Sort by
Items per page

Send to

Choose Destination

Search results

Items: 28


Roles of HIF1 and HIF2 in pulmonary hypertension: it all depends on the context.

Waypa GB, Schumacker PT.

Eur Respir J. 2019 Dec 12;54(6). pii: 1901929. doi: 10.1183/13993003.01929-2019. Print 2019 Dec. No abstract available.


JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension.

Sala MA, Chen C, Zhang Q, Do-Umehara HC, Wu W, Misharin AV, Waypa GB, Fang D, Budinger GRS, Liu S, Chandel NS, Schumacker PT, Sznajder JI, Liu J.

J Biol Chem. 2018 Jan 5;293(1):271-284. doi: 10.1074/jbc.RA117.000440. Epub 2017 Nov 8.


Aberrant cGMP signaling persists during recovery in mice with oxygen-induced pulmonary hypertension.

Perez M, Lee KJ, Cardona HJ, Taylor JM, Robbins ME, Waypa GB, Berkelhamer SK, Farrow KN.

PLoS One. 2017 Aug 9;12(8):e0180957. doi: 10.1371/journal.pone.0180957. eCollection 2017.


Redox signaling during hypoxia in mammalian cells.

Smith KA, Waypa GB, Schumacker PT.

Redox Biol. 2017 Oct;13:228-234. doi: 10.1016/j.redox.2017.05.020. Epub 2017 May 31. Review.


O2 sensing, mitochondria and ROS signaling: The fog is lifting.

Waypa GB, Smith KA, Schumacker PT.

Mol Aspects Med. 2016 Feb-Mar;47-48:76-89. doi: 10.1016/j.mam.2016.01.002. Epub 2016 Jan 14. Review.


Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α.

Ball MK, Waypa GB, Mungai PT, Nielsen JM, Czech L, Dudley VJ, Beussink L, Dettman RW, Berkelhamer SK, Steinhorn RH, Shah SJ, Schumacker PT.

Am J Respir Crit Care Med. 2014 Feb 1;189(3):314-24. doi: 10.1164/rccm.201302-0302OC.


Isolation of pulmonary artery smooth muscle cells from neonatal mice.

Lee KJ, Czech L, Waypa GB, Farrow KN.

J Vis Exp. 2013 Oct 19;(80):e50889. doi: 10.3791/50889.


Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension.

Waypa GB, Osborne SW, Marks JD, Berkelhamer SK, Kondapalli J, Schumacker PT.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):885-91. doi: 10.1165/rcmb.2013-0191OC.


Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling.

Sabharwal SS, Waypa GB, Marks JD, Schumacker PT.

Biochem J. 2013 Dec 15;456(3):337-46. doi: 10.1042/BJ20130740.


Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation.

Waypa GB, Marks JD, Guzy RD, Mungai PT, Schriewer JM, Dokic D, Ball MK, Schumacker PT.

Am J Respir Crit Care Med. 2013 Feb 15;187(4):424-32. doi: 10.1164/rccm.201207-1294OC. Epub 2013 Jan 17.


Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels.

Mungai PT, Waypa GB, Jairaman A, Prakriya M, Dokic D, Ball MK, Schumacker PT.

Mol Cell Biol. 2011 Sep;31(17):3531-45. doi: 10.1128/MCB.05124-11. Epub 2011 Jun 13.


Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion.

Loor G, Kondapalli J, Iwase H, Chandel NS, Waypa GB, Guzy RD, Vanden Hoek TL, Schumacker PT.

Biochim Biophys Acta. 2011 Jul;1813(7):1382-94. doi: 10.1016/j.bbamcr.2010.12.008. Epub 2010 Dec 23.


Hypoxia-induced changes in pulmonary and systemic vascular resistance: where is the O2 sensor?

Waypa GB, Schumacker PT.

Respir Physiol Neurobiol. 2010 Dec 31;174(3):201-11. doi: 10.1016/j.resp.2010.08.007. Epub 2010 Aug 14. Review.


Grape seed proanthocyanidins ameliorate Doxorubicin-induced cardiotoxicity.

Li J, Liu H, Ramachandran S, Waypa GB, Yin JJ, Li CQ, Han M, Huang HH, Sillard WW, Vanden Hoek TL, Shao ZH.

Am J Chin Med. 2010;38(3):569-84.


Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells.

Waypa GB, Marks JD, Guzy R, Mungai PT, Schriewer J, Dokic D, Schumacker PT.

Circ Res. 2010 Feb 19;106(3):526-35. doi: 10.1161/CIRCRESAHA.109.206334. Epub 2009 Dec 17.


Hypoxia increases ROS signaling and cytosolic Ca(2+) in pulmonary artery smooth muscle cells of mouse lungs slices.

Desireddi JR, Farrow KN, Marks JD, Waypa GB, Schumacker PT.

Antioxid Redox Signal. 2010 Mar 1;12(5):595-602. doi: 10.1089/ars.2009.2862.


Prolonged hypoxia increases ROS signaling and RhoA activation in pulmonary artery smooth muscle and endothelial cells.

Chi AY, Waypa GB, Mungai PT, Schumacker PT.

Antioxid Redox Signal. 2010 Mar 1;12(5):603-10. doi: 10.1089/ars.2009.2861.


Oxygen sensing in hypoxic pulmonary vasoconstriction: using new tools to answer an age-old question.

Waypa GB, Schumacker PT.

Exp Physiol. 2008 Jan;93(1):133-8. Epub 2007 Nov 9. Review.


Oxidant stress during simulated ischemia primes cardiomyocytes for cell death during reperfusion.

Robin E, Guzy RD, Loor G, Iwase H, Waypa GB, Marks JD, Hoek TL, Schumacker PT.

J Biol Chem. 2007 Jun 29;282(26):19133-43. Epub 2007 May 7.


Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells.

Waypa GB, Guzy R, Mungai PT, Mack MM, Marks JD, Roe MW, Schumacker PT.

Circ Res. 2006 Oct 27;99(9):970-8. Epub 2006 Sep 28.


Role for mitochondrial reactive oxygen species in hypoxic pulmonary vasoconstriction.

Waypa GB, Schumacker PT.

Novartis Found Symp. 2006;272:176-92; discussion 192-5, 214-7. Review.


Cytotoxicity induced by grape seed proanthocyanidins: role of nitric oxide.

Shao ZH, Hsu CW, Chang WT, Waypa GB, Li J, Li D, Li CQ, Anderson T, Qin Y, Schumacker PT, Becker LB, Hoek TL.

Cell Biol Toxicol. 2006 May;22(3):149-58.


Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing.

Waypa GB, Schumacker PT.

J Appl Physiol (1985). 2005 Jan;98(1):404-14. Review.


Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes.

Waypa GB, Marks JD, Mack MM, Boriboun C, Mungai PT, Schumacker PT.

Circ Res. 2002 Oct 18;91(8):719-26.


O(2) sensing in hypoxic pulmonary vasoconstriction: the mitochondrial door re-opens.

Waypa GB, Schumacker PT.

Respir Physiol Neurobiol. 2002 Aug 22;132(1):81-91. Review.


Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing.

Waypa GB, Chandel NS, Schumacker PT.

Circ Res. 2001 Jun 22;88(12):1259-66.


Oxidant-increased endothelial permeability: prevention with phosphodiesterase inhibition vs. cAMP production.

Waypa GB, Morton CA, Vincent PA, Mahoney JR Jr, Johnston WK 3rd, Minnear FL.

J Appl Physiol (1985). 2000 Mar;88(3):835-42.


Thrombin increases fluid flux in isolated rat lungs by a hemodynamic and not a permeability mechanism.

Waypa GB, Vincent PA, Morton CA, Minnear FL.

J Appl Physiol (1985). 1996 Apr;80(4):1197-204.


Supplemental Content

Loading ...
Support Center