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Items: 1 to 50 of 133

1.

Prior reproduction alters how mitochondria respond to an oxidative event.

Hood WR, Zhang Y, Taylor HA, Park NR, Beatty AE, Weaver RJ, Yap KN, Kavazis AN.

J Exp Biol. 2019 Jun 3. pii: jeb.195545. doi: 10.1242/jeb.195545. [Epub ahead of print]

PMID:
31160425
2.

Hypothesized evolutionary consequences of the alternative oxidase (AOX) in animal mitochondria.

Weaver RJ.

Integr Comp Biol. 2019 Mar 26. pii: icz015. doi: 10.1093/icb/icz015. [Epub ahead of print]

PMID:
30912813
3.

Identification and characterization of a naïve CD8+ T cell repertoire for benzylpenicillin.

Bechara R, Maillere B, Joseph D, Weaver RJ, Pallardy M.

Clin Exp Allergy. 2019 May;49(5):636-643. doi: 10.1111/cea.13338. Epub 2019 Feb 8.

PMID:
30657219
4.

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists.

Patil R, Mohanty B, Liu B, Chandrashekaran IR, Headey SJ, Williams ML, Clements CS, Ilyichova O, Doak BC, Genissel P, Weaver RJ, Vuillard L, Halls ML, Porter CJH, Scanlon MJ.

J Biol Chem. 2019 Mar 8;294(10):3720-3734. doi: 10.1074/jbc.RA118.006848. Epub 2018 Dec 31.

PMID:
30598509
5.

Optimizing drug discovery by Investigative Toxicology: Current and future trends.

Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, Mow T, Newham P, Oinonen T, Pognan F, Roth A, Valentin JP, Van Goethem F, Weaver RJ, Birk B, Boyer S, Caloni F, Chen AE, Corvi R, Cronin MTD, Daneshian M, Ewart LC, Fitzgerald RE, Hamilton GA, Hartung T, Kangas JD, Kramer NI, Leist M, Marx U, Polak S, Rovida C, Testai E, Van der Water B, Vulto P, Steger-Hartmann T.

ALTEX. 2018 Dec 20. doi: 10.14573/altex.1808181. [Epub ahead of print]

6.

Today's Challenges to De-Risk and Predict Drug Safety in Human "Mind-the-Gap".

Weaver RJ, Valentin JP.

Toxicol Sci. 2019 Feb 1;167(2):307-321. doi: 10.1093/toxsci/kfy270.

PMID:
30371856
7.

Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement.

Giustarini G, Vrisekoop N, Kruijssen L, Wagenaar L, van Staveren S, van Roest M, Bleumink R, Bol-Schoenmakers M, Weaver RJ, Koenderman L, Smit J, Pieters R.

Toxicol Sci. 2019 Feb 1;167(2):385-396. doi: 10.1093/toxsci/kfy244.

PMID:
30247740
8.

An in vivo test of the biologically relevant roles of carotenoids as antioxidants in animals.

Weaver RJ, Wang P, Hill GE, Cobine PA.

J Exp Biol. 2018 Aug 13;221(Pt 15). pii: jeb183665. doi: 10.1242/jeb.183665.

9.

Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency.

Tóth B, Jani M, Beéry E, Heslop T, Bayliss M, Kitteringham NR, Park BK, Weaver RJ, Krajcsi P.

Toxicol In Vitro. 2018 Oct;52:189-194. doi: 10.1016/j.tiv.2018.06.018. Epub 2018 Jun 19.

PMID:
29933103
10.

Draft Genome Assembly of the Sheep Scab Mite, Psoroptes ovis.

Burgess STG, Bartley K, Marr EJ, Wright HW, Weaver RJ, Prickett JC, Hughes M, Haldenby S, Thi Le P, Rombauts S, Van Leeuwen T, Van de Peer Y, Nisbet AJ.

Genome Announc. 2018 Apr 19;6(16). pii: e00265-18. doi: 10.1128/genomeA.00265-18.

11.

Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin-induced tumor necrosis factor-dependent liver injury in mice.

Giustarini G, Kruijssen L, van Roest M, Bleumink R, Weaver RJ, Bol-Schoenmakers M, Smit J, Pieters R.

J Appl Toxicol. 2018 May;38(5):753-765. doi: 10.1002/jat.3585. Epub 2018 Jan 26.

PMID:
29377180
12.

Identification of T-cell epitopes from benzylpenicillin conjugated to human serum albumin and implication in penicillin allergy.

Azoury ME, Filì L, Bechara R, Scornet N, de Chaisemartin L, Weaver RJ, Claude N, Maillere B, Parronchi P, Joseph D, Pallardy M.

Allergy. 2018 Aug;73(8):1662-1672. doi: 10.1111/all.13418. Epub 2018 Feb 27.

PMID:
29355985
13.

Carotenoid metabolism strengthens the link between feather coloration and individual quality.

Weaver RJ, Santos ESA, Tucker AM, Wilson AE, Hill GE.

Nat Commun. 2018 Jan 8;9(1):73. doi: 10.1038/s41467-017-02649-z.

14.

A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.

Kaschek D, Sharanek A, Guillouzo A, Timmer J, Weaver RJ.

Toxicol Sci. 2018 Jan 1;161(1):48-57. doi: 10.1093/toxsci/kfx199.

15.

Kinetic characterization of bile salt transport by human NTCP (SLC10A1).

Jani M, Beéry E, Heslop T, Tóth B, Jagota B, Kis E, Kevin Park B, Krajcsi P, Weaver RJ.

Toxicol In Vitro. 2018 Feb;46:189-193. doi: 10.1016/j.tiv.2017.10.012. Epub 2017 Oct 9.

PMID:
29024779
16.

Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury.

Weaver RJ, Betts C, Blomme EAG, Gerets HHJ, Gjervig Jensen K, Hewitt PG, Juhila S, Labbe G, Liguori MJ, Mesens N, Ogese MO, Persson M, Snoeys J, Stevens JL, Walker T, Park BK.

Expert Opin Drug Metab Toxicol. 2017 Jul;13(7):767-782. doi: 10.1080/17425255.2017.1341489. Epub 2017 Jun 28. Review.

PMID:
28604124
17.

What maintains signal honesty in animal colour displays used in mate choice?

Weaver RJ, Koch RE, Hill GE.

Philos Trans R Soc Lond B Biol Sci. 2017 Jul 5;372(1724). pii: 20160343. doi: 10.1098/rstb.2016.0343. Review.

18.

From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells.

Burbank MG, Sharanek A, Burban A, Mialanne H, Aerts H, Guguen-Guillouzo C, Weaver RJ, Guillouzo A.

Toxicol Sci. 2017 Jun 1;157(2):451-464. doi: 10.1093/toxsci/kfx062.

19.

Effect of stress on heat shock protein levels, immune response and survival to fungal infection of Mamestra brassicae larvae.

Richards EH, Dani MP, Lu Y, Butt T, Weaver RJ.

J Insect Physiol. 2017 Jan;96:53-63. doi: 10.1016/j.jinsphys.2016.10.013. Epub 2016 Oct 24.

PMID:
27789295
20.

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.

Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, Hanley NA, Hay DC, Ingelman-Sundberg M, Juhila S, Kitteringham N, Silva-Lima B, Norris A, Pridgeon C, Ross JA, Young RS, Tagle D, Tornesi B, van de Water B, Weaver RJ, Zhang F, Park BK.

Hepatology. 2017 Feb;65(2):710-721. doi: 10.1002/hep.28886. Epub 2016 Nov 30. Review.

21.

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans.

Atienzar FA, Blomme EA, Chen M, Hewitt P, Kenna JG, Labbe G, Moulin F, Pognan F, Roth AB, Suter-Dick L, Ukairo O, Weaver RJ, Will Y, Dambach DM.

Biomed Res Int. 2016;2016:9737920. Epub 2016 Sep 5. Review.

22.

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man.

Dragovic S, Vermeulen NP, Gerets HH, Hewitt PG, Ingelman-Sundberg M, Park BK, Juhila S, Snoeys J, Weaver RJ.

Arch Toxicol. 2016 Dec;90(12):2979-3003. Epub 2016 Sep 22. Review.

23.

Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis.

Burbank MG, Burban A, Sharanek A, Weaver RJ, Guguen-Guillouzo C, Guillouzo A.

Drug Metab Dispos. 2016 Nov;44(11):1780-1793. Epub 2016 Aug 18.

24.

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.

Sison-Young RL, Lauschke VM, Johann E, Alexandre E, Antherieu S, Aerts H, Gerets HHJ, Labbe G, Hoët D, Dorau M, Schofield CA, Lovatt CA, Holder JC, Stahl SH, Richert L, Kitteringham NR, Jones RP, Elmasry M, Weaver RJ, Hewitt PG, Ingelman-Sundberg M, Goldring CE, Park BK.

Arch Toxicol. 2017 Mar;91(3):1385-1400. doi: 10.1007/s00204-016-1745-4. Epub 2016 Jun 25.

25.

Primary screen for potential sheep scab control agents.

Dunn JA, Prickett JC, Collins DA, Weaver RJ.

Vet Parasitol. 2016 Jul 15;224:68-76. doi: 10.1016/j.vetpar.2016.05.019. Epub 2016 May 17.

PMID:
27270393
26.

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication.

Sison-Young RL, Mitsa D, Jenkins RE, Mottram D, Alexandre E, Richert L, Aerts H, Weaver RJ, Jones RP, Johann E, Hewitt PG, Ingelman-Sundberg M, Goldring CE, Kitteringham NR, Park BK.

Toxicol Sci. 2015 Oct;147(2):412-24. doi: 10.1093/toxsci/kfv136. Epub 2015 Jul 8.

27.

Implications of in vitro bioaccessibility differences for the assessment of risks of metals to bats.

Hernout BV, Bowman SR, Weaver RJ, Jayasinghe CJ, Boxall AB.

Environ Toxicol Chem. 2015 Apr;34(4):898-906. doi: 10.1002/etc.2871. Epub 2015 Feb 27.

PMID:
25557058
28.

Quantification of biliary excretion and sinusoidal excretion of 5(6)-carboxy-2',7'-dichlorofluorescein (CDF) in cultured hepatocytes isolated from Sprague Dawley, Wistar and Mrp2-deficient Wistar (TR(-)) rats.

Ellis LC, Grant MH, Hawksworth GM, Weaver RJ.

Toxicol In Vitro. 2014 Sep;28(6):1165-75. doi: 10.1016/j.tiv.2014.05.010. Epub 2014 Jun 4.

PMID:
24907646
29.

PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells.

Rogue A, Anthérieu S, Vluggens A, Umbdenstock T, Claude N, de la Moureyre-Spire C, Weaver RJ, Guillouzo A.

Toxicol Appl Pharmacol. 2014 Apr 1;276(1):73-81. doi: 10.1016/j.taap.2014.02.001. Epub 2014 Feb 15.

30.

Identification and frequency of circulating CD4(+) T lymphocytes specific to Benzylpenicillin in healthy donors.

Nhim C, Delluc S, Halgand F, de Chaisemartin L, Weaver RJ, Claude N, Joseph D, Maillère B, Pallardy M.

Allergy. 2013 Jul;68(7):899-905. doi: 10.1111/all.12173. Epub 2013 Jun 10.

PMID:
23751122
31.

ATP-dependent transport of statins by human and rat MRP2/Mrp2.

Ellis LC, Hawksworth GM, Weaver RJ.

Toxicol Appl Pharmacol. 2013 Jun 1;269(2):187-94. doi: 10.1016/j.taap.2013.03.019. Epub 2013 Apr 2.

PMID:
23562342
32.

Challenges and approaches for the development of safer immunomodulatory biologics.

Sathish JG, Sethu S, Bielsky MC, de Haan L, French NS, Govindappa K, Green J, Griffiths CE, Holgate S, Jones D, Kimber I, Moggs J, Naisbitt DJ, Pirmohamed M, Reichmann G, Sims J, Subramanyam M, Todd MD, Van Der Laan JW, Weaver RJ, Park BK.

Nat Rev Drug Discov. 2013 Apr;12(4):306-24. doi: 10.1038/nrd3974. Review.

PMID:
23535934
33.

Validation of a Gyrolab™ assay for quantification of rituximab in human serum.

Liu XF, Wang X, Weaver RJ, Calliste L, Xia C, He YJ, Chen L.

J Pharmacol Toxicol Methods. 2012 May-Jun;65(3):107-14. doi: 10.1016/j.vascn.2012.03.001. Epub 2012 Mar 8.

PMID:
22406436
34.

Allatotropin, leucokinin and AKH in honey bees and other Hymenoptera.

Veenstra JA, Rodriguez L, Weaver RJ.

Peptides. 2012 May;35(1):122-30. doi: 10.1016/j.peptides.2012.02.019. Epub 2012 Mar 3.

PMID:
22406227
35.

Adipokinetic hormones (AKHs) of sphingid Lepidoptera, including the identification of a second M. sexta AKH.

Weaver RJ, Marco HG, Simek P, Audsley N, Clark KD, Gäde G.

Peptides. 2012 Mar;34(1):44-50. doi: 10.1016/j.peptides.2012.01.009. Epub 2012 Jan 20. Erratum in: Peptides. 2012 Dec;38(2):523.

PMID:
22285789
36.

Determining the source of house flies (Musca domestica) using stable isotope analysis.

Heinrich K, Weaver RJ, Bell HA.

Pest Manag Sci. 2012 Jan;68(1):31-7. doi: 10.1002/ps.2215. Epub 2011 Jun 14.

PMID:
21674752
37.

Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers.

Lappin G, Shishikura Y, Jochemsen R, Weaver RJ, Gesson C, Brian Houston J, Oosterhuis B, Bjerrum OJ, Grynkiewicz G, Alder J, Rowland M, Garner C.

Eur J Pharm Sci. 2011 Jun 14;43(3):141-50. doi: 10.1016/j.ejps.2011.04.009. Epub 2011 Apr 20.

PMID:
21540108
38.

Molecular interactions between wheat and cereal aphid (Sitobion avenae): analysis of changes to the wheat proteome.

Ferry N, Stavroulakis S, Guan W, Davison GM, Bell HA, Weaver RJ, Down RE, Gatehouse JA, Gatehouse AM.

Proteomics. 2011 May;11(10):1985-2002. doi: 10.1002/pmic.200900801. Epub 2011 Apr 18.

PMID:
21500340
39.

Neuropeptides associated with the central nervous system of the cabbage root fly, Delia radicum (L).

Audsley N, Matthews HJ, Down RE, Weaver RJ.

Peptides. 2011 Mar;32(3):434-40. doi: 10.1016/j.peptides.2010.08.028. Epub 2010 Oct 1.

PMID:
20869420
40.

First report of cyromazine resistance in a population of UK house fly (Musca domestica) associated with intensive livestock production.

Bell HA, Robinson KA, Weaver RJ.

Pest Manag Sci. 2010 Jul;66(7):693-5. doi: 10.1002/ps.1945.

PMID:
20533379
41.

Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability.

Lappin G, Shishikura Y, Jochemsen R, Weaver RJ, Gesson C, Houston B, Oosterhuis B, Bjerrum OJ, Rowland M, Garner C.

Eur J Pharm Sci. 2010 May 12;40(2):125-31. doi: 10.1016/j.ejps.2010.03.009. Epub 2010 Mar 20.

PMID:
20307657
42.

MALDI-TOF mass spectrometry approaches to the characterisation of insect neuropeptides.

Weaver RJ, Audsley N.

Methods Mol Biol. 2010;615:101-15. doi: 10.1007/978-1-60761-535-4_8.

PMID:
20013203
43.

Insecticidal activity of scorpion toxin (ButaIT) and snowdrop lectin (GNA) containing fusion proteins towards pest species of different orders.

Fitches EC, Bell HA, Powell ME, Back E, Sargiotti C, Weaver RJ, Gatehouse JA.

Pest Manag Sci. 2010 Jan;66(1):74-83. doi: 10.1002/ps.1833.

PMID:
19728320
44.

Neuropeptide regulators of juvenile hormone synthesis: structures, functions, distribution, and unanswered questions.

Weaver RJ, Audsley N.

Ann N Y Acad Sci. 2009 Apr;1163:316-29. doi: 10.1111/j.1749-6632.2009.04459.x. Review.

PMID:
19456353
45.

The immediate early genes, c-fos, c-jun and AP-1, are early markers of platinum analogue toxicity in human proximal tubular cell primary cultures.

Wainford RD, Weaver RJ, Hawksworth GM.

Toxicol In Vitro. 2009 Aug;23(5):780-8. doi: 10.1016/j.tiv.2009.04.004. Epub 2009 Apr 19.

PMID:
19383537
46.

Degradation of leucomyosuppressin by enzymes in the hemolymph and midgut of Lacanobia oleracea and Spodoptera littoralis (Lepidoptera: Noctuidae) larvae.

Matthews HJ, Audsley N, Weaver RJ.

Peptides. 2009 Mar;30(3):565-70. doi: 10.1016/j.peptides.2008.12.020. Epub 2008 Dec 30.

PMID:
19154766
47.

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

Dauchy S, Dutheil F, Weaver RJ, Chassoux F, Daumas-Duport C, Couraud PO, Scherrmann JM, De Waziers I, Declèves X.

J Neurochem. 2008 Dec;107(6):1518-28. doi: 10.1111/j.1471-4159.2008.05720.x.

48.

Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells.

Dauchy S, Miller F, Couraud PO, Weaver RJ, Weksler B, Romero IA, Scherrmann JM, De Waziers I, Declèves X.

Biochem Pharmacol. 2009 Mar 1;77(5):897-909. doi: 10.1016/j.bcp.2008.11.001. Epub 2008 Nov 12.

PMID:
19041851
49.

N-Methyl-N-Nitrosourea (MNU): A positive control chemical for p53+/- mouse carcinogenicity studies.

Morton D, Bailey KL, Stout CL, Weaver RJ, White KA, Lorenzen MJ, Ball DJ.

Toxicol Pathol. 2008 Dec;36(7):926-31. doi: 10.1177/0192623308324959. Epub 2008 Sep 30.

PMID:
18827072
50.

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