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Rational Design of a Bifunctional AND-Gate Ligand to Modulate Cell-Cell Interactions.

Lee J, Vernet A, Redfield K, Lu S, Ghiran IC, Way JC, Silver PA.

ACS Synth Biol. 2019 Dec 13. doi: 10.1021/acssynbio.9b00273. [Epub ahead of print]


Engineered Interspecies Amino Acid Cross-Feeding Increases Population Evenness in a Synthetic Bacterial Consortium.

Ziesack M, Gibson T, Oliver JKW, Shumaker AM, Hsu BB, Riglar DT, Giessen TW, DiBenedetto NV, Bry L, Way JC, Silver PA, Gerber GK.

mSystems. 2019 Aug 13;4(4). pii: e00352-19. doi: 10.1128/mSystems.00352-19.


Synthetic Gene Circuits Enable Systems-Level Biosensor Trigger Discovery at the Host-Microbe Interface.

Naydich AD, Nangle SN, Bues JJ, Trivedi D, Nissar N, Inniss MC, Niederhuber MJ, Way JC, Silver PA, Riglar DT.

mSystems. 2019 Jun 11;4(4). pii: e00125-19. doi: 10.1128/mSystems.00125-19.


Quorum Sensing Can Be Repurposed To Promote Information Transfer between Bacteria in the Mammalian Gut.

Kim S, Kerns SJ, Ziesack M, Bry L, Gerber GK, Way JC, Silver PA.

ACS Synth Biol. 2018 Sep 21;7(9):2270-2281. doi: 10.1021/acssynbio.8b00271. Epub 2018 Aug 31.


Mammalian Cells Engineered To Produce New Steroids.

Spady ES, Wyche TP, Rollins NJ, Clardy J, Way JC, Silver PA.

Chembiochem. 2018 Sep 4;19(17):1827-1833. doi: 10.1002/cbic.201800214. Epub 2018 Jul 26.


Chimeric Fatty Acyl-Acyl Carrier Protein Thioesterases Provide Mechanistic Insight into Enzyme Specificity and Expression.

Ziesack M, Rollins N, Shah A, Dusel B, Webster G, Silver PA, Way JC.

Appl Environ Microbiol. 2018 May 1;84(10). pii: e02868-17. doi: 10.1128/AEM.02868-17. Print 2018 May 15.


Synthetic genome recoding: new genetic codes for new features.

Kuo J, Stirling F, Lau YH, Shulgina Y, Way JC, Silver PA.

Curr Genet. 2018 Apr;64(2):327-333. doi: 10.1007/s00294-017-0754-z. Epub 2017 Oct 5. Review.


Using Engineered Bacteria to Characterize Infection Dynamics and Antibiotic Effects In Vivo.

Certain LK, Way JC, Pezone MJ, Collins JJ.

Cell Host Microbe. 2017 Sep 13;22(3):263-268.e4. doi: 10.1016/j.chom.2017.08.001. Epub 2017 Aug 31.


Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation.

Riglar DT, Giessen TW, Baym M, Kerns SJ, Niederhuber MJ, Bronson RT, Kotula JW, Gerber GK, Way JC, Silver PA.

Nat Biotechnol. 2017 Jul;35(7):653-658. doi: 10.1038/nbt.3879. Epub 2017 May 29.


Large-scale recoding of a bacterial genome by iterative recombineering of synthetic DNA.

Lau YH, Stirling F, Kuo J, Karrenbelt MAP, Chan YA, Riesselman A, Horton CA, Schäfer E, Lips D, Weinstock MT, Gibson DG, Way JC, Silver PA.

Nucleic Acids Res. 2017 Jun 20;45(11):6971-6980. doi: 10.1093/nar/gkx415.


Efficient size-independent chromosome delivery from yeast to cultured cell lines.

Brown DM, Chan YA, Desai PJ, Grzesik P, Oldfield LM, Vashee S, Way JC, Silver PA, Glass JI.

Nucleic Acids Res. 2017 Apr 20;45(7):e50. doi: 10.1093/nar/gkw1252.


Pulse Detecting Genetic Circuit - A New Design Approach.

Noman N, Inniss M, Iba H, Way JC.

PLoS One. 2016 Dec 1;11(12):e0167162. doi: 10.1371/journal.pone.0167162. eCollection 2016.


Engineering Genetically-Encoded Mineralization and Magnetism via Directed Evolution.

Liu X, Lopez PA, Giessen TW, Giles M, Way JC, Silver PA.

Sci Rep. 2016 Nov 29;6:38019. doi: 10.1038/srep38019.


Creating Single-Copy Genetic Circuits.

Lee JW, Gyorgy A, Cameron DE, Pyenson N, Choi KR, Way JC, Silver PA, Del Vecchio D, Collins JJ.

Mol Cell. 2016 Jul 21;63(2):329-336. doi: 10.1016/j.molcel.2016.06.006. Epub 2016 Jul 14.


GENOME ENGINEERING. The Genome Project-Write.

Boeke JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R, Chakravarti A, Cornish VW, Holt L, Isaacs FJ, Kuiken T, Lajoie M, Lessor T, Lunshof J, Maurano MT, Mitchell LA, Rine J, Rosser S, Sanjana NE, Silver PA, Valle D, Wang H, Way JC, Yang L.

Science. 2016 Jul 8;353(6295):126-7. doi: 10.1126/science.aaf6850. Epub 2016 Jun 2. No abstract available.


Targeted erythropoietin selectively stimulates red blood cell expansion in vivo.

Burrill DR, Vernet A, Collins JJ, Silver PA, Way JC.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5245-50. doi: 10.1073/pnas.1525388113. Epub 2016 Apr 25.


Engineering acyl carrier protein to enhance production of shortened fatty acids.

Liu X, Hicks WM, Silver PA, Way JC.

Biotechnol Biofuels. 2016 Feb 2;9:24. doi: 10.1186/s13068-016-0430-4. eCollection 2016.


Production of fatty acids in Ralstonia eutropha H16 by engineering β-oxidation and carbon storage.

Chen JS, Colón B, Dusel B, Ziesack M, Way JC, Torella JP.

PeerJ. 2015 Dec 7;3:e1468. doi: 10.7717/peerj.1468. eCollection 2015.


Enhancement of E. coli acyl-CoA synthetase FadD activity on medium chain fatty acids.

Ford TJ, Way JC.

PeerJ. 2015 Jun 30;3:e1040. doi: 10.7717/peerj.1040. eCollection 2015.


Efficient solar-to-fuels production from a hybrid microbial-water-splitting catalyst system.

Torella JP, Gagliardi CJ, Chen JS, Bediako DK, Colón B, Way JC, Silver PA, Nocera DG.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2337-42. doi: 10.1073/pnas.1424872112. Epub 2015 Feb 9. Erratum in: Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1507.


Unique nucleotide sequence-guided assembly of repetitive DNA parts for synthetic biology applications.

Torella JP, Lienert F, Boehm CR, Chen JH, Way JC, Silver PA.

Nat Protoc. 2014 Sep;9(9):2075-89. doi: 10.1038/nprot.2014.145. Epub 2014 Aug 7.


In vivo co-localization of enzymes on RNA scaffolds increases metabolic production in a geometrically dependent manner.

Sachdeva G, Garg A, Godding D, Way JC, Silver PA.

Nucleic Acids Res. 2014 Aug;42(14):9493-503. doi: 10.1093/nar/gku617. Epub 2014 Jul 17.


Synthetic biology: Engineering explored.

Silver PA, Way JC, Arnold FH, Meyerowitz JT.

Nature. 2014 May 8;509(7499):166-7. doi: 10.1038/509166a. No abstract available.


Transient gene expression in tobacco using Gibson assembly and the Gene Gun.

Mattozzi MD, Voges MJ, Silver PA, Way JC.

J Vis Exp. 2014 Apr 18;(86). doi: 10.3791/51234.


Integrating biological redesign: where synthetic biology came from and where it needs to go.

Way JC, Collins JJ, Keasling JD, Silver PA.

Cell. 2014 Mar 27;157(1):151-61. doi: 10.1016/j.cell.2014.02.039. Review.


Programmable bacteria detect and record an environmental signal in the mammalian gut.

Kotula JW, Kerns SJ, Shaket LA, Siraj L, Collins JJ, Way JC, Silver PA.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4838-43. doi: 10.1073/pnas.1321321111. Epub 2014 Mar 17.


Rapid construction of insulated genetic circuits via synthetic sequence-guided isothermal assembly.

Torella JP, Boehm CR, Lienert F, Chen JH, Way JC, Silver PA.

Nucleic Acids Res. 2014 Jan;42(1):681-9. doi: 10.1093/nar/gkt860. Epub 2013 Sep 26.


Targeting a heterologous protein to multiple plant organelles via rationally designed 5' mRNA tags.

Voges MJ, Silver PA, Way JC, Mattozzi MD.

J Biol Eng. 2013 Sep 8;7(1):20. doi: 10.1186/1754-1611-7-20.


Tailored fatty acid synthesis via dynamic control of fatty acid elongation.

Torella JP, Ford TJ, Kim SN, Chen AM, Way JC, Silver PA.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11290-5. doi: 10.1073/pnas.1307129110. Epub 2013 Jun 24.


Expression of the sub-pathways of the Chloroflexus aurantiacus 3-hydroxypropionate carbon fixation bicycle in E. coli: Toward horizontal transfer of autotrophic growth.

Mattozzi Md, Ziesack M, Voges MJ, Silver PA, Way JC.

Metab Eng. 2013 Mar;16:130-9. doi: 10.1016/j.ymben.2013.01.005. Epub 2013 Jan 29.


Rerouting carbon flux to enhance photosynthetic productivity.

Ducat DC, Avelar-Rivas JA, Way JC, Silver PA.

Appl Environ Microbiol. 2012 Apr;78(8):2660-8. doi: 10.1128/AEM.07901-11. Epub 2012 Feb 3.


Towards a synthetic chloroplast.

Agapakis CM, Niederholtmeyer H, Noche RR, Lieberman TD, Megason SG, Way JC, Silver PA.

PLoS One. 2011 Apr 20;6(4):e18877. doi: 10.1371/journal.pone.0018877.


Engineering cyanobacteria to generate high-value products.

Ducat DC, Way JC, Silver PA.

Trends Biotechnol. 2011 Feb;29(2):95-103. doi: 10.1016/j.tibtech.2010.12.003. Epub 2011 Jan 5. Review.


A structurally tunable DNA-based extracellular matrix.

Aldaye FA, Senapedis WT, Silver PA, Way JC.

J Am Chem Soc. 2010 Oct 27;132(42):14727-9. doi: 10.1021/ja105431h.


Engineering cyanobacteria to synthesize and export hydrophilic products.

Niederholtmeyer H, Wolfstädter BT, Savage DF, Silver PA, Way JC.

Appl Environ Microbiol. 2010 Jun;76(11):3462-6. doi: 10.1128/AEM.00202-10. Epub 2010 Apr 2. Erratum in: Appl Environ Microbiol. 2010 Sep;76(17):6023.


Insulation of a synthetic hydrogen metabolism circuit in bacteria.

Agapakis CM, Ducat DC, Boyle PM, Wintermute EH, Way JC, Silver PA.

J Biol Eng. 2010 Feb 25;4:3. doi: 10.1186/1754-1611-4-3.


Anti-glycophorin single-chain Fv fusion to low-affinity mutant erythropoietin improves red blood cell-lineage specificity.

Taylor ND, Way JC, Silver PA, Cironi P.

Protein Eng Des Sel. 2010 Apr;23(4):251-60. doi: 10.1093/protein/gzp085. Epub 2010 Jan 18.


Molecular systems biology in drug development.

Silver PA, Way JC.

Clin Pharmacol Ther. 2007 Nov;82(5):586-90. Epub 2007 Jul 18.


Designing biological systems.

Drubin DA, Way JC, Silver PA.

Genes Dev. 2007 Feb 1;21(3):242-54. Review.


Improvement of Fc-erythropoietin structure and pharmacokinetics by modification at a disulfide bond.

Way JC, Lauder S, Brunkhorst B, Kong SM, Qi A, Webster G, Campbell I, McKenzie S, Lan Y, Marelli B, Nguyen LA, Degon S, Lo KM, Gillies SD.

Protein Eng Des Sel. 2005 Mar;18(3):111-8. Epub 2005 Apr 8.


Nuclear transport and cancer: from mechanism to intervention.

Kau TR, Way JC, Silver PA.

Nat Rev Cancer. 2004 Feb;4(2):106-17. Review. No abstract available.


Phyllodes tumour in pregnancy: a case report.

Way JC, Culham BA.

Can J Surg. 1998 Oct;41(5):407-9.


FP-21399 blocks HIV envelope protein-mediated membrane fusion and concentrates in lymph nodes.

Ono M, Wada Y, Wu Y, Nemori R, Jinbo Y, Wang H, Lo KM, Yamaguchi N, Brunkhorst B, Otomo H, Wesolowski J, Way JC, Itoh I, Gillies S, Chen LB.

Nat Biotechnol. 1997 Apr;15(4):343-8.


Establishment and cost analysis of an office surgical suite.

Way JC, Culham BA.

Can J Surg. 1996 Oct;39(5):379-83.


Retroareolar leiomyoma.

Way JC.

Can J Surg. 1996 Aug;39(4):339. Review. No abstract available.


Suppressors of the unc-73 gene of Caenorhabditis elegans.

Run JQ, Steven R, Hung MS, van Weeghel R, Culotti JG, Way JC.

Genetics. 1996 May;143(1):225-36.

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