nephrol. 2016 Nov;27(11):3345-3355. Epub 2016 Mar 28.


Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury.

Vliegenthart A, Kimmitt RA, Seymour JH, Homer NZ, Clarke JI, Eddleston M, Gray A, Wood DM, Dargan PI, Cooper JG, Antoine DJ, Webb DJ, Lewis SC, Bateman DN, Dear JW.

Clin Pharmacol Ther. 2017 Apr;101(4):531-540. doi: 10.1002/cpt.541. Epub 2016 Nov 30.


Arterial stiffness &Sri Lankan chronic kidney disease of unknown origin.

Gifford F, Kimmitt R, Herath C, Webb DJ, Melville V, Siribaddana S, Eddleston M, Dhaun N.

Sci Rep. 2016 Sep 2;6:32599. doi: 10.1038/srep32599.


Hand eczema and steroid-refractory chronic hand eczema in general practice: prevalence and initial treatment.

Crane MM, Webb DJ, Watson E, Cunliffe T, English J.

Br J Dermatol. 2017 Apr;176(4):955-964. doi: 10.1111/bjd.14974. Epub 2017 Mar 8.


Super resolution microscopy is poised to reveal new insights into the formation and maturation of dendritic spines.

Robinson CM, Patel MR, Webb DJ.

F1000Res. 2016 Jun 22;5. pii: F1000 Faculty Rev-1468. doi: 10.12688/f1000research.8649.1. eCollection 2016. Review.


Modelling estimates of the burden of respiratory syncytial virus infection in children in the UK.

Taylor S, Taylor RJ, Lustig RL, Schuck-Paim C, Haguinet F, Webb DJ, Logie J, Matias G, Fleming DM.

BMJ Open. 2016 Jun 2;6(6):e009337. doi: 10.1136/bmjopen-2015-009337.


Thermal effects on the photoelastic coefficient of polymer optical fibers.

Sophie A, Patrick M, Heidi O, Thomas G, Hugo T, Marques CA, Webb DJ, Peng GD, Mergo P, Francis B.

Opt Lett. 2016 Jun 1;41(11):2517-20. doi: 10.1364/OL.41.002517.


A Cross-sectional Study of Current Doctors' Performance in a Modified Version of a Medical School Admission Aptitude Test: The UKCAT.

Blackmur JP, Lone NI, Stone OD, Webb DJ, Dhaun N.

Medicine (Baltimore). 2016 May;95(18):e3506. doi: 10.1097/MD.0000000000003506.


Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes.

Betz BB, Jenks SJ, Cronshaw AD, Lamont DJ, Cairns C, Manning JR, Goddard J, Webb DJ, Mullins JJ, Hughes J, McLachlan S, Strachan MWJ, Price JF, Conway BR.

Kidney Int. 2016 May;89(5):1125-1135. doi: 10.1016/j.kint.2016.01.015. Epub 2016 Mar 7.


New Evidence Supporting the Use of Mineralocorticoid Receptor Blockers in Drug-Resistant Hypertension.

Narayan H, Webb DJ.

Curr Hypertens Rep. 2016 Apr;18(5):34. doi: 10.1007/s11906-016-0643-8. Review.


Implications of the BIA-102474-101 study for review of first-into-human clinical trials.

Eddleston M, Cohen AF, Webb DJ.

Br J Clin Pharmacol. 2016 Apr;81(4):582-6. doi: 10.1111/bcp.12920.



Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ.

Pharmacol Rev. 2016 Apr;68(2):357-418. doi: 10.1124/pr.115.011833. Review.


Glucocorticoids Induce Nondipping Blood Pressure by Activating the Thiazide-Sensitive Cotransporter.

Ivy JR, Oosthuyzen W, Peltz TS, Howarth AR, Hunter RW, Dhaun N, Al-Dujaili EA, Webb DJ, Dear JW, Flatman PW, Bailey MA.

Hypertension. 2016 May;67(5):1029-37. doi: 10.1161/HYPERTENSIONAHA.115.06977. Epub 2016 Mar 7. Erratum in: Hypertension. 2016 Jul;68(1):e5.


Photonic gas sensors exploiting directly the optical properties of hybrid carbon nanotube localized surface plasmon structures.

Allsop T, Arif R, Neal R, Kalli K, Kundrát V, Rozhin A, Culverhouse P, Webb DJ.

Light Sci Appl. 2016 Feb 26;5(2):e16036. doi: 10.1038/lsa.2016.36. eCollection 2016 Feb.


Methods of a large prospective, randomised, open-label, blinded end-point study comparing morning versus evening dosing in hypertensive patients: the Treatment In Morning versus Evening (TIME) study.

Rorie DA, Rogers A, Mackenzie IS, Ford I, Webb DJ, Willams B, Brown M, Poulter N, Findlay E, Saywood W, MacDonald TM.

BMJ Open. 2016 Feb 9;6(2):e010313. doi: 10.1136/bmjopen-2015-010313.

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