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Yield of peripheral sodium channels gene screening in pure small fibre neuropathy.

Eijkenboom I, Sopacua M, Hoeijmakers JGJ, de Greef BTA, Lindsey P, Almomani R, Marchi M, Vanoevelen J, Smeets HJM, Waxman SG, Lauria G, Merkies ISJ, Faber CG, Gerrits MM.

J Neurol Neurosurg Psychiatry. 2018 Dec 15. pii: jnnp-2018-319042. doi: 10.1136/jnnp-2018-319042. [Epub ahead of print]


Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter system.

Hashimoto-Torii K, Sasaki M, Chang YW, Hwang H, Waxman SG, Kocsis JD, Rakic P, Torii M.

IBRO Rep. 2018 Nov 6;5:91-98. doi: 10.1016/j.ibror.2018.11.003. eCollection 2018 Dec.


Resilience to Pain: A Peripheral Component Identified using induced Pluripotent Stem Cells and Dynamic Clamp.

Mis MA, Yang Y, Tanaka BS, Gomis-Perez C, Liu S, Dib-Hajj F, Adi T, Garcia-Milian R, Schulman BR, Dib-Hajj SD, Waxman SG.

J Neurosci. 2018 Nov 20. pii: 2433-18. doi: 10.1523/JNEUROSCI.2433-18.2018. [Epub ahead of print]


RKI-1447, a Rho kinase inhibitor, causes ocular hypotension, actin stress fiber disruption, and increased phagocytosis.

Dang Y, Wang C, Shah P, Waxman S, Loewen RT, Loewen NA.

Graefes Arch Clin Exp Ophthalmol. 2018 Nov 19. doi: 10.1007/s00417-018-4175-6. [Epub ahead of print]


When veps cry: Two-year-olds efficiently learn novel words from linguistic contexts alone.

Ferguson B, Graf E, Waxman SR.

Lang Learn Dev. 2018;14(1):1-12. doi: 10.1080/15475441.2017.1311260. Epub 2017 May 12.


Pediatric Erythromelalgia and SCN9A Mutations: Systematic Review and Single-Center Case Series.

Arthur L, Keen K, Verriotis M, Peters J, Kelly A, Howard RF, Dib-Hajj SD, Waxman SG, Walker SM.

J Pediatr. 2018 Nov 9. pii: S0022-3476(18)31464-1. doi: 10.1016/j.jpeds.2018.10.024. [Epub ahead of print]


A novel gain-of-function Nav1.7 mutation in a carbamazepine-responsive patient with adult-onset painful peripheral neuropathy.

Adi T, Estacion M, Schulman BR, Vernino S, Dib-Hajj SD, Waxman SG.

Mol Pain. 2018 Jan-Dec;14:1744806918815007. doi: 10.1177/1744806918815007. Epub 2018 Nov 5.


Structure-Function Changes of the Porcine Distal Outflow Tract in Response to Nitric Oxide.

Waxman S, Wang C, Dang Y, Hong Y, Esfandiari H, Shah P, Lathrop KL, Loewen RT, Loewen NA.

Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):4886-4895. doi: 10.1167/iovs.18-24943.


Characterization of small fiber pathology in a mouse model of Fabry disease.

Hofmann L, Hose D, Grießhammer A, Blum R, Döring F, Dib-Hajj S, Waxman S, Sommer C, Wischmeyer E, Üçeyler N.

Elife. 2018 Oct 17;7. pii: e39300. doi: 10.7554/eLife.39300.


Expression of pathogenic SCN9A mutations in the zebrafish: A model to study small-fiber neuropathy.

Eijkenboom I, Sopacua M, Otten ABC, Gerrits MM, Hoeijmakers JGJ, Waxman SG, Lombardi R, Lauria G, Merkies ISJ, Smeets HJM, Faber CG, Vanoevelen JM; PROPANE Study Group.

Exp Neurol. 2019 Jan;311:257-264. doi: 10.1016/j.expneurol.2018.10.008. Epub 2018 Oct 11.


Nav1.5 in astrocytes plays a sex-specific role in clinical outcomes in a mouse model of multiple sclerosis.

Pappalardo LW, Samad OA, Liu S, Zwinger PJ, Black JA, Waxman SG.

Glia. 2018 Oct;66(10):2174-2187. doi: 10.1002/glia.23470. Epub 2018 Sep 8.


Somatosensory Neurons Enter a State of Altered Excitability during Hibernation.

Hoffstaetter LJ, Mastrotto M, Merriman DK, Dib-Hajj SD, Waxman SG, Bagriantsev SN, Gracheva EO.

Curr Biol. 2018 Sep 24;28(18):2998-3004.e3. doi: 10.1016/j.cub.2018.07.020. Epub 2018 Aug 30.


A little labeling goes a long way: Semi-supervised learning in infancy.

LaTourrette A, Waxman SR.

Dev Sci. 2019 Jan;22(1):e12736. doi: 10.1111/desc.12736. Epub 2018 Sep 18.


The Novel Activity of Carbamazepine as an Activation Modulator Extends from NaV1.7 Mutations to the NaV1.8-S242T Mutant Channel from a Patient with Painful Diabetic Neuropathy.

Han C, Themistocleous AC, Estacion M, Dib-Hajj FB, Blesneac I, Macala L, Fratter C, Bennett DL, Waxman SG, Dib-Hajj SD.

Mol Pharmacol. 2018 Nov;94(5):1256-1269. doi: 10.1124/mol.118.113076. Epub 2018 Aug 22.


Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits.

Dash B, Dib-Hajj SD, Waxman SG.

Mol Brain. 2018 Aug 7;11(1):45. doi: 10.1186/s13041-018-0388-1.


Loss-of-function mutations of SCN10A encoding NaV1.8 α subunit of voltage-gated sodium channel in patients with human kidney stone disease.

Nettuwakul C, Praditsap O, Sawasdee N, Rungroj N, Ruamyod K, Watanapa WB, Junking M, Sangnual S, Sritippayawan S, Cheunsuchon B, Chuawattana D, Rojsatapong S, Chaowagul W, Dib-Hajj SD, Waxman SG, Yenchitsomanus PT.

Sci Rep. 2018 Jul 11;8(1):10453. doi: 10.1038/s41598-018-28623-3.


Arsenic Trioxide and Sorafenib Induce Synthetic Lethality of FLT3-ITD Acute Myeloid Leukemia Cells.

Wang R, Li Y, Gong P, Gabrilove J, Waxman S, Jing Y.

Mol Cancer Ther. 2018 Sep;17(9):1871-1880. doi: 10.1158/1535-7163.MCT-17-0298. Epub 2018 Jun 29.


Therapeutic potential of Pak1 inhibition for pain associated with cutaneous burn injury.

Guo Y, Benson C, Hill M, Henry S, Effraim P, Waxman SG, Dib-Hajj S, Tan AM.

Mol Pain. 2018 Jan-Dec;14:1744806918788648. doi: 10.1177/1744806918788648. Epub 2018 Jun 29.


Nonmuscle myosin II isoforms interact with sodium channel alpha subunits.

Dash B, Han C, Waxman SG, Dib-Hajj SD.

Mol Pain. 2018 Jan-Dec;14:1744806918788638. doi: 10.1177/1744806918788638. Epub 2018 Jun 29.


Differential aging-related changes in neurophysiology and gene expression in IB4-positive and IB4-negative nociceptive neurons.

Mis MA, Rogers MF, Jeffries AR, Wilbrey AL, Chen L, Yang Y, Dib-Hajj S, Waxman SG, Stevens EB, Randall AD.

Aging Cell. 2018 Jun 25:e12795. doi: 10.1111/acel.12795. [Epub ahead of print]


High-Resolution, Three-Dimensional Reconstruction of the Outflow Tract Demonstrates Segmental Differences in Cleared Eyes.

Waxman S, Loewen RT, Dang Y, Watkins SC, Watson AM, Loewen NA.

Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2371-2380. doi: 10.1167/iovs.17-23075.


Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner.

Li Y, Zhu T, Yang H, Dib-Hajj SD, Waxman SG, Yu Y, Xu TL, Cheng X.

Mol Pain. 2018 Jan-Dec;14:1744806918782229. doi: 10.1177/1744806918782229. Epub 2018 May 23.


Intraocular pressure elevation precedes a phagocytosis decline in a model of pigmentary glaucoma.

Dang Y, Waxman S, Wang C, Shah P, Loewen RT, Loewen NA.

Version 2. F1000Res. 2018 Feb 12 [revised 2018 Jan 1];7:174. doi: 10.12688/f1000research.13797.2. eCollection 2018.


Outflow enhancement by three different ab interno trabeculectomy procedures in a porcine anterior segment model.

Dang Y, Wang C, Shah P, Waxman S, Loewen RT, Hong Y, Esfandiari H, Loewen NA.

Graefes Arch Clin Exp Ophthalmol. 2018 Jul;256(7):1305-1312. doi: 10.1007/s00417-018-3990-0. Epub 2018 May 2.


A porcine ex vivo model of pigmentary glaucoma.

Dang Y, Waxman S, Wang C, Loewen RT, Sun M, Loewen NA.

Sci Rep. 2018 Apr 3;8(1):5468. doi: 10.1038/s41598-018-23861-x.


Similar Performance of Trabectome and Ahmed Glaucoma Devices in a Propensity Score-matched Comparison.

Esfandiari H, Shazly TA, Waxman SA, Kola S, Kaplowitz KB, Brown EN, Loewen NA.

J Glaucoma. 2018 Jun;27(6):490-495. doi: 10.1097/IJG.0000000000000960.


Conditional knockout of NaV1.6 in adult mice ameliorates neuropathic pain.

Chen L, Huang J, Zhao P, Persson AK, Dib-Hajj FB, Cheng X, Tan A, Waxman SG, Dib-Hajj SD.

Sci Rep. 2018 Mar 1;8(1):3845. doi: 10.1038/s41598-018-22216-w.


Impella removal with access site salvage.

Yager N, Waxman S.

Catheter Cardiovasc Interv. 2018 Feb 26. doi: 10.1002/ccd.27542. [Epub ahead of print]


Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Nav1.7 mutation that massively hyperpolarizes activation.

Huang J, Mis MA, Tanaka B, Adi T, Estacion M, Liu S, Walker S, Dib-Hajj SD, Waxman SG.

Sci Rep. 2018 Jan 29;8(1):1811. doi: 10.1038/s41598-018-20221-7.


NaV1.7 as a Pharmacogenomic Target for Pain: Moving Toward Precision Medicine.

Yang Y, Mis MA, Estacion M, Dib-Hajj SD, Waxman SG.

Trends Pharmacol Sci. 2018 Mar;39(3):258-275. doi: 10.1016/ Epub 2018 Jan 20. Review.


Very young infants learn abstract rules in the visual modality.

Ferguson B, Franconeri SL, Waxman SR.

PLoS One. 2018 Jan 2;13(1):e0190185. doi: 10.1371/journal.pone.0190185. eCollection 2018.


2:32 a.m.

Waxman S.

Ann Intern Med. 2017 Nov 21;167(10):752. doi: 10.7326/M17-0175. No abstract available.


Ode to Glia: A Tribute to Bruce Ransom.

Waxman SG, Black JA.

Neurochem Res. 2017 Sep;42(9):2442. doi: 10.1007/s11064-017-2368-8. No abstract available.


Linking Language and Cognition in Infancy.

Perszyk DR, Waxman SR.

Annu Rev Psychol. 2018 Jan 4;69:231-250. doi: 10.1146/annurev-psych-122216-011701. Epub 2017 Sep 6. Review.


Freeze-thaw decellularization of the trabecular meshwork in an ex vivo eye perfusion model.

Dang Y, Waxman S, Wang C, Jensen A, Loewen RT, Bilonick RA, Loewen NA.

PeerJ. 2017 Aug 14;5:e3629. doi: 10.7717/peerj.3629. eCollection 2017.


Between fire and ice: refractory hypothermia and warmth-induced pain in inherited erythromelalgia.

Tham SW, Li L, Effraim P, Waxman S.

BMJ Case Rep. 2017 Jul 26;2017. pii: bcr-2017-219486. doi: 10.1136/bcr-2017-219486.


Randomized phase II trial of fulvestrant alone or in combination with bortezomib in hormone receptor-positive metastatic breast cancer resistant to aromatase inhibitors: a New York Cancer Consortium trial.

Adelson K, Ramaswamy B, Sparano JA, Christos PJ, Wright JJ, Raptis G, Han G, Villalona-Calero M, Ma CX, Hershman D, Baar J, Klein P, Cigler T, Budd GT, Novik Y, Tan AR, Tannenbaum S, Goel A, Levine E, Shapiro CL, Andreopoulou E, Naughton M, Kalinsky K, Waxman S, Germain D.

NPJ Breast Cancer. 2016 Dec 14;2:16037. doi: 10.1038/npjbcancer.2016.37. eCollection 2016.


Reverse pharmacogenomics: carbamazepine normalizes activation and attenuates thermal hyperexcitability of sensory neurons due to Nav 1.7 mutation I234T.

Yang Y, Adi T, Effraim PR, Chen L, Dib-Hajj SD, Waxman SG.

Br J Pharmacol. 2018 Jun;175(12):2261-2271. doi: 10.1111/bph.13935. Epub 2017 Jul 30.


Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features.

Sia D, Jiao Y, Martinez-Quetglas I, Kuchuk O, Villacorta-Martin C, Castro de Moura M, Putra J, Camprecios G, Bassaganyas L, Akers N, Losic B, Waxman S, Thung SN, Mazzaferro V, Esteller M, Friedman SL, Schwartz M, Villanueva A, Llovet JM.

Gastroenterology. 2017 Sep;153(3):812-826. doi: 10.1053/j.gastro.2017.06.007. Epub 2017 Jun 15.


Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.


Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability.

Huang J, Vanoye CG, Cutts A, Goldberg YP, Dib-Hajj SD, Cohen CJ, Waxman SG, George AL Jr.

J Clin Invest. 2017 Jun 30;127(7):2805-2814. doi: 10.1172/JCI92373. Epub 2017 May 22.


Rapid learning curve assessment in an ex vivo training system for microincisional glaucoma surgery.

Dang Y, Waxman S, Wang C, Parikh HA, Bussel II, Loewen RT, Xia X, Lathrop KL, Bilonick RA, Loewen NA.

Sci Rep. 2017 May 9;7(1):1605. doi: 10.1038/s41598-017-01815-z.


Angle stability and outflow in dual blade ab interno trabeculectomy with active versus passive chamber management.

Wang C, Dang Y, Waxman S, Xia X, Weinreb RN, Loewen NA.

PLoS One. 2017 May 9;12(5):e0177238. doi: 10.1371/journal.pone.0177238. eCollection 2017.


Multivessel stent thrombosis with optical coherence tomography (OCT) utilization for therapeutic guidance.

Yager N, Majithia A, Waxman S.

Cardiovasc Revasc Med. 2017 Sep;18(6):445-446. doi: 10.1016/j.carrev.2017.03.028. Epub 2017 Mar 31.


Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development.

Tanaka BS, Nguyen PT, Zhou EY, Yang Y, Yarov-Yarovoy V, Dib-Hajj SD, Waxman SG.

J Biol Chem. 2017 Jun 2;292(22):9262-9272. doi: 10.1074/jbc.M117.778779. Epub 2017 Apr 5.


Dendritic spine dysgenesis in superficial dorsal horn sensory neurons after spinal cord injury.

Cao XC, Pappalardo LW, Waxman SG, Tan AM.

Mol Pain. 2017 Jan;13:1744806916688016. doi: 10.1177/1744806916688016.


Sodium channels in pain disorders: pathophysiology and prospects for treatment.

Dib-Hajj SD, Geha P, Waxman SG.

Pain. 2017 Apr;158 Suppl 1:S97-S107. doi: 10.1097/j.pain.0000000000000854. Review. No abstract available.


Network topology of NaV1.7 mutations in sodium channel-related painful disorders.

Kapetis D, Sassone J, Yang Y, Galbardi B, Xenakis MN, Westra RL, Szklarczyk R, Lindsey P, Faber CG, Gerrits M, Merkies IS, Dib-Hajj SD, Mantegazza M, Waxman SG, Lauria G; PROPANE Study Group.

BMC Syst Biol. 2017 Feb 24;11(1):28. doi: 10.1186/s12918-016-0382-0.


Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial.

Zakrzewska JM, Palmer J, Morisset V, Giblin GM, Obermann M, Ettlin DA, Cruccu G, Bendtsen L, Estacion M, Derjean D, Waxman SG, Layton G, Gunn K, Tate S; study investigators.

Lancet Neurol. 2017 Apr;16(4):291-300. doi: 10.1016/S1474-4422(17)30005-4. Epub 2017 Feb 17.


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