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Items: 1 to 50 of 113

1.

Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1.

Powell JA, Pitman MR, Zebol JR, Moretti PAB, Neubauer HA, Davies LT, Lewis AC, Dagley LF, Webb AI, Costabile M, Pitson SM.

Biochem J. 2019 Nov 15;476(21):3211-3226. doi: 10.1042/BCJ20190245.

PMID:
31652307
2.

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.

van Delft MF, Chappaz S, Khakham Y, Bui CT, Debrincat MA, Lowes KN, Brouwer JM, Grohmann C, Sharp PP, Dagley LF, Li L, McArthur K, Luo MX, Chin HS, Fairlie WD, Lee EF, Segal D, Duflocq S, Lessene R, Bernard S, Peilleron L, Nguyen T, Miles C, Wan SS, Lane RM, Wardak A, Lackovic K, Colman PM, Sandow JJ, Webb AI, Czabotar PE, Dewson G, Watson KG, Huang DCS, Lessene G, Kile BT.

Nat Chem Biol. 2019 Oct 7. doi: 10.1038/s41589-019-0365-8. [Epub ahead of print]

PMID:
31591564
3.

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3.

Petrie EJ, Sandow JJ, Lehmann WIL, Liang LY, Coursier D, Young SN, Kersten WJA, Fitzgibbon C, Samson AL, Jacobsen AV, Lowes KN, Au AE, Jousset Sabroux H, Lalaoui N, Webb AI, Lessene G, Manning G, Lucet IS, Murphy JM.

Cell Rep. 2019 Sep 24;28(13):3309-3319.e5. doi: 10.1016/j.celrep.2019.08.055.

4.

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity.

Rautela J, Dagley LF, de Oliveira CC, Schuster IS, Hediyeh-Zadeh S, Delconte RB, Cursons J, Hennessy R, Hutchinson DS, Harrison C, Kita B, Vivier E, Webb AI, Degli-Esposti MA, Davis MJ, Huntington ND, Souza-Fonseca-Guimaraes F.

Sci Signal. 2019 Aug 27;12(596). pii: eaat7527. doi: 10.1126/scisignal.aat7527.

PMID:
31455725
5.

RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses.

Hayman TJ, Hsu AC, Kolesnik TB, Dagley LF, Willemsen J, Tate MD, Baker PJ, Kershaw NJ, Kedzierski L, Webb AI, Wark PA, Kedzierska K, Masters SL, Belz GT, Binder M, Hansbro PM, Nicola NA, Nicholson SE.

Immunol Cell Biol. 2019 Oct;97(9):840-852. doi: 10.1111/imcb.12284. Epub 2019 Aug 19.

PMID:
31335993
6.

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer.

Nguyen PM, Dagley LF, Preaudet A, Lam N, Giam M, Fung KY, Aizel K, van Duijneveldt G, Tan CW, Hirokawa Y, Yip HYK, Love CG, Poh AR, Cruz A, Burstroem C, Feltham R, Abdirahman SM, Meiselbach K, Low RRJ, Palmieri M, Ernst M, Webb AI, Burgess T, Sieber OM, Bouillet P, Putoczki TL.

Cell Death Differ. 2019 Jul 11. doi: 10.1038/s41418-019-0383-9. [Epub ahead of print]

PMID:
31296963
7.

Universal Solid-Phase Protein Preparation (USP3) for Bottom-up and Top-down Proteomics.

Dagley LF, Infusini G, Larsen RH, Sandow JJ, Webb AI.

J Proteome Res. 2019 Jul 5;18(7):2915-2924. doi: 10.1021/acs.jproteome.9b00217. Epub 2019 Jun 10.

PMID:
31137935
8.

BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association.

Dengler MA, Robin AY, Gibson L, Li MX, Sandow JJ, Iyer S, Webb AI, Westphal D, Dewson G, Adams JM.

Cell Rep. 2019 Apr 9;27(2):359-373.e6. doi: 10.1016/j.celrep.2019.03.040.

9.

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.

Wong W, Huang R, Menant S, Hong C, Sandow JJ, Birkinshaw RW, Healer J, Hodder AN, Kanjee U, Tonkin CJ, Heckmann D, Soroka V, Søgaard TMM, Jørgensen T, Duraisingh MT, Czabotar PE, de Jongh WA, Tham WH, Webb AI, Yu Z, Cowman AF.

Nature. 2019 Jan;565(7737):118-121. doi: 10.1038/s41586-018-0779-6. Epub 2018 Dec 12.

PMID:
30542156
10.

Aspartyl Protease 5 Matures Dense Granule Proteins That Reside at the Host-Parasite Interface in Toxoplasma gondii.

Coffey MJ, Dagley LF, Seizova S, Kapp EA, Infusini G, Roos DS, Boddey JA, Webb AI, Tonkin CJ.

MBio. 2018 Oct 30;9(5). pii: e01796-18. doi: 10.1128/mBio.01796-18.

11.

Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii.

Uboldi AD, Wilde ML, McRae EA, Stewart RJ, Dagley LF, Yang L, Katris NJ, Hapuarachchi SV, Coffey MJ, Lehane AM, Botte CY, Waller RF, Webb AI, McConville MJ, Tonkin CJ.

PLoS Biol. 2018 Sep 12;16(9):e2005642. doi: 10.1371/journal.pbio.2005642. eCollection 2018 Sep.

12.

Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase.

Seidi A, Muellner-Wong LS, Rajendran E, Tjhin ET, Dagley LF, Aw VY, Faou P, Webb AI, Tonkin CJ, van Dooren GG.

Elife. 2018 Sep 11;7. pii: e38131. doi: 10.7554/eLife.38131.

13.

Plasma membrane profiling during enterohemorrhagic E. coli infection reveals that the metalloprotease StcE cleaves CD55 from host epithelial surfaces.

Furniss RCD, Low WW, Mavridou DAI, Dagley LF, Webb AI, Tate EW, Clements A.

J Biol Chem. 2018 Nov 2;293(44):17188-17199. doi: 10.1074/jbc.RA118.005114. Epub 2018 Sep 6.

14.

Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells.

Rautela J, Dagley LF, Kratina T, Anthony A, Goh W, Surgenor E, Delconte RB, Webb AI, Elwood N, Groom JR, Souza-Fonseca-Guimaraes F, Corcoran L, Huntington ND.

Mol Immunol. 2018 Aug 23. pii: S0161-5890(18)30681-3. doi: 10.1016/j.molimm.2018.08.017. [Epub ahead of print]

PMID:
30144957
15.

Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte.

Marapana DS, Dagley LF, Sandow JJ, Nebl T, Triglia T, Pasternak M, Dickerman BK, Crabb BS, Gilson PR, Webb AI, Boddey JA, Cowman AF.

Nat Microbiol. 2018 Sep;3(9):1010-1022. doi: 10.1038/s41564-018-0219-2. Epub 2018 Aug 20.

PMID:
30127496
16.

Ensemble Properties of Bax Determine Its Function.

Robin AY, Iyer S, Birkinshaw RW, Sandow J, Wardak A, Luo CS, Shi M, Webb AI, Czabotar PE, Kluck RM, Colman PM.

Structure. 2018 Oct 2;26(10):1346-1359.e5. doi: 10.1016/j.str.2018.07.006. Epub 2018 Aug 16.

17.

Enrichment of extracellular vesicles from human synovial fluid using size exclusion chromatography.

Foers AD, Chatfield S, Dagley LF, Scicluna BJ, Webb AI, Cheng L, Hill AF, Wicks IP, Pang KC.

J Extracell Vesicles. 2018 Jun 26;7(1):1490145. doi: 10.1080/20013078.2018.1490145. eCollection 2018.

18.

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

Petrie EJ, Sandow JJ, Jacobsen AV, Smith BJ, Griffin MDW, Lucet IS, Dai W, Young SN, Tanzer MC, Wardak A, Liang LY, Cowan AD, Hildebrand JM, Kersten WJA, Lessene G, Silke J, Czabotar PE, Webb AI, Murphy JM.

Nat Commun. 2018 Jun 21;9(1):2422. doi: 10.1038/s41467-018-04714-7.

19.

Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL.

Schuelein R, Spencer H, Dagley LF, Li PF, Luo L, Stow JL, Abraham G, Naderer T, Gomez-Valero L, Buchrieser C, Sugimoto C, Yamagishi J, Webb AI, Pasricha S, Hartland EL.

Cell Microbiol. 2018 Sep;20(9):e12852. doi: 10.1111/cmi.12852. Epub 2018 May 18.

PMID:
29691989
20.

Discovery and Validation of Novel Protein Biomarkers in Ovarian Cancer Patient Urine.

Sandow JJ, Rainczuk A, Infusini G, Makanji M, Bilandzic M, Wilson AL, Fairweather N, Stanton PG, Garama D, Gough D, Jobling TW, Webb AI, Stephens AN.

Proteomics Clin Appl. 2018 May;12(3):e1700135. doi: 10.1002/prca.201700135. Epub 2018 Mar 2.

PMID:
29426060
21.

Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted.

Stutz MD, Ojaimi S, Allison C, Preston S, Arandjelovic P, Hildebrand JM, Sandow JJ, Webb AI, Silke J, Alexander WS, Pellegrini M.

Cell Death Differ. 2018 May;25(5):951-965. doi: 10.1038/s41418-017-0031-1. Epub 2017 Dec 11.

22.

Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity.

Woodcock JM, Goodwin KL, Sandow JJ, Coolen C, Perugini MA, Webb AI, Pitson SM, Lopez AF, Carver JA.

J Biol Chem. 2018 Jan 5;293(1):89-99. doi: 10.1074/jbc.M117.801019. Epub 2017 Nov 6.

23.

The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD).

Scott NE, Giogha C, Pollock GL, Kennedy CL, Webb AI, Williamson NA, Pearson JS, Hartland EL.

J Biol Chem. 2017 Oct 20;292(42):17337-17350. doi: 10.1074/jbc.M117.805036. Epub 2017 Aug 31.

24.

Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death.

Sandow JJ, Infusini G, Holik AZ, Brumatti G, Averink TV, Ekert PG, Webb AI.

Proteomics Clin Appl. 2017 Sep;11(9-10). doi: 10.1002/prca.201700013. Epub 2017 May 15.

PMID:
28447382
25.

Pathogenic Acinetobacter species have a functional type I secretion system and contact-dependent inhibition systems.

Harding CM, Pulido MR, Di Venanzio G, Kinsella RL, Webb AI, Scott NE, Pachón J, Feldman MF.

J Biol Chem. 2017 Jun 2;292(22):9075-9087. doi: 10.1074/jbc.M117.781575. Epub 2017 Apr 3.

26.

Erratum: EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Pearson JS, Giogha C, Mühlen S, Nachbur U, Pham CL, Zhang Y, Hildebrand JM, Oates CV, Lung TW, Ingle D, Dagley LF, Bankovacki A, Petrie EJ, Schroeder GN, Crepin VF, Frankel G, Masters SL, Vince J, Murphy JM, Sunde M, Webb AI, Silke J, Hartland EL.

Nat Microbiol. 2017 Feb 13;2:17024. doi: 10.1038/nmicrobiol.2017.24. No abstract available.

27.

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.

Pearson JS, Giogha C, Mühlen S, Nachbur U, Pham CL, Zhang Y, Hildebrand JM, Oates CV, Lung TW, Ingle D, Dagley LF, Bankovacki A, Petrie EJ, Schroeder GN, Crepin VF, Frankel G, Masters SL, Vince J, Murphy JM, Sunde M, Webb AI, Silke J, Hartland EL.

Nat Microbiol. 2017 Jan 13;2:16258. doi: 10.1038/nmicrobiol.2016.258. Erratum in: Nat Microbiol. 2017 Feb 13;2:17024.

28.

SPATA2 - Keeping the TNF signal short and sweet.

Feltham R, Webb AI, Silke J.

EMBO J. 2016 Sep 1;35(17):1848-50. doi: 10.15252/embj.201695061. Epub 2016 Jul 28. No abstract available.

29.

CIS is a potent checkpoint in NK cell-mediated tumor immunity.

Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang JG, Teh C, Firth M, Ushiki T, Andoniou CE, Degli-Esposti MA, Sharp PP, Sanvitale CE, Infusini G, Liau NP, Linossi EM, Burns CJ, Carotta S, Gray DH, Seillet C, Hutchinson DS, Belz GT, Webb AI, Alexander WS, Li SS, Bullock AN, Babon JJ, Smyth MJ, Nicholson SE, Huntington ND.

Nat Immunol. 2016 Jul;17(7):816-24. doi: 10.1038/ni.3470. Epub 2016 May 23.

PMID:
27213690
30.

Proteomic Profiling of Cell Death: Stable Isotope Labeling and Mass Spectrometry Analysis.

Webb AI.

Methods Mol Biol. 2016;1419:277-86. doi: 10.1007/978-1-4939-3581-9_20.

PMID:
27108446
31.

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.

Masters SL, Lagou V, Jéru I, Baker PJ, Van Eyck L, Parry DA, Lawless D, De Nardo D, Garcia-Perez JE, Dagley LF, Holley CL, Dooley J, Moghaddas F, Pasciuto E, Jeandel PY, Sciot R, Lyras D, Webb AI, Nicholson SE, De Somer L, van Nieuwenhove E, Ruuth-Praz J, Copin B, Cochet E, Medlej-Hashim M, Megarbane A, Schroder K, Savic S, Goris A, Amselem S, Wouters C, Liston A.

Sci Transl Med. 2016 Mar 30;8(332):332ra45. doi: 10.1126/scitranslmed.aaf1471.

32.

Regulation of Starch Stores by a Ca(2+)-Dependent Protein Kinase Is Essential for Viable Cyst Development in Toxoplasma gondii.

Uboldi AD, McCoy JM, Blume M, Gerlic M, Ferguson DJ, Dagley LF, Beahan CT, Stapleton DI, Gooley PR, Bacic A, Masters SL, Webb AI, McConville MJ, Tonkin CJ.

Cell Host Microbe. 2015 Dec 9;18(6):670-81. doi: 10.1016/j.chom.2015.11.004.

33.

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.

Tanzer MC, Tripaydonis A, Webb AI, Young SN, Varghese LN, Hall C, Alexander WS, Hildebrand JM, Silke J, Murphy JM.

Biochem J. 2015 Oct 15;471(2):255-65. doi: 10.1042/BJ20150678. Epub 2015 Aug 17.

PMID:
26283547
34.

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production.

Nachbur U, Stafford CA, Bankovacki A, Zhan Y, Lindqvist LM, Fiil BK, Khakham Y, Ko HJ, Sandow JJ, Falk H, Holien JK, Chau D, Hildebrand J, Vince JE, Sharp PP, Webb AI, Jackman KA, Mühlen S, Kennedy CL, Lowes KN, Murphy JM, Gyrd-Hansen M, Parker MW, Hartland EL, Lew AM, Huang DC, Lessene G, Silke J.

Nat Commun. 2015 Mar 17;6:6442. doi: 10.1038/ncomms7442.

PMID:
25778803
35.

Proprotein convertase 5/6 cleaves platelet-derived growth factor A in the human endometrium in preparation for embryo implantation.

Paule S, Nebl T, Webb AI, Vollenhoven B, Rombauts LJ, Nie G.

Mol Hum Reprod. 2015 Mar;21(3):262-70. doi: 10.1093/molehr/gau109. Epub 2014 Nov 27.

PMID:
25429785
36.

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.

Hildebrand JM, Tanzer MC, Lucet IS, Young SN, Spall SK, Sharma P, Pierotti C, Garnier JM, Dobson RC, Webb AI, Tripaydonis A, Babon JJ, Mulcair MD, Scanlon MJ, Alexander WS, Wilks AF, Czabotar PE, Lessene G, Murphy JM, Silke J.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7. doi: 10.1073/pnas.1408987111. Epub 2014 Oct 6.

37.

The cellular redox environment alters antigen presentation.

Trujillo JA, Croft NP, Dudek NL, Channappanavar R, Theodossis A, Webb AI, Dunstone MA, Illing PT, Butler NS, Fett C, Tscharke DC, Rossjohn J, Perlman S, Purcell AW.

J Biol Chem. 2014 Oct 3;289(40):27979-91. doi: 10.1074/jbc.M114.573402. Epub 2014 Aug 18.

38.

A mechanism for actin filament severing by malaria parasite actin depolymerizing factor 1 via a low affinity binding interface.

Wong W, Webb AI, Olshina MA, Infusini G, Tan YH, Hanssen E, Catimel B, Suarez C, Condron M, Angrisano F, Nebi T, Kovar DR, Baum J.

J Biol Chem. 2014 Feb 14;289(7):4043-54. doi: 10.1074/jbc.M113.523365. Epub 2013 Dec 26.

39.

A type III effector antagonizes death receptor signalling during bacterial gut infection.

Pearson JS, Giogha C, Ong SY, Kennedy CL, Kelly M, Robinson KS, Lung TW, Mansell A, Riedmaier P, Oates CV, Zaid A, Mühlen S, Crepin VF, Marches O, Ang CS, Williamson NA, O'Reilly LA, Bankovacki A, Nachbur U, Infusini G, Webb AI, Silke J, Strasser A, Frankel G, Hartland EL.

Nature. 2013 Sep 12;501(7466):247-51. doi: 10.1038/nature12524.

40.

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS.

Immunity. 2013 Sep 19;39(3):443-53. doi: 10.1016/j.immuni.2013.06.018. Epub 2013 Sep 5.

41.

High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties.

Hercus TR, Barry EF, Dottore M, McClure BJ, Webb AI, Lopez AF, Young IG, Murphy JM.

PLoS One. 2013 Aug 26;8(8):e74376. doi: 10.1371/journal.pone.0074376. eCollection 2013.

42.

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

Linossi EM, Chandrashekaran IR, Kolesnik TB, Murphy JM, Webb AI, Willson TA, Kedzierski L, Bullock AN, Babon JJ, Norton RS, Nicola NA, Nicholson SE.

PLoS One. 2013 Aug 21;8(8):e70536. doi: 10.1371/journal.pone.0070536. eCollection 2013.

43.

Lectin switching during dengue virus infection.

Dejnirattisai W, Webb AI, Chan V, Jumnainsong A, Davidson A, Mongkolsapaya J, Screaton G.

J Infect Dis. 2011 Jun 15;203(12):1775-83. doi: 10.1093/infdis/jir173.

44.

Linear ubiquitination prevents inflammation and regulates immune signalling.

Gerlach B, Cordier SM, Schmukle AC, Emmerich CH, Rieser E, Haas TL, Webb AI, Rickard JA, Anderton H, Wong WW, Nachbur U, Gangoda L, Warnken U, Purcell AW, Silke J, Walczak H.

Nature. 2011 Mar 31;471(7340):591-6. doi: 10.1038/nature09816.

PMID:
21455173
45.

Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition.

Theodossis A, Guillonneau C, Welland A, Ely LK, Clements CS, Williamson NA, Webb AI, Wilce JA, Mulder RJ, Dunstone MA, Doherty PC, McCluskey J, Purcell AW, Turner SJ, Rossjohn J.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5534-9. doi: 10.1073/pnas.1000032107. Epub 2010 Mar 8.

46.

Update on drugs prohibited from extralabel use in food animals.

Davis JL, Smith GW, Baynes RE, Tell LA, Webb AI, Riviere JE.

J Am Vet Med Assoc. 2009 Sep 1;235(5):528-34. doi: 10.2460/javma.235.5.528. No abstract available.

PMID:
19719442
47.

Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant.

Butler NS, Theodossis A, Webb AI, Nastovska R, Ramarathinam SH, Dunstone MA, Rossjohn J, Purcell AW, Perlman S.

PLoS Pathog. 2008 Oct;4(10):e1000186. doi: 10.1371/journal.ppat.1000186. Epub 2008 Oct 24.

48.

Structural and biological basis of CTL escape in coronavirus-infected mice.

Butler NS, Theodossis A, Webb AI, Dunstone MA, Nastovska R, Ramarathinam SH, Rossjohn J, Purcell AW, Perlman S.

J Immunol. 2008 Mar 15;180(6):3926-37.

49.

Extralabel use of nonsteroidal anti-inflammatory drugs in cattle.

Smith GW, Davis JL, Tell LA, Webb AI, Riviere JE.

J Am Vet Med Assoc. 2008 Mar 1;232(5):697-701. doi: 10.2460/javma.232.5.697. No abstract available.

PMID:
18312175
50.

Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides.

La Gruta NL, Thomas PG, Webb AI, Dunstone MA, Cukalac T, Doherty PC, Purcell AW, Rossjohn J, Turner SJ.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2034-9. doi: 10.1073/pnas.0711682102. Epub 2008 Jan 31.

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