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Items: 1 to 50 of 183

1.

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics.

Muncie JM, Falcón-Banchs R, Lakins JN, Sohn LL, Weaver VM.

J Vis Exp. 2019 Sep 28;(151). doi: 10.3791/60334.

PMID:
31609314
2.

Controlled modelling of human epiblast and amnion development using stem cells.

Zheng Y, Xue X, Shao Y, Wang S, Esfahani SN, Li Z, Muncie JM, Lakins JN, Weaver VM, Gumucio DL, Fu J.

Nature. 2019 Sep;573(7774):421-425. doi: 10.1038/s41586-019-1535-2. Epub 2019 Sep 11.

PMID:
31511693
3.

Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells.

Eliazer S, Muncie JM, Christensen J, Sun X, D'Urso RS, Weaver VM, Brack AS.

Cell Stem Cell. 2019 Nov 7;25(5):654-665.e4. doi: 10.1016/j.stem.2019.08.007. Epub 2019 Sep 5.

PMID:
31495781
4.

Tissue mechanics, an important regulator of development and disease.

Ayad NME, Kaushik S, Weaver VM.

Philos Trans R Soc Lond B Biol Sci. 2019 Aug 19;374(1779):20180215. doi: 10.1098/rstb.2018.0215. Epub 2019 Jul 1.

PMID:
31431174
5.

The Extracellular Matrix Modulates the Metastatic Journey.

Kai F, Drain AP, Weaver VM.

Dev Cell. 2019 May 6;49(3):332-346. doi: 10.1016/j.devcel.2019.03.026. Review.

PMID:
31063753
6.

Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.

Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC.

Elife. 2018 Oct 9;7. pii: e36045. doi: 10.7554/eLife.36045.

7.

A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.

Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM.

Nat Cell Biol. 2018 Oct;20(10):1203-1214. doi: 10.1038/s41556-018-0183-3. Epub 2018 Sep 10.

PMID:
30202050
8.

More security may actually make us feel less secure.

Weaver VM.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9649-9651. doi: 10.1073/pnas.1813014115. Epub 2018 Sep 10. No abstract available.

9.

Modeling Tissue Polarity in Context.

Tharp KM, Weaver VM.

J Mol Biol. 2018 Sep 28;430(19):3613-3628. doi: 10.1016/j.jmb.2018.07.015. Epub 2018 Jul 25. Review.

10.

Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells.

Sampayo RG, Toscani AM, Rubashkin MG, Thi K, Masullo LA, Violi IL, Lakins JN, Cáceres A, Hines WC, Coluccio Leskow F, Stefani FD, Chialvo DR, Bissell MJ, Weaver VM, Simian M.

J Cell Biol. 2018 Aug 6;217(8):2777-2798. doi: 10.1083/jcb.201703037. Epub 2018 Jul 6.

11.

The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate.

Muncie JM, Weaver VM.

Curr Top Dev Biol. 2018;130:1-37. doi: 10.1016/bs.ctdb.2018.02.002. Epub 2018 Mar 21. Review.

12.

New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.

Samson S, Northey JJ, Plaks V, Baas C, Dean I, LaBarge MA, Goga A, Van't Veer LJ, Weaver VM.

Trends Cancer. 2018 Apr;4(4):260-264. doi: 10.1016/j.trecan.2018.02.002. Epub 2018 Mar 15. Review.

PMID:
29606307
13.

Feeling Stress: The Mechanics of Cancer Progression and Aggression.

Northcott JM, Dean IS, Mouw JK, Weaver VM.

Front Cell Dev Biol. 2018 Feb 28;6:17. doi: 10.3389/fcell.2018.00017. eCollection 2018. Review.

14.

Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers.

Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z.

Genes Dev. 2018 Feb 1;32(3-4):244-257. doi: 10.1101/gad.301366.117. Epub 2018 Feb 26.

15.

Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma.

Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI.

Mol Cancer Res. 2018 May;16(5):777-790. doi: 10.1158/1541-7786.MCR-17-0413. Epub 2018 Feb 5.

16.

A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression.

Woods EC, Kai F, Barnes JM, Pedram K, Pickup MW, Hollander MJ, Weaver VM, Bertozzi CR.

Elife. 2017 Dec 21;6. pii: e25752. doi: 10.7554/eLife.25752.

17.

Excess area dependent scaling behavior of nano-sized membrane tethers.

Ramakrishnan N, Sreeja KK, Roychoudhury A, Eckmann DM, Ayyaswamy PS, Baumgart T, Pucadyil T, Patil S, Weaver VM, Radhakrishnan R.

Phys Biol. 2018 Jan 11;15(2):026002. doi: 10.1088/1478-3975/aa9905.

18.

Tissue Force Programs Cell Fate and Tumor Aggression.

Northey JJ, Przybyla L, Weaver VM.

Cancer Discov. 2017 Nov;7(11):1224-1237. doi: 10.1158/2159-8290.CD-16-0733. Epub 2017 Oct 16. Review.

19.

α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site.

Miroshnikova YA, Rozenberg GI, Cassereau L, Pickup M, Mouw JK, Ou G, Templeman KL, Hannachi EI, Gooch KJ, Sarang-Sieminski AL, García AJ, Weaver VM.

Mol Biol Cell. 2017 Nov 1;28(22):2958-2977. doi: 10.1091/mbc.E17-02-0126. Epub 2017 Sep 6.

20.

Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells.

Pickup MW, Owens P, Gorska AE, Chytil A, Ye F, Shi C, Weaver VM, Kalluri R, Moses HL, Novitskiy SV.

Cancer Immunol Res. 2017 Sep;5(9):718-729. doi: 10.1158/2326-6066.CIR-16-0311. Epub 2017 Aug 3.

21.

Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.

Salvador F, Martin A, López-Menéndez C, Moreno-Bueno G, Santos V, Vázquez-Naharro A, Santamaria PG, Morales S, Dubus PR, Muinelo-Romay L, López-López R, Tung JC, Weaver VM, Portillo F, Cano A.

Cancer Res. 2017 Nov 1;77(21):5846-5859. doi: 10.1158/0008-5472.CAN-16-3152. Epub 2017 Jul 18.

22.

Cell and tissue mechanics: the new cell biology frontier.

Weaver VM.

Mol Biol Cell. 2017 Jul 7;28(14):1815-1818. doi: 10.1091/mbc.E17-05-0320. No abstract available.

23.

Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.

Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF.

Science. 2017 May 12;356(6338). pii: eaal3118. doi: 10.1126/science.aal3118.

24.

Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis.

Oudin MJ, Weaver VM.

Cold Spring Harb Symp Quant Biol. 2016;81:189-205. doi: 10.1101/sqb.2016.81.030817. Epub 2017 Apr 19. Review.

PMID:
28424337
25.

Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy.

Khuc E, Bainer R, Wolf M, Clay SM, Weisenberger DJ, Kemmer J, Weaver VM, Hwang DG, Chan MF.

PLoS One. 2017 Apr 6;12(4):e0175112. doi: 10.1371/journal.pone.0175112. eCollection 2017.

26.

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.

Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM.

Mol Biol Cell. 2017 Jun 1;28(11):1467-1488. doi: 10.1091/mbc.E16-09-0654. Epub 2017 Apr 5.

27.

Tissue mechanics regulate brain development, homeostasis and disease.

Barnes JM, Przybyla L, Weaver VM.

J Cell Sci. 2017 Jan 1;130(1):71-82. doi: 10.1242/jcs.191742. Review.

28.

Force-dependent breaching of the basement membrane.

Chang TT, Thakar D, Weaver VM.

Matrix Biol. 2017 Jan;57-58:178-189. doi: 10.1016/j.matbio.2016.12.005. Epub 2016 Dec 23. Review.

29.

From transformation to metastasis: deconstructing the extracellular matrix in breast cancer.

Kaushik S, Pickup MW, Weaver VM.

Cancer Metastasis Rev. 2016 Dec;35(4):655-667. doi: 10.1007/s10555-016-9650-0.

30.

Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells.

Chan TS, Hsu CC, Pai VC, Liao WY, Huang SS, Tan KT, Yen CJ, Hsu SC, Chen WY, Shan YS, Li CR, Lee MT, Jiang KY, Chu JM, Lien GS, Weaver VM, Tsai KK.

J Exp Med. 2016 Dec 12;213(13):2967-2988. Epub 2016 Nov 23.

31.

Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.

Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM.

Nat Cell Biol. 2016 Dec;18(12):1336-1345. doi: 10.1038/ncb3429. Epub 2016 Nov 7.

32.

Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer.

Takai K, Le A, Weaver VM, Werb Z.

Oncotarget. 2016 Dec 13;7(50):82889-82901. doi: 10.18632/oncotarget.12658.

33.

Cellular adaptation to biomechanical stress across length scales in tissue homeostasis and disease.

Gilbert PM, Weaver VM.

Semin Cell Dev Biol. 2017 Jul;67:141-152. doi: 10.1016/j.semcdb.2016.09.004. Epub 2016 Sep 15. Review.

34.

Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.

Przybyla L, Lakins JN, Weaver VM.

Cell Stem Cell. 2016 Oct 6;19(4):462-475. doi: 10.1016/j.stem.2016.06.018. Epub 2016 Jul 21.

35.

Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions.

Ou G, Thakar D, Tung JC, Miroshnikova YA, Dufort CC, Gutierrez E, Groisman A, Weaver VM.

Integr Biol (Camb). 2016 Jul 11;8(7):795-804. doi: 10.1039/c6ib00031b. Epub 2016 Jun 23.

36.

Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer.

Przybyla L, Muncie JM, Weaver VM.

Annu Rev Cell Dev Biol. 2016 Oct 6;32:527-554. Epub 2016 Jun 8. Review.

PMID:
27298087
37.

Site-Specific Modulation of Charge Controls the Structure and Stimulus Responsiveness of Intrinsically Disordered Peptide Brushes.

Bhagawati M, Rubashkin MG, Lee JP, Ananthanarayanan B, Weaver VM, Kumar S.

Langmuir. 2016 Jun 14;32(23):5990-6. doi: 10.1021/acs.langmuir.6b01099. Epub 2016 Jun 2.

38.

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM.

Nat Med. 2016 May;22(5):497-505. doi: 10.1038/nm.4082. Epub 2016 Apr 18.

39.

Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.

Kai F, Laklai H, Weaver VM.

Trends Cell Biol. 2016 Jul;26(7):486-497. doi: 10.1016/j.tcb.2016.03.007. Epub 2016 Apr 4. Review.

40.

Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness.

Le LT, Cazares O, Mouw JK, Chatterjee S, Macias H, Moran A, Ramos J, Keely PJ, Weaver VM, Hinck L.

J Cell Biol. 2016 Mar 14;212(6):707-19. doi: 10.1083/jcb.201507054.

41.

Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha.

Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang TT.

Hepatology. 2016 Jul;64(1):261-75. doi: 10.1002/hep.28450. Epub 2016 Mar 9.

42.

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.

Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R.

Cancer Cell. 2015 Dec 14;28(6):831-833. doi: 10.1016/j.ccell.2015.11.002. Epub 2015 Dec 14. No abstract available.

43.

Is Early Prescribing of Opioid and Psychotropic Medications Associated With Delayed Return to Work and Increased Final Workers' Compensation Cost?

Tao XG, Lavin RA, Yuspeh L, Weaver VM, Bernacki EJ.

J Occup Environ Med. 2015 Dec;57(12):1315-8. doi: 10.1097/JOM.0000000000000557.

PMID:
26641828
44.

Toxic environmental exposures and kidney health in children.

Weidemann DK, Weaver VM, Fadrowski JJ.

Pediatr Nephrol. 2016 Nov;31(11):2043-54. doi: 10.1007/s00467-015-3222-3. Epub 2015 Oct 12. Review.

45.

Tumor-induced solid stress activates β-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells.

Ou G, Weaver VM.

Bioessays. 2015 Dec;37(12):1293-7. doi: 10.1002/bies.201500090. Epub 2015 Oct 6. Review.

46.

Monitoring developmental force distributions in reconstituted embryonic epithelia.

Przybyla L, Lakins JN, Sunyer R, Trepat X, Weaver VM.

Methods. 2016 Feb 1;94:101-13. doi: 10.1016/j.ymeth.2015.09.003. Epub 2015 Sep 2.

47.

Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors.

Lin CH, Pelissier FA, Zhang H, Lakins J, Weaver VM, Park C, LaBarge MA.

Mol Biol Cell. 2015 Nov 5;26(22):3946-53. doi: 10.1091/mbc.E15-07-0456. Epub 2015 Sep 2.

48.

Global dimensions of chronic kidney disease of unknown etiology (CKDu): a modern era environmental and/or occupational nephropathy?

Weaver VM, Fadrowski JJ, Jaar BG.

BMC Nephrol. 2015 Aug 19;16:145. doi: 10.1186/s12882-015-0105-6. No abstract available.

49.

STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma.

Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA, Persson AI.

Cancer Res. 2015 Oct 15;75(20):4302-11. doi: 10.1158/0008-5472.CAN-14-3331. Epub 2015 Aug 17.

50.

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.

Acerbi I, Cassereau L, Dean I, Shi Q, Au A, Park C, Chen YY, Liphardt J, Hwang ES, Weaver VM.

Integr Biol (Camb). 2015 Oct;7(10):1120-34. doi: 10.1039/c5ib00040h. Epub 2015 May 11.

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