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Items: 1 to 50 of 692

1.

Nav1.5 in astrocytes plays a sex-specific role in clinical outcomes in a mouse model of multiple sclerosis.

Pappalardo LW, Samad OA, Liu S, Zwinger PJ, Black JA, Waxman SG.

Glia. 2018 Sep 8. doi: 10.1002/glia.23470. [Epub ahead of print]

PMID:
30194875
2.

Somatosensory Neurons Enter a State of Altered Excitability during Hibernation.

Hoffstaetter LJ, Mastrotto M, Merriman DK, Dib-Hajj SD, Waxman SG, Bagriantsev SN, Gracheva EO.

Curr Biol. 2018 Aug 22. pii: S0960-9822(18)30919-9. doi: 10.1016/j.cub.2018.07.020. [Epub ahead of print]

3.

The novel activity of carbamazepine as an activation modulator extends from NaV1.7 mutations to the NaV1.8-S242T mutant channel from a patient with painful diabetic neuropathy.

Han C, Themistocleous AC, Estacion M, Dib-Hajj FB, Blesneac I, Macala L, Fratter C, Bennett DL, Waxman SG, Dib-Hajj SD.

Mol Pharmacol. 2018 Aug 22. pii: mol.118.113076. doi: 10.1124/mol.118.113076. [Epub ahead of print]

4.

Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits.

Dash B, Dib-Hajj SD, Waxman SG.

Mol Brain. 2018 Aug 7;11(1):45. doi: 10.1186/s13041-018-0388-1.

5.

Loss-of-function mutations of SCN10A encoding NaV1.8 α subunit of voltage-gated sodium channel in patients with human kidney stone disease.

Nettuwakul C, Praditsap O, Sawasdee N, Rungroj N, Ruamyod K, Watanapa WB, Junking M, Sangnual S, Sritippayawan S, Cheunsuchon B, Chuawattana D, Rojsatapong S, Chaowagul W, Dib-Hajj SD, Waxman SG, Yenchitsomanus PT.

Sci Rep. 2018 Jul 11;8(1):10453. doi: 10.1038/s41598-018-28623-3.

6.

Therapeutic potential of Pak1 inhibition for pain associated with cutaneous burn injury.

Guo Y, Benson C, Hill M, Henry S, Effraim P, Waxman SG, Dib-Hajj S, Tan AM.

Mol Pain. 2018 Jan-Dec;14:1744806918788648. doi: 10.1177/1744806918788648. Epub 2018 Jun 29.

7.

Nonmuscle myosin II isoforms interact with sodium channel alpha subunits.

Dash B, Han C, Waxman SG, Dib-Hajj SD.

Mol Pain. 2018 Jan-Dec;14:1744806918788638. doi: 10.1177/1744806918788638. Epub 2018 Jun 29.

8.

Differential aging-related changes in neurophysiology and gene expression in IB4-positive and IB4-negative nociceptive neurons.

Mis MA, Rogers MF, Jeffries AR, Wilbrey AL, Chen L, Yang Y, Dib-Hajj S, Waxman SG, Stevens EB, Randall AD.

Aging Cell. 2018 Jun 25:e12795. doi: 10.1111/acel.12795. [Epub ahead of print]

9.

Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner.

Li Y, Zhu T, Yang H, Dib-Hajj SD, Waxman SG, Yu Y, Xu TL, Cheng X.

Mol Pain. 2018 Jan-Dec;14:1744806918782229. doi: 10.1177/1744806918782229. Epub 2018 May 23.

10.

Conditional knockout of NaV1.6 in adult mice ameliorates neuropathic pain.

Chen L, Huang J, Zhao P, Persson AK, Dib-Hajj FB, Cheng X, Tan A, Waxman SG, Dib-Hajj SD.

Sci Rep. 2018 Mar 1;8(1):3845. doi: 10.1038/s41598-018-22216-w.

11.

Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Nav1.7 mutation that massively hyperpolarizes activation.

Huang J, Mis MA, Tanaka B, Adi T, Estacion M, Liu S, Walker S, Dib-Hajj SD, Waxman SG.

Sci Rep. 2018 Jan 29;8(1):1811. doi: 10.1038/s41598-018-20221-7.

12.

NaV1.7 as a Pharmacogenomic Target for Pain: Moving Toward Precision Medicine.

Yang Y, Mis MA, Estacion M, Dib-Hajj SD, Waxman SG.

Trends Pharmacol Sci. 2018 Mar;39(3):258-275. doi: 10.1016/j.tips.2017.11.010. Epub 2018 Jan 20. Review.

PMID:
29370938
13.

Ode to Glia: A Tribute to Bruce Ransom.

Waxman SG, Black JA.

Neurochem Res. 2017 Sep;42(9):2442. doi: 10.1007/s11064-017-2368-8. No abstract available.

PMID:
28921457
14.

Reverse pharmacogenomics: carbamazepine normalizes activation and attenuates thermal hyperexcitability of sensory neurons due to Nav 1.7 mutation I234T.

Yang Y, Adi T, Effraim PR, Chen L, Dib-Hajj SD, Waxman SG.

Br J Pharmacol. 2018 Jun;175(12):2261-2271. doi: 10.1111/bph.13935. Epub 2017 Jul 30.

PMID:
28658526
15.

Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.

16.

Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability.

Huang J, Vanoye CG, Cutts A, Goldberg YP, Dib-Hajj SD, Cohen CJ, Waxman SG, George AL Jr.

J Clin Invest. 2017 Jun 30;127(7):2805-2814. doi: 10.1172/JCI92373. Epub 2017 May 22.

17.

Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development.

Tanaka BS, Nguyen PT, Zhou EY, Yang Y, Yarov-Yarovoy V, Dib-Hajj SD, Waxman SG.

J Biol Chem. 2017 Jun 2;292(22):9262-9272. doi: 10.1074/jbc.M117.778779. Epub 2017 Apr 5.

18.

Dendritic spine dysgenesis in superficial dorsal horn sensory neurons after spinal cord injury.

Cao XC, Pappalardo LW, Waxman SG, Tan AM.

Mol Pain. 2017 Jan;13:1744806916688016. doi: 10.1177/1744806916688016.

19.

Sodium channels in pain disorders: pathophysiology and prospects for treatment.

Dib-Hajj SD, Geha P, Waxman SG.

Pain. 2017 Apr;158 Suppl 1:S97-S107. doi: 10.1097/j.pain.0000000000000854. No abstract available.

20.

Network topology of NaV1.7 mutations in sodium channel-related painful disorders.

Kapetis D, Sassone J, Yang Y, Galbardi B, Xenakis MN, Westra RL, Szklarczyk R, Lindsey P, Faber CG, Gerrits M, Merkies IS, Dib-Hajj SD, Mantegazza M, Waxman SG, Lauria G; PROPANE Study Group.

BMC Syst Biol. 2017 Feb 24;11(1):28. doi: 10.1186/s12918-016-0382-0.

21.

Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial.

Zakrzewska JM, Palmer J, Morisset V, Giblin GM, Obermann M, Ettlin DA, Cruccu G, Bendtsen L, Estacion M, Derjean D, Waxman SG, Layton G, Gunn K, Tate S; study investigators.

Lancet Neurol. 2017 Apr;16(4):291-300. doi: 10.1016/S1474-4422(17)30005-4. Epub 2017 Feb 17.

PMID:
28216232
22.

Nonlinear effects of hyperpolarizing shifts in activation of mutant Nav1.7 channels on resting membrane potential.

Estacion M, Waxman SG.

J Neurophysiol. 2017 Apr 1;117(4):1702-1712. doi: 10.1152/jn.00898.2016. Epub 2017 Feb 1.

23.

Detection of vulnerable neurons damaged by environmental insults in utero.

Torii M, Sasaki M, Chang YW, Ishii S, Waxman SG, Kocsis JD, Rakic P, Hashimoto-Torii K.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2367-2372. doi: 10.1073/pnas.1620641114. Epub 2017 Jan 25.

24.

The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development.

Asiedu MN, Han C, Dib-Hajj SD, Waxman SG, Price TJ, Dussor G.

PLoS One. 2017 Jan 24;12(1):e0169882. doi: 10.1371/journal.pone.0169882. eCollection 2017.

25.

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883. Erratum in: Sci Rep. 2017 May 26;7:46816.

26.

COL6A5 variants in familial neuropathic chronic itch.

Martinelli-Boneschi F, Colombi M, Castori M, Devigili G, Eleopra R, Malik RA, Ritelli M, Zoppi N, Dordoni C, Sorosina M, Grammatico P, Fadavi H, Gerrits MM, Almomani R, Faber CG, Merkies IS, Toniolo D; INGI Network, Cocca M, Doglioni C, Waxman SG, Dib-Hajj SD, Taiana MM, Sassone J, Lombardi R, Cazzato D, Zauli A, Santoro S, Marchi M, Lauria G.

Brain. 2017 Mar 1;140(3):555-567. doi: 10.1093/brain/aww343.

PMID:
28073787
27.

Mechanism of inhibition by chlorpromazine of the human pain threshold sodium channel, Nav1.7.

Lee SJ, Kim DH, Hahn SJ, Waxman SG, Choi JS.

Neurosci Lett. 2017 Feb 3;639:1-7. doi: 10.1016/j.neulet.2016.12.051. Epub 2016 Dec 22.

PMID:
28017662
28.

A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels.

Rolyan H, Liu S, Hoeijmakers JG, Faber CG, Merkies IS, Lauria G, Black JA, Waxman SG.

Mol Pain. 2016 Nov 7;12. pii: 1744806916674472. Print 2016.

29.

A SCN10A SNP biases human pain sensitivity.

Duan G, Han C, Wang Q, Guo S, Zhang Y, Ying Y, Huang P, Zhang L, Macala L, Shah P, Zhang M, Li N, Dib-Hajj SD, Waxman SG, Zhang X.

Mol Pain. 2016 Sep 2;12. pii: 1744806916666083. doi: 10.1177/1744806916666083. Print 2016.

30.

Familial gain-of-function Nav1.9 mutation in a painful channelopathy.

Han C, Yang Y, Te Morsche RH, Drenth JP, Politei JM, Waxman SG, Dib-Hajj SD.

J Neurol Neurosurg Psychiatry. 2017 Mar;88(3):233-240. doi: 10.1136/jnnp-2016-313804. Epub 2016 Aug 8.

PMID:
27503742
31.

A gain-of-function mutation in Nav1.6 in a case of trigeminal neuralgia.

Tanaka BS, Zhao P, Dib-Hajj FB, Morisset V, Tate S, Waxman SG, Dib-Hajj SD.

Mol Med. 2016 Aug 3;22. doi: 10.2119/molmed.2016.00131. [Epub ahead of print]

32.

Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli.

Yang Y, Huang J, Mis MA, Estacion M, Macala L, Shah P, Schulman BR, Horton DB, Dib-Hajj SD, Waxman SG.

J Neurosci. 2016 Jul 13;36(28):7511-22. doi: 10.1523/JNEUROSCI.0462-16.2016.

33.

Pain Perception: Multiple Matrices or One?

Geha P, Waxman SG.

JAMA Neurol. 2016 Jun 1;73(6):628-30. doi: 10.1001/jamaneurol.2016.0757. No abstract available.

PMID:
27111104
34.

Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia.

Cao L, McDonnell A, Nitzsche A, Alexandrou A, Saintot PP, Loucif AJ, Brown AR, Young G, Mis M, Randall A, Waxman SG, Stanley P, Kirby S, Tarabar S, Gutteridge A, Butt R, McKernan RM, Whiting P, Ali Z, Bilsland J, Stevens EB.

Sci Transl Med. 2016 Apr 20;8(335):335ra56. doi: 10.1126/scitranslmed.aad7653.

PMID:
27099175
35.

Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling.

Geha P, Yang Y, Estacion M, Schulman BR, Tokuno H, Apkarian AV, Dib-Hajj SD, Waxman SG.

JAMA Neurol. 2016 Jun 1;73(6):659-67. doi: 10.1001/jamaneurol.2016.0389.

PMID:
27088781
36.

Sodium Channels, Mitochondria, and Axonal Degeneration in Peripheral Neuropathy.

Persson AK, Hoeijmakers JGJ, Estacion M, Black JA, Waxman SG.

Trends Mol Med. 2016 May;22(5):377-390. doi: 10.1016/j.molmed.2016.03.008. Epub 2016 Apr 13. Review.

PMID:
27085813
37.

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.

Alexandrou AJ, Brown AR, Chapman ML, Estacion M, Turner J, Mis MA, Wilbrey A, Payne EC, Gutteridge A, Cox PJ, Doyle R, Printzenhoff D, Lin Z, Marron BE, West C, Swain NA, Storer RI, Stupple PA, Castle NA, Hounshell JA, Rivara M, Randall A, Dib-Hajj SD, Krafte D, Waxman SG, Patel MK, Butt RP, Stevens EB.

PLoS One. 2016 Apr 6;11(4):e0152405. doi: 10.1371/journal.pone.0152405. eCollection 2016.

38.

Dendritic spine remodeling following early and late Rac1 inhibition after spinal cord injury: evidence for a pain biomarker.

Zhao P, Hill M, Liu S, Chen L, Bangalore L, Waxman SG, Tan AM.

J Neurophysiol. 2016 Jun 1;115(6):2893-910. doi: 10.1152/jn.01057.2015. Epub 2016 Mar 2.

39.

Inherited erythromelalgia due to mutations in SCN9A: natural history, clinical phenotype and somatosensory profile.

McDonnell A, Schulman B, Ali Z, Dib-Hajj SD, Brock F, Cobain S, Mainka T, Vollert J, Tarabar S, Waxman SG.

Brain. 2016 Apr;139(Pt 4):1052-65. doi: 10.1093/brain/aww007. Epub 2016 Feb 26.

PMID:
26920677
40.

Sodium channels in astroglia and microglia.

Pappalardo LW, Black JA, Waxman SG.

Glia. 2016 Oct;64(10):1628-45. doi: 10.1002/glia.22967. Epub 2016 Feb 26. Review.

41.

Sodium channel Nav1.8: Emerging links to human disease.

Han C, Huang J, Waxman SG.

Neurology. 2016 Feb 2;86(5):473-83. doi: 10.1212/WNL.0000000000002333. Epub 2016 Jan 8. Review.

PMID:
26747884
42.

The cerebellar channelopathy of multiple sclerosis.

Waxman SG, Kantarci O.

Neurology. 2016 Feb 2;86(5):406-7. doi: 10.1212/WNL.0000000000002338. Epub 2016 Jan 6. No abstract available.

PMID:
26740676
43.

Diversity of composition and function of sodium channels in peripheral sensory neurons.

Dib-Hajj SD, Waxman SG.

Pain. 2015 Dec;156(12):2406-7. doi: 10.1097/j.pain.0000000000000353. No abstract available.

PMID:
26580678
44.

Neurology--the next 10 years.

Baron R, Ferriero DM, Frisoni GB, Bettegowda C, Gokaslan ZL, Kessler JA, Vezzani A, Waxman SG, Jarius S, Wildemann B, Weller M.

Nat Rev Neurol. 2015 Nov;11(11):658-64. doi: 10.1038/nrneurol.2015.196. Epub 2015 Oct 27. Review.

45.

Correction: Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy.

Doppler K, Appeltshauser L, Krämer HH, Ng JK, Meinl E, Villmann C, Brophy P, Dib-Hajj SD, Waxman SG, Weishaupt A, Sommer C.

PLoS One. 2015 Aug 28;10(8):e0137443. doi: 10.1371/journal.pone.0137443. eCollection 2015. No abstract available.

46.

NaV1.9: a sodium channel linked to human pain.

Dib-Hajj SD, Black JA, Waxman SG.

Nat Rev Neurosci. 2015 Sep;16(9):511-9. doi: 10.1038/nrn3977. Epub 2015 Aug 5. Review.

PMID:
26243570
47.

Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy.

Doppler K, Appeltshauser L, Krämer HH, Ng JK, Meinl E, Villmann C, Brophy P, Dib-Hajj SD, Waxman SG, Weishaupt A, Sommer C.

PLoS One. 2015 Jul 28;10(7):e0134274. doi: 10.1371/journal.pone.0134274. eCollection 2015. Erratum in: PLoS One. 2015;10(8):e0137443.

48.

Ca2+ toxicity due to reverse Na+/Ca2+ exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation.

Estacion M, Vohra BP, Liu S, Hoeijmakers J, Faber CG, Merkies IS, Lauria G, Black JA, Waxman SG.

J Neurophysiol. 2015 Sep;114(3):1554-64. doi: 10.1152/jn.00195.2015. Epub 2015 Jul 8.

49.

Virus-Mediated Knockdown of Nav1.3 in Dorsal Root Ganglia of STZ-Induced Diabetic Rats Alleviates Tactile Allodynia.

Tan AM, Samad OA, Dib-Hajj SD, Waxman SG.

Mol Med. 2015 Jun 18;21:544-52. doi: 10.2119/molmed.2015.00063.

50.

Specific changes in conduction velocity recovery cycles of single nociceptors in a patient with erythromelalgia with the I848T gain-of-function mutation of Nav1.7.

Namer B, Ørstavik K, Schmidt R, Kleggetveit IP, Weidner C, Mørk C, Kvernebo MS, Kvernebo K, Salter H, Carr TH, Segerdahl M, Quiding H, Waxman SG, Handwerker HO, Torebjörk HE, Jørum E, Schmelz M.

Pain. 2015 Sep;156(9):1637-46. doi: 10.1097/j.pain.0000000000000229.

PMID:
25993546

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