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Widespread dysregulation of long non-coding genes associated with fatty acid metabolism, cell division, and immune response gene networks in xenobiotic-exposed rat liver.

Karri K, Waxman DJ.

Toxicol Sci. 2020 Jan 11. pii: kfaa001. doi: 10.1093/toxsci/kfaa001. [Epub ahead of print]


Medium dose intermittent cyclophosphamide induces immunogenic cell death and cancer cell autonomous type I interferon production in glioma models.

Du B, Waxman DJ.

Cancer Lett. 2020 Feb 1;470:170-180. doi: 10.1016/j.canlet.2019.11.025. Epub 2019 Nov 22.


Widespread epigenetic changes to the enhancer landscape of mouse liver induced by a specific xenobiotic agonist ligand of the nuclear receptor CAR.

Rampersaud A, Lodato NJ, Shin A, Waxman DJ.

Toxicol Sci. 2019 Jun 24. pii: kfz148. doi: 10.1093/toxsci/kfz148. [Epub ahead of print]


Sex-Biased lncRNAs Inversely Correlate With Sex-Opposite Gene Coexpression Networks in Diversity Outbred Mouse Liver.

Melia T, Waxman DJ.

Endocrinology. 2019 May 1;160(5):989-1007. doi: 10.1210/en.2018-00949.


Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity.

Chhabra Y, Nelson CN, Plescher M, Barclay JL, Smith AG, Andrikopoulos S, Mangiafico S, Waxman DJ, Brooks AJ, Waters MJ.

FASEB J. 2019 May;33(5):6412-6430. doi: 10.1096/fj.201802328R. Epub 2019 Feb 19.


Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models.

Sulheim E, Kim J, van Wamel A, Kim E, Snipstad S, Vidic I, Grimstad IH, Widerøe M, Torp SH, Lundgren S, Waxman DJ, de Lange Davies C.

J Control Release. 2018 Jun 10;279:292-305. doi: 10.1016/j.jconrel.2018.04.026. Epub 2018 Apr 21.


Impact of CAR Agonist Ligand TCPOBOP on Mouse Liver Chromatin Accessibility.

Lodato NJ, Rampersaud A, Waxman DJ.

Toxicol Sci. 2018 Jul 1;164(1):115-128. doi: 10.1093/toxsci/kfy070.


Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy.

Wu J, Waxman DJ.

Cancer Lett. 2018 Apr 10;419:210-221. doi: 10.1016/j.canlet.2018.01.050. Review.


Functional Roles of Sex-Biased, Growth Hormone-Regulated MicroRNAs miR-1948 and miR-802 in Young Adult Mouse Liver.

Hao P, Waxman DJ.

Endocrinology. 2018 Mar 1;159(3):1377-1392. doi: 10.1210/en.2017-03109.


Feminization of Male Mouse Liver by Persistent Growth Hormone Stimulation: Activation of Sex-Biased Transcriptional Networks and Dynamic Changes in Chromatin States.

Lau-Corona D, Suvorov A, Waxman DJ.

Mol Cell Biol. 2017 Sep 12;37(19). pii: e00301-17. doi: 10.1128/MCB.00301-17. Print 2017 Oct 1.


Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).

Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan ET, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, Zhong XB.

Acta Pharm Sin B. 2017 Mar;7(2):241-248. doi: 10.1016/j.apsb.2016.12.006. Epub 2017 Feb 1.


Activation of Male Liver Chromatin Accessibility and STAT5-Dependent Gene Transcription by Plasma Growth Hormone Pulses.

Connerney J, Lau-Corona D, Rampersaud A, Waxman DJ.

Endocrinology. 2017 May 1;158(5):1386-1405. doi: 10.1210/en.2017-00060.


Next generation metronomic chemotherapy-report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6-8 May 2016, Mumbai.

Pantziarka P, Hutchinson L, André N, Benzekry S, Bertolini F, Bhattacharjee A, Chiplunkar S, Duda DG, Gota V, Gupta S, Joshi A, Kannan S, Kerbel R, Kieran M, Palazzo A, Parikh A, Pasquier E, Patil V, Prabhash K, Shaked Y, Sholler GS, Sterba J, Waxman DJ, Banavali S.

Ecancermedicalscience. 2016 Nov 2;10:689. eCollection 2016.


Feasibility of spatial frequency domain imaging (SFDI) for optically characterizing a preclinical oncology model.

Tabassum S, Zhao Y, Istfan R, Wu J, Waxman DJ, Roblyer D.

Biomed Opt Express. 2016 Sep 19;7(10):4154-4170. eCollection 2016 Oct 1.


Correction: Chemical and Hormonal Effects on STAT5b- Dependent Sexual Dimorphism of the Liver Transcriptome.

Oshida K, Waxman DJ, Corton JC.

PLoS One. 2016 Aug 16;11(8):e0161519. doi: 10.1371/journal.pone.0161519. eCollection 2016.


Evidence for an oncogenic modifier role for mutant histone acetyltransferases in diffuse large B-cell lymphoma.

Haery L, Mussakhan S, Waxman DJ, Gilmore TD.

Leuk Lymphoma. 2016 Nov;57(11):2661-71. doi: 10.3109/10428194.2016.1160083. Epub 2016 Mar 22.


Disruption of STAT5b-Regulated Sexual Dimorphism of the Liver Transcriptome by Diverse Factors Is a Common Event.

Oshida K, Vasani N, Waxman DJ, Corton JC.

PLoS One. 2016 Mar 9;11(3):e0148308. doi: 10.1371/journal.pone.0148308. eCollection 2016.


Chemical and Hormonal Effects on STAT5b-Dependent Sexual Dimorphism of the Liver Transcriptome.

Oshida K, Waxman DJ, Corton JC.

PLoS One. 2016 Mar 9;11(3):e0150284. doi: 10.1371/journal.pone.0150284. eCollection 2016. Erratum in: PLoS One. 2016;11(8):e0161519.


CpG-1826 immunotherapy potentiates chemotherapeutic and anti-tumor immune responses to metronomic cyclophosphamide in a preclinical glioma model.

Jordan M, Waxman DJ.

Cancer Lett. 2016 Apr 1;373(1):88-96. doi: 10.1016/j.canlet.2015.11.029. Epub 2015 Dec 3.


Hepatic Long Intergenic Noncoding RNAs: High Promoter Conservation and Dynamic, Sex-Dependent Transcriptional Regulation by Growth Hormone.

Melia T, Hao P, Yilmaz F, Waxman DJ.

Mol Cell Biol. 2015 Oct 12;36(1):50-69. doi: 10.1128/MCB.00861-15. Print 2016 Jan 1.


Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver.

Conforto TL, Steinhardt GF 4th, Waxman DJ.

Mol Endocrinol. 2015 Sep;29(9):1286-302. doi: 10.1210/me.2015-1028. Epub 2015 Jul 28.


Early programing of uterine tissue by bisphenol A: Critical evaluation of evidence from animal exposure studies.

Suvorov A, Waxman DJ.

Reprod Toxicol. 2015 Nov;57:59-72. doi: 10.1016/j.reprotox.2015.05.008. Epub 2015 May 28. Review.


Metronomic chemotherapy: an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance.

Kareva I, Waxman DJ, Lakka Klement G.

Cancer Lett. 2015 Mar 28;358(2):100-106. doi: 10.1016/j.canlet.2014.12.039. Epub 2014 Dec 23. Review.


Metronomic cyclophosphamide schedule-dependence of innate immune cell recruitment and tumor regression in an implanted glioma model.

Wu J, Waxman DJ.

Cancer Lett. 2014 Oct 28;353(2):272-80. doi: 10.1016/j.canlet.2014.07.033. Epub 2014 Jul 25.


H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity.

Manley E Jr, Waxman DJ.

Cancer Lett. 2014 Apr 28;346(1):63-73. doi: 10.1016/j.canlet.2013.12.012. Epub 2013 Dec 12.


Adenoviral vectors for prodrug activation-based gene therapy for cancer.

Doloff JC, Waxman DJ.

Anticancer Agents Med Chem. 2014 Jan;14(1):115-26. Review.


Genome-wide analysis of chromatin states reveals distinct mechanisms of sex-dependent gene regulation in male and female mouse liver.

Sugathan A, Waxman DJ.

Mol Cell Biol. 2013 Sep;33(18):3594-610. doi: 10.1128/MCB.00280-13. Epub 2013 Jul 8.


Changes in mouse uterine transcriptome in estrus and proestrus.

Yip KS, Suvorov A, Connerney J, Lodato NJ, Waxman DJ.

Biol Reprod. 2013 Jul 18;89(1):13. doi: 10.1095/biolreprod.112.107334. Print 2013 Jul.


Impact of tumor vascularity on responsiveness to antiangiogenesis in a prostate cancer stem cell-derived tumor model.

Zhang K, Waxman DJ.

Mol Cancer Ther. 2013 May;12(5):787-98. doi: 10.1158/1535-7163.MCT-12-1240. Epub 2013 May 1.


DNase I digestion of isolated nulcei for genome-wide mapping of DNase hypersensitivity sites in chromatin.

Ling G, Waxman DJ.

Methods Mol Biol. 2013;977:21-33. doi: 10.1007/978-1-62703-284-1_3.


Isolation of nuclei for use in genome-wide DNase hypersensitivity assays to probe chromatin structure.

Ling G, Waxman DJ.

Methods Mol Biol. 2013;977:13-9. doi: 10.1007/978-1-62703-284-1_2.


Impact of tumor blood flow modulation on tumor sensitivity to the bioreductive drug banoxantrone.

Manley E Jr, Waxman DJ.

J Pharmacol Exp Ther. 2013 Feb;344(2):368-77. doi: 10.1124/jpet.112.200089. Epub 2012 Nov 28.


Impact of CUX2 on the female mouse liver transcriptome: activation of female-biased genes and repression of male-biased genes.

Conforto TL, Zhang Y, Sherman J, Waxman DJ.

Mol Cell Biol. 2012 Nov;32(22):4611-27. doi: 10.1128/MCB.00886-12. Epub 2012 Sep 10.


MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets.

Shao Z, Zhang Y, Yuan GC, Orkin SH, Waxman DJ.

Genome Biol. 2012 Mar 16;13(3):R16. doi: 10.1186/gb-2012-13-3-r16.


VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression.

Doloff JC, Waxman DJ.

Cancer Res. 2012 Mar 1;72(5):1103-15. doi: 10.1158/0008-5472.CAN-11-3380. Epub 2012 Jan 11.


Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver.

Zhang Y, Laz EV, Waxman DJ.

Mol Cell Biol. 2012 Feb;32(4):880-96. doi: 10.1128/MCB.06312-11. Epub 2011 Dec 12.


Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease.

Zhang Y, Klein K, Sugathan A, Nassery N, Dombkowski A, Zanger UM, Waxman DJ.

PLoS One. 2011;6(8):e23506. doi: 10.1371/journal.pone.0023506. Epub 2011 Aug 12.


Complex modulation of androgen responsive gene expression by methoxyacetic acid.

Bagchi G, Zhang Y, Stanley KA, Waxman DJ.

Reprod Biol Endocrinol. 2011 Mar 31;9:42. doi: 10.1186/1477-7827-9-42.


Antiangiogenesis enhances intratumoral drug retention.

Ma J, Chen CS, Blute T, Waxman DJ.

Cancer Res. 2011 Apr 1;71(7):2675-85. doi: 10.1158/0008-5472.CAN-10-3242. Epub 2011 Mar 29.

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