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Items: 29


Host-Response Subphenotypes Offer Prognostic Enrichment in Patients With or at Risk for Acute Respiratory Distress Syndrome.

Kitsios GD, Yang L, Manatakis DV, Nouraie M, Evankovich J, Bain W, Dunlap DG, Shah F, Barbash IJ, Rapport SF, Zhang Y, DeSensi RS, Weathington NM, Chen BB, Ray P, Mallampalli RK, Benos PV, Lee JS, Morris A, McVerry BJ.

Crit Care Med. 2019 Dec;47(12):1724-1734. doi: 10.1097/CCM.0000000000004018.


The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation.

Li L, Wei J, Li S, Jacko AM, Weathington NM, Mallampalli RK, Zhao J, Zhao Y.

EBioMedicine. 2019 Jul;45:553-562. doi: 10.1016/j.ebiom.2019.06.011. Epub 2019 Jun 14.


Ex vivo lung perfusion as a human platform for preclinical small molecule testing.

Weathington NM, Álvarez D, Sembrat J, Radder J, Cárdenes N, Noda K, Gong Q, Wong H, Kolls J, D'Cunha J, Mallampalli RK, Chen BB, Rojas M.

JCI Insight. 2018 Oct 4;3(19). pii: 95515. doi: 10.1172/jci.insight.95515.


IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription.

Whitley SK, Balasubramani A, Zindl CL, Sen R, Shibata Y, Crawford GE, Weathington NM, Hatton RD, Weaver CT.

J Biol Chem. 2018 Oct 12;293(41):15790-15800. doi: 10.1074/jbc.RA118.002721. Epub 2018 Aug 9.


Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells.

Wang D, Zhao J, Li S, Wei J, Nan L, Mallampalli RK, Weathington NM, Ma H, Zhao Y.

J Mol Cell Biol. 2018 Feb 1;10(1):60-73. doi: 10.1093/jmcb/mjx034.


Post-translational modification of the interferon-gamma receptor alters its stability and signaling.

Londino JD, Gulick DL, Lear TB, Suber TL, Weathington NM, Masa LS, Chen BB, Mallampalli RK.

Biochem J. 2017 Oct 10;474(20):3543-3557. doi: 10.1042/BCJ20170548.


The deubiquitinating enzyme USP48 stabilizes TRAF2 and reduces E-cadherin-mediated adherens junctions.

Li S, Wang D, Zhao J, Weathington NM, Shang D, Zhao Y.

FASEB J. 2018 Jan;32(1):230-242. doi: 10.1096/fj.201700415RR. Epub 2017 Sep 5.


Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation.

Lendermon EA, Coon TA, Bednash JS, Weathington NM, McDyer JF, Mallampalli RK.

Respir Res. 2017 Jun 28;18(1):131. doi: 10.1186/s12931-017-0608-8.


IL-4 Induces IL17Rb Gene Transcription in Monocytic Cells with Coordinate Autocrine IL-25 Signaling.

Weathington NM, Kanth SM, Gong Q, Londino J, Hoji A, Rojas M, Trudeau J, Wenzel S, Mallampalli RK.

Am J Respir Cell Mol Biol. 2017 Sep;57(3):346-354. doi: 10.1165/rcmb.2016-0316OC.


Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia.

Zou C, Li J, Xiong S, Chen Y, Wu Q, Li X, Weathington NM, Han S, Snavely C, Chen BB, Mallampalli RK.

Sci Transl Med. 2015 Oct 28;7(311):311ra171. doi: 10.1126/scitranslmed.aac7793.


The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor.

Franz J, Jerome J, Lear T, Gong Q, Weathington NM.

J Immunol Res. 2015;2015:912713. doi: 10.1155/2015/912713. Epub 2015 Jun 11.


The proinflammatory role of HECTD2 in innate immunity and experimental lung injury.

Coon TA, McKelvey AC, Lear T, Rajbhandari S, Dunn SR, Connelly W, Zhao JY, Han S, Liu Y, Weathington NM, McVerry BJ, Zhang Y, Chen BB.

Sci Transl Med. 2015 Jul 8;7(295):295ra109. doi: 10.1126/scitranslmed.aab3881.


Novel PDE4 inhibitors derived from Chinese medicine forsythia.

Coon TA, McKelvey AC, Weathington NM, Birru RL, Lear T, Leikauf GD, Chen BB.

PLoS One. 2014 Dec 30;9(12):e115937. doi: 10.1371/journal.pone.0115937. eCollection 2014.


CD8(+)IL-17(+) T Cells Mediate Neutrophilic Airway Obliteration in T-bet-Deficient Mouse Lung Allograft Recipients.

Lendermon EA, Dodd-o JM, Coon TA, Miller HL, Ganguly S, Popescu I, O'Donnell CP, Cardenes N, Levine M, Rojas M, Weathington NM, Zhao J, Zhao Y, McDyer JF.

Am J Respir Cell Mol Biol. 2015 May;52(5):622-33. doi: 10.1165/rcmb.2014-0059OC.


Serum starvation regulates E-cadherin upregulation via activation of c-Src in non-small-cell lung cancer A549 cells.

Dong S, Khoo A, Wei J, Bowser RK, Weathington NM, Xiao S, Zhang L, Ma H, Zhao Y, Zhao J.

Am J Physiol Cell Physiol. 2014 Nov 1;307(9):C893-9. doi: 10.1152/ajpcell.00132.2014. Epub 2014 Aug 27.


Glycogen synthase kinase-3β stabilizes the interleukin (IL)-22 receptor from proteasomal degradation in murine lung epithelia.

Weathington NM, Snavely CA, Chen BB, Zhao J, Zhao Y, Mallampalli RK.

J Biol Chem. 2014 Jun 20;289(25):17610-9. doi: 10.1074/jbc.M114.551747. Epub 2014 Apr 17.


Emerging therapies targeting the ubiquitin proteasome system in cancer.

Weathington NM, Mallampalli RK.

J Clin Invest. 2014 Jan;124(1):6-12. doi: 10.1172/JCI71602. Epub 2014 Jan 2.


Targeting F box protein Fbxo3 to control cytokine-driven inflammation.

Mallampalli RK, Coon TA, Glasser JR, Wang C, Dunn SR, Weathington NM, Zhao J, Zou C, Zhao Y, Chen BB.

J Immunol. 2013 Nov 15;191(10):5247-55. doi: 10.4049/jimmunol.1300456. Epub 2013 Oct 11.


The emerging role of the ubiquitin proteasome in pulmonary biology and disease.

Weathington NM, Sznajder JI, Mallampalli RK.

Am J Respir Crit Care Med. 2013 Sep 1;188(5):530-7. doi: 10.1164/rccm.201304-0754PP. Review. Erratum in: Am J Respir Crit Care Med. 2013 Nov 15;188(10):1271.


New insights on the function of SCF ubiquitin E3 ligases in the lung.

Weathington NM, Mallampalli RK.

Cell Signal. 2013 Sep;25(9):1792-8. doi: 10.1016/j.cellsig.2013.05.003. Epub 2013 May 14. Review.


MMP-9 cleaves SP-D and abrogates its innate immune functions in vitro.

Bratcher PE, Weathington NM, Nick HJ, Jackson PL, Snelgrove RJ, Gaggar A.

PLoS One. 2012;7(7):e41881. doi: 10.1371/journal.pone.0041881. Epub 2012 Jul 30.


Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: implications to cystic fibrosis proteolytic dysfunction.

Jackson PL, Xu X, Wilson L, Weathington NM, Clancy JP, Blalock JE, Gaggar A.

Mol Med. 2010 May-Jun;16(5-6):159-66. doi: 10.2119/molmed.2009.00109. Epub 2010 Jan 22.


Attacking the multi-tiered proteolytic pathology of COPD: new insights from basic and translational studies.

Djekic UV, Gaggar A, Weathington NM.

Pharmacol Ther. 2009 Feb;121(2):132-46. doi: 10.1016/j.pharmthera.2008.09.008. Epub 2008 Oct 31. Review.


Induction of lung emphysema is prevented by L-arginine-threonine-arginine.

van Houwelingen AH, Weathington NM, Verweij V, Blalock JE, Nijkamp FP, Folkerts G.

FASEB J. 2008 Sep;22(9):3403-8. doi: 10.1096/fj.07-096230. Epub 2008 Jun 12.


Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation.

Xing D, Feng W, Miller AP, Weathington NM, Chen YF, Novak L, Blalock JE, Oparil S.

Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2607-12. Epub 2007 Jan 19.


Possible therapeutic vaccines for canine myasthenia gravis: implications for the human disease and associated fatigue.

Galin FS, Chrisman CL, Cook JR Jr, Xu L, Jackson PL, Noerager BD, Weathington NM, Blalock JE.

Brain Behav Immun. 2007 Mar;21(3):323-31. Epub 2006 Nov 20.


A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation.

Weathington NM, van Houwelingen AH, Noerager BD, Jackson PL, Kraneveld AD, Galin FS, Folkerts G, Nijkamp FP, Blalock JE.

Nat Med. 2006 Mar;12(3):317-23. Epub 2006 Feb 12.


Estrogen modulates inflammatory mediator expression and neutrophil chemotaxis in injured arteries.

Miller AP, Feng W, Xing D, Weathington NM, Blalock JE, Chen YF, Oparil S.

Circulation. 2004 Sep 21;110(12):1664-9. Epub 2004 Sep 7.


Rational design of peptide vaccines for autoimmune disease: harnessing molecular recognition to fix a broken network.

Weathington NM, Blalock JE.

Expert Rev Vaccines. 2003 Feb;2(1):61-73. Review.


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