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Preventing dysbiosis of the neonatal mouse intestinal microbiome protects against late-onset sepsis.

Singer JR, Blosser EG, Zindl CL, Silberger DJ, Conlan S, Laufer VA, DiToro D, Deming C, Kumar R, Morrow CD, Segre JA, Gray MJ, Randolph DA, Weaver CT.

Nat Med. 2019 Nov;25(11):1772-1782. doi: 10.1038/s41591-019-0640-y. Epub 2019 Nov 7.


Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf.

Pham D, Moseley CE, Gao M, Savic D, Winstead CJ, Sun M, Kee BL, Myers RM, Weaver CT, Hatton RD.

Cell Rep. 2019 Oct 29;29(5):1203-1220.e7. doi: 10.1016/j.celrep.2019.09.064.


Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection.

Amezcua Vesely MC, Pallis P, Bielecki P, Low JS, Zhao J, Harman CCD, Kroehling L, Jackson R, Bailis W, Licona-Limón P, Xu H, Iijima N, Pillai PS, Kaplan DH, Weaver CT, Kluger Y, Kowalczyk MS, Iwasaki A, Pereira JP, Esplugues E, Gagliani N, Flavell RA.

Cell. 2019 Aug 22;178(5):1176-1188.e15. doi: 10.1016/j.cell.2019.07.032.


Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells.

DiToro D, Winstead CJ, Pham D, Witte S, Andargachew R, Singer JR, Wilson CG, Zindl CL, Luther RJ, Silberger DJ, Weaver BT, Kolawole EM, Martinez RJ, Turner H, Hatton RD, Moon JJ, Way SS, Evavold BD, Weaver CT.

Science. 2018 Sep 14;361(6407). pii: eaao2933. doi: 10.1126/science.aao2933.


IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription.

Whitley SK, Balasubramani A, Zindl CL, Sen R, Shibata Y, Crawford GE, Weathington NM, Hatton RD, Weaver CT.

J Biol Chem. 2018 Oct 12;293(41):15790-15800. doi: 10.1074/jbc.RA118.002721. Epub 2018 Aug 9.


Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection.

Huynh JP, Lin CC, Kimmey JM, Jarjour NN, Schwarzkopf EA, Bradstreet TR, Shchukina I, Shpynov O, Weaver CT, Taneja R, Artyomov MN, Edelson BT, Stallings CL.

J Exp Med. 2018 Jul 2;215(7):1823-1838. doi: 10.1084/jem.20171704. Epub 2018 May 17.


Citrobacter rodentium: a model enteropathogen for understanding the interplay of innate and adaptive components of type 3 immunity.

Silberger DJ, Zindl CL, Weaver CT.

Mucosal Immunol. 2017 Sep;10(5):1108-1117. doi: 10.1038/mi.2017.47. Epub 2017 Jun 14. Review.


T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection.

Moreira-Teixeira L, Redford PS, Stavropoulos E, Ghilardi N, Maynard CL, Weaver CT, Freitas do Rosário AP, Wu X, Langhorne J, O'Garra A.

J Immunol. 2017 Jul 15;199(2):613-623. doi: 10.4049/jimmunol.1601340. Epub 2017 Jun 5.


Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota.

Zhao Q, Harbour SN, Kolde R, Latorre IJ, Tun HM, Schoeb TR, Turner H, Moon JJ, Khafipour E, Xavier RJ, Weaver CT, Elson CO.

J Immunol. 2017 Jul 1;199(1):312-322. doi: 10.4049/jimmunol.1700171. Epub 2017 May 24.


Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence.

Clement M, Marsden M, Stacey MA, Abdul-Karim J, Gimeno Brias S, Costa Bento D, Scurr MJ, Ghazal P, Weaver CT, Carlesso G, Clare S, Jones SA, Godkin A, Jones GW, Humphreys IR.

PLoS Pathog. 2016 Dec 7;12(12):e1006050. doi: 10.1371/journal.ppat.1006050. eCollection 2016 Dec.


IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells.

Yang R, Masters AR, Fortner KA, Champagne DP, Yanguas-Casás N, Silberger DJ, Weaver CT, Haynes L, Rincon M.

J Exp Med. 2016 Oct 17;213(11):2281-2291. Epub 2016 Sep 26.


Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination.

Evonuk KS, Moseley CE, Doyle RE, Weaver CT, DeSilva TM.

J Vis Exp. 2016 Sep 12;(115). doi: 10.3791/54348.


Regulation of Effector Treg Cells in Murine Lupus.

Chandrasekaran U, Yi W, Gupta S, Weng CH, Giannopoulou E, Chinenov Y, Jessberger R, Weaver CT, Bhagat G, Pernis AB.

Arthritis Rheumatol. 2016 Jun;68(6):1454-66. doi: 10.1002/art.39599.


Colonization potential to reconstitute a microbe community in patients detected early after fecal microbe transplant for recurrent C. difficile.

Kumar R, Maynard CL, Eipers P, Goldsmith KT, Ptacek T, Grubbs JA, Dixon P, Howard D, Crossman DK, Crowley MR, Benjamin WH Jr, Lefkowitz EJ, Weaver CT, Rodriguez JM, Morrow CD.

BMC Microbiol. 2016 Jan 13;16:5. doi: 10.1186/s12866-015-0622-2.


IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus.

Manni M, Gupta S, Nixon BG, Weaver CT, Jessberger R, Pernis AB.

PLoS One. 2015 Nov 6;10(11):e0141927. doi: 10.1371/journal.pone.0141927. eCollection 2015.


Daughter's Tolerance of Mom Matters in Mate Choice.

Singer JR, Weaver CT.

Cell. 2015 Jul 30;162(3):467-9. doi: 10.1016/j.cell.2015.07.030.


Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection.

Glennie ND, Yeramilli VA, Beiting DP, Volk SW, Weaver CT, Scott P.

J Exp Med. 2015 Aug 24;212(9):1405-14. doi: 10.1084/jem.20142101. Epub 2015 Jul 27.


Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination.

Evonuk KS, Baker BJ, Doyle RE, Moseley CE, Sestero CM, Johnston BP, De Sarno P, Tang A, Gembitsky I, Hewett SJ, Weaver CT, Raman C, DeSilva TM.

J Immunol. 2015 Jul 15;195(2):450-463. doi: 10.4049/jimmunol.1401108. Epub 2015 Jun 12.


Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis.

Harbour SN, Maynard CL, Zindl CL, Schoeb TR, Weaver CT.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7061-6. doi: 10.1073/pnas.1415675112. Epub 2015 May 18.


T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine.

Dennis KL, Saadalla A, Blatner NR, Wang S, Venkateswaran V, Gounari F, Cheroutre H, Weaver CT, Roers A, Egilmez NK, Khazaie K.

Cancer Immunol Res. 2015 Jul;3(7):806-14. doi: 10.1158/2326-6066.CIR-14-0169. Epub 2015 Apr 8.


Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.

Khan AR, Amu S, Saunders SP, Hams E, Blackshields G, Leonard MO, Weaver CT, Sparwasser T, Sheils O, Fallon PG.

Eur J Immunol. 2015 Jun;45(6):1842-54. doi: 10.1002/eji.201445211. Epub 2015 Apr 14.


IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.

Basu R, Whitley SK, Bhaumik S, Zindl CL, Schoeb TR, Benveniste EN, Pear WS, Hatton RD, Weaver CT.

Nat Immunol. 2015 Mar;16(3):286-95. doi: 10.1038/ni.3099. Epub 2015 Feb 2.


PD-L1hi B cells are critical regulators of humoral immunity.

Khan AR, Hams E, Floudas A, Sparwasser T, Weaver CT, Fallon PG.

Nat Commun. 2015 Jan 22;6:5997. doi: 10.1038/ncomms6997.


Development and survival of Th17 cells within the intestines: the influence of microbiome- and diet-derived signals.

Chewning JH, Weaver CT.

J Immunol. 2014 Nov 15;193(10):4769-77. doi: 10.4049/jimmunol.1401835. Review.


Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1.

Parish IA, Marshall HD, Staron MM, Lang PA, Brüstle A, Chen JH, Cui W, Tsui YC, Perry C, Laidlaw BJ, Ohashi PS, Weaver CT, Kaech SM.

J Clin Invest. 2014 Aug;124(8):3455-68. doi: 10.1172/JCI66108. Epub 2014 Jul 8.


The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells.

Wang Y, Godec J, Ben-Aissa K, Cui K, Zhao K, Pucsek AB, Lee YK, Weaver CT, Yagi R, Lazarevic V.

Immunity. 2014 Mar 20;40(3):355-66. doi: 10.1016/j.immuni.2014.01.002. Epub 2014 Feb 13.


Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription.

Balasubramani A, Winstead CJ, Turner H, Janowski KM, Harbour SN, Shibata Y, Crawford GE, Hatton RD, Weaver CT.

PLoS Genet. 2014 Jan;10(1):e1003969. doi: 10.1371/journal.pgen.1003969. Epub 2014 Jan 9.


Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells.

Dennis KL, Wang Y, Blatner NR, Wang S, Saadalla A, Trudeau E, Roers A, Weaver CT, Lee JJ, Gilbert JA, Chang EB, Khazaie K.

Cancer Res. 2013 Oct 1;73(19):5905-13. doi: 10.1158/0008-5472.CAN-13-1511. Epub 2013 Aug 16.


Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice.

Maseda D, Candando KM, Smith SH, Kalampokis I, Weaver CT, Plevy SE, Poe JC, Tedder TF.

J Immunol. 2013 Sep 1;191(5):2780-2795. doi: 10.4049/jimmunol.1300649. Epub 2013 Aug 5.


Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals.

Bailis W, Yashiro-Ohtani Y, Fang TC, Hatton RD, Weaver CT, Artis D, Pear WS.

Immunity. 2013 Jul 25;39(1):148-59. doi: 10.1016/j.immuni.2013.07.006.


Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.

Pierson W, Cauwe B, Policheni A, Schlenner SM, Franckaert D, Berges J, Humblet-Baron S, Schönefeldt S, Herold MJ, Hildeman D, Strasser A, Bouillet P, Lu LF, Matthys P, Freitas AA, Luther RJ, Weaver CT, Dooley J, Gray DH, Liston A.

Nat Immunol. 2013 Sep;14(9):959-65. doi: 10.1038/ni.2649. Epub 2013 Jul 14.


IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis.

Zindl CL, Lai JF, Lee YK, Maynard CL, Harbour SN, Ouyang W, Chaplin DD, Weaver CT.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12768-73. doi: 10.1073/pnas.1300318110. Epub 2013 Jun 18.


IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism.

Zhao Y, Zhao H, Sun Y, Hao J, Qi X, Zhou X, Wu Z, Wang P, Kaech SM, Weaver CT, Flavell RA, Zhao L, Yao Z, Yin Z.

J Leukoc Biol. 2013 Dec;94(6):1103-12. doi: 10.1189/jlb.0213064. Epub 2013 Jun 14.


Dwelling on T cell fate decisions.

Winstead CJ, Weaver CT.

Cell. 2013 May 9;153(4):739-41. doi: 10.1016/j.cell.2013.04.026.


Linking vitamin d deficiency to inflammatory bowel disease.

Palmer MT, Weaver CT.

Inflamm Bowel Dis. 2013 Sep;19(10):2245-56. doi: 10.1097/MIB.0b013e31828a3b6f. Review.


Allogeneic Th1 cells home to host bone marrow and spleen and mediate IFNγ-dependent aplasia.

Chewning JH, Zhang W, Randolph DA, Swindle CS, Schoeb TR, Weaver CT.

Biol Blood Marrow Transplant. 2013 Jun;19(6):876-87. doi: 10.1016/j.bbmt.2013.03.007. Epub 2013 Mar 21.


The Th17 family: flexibility follows function.

Basu R, Hatton RD, Weaver CT.

Immunol Rev. 2013 Mar;252(1):89-103. doi: 10.1111/imr.12035. Review.


Retinoic acid hypersensitivity promotes peripheral tolerance in recent thymic emigrants.

Bhaumik S, Giffon T, Bolinger D, Kirkman R, Lewis DB, Weaver CT, Randolph DA.

J Immunol. 2013 Mar 15;190(6):2603-13. doi: 10.4049/jimmunol.1200852. Epub 2013 Feb 11.


Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria.

Basu R, O'Quinn DB, Silberger DJ, Schoeb TR, Fouser L, Ouyang W, Hatton RD, Weaver CT.

Immunity. 2012 Dec 14;37(6):1061-75. doi: 10.1016/j.immuni.2012.08.024. Epub 2012 Nov 29.


The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin.

Weaver CT, Elson CO, Fouser LA, Kolls JK.

Annu Rev Pathol. 2013 Jan 24;8:477-512. doi: 10.1146/annurev-pathol-011110-130318. Epub 2012 Nov 15. Review.


Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to Porphyromonas gingivalis.

Gaddis DE, Maynard CL, Weaver CT, Michalek SM, Katz J.

J Leukoc Biol. 2013 Jan;93(1):21-31. doi: 10.1189/jlb.0512220. Epub 2012 Oct 17.


Reciprocal interactions of the intestinal microbiota and immune system.

Maynard CL, Elson CO, Hatton RD, Weaver CT.

Nature. 2012 Sep 13;489(7415):231-41. doi: 10.1038/nature11551. Review.


γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.

Zeng X, Wei YL, Huang J, Newell EW, Yu H, Kidd BA, Kuhns MS, Waters RW, Davis MM, Weaver CT, Chien YH.

Immunity. 2012 Sep 21;37(3):524-34. doi: 10.1016/j.immuni.2012.06.011. Epub 2012 Sep 6.


The β-glucan receptor dectin-1 promotes lung immunopathology during fungal allergy via IL-22.

Lilly LM, Gessner MA, Dunaway CW, Metz AE, Schwiebert L, Weaver CT, Brown GD, Steele C.

J Immunol. 2012 Oct 1;189(7):3653-60. Epub 2012 Aug 29.


Stem-cell-like qualities of immune memory; CD4+ T cells join the party.

Luckey CJ, Weaver CT.

Cell Stem Cell. 2012 Feb 3;10(2):107-8. doi: 10.1016/j.stem.2012.01.011.


Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo.

Maseda D, Smith SH, DiLillo DJ, Bryant JM, Candando KM, Weaver CT, Tedder TF.

J Immunol. 2012 Feb 1;188(3):1036-48. doi: 10.4049/jimmunol.1102500. Epub 2011 Dec 23.


Th17 cells mediate clade-specific, serotype-independent mucosal immunity.

Chen K, McAleer JP, Lin Y, Paterson DL, Zheng M, Alcorn JF, Weaver CT, Kolls JK.

Immunity. 2011 Dec 23;35(6):997-1009. doi: 10.1016/j.immuni.2011.10.018.


Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity.

Lang PA, Lang KS, Xu HC, Grusdat M, Parish IA, Recher M, Elford AR, Dhanji S, Shaabani N, Tran CW, Dissanayake D, Rahbar R, Ghazarian M, Brüstle A, Fine J, Chen P, Weaver CT, Klose C, Diefenbach A, Häussinger D, Carlyle JR, Kaech SM, Mak TW, Ohashi PS.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1210-5. doi: 10.1073/pnas.1118834109. Epub 2011 Dec 13.


B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice.

Teichmann LL, Kashgarian M, Weaver CT, Roers A, Müller W, Shlomchik MJ.

J Immunol. 2012 Jan 15;188(2):678-85. doi: 10.4049/jimmunol.1102456. Epub 2011 Dec 9.


Developmental regulation of Th17-cell capacity in human neonates.

Black A, Bhaumik S, Kirkman RL, Weaver CT, Randolph DA.

Eur J Immunol. 2012 Feb;42(2):311-9. doi: 10.1002/eji.201141847. Epub 2011 Dec 19.

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