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Unlike Th1/Th17 cells, Th2/Th9 cells selectively migrate to the limbus/conjunctiva and initiate an eosinophilic infiltration process.

Tan C, Wandu WS, St Leger A, Kielczewski J, Wawrousek EF, Chan CC, Gery I.

Exp Eye Res. 2018 Jan;166:116-119. doi: 10.1016/j.exer.2017.10.019. Epub 2017 Oct 24.


Phenotypes of Th lineages generated by the commonly used activation with anti-CD3/CD28 antibodies differ from those generated by the physiological activation with the specific antigen.

Tan C, Wei L, Vistica BP, Shi G, Wawrousek EF, Gery I.

Cell Mol Immunol. 2014 May;11(3):305-13. doi: 10.1038/cmi.2014.8. Epub 2014 Mar 3.


Differential involvement of Th1 and Th17 in pathogenic autoimmune processes triggered by different TLR ligands.

Shi G, Vistica BP, Nugent LF, Tan C, Wawrousek EF, Klinman DM, Gery I.

J Immunol. 2013 Jul 1;191(1):415-23. doi: 10.4049/jimmunol.1201732. Epub 2013 May 29.


Impaired endolysosomal function disrupts Notch signalling in optic nerve astrocytes.

Valapala M, Hose S, Gongora C, Dong L, Wawrousek EF, Samuel Zigler J Jr, Sinha D.

Nat Commun. 2013;4:1629. doi: 10.1038/ncomms2624.


αB-Crystallin regulates expansion of CD11b⁺Gr-1⁺ immature myeloid cells during tumor progression.

Dieterich LC, Schiller P, Huang H, Wawrousek EF, Loskog A, Wanders A, Moons L, Dimberg A.

FASEB J. 2013 Jan;27(1):151-62. doi: 10.1096/fj.12-213017. Epub 2012 Oct 2.


Cell-cell interaction with APC, not IL-23, is required for naive CD4 cells to acquire pathogenicity during Th17 lineage commitment.

Shi G, Lovaas JD, Tan C, Vistica BP, Wawrousek EF, Aziz MK, Rigden RC, Caspi RR, Gery I.

J Immunol. 2012 Aug 1;189(3):1220-7. doi: 10.4049/jimmunol.1103033. Epub 2012 Jun 27.


The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes.

Mattapallil MJ, Wawrousek EF, Chan CC, Zhao H, Roychoudhury J, Ferguson TA, Caspi RR.

Invest Ophthalmol Vis Sci. 2012 May 17;53(6):2921-7. doi: 10.1167/iovs.12-9662. Print 2012.


βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina.

Sinha D, Valapala M, Bhutto I, Patek B, Zhang C, Hose S, Yang F, Cano M, Stark WJ, Lutty GA, Zigler JS, Wawrousek EF.

Transgenic Res. 2012 Oct;21(5):1033-42. doi: 10.1007/s11248-012-9608-0. Epub 2012 Mar 17.


Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.

Tan C, Aziz MK, Lovaas JD, Vistica BP, Shi G, Wawrousek EF, Gery I.

J Immunol. 2010 Dec 1;185(11):6795-801. doi: 10.4049/jimmunol.1001676. Epub 2010 Oct 22.


Unlike Th1, Th17 cells mediate sustained autoimmune inflammation and are highly resistant to restimulation-induced cell death.

Shi G, Ramaswamy M, Vistica BP, Cox CA, Tan C, Wawrousek EF, Siegel RM, Gery I.

J Immunol. 2009 Dec 1;183(11):7547-56. doi: 10.4049/jimmunol.0900519. Epub 2009 Nov 4.


A suppressive oligodeoxynucleotide inhibits ocular inflammation.

Fujimoto C, Klinman DM, Shi G, Yin H, Vistica BP, Lovaas JD, Wawrousek EF, Igarashi T, Chan CC, Gery I.

Clin Exp Immunol. 2009 Jun;156(3):528-34. doi: 10.1111/j.1365-2249.2009.03918.x.


Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease.

Hagemann TL, Boelens WC, Wawrousek EF, Messing A.

Hum Mol Genet. 2009 Apr 1;18(7):1190-9. doi: 10.1093/hmg/ddp013. Epub 2009 Jan 7.


Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells.

Shi G, Cox CA, Vistica BP, Tan C, Wawrousek EF, Gery I.

J Immunol. 2008 Nov 15;181(10):7205-13.


Both Th1 and Th17 are immunopathogenic but differ in other key biological activities.

Cox CA, Shi G, Yin H, Vistica BP, Wawrousek EF, Chan CC, Gery I.

J Immunol. 2008 Jun 1;180(11):7414-22.


Elevated retina-specific expression of the small heat shock protein, alphaA-crystallin, is associated with photoreceptor protection in experimental uveitis.

Rao NA, Saraswathy S, Wu GS, Katselis GS, Wawrousek EF, Bhat S.

Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1161-71. doi: 10.1167/iovs.07-1259.


alphaB-crystallin protects retinal tissue during Staphylococcus aureus-induced endophthalmitis.

Whiston EA, Sugi N, Kamradt MC, Sack C, Heimer SR, Engelbert M, Wawrousek EF, Gilmore MS, Ksander BR, Gregory MS.

Infect Immun. 2008 Apr;76(4):1781-90. doi: 10.1128/IAI.01285-07. Epub 2008 Jan 28.


Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia.

Yaung J, Kannan R, Wawrousek EF, Spee C, Sreekumar PG, Hinton DR.

Exp Eye Res. 2008 Feb;86(2):355-65. doi: 10.1016/j.exer.2007.11.007. Epub 2007 Nov 17.


alphaB-crystallin promotes tumor angiogenesis by increasing vascular survival during tube morphogenesis.

Dimberg A, Rylova S, Dieterich LC, Olsson AK, Schiller P, Wikner C, Bohman S, Botling J, Lukinius A, Wawrousek EF, Claesson-Welsh L.

Blood. 2008 Feb 15;111(4):2015-23. Epub 2007 Dec 6.


Complement deposits on ocular tissues adjacent to sites of inflammation.

Montalvo V, Campos MM, Chan CC, Wawrousek EF, Bush RA, Lambris JD, Gery I.

Curr Eye Res. 2007 Nov;32(11):917-22. Erratum in: Curr Eye Res. 2008 Jan;33(1):109.


CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice.

Benjamin IJ, Guo Y, Srinivasan S, Boudina S, Taylor RP, Rajasekaran NS, Gottlieb R, Wawrousek EF, Abel ED, Bolli R.

Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3201-9. Epub 2007 Sep 14.


Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination.

Ousman SS, Tomooka BH, van Noort JM, Wawrousek EF, O'Connor KC, Hafler DA, Sobel RA, Robinson WH, Steinman L.

Nature. 2007 Jul 26;448(7152):474-9. Epub 2007 Jun 13.


alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress.

Yaung J, Jin M, Barron E, Spee C, Wawrousek EF, Kannan R, Hinton DR.

Mol Vis. 2007 Apr 4;13:566-77.


Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function.

Kreslova J, Machon O, Ruzickova J, Lachova J, Wawrousek EF, Kemler R, Krauss S, Piatigorsky J, Kozmik Z.

Genesis. 2007 Apr;45(4):157-68.


Tolerization of an established alphaB-crystallin-reactive T-cell response by intravenous antigen.

Verbeek R, van der Mark K, Wawrousek EF, Plomp AC, van Noort JM.

Immunology. 2007 Jul;121(3):416-26. Epub 2007 Apr 26.


Induction of EAE by T cells specific for alpha B-crystallin depends on prior viral infection in the CNS.

Verbeek R, van Dongen H, Wawrousek EF, Amor S, van Noort JM.

Int Immunol. 2007 Mar;19(3):277-85. Epub 2007 Jan 30.


Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice.

Senatorov V, Malyukova I, Fariss R, Wawrousek EF, Swaminathan S, Sharan SK, Tomarev S.

J Neurosci. 2006 Nov 15;26(46):11903-14.


Pertussis toxin is superior to TLR ligands in enhancing pathogenic autoimmunity, targeted at a neo-self antigen, by triggering robust expansion of Th1 cells and their cytokine production.

Fujimoto C, Yu CR, Shi G, Vistica BP, Wawrousek EF, Klinman DM, Chan CC, Egwuagu CE, Gery I.

J Immunol. 2006 Nov 15;177(10):6896-903.


Inbred FVB/N mice are mutant at the cp49/Bfsp2 locus and lack beaded filament proteins in the lens.

Simirskii VN, Lee RS, Wawrousek EF, Duncan MK.

Invest Ophthalmol Vis Sci. 2006 Nov;47(11):4931-4.


Active participation of antigen-nonspecific lymphoid cells in immune-mediated inflammation.

Chen J, Fujimoto C, Vistica BP, He J, Wawrousek EF, Kelsall B, Gery I.

J Immunol. 2006 Sep 1;177(5):3362-8. Erratum in: J Immunol. 2007 Apr 15;178(8):5398. He, JianPing [added].


AlphaB-crystallin-reactive T cells from knockout mice are not encephalitogenic.

Wang C, Chou YK, Rich CM, Link JM, Afentoulis ME, van Noort JM, Wawrousek EF, Offner H, Vandenbark AA.

J Neuroimmunol. 2006 Jul;176(1-2):51-62. Epub 2006 Jul 14. Erratum in: J Neuroimmunol. 2008 Dec 15;205(1-2):162.


Inflammatory processes triggered by TCR engagement or by local cytokine expression: differences in profiles of gene expression and infiltrating cell populations.

Takase H, Yu CR, Ham DI, Chan CC, Chen J, Vistica BP, Wawrousek EF, Durum SK, Egwuagu CE, Gery I.

J Leukoc Biol. 2006 Sep;80(3):538-45. Epub 2006 Jun 22.


Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice.

Morozov V, Wawrousek EF.

Development. 2006 Mar;133(5):813-21. Epub 2006 Jan 26.


Ischemia-induced increase of stiffness of alphaB-crystallin/HSPB2-deficient myocardium.

Golenhofen N, Redel A, Wawrousek EF, Drenckhahn D.

Pflugers Arch. 2006 Jan;451(4):518-25. Epub 2005 Oct 11.


Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake.

Chen Q, Liu JB, Horak KM, Zheng H, Kumarapeli AR, Li J, Li F, Gerdes AM, Wawrousek EF, Wang X.

Circ Res. 2005 Nov 11;97(10):1018-26. Epub 2005 Oct 6.


A unique pattern of up- and down-regulation of chemokine receptor CXCR3 on inflammation-inducing Th1 cells.

Chen J, Vistica BP, Takase H, Ham DI, Fariss RN, Wawrousek EF, Chan CC, DeMartino JA, Farber JM, Gery I.

Eur J Immunol. 2004 Oct;34(10):2885-94.


Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse.

Maddala R, Deng PF, Costello JM, Wawrousek EF, Zigler JS, Rao VP.

Lab Invest. 2004 Jun;84(6):679-92.


Central immunotolerance in transgenic mice expressing a foreign antigen under control of the rhodopsin promoter.

Ham DI, Kim SJ, Chen J, Vistica BP, Fariss RN, Lee RS, Wawrousek EF, Takase H, Yu CR, Egwuagu CE, Chan CC, Gery I.

Invest Ophthalmol Vis Sci. 2004 Mar;45(3):857-62.


Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model.

Morrison LE, Whittaker RJ, Klepper RE, Wawrousek EF, Glembotski CC.

Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H847-55. Epub 2003 Oct 30.


Immunotolerance toward native alphaA-crystallin in knockout mice deficient in the functional protein.

Charukamnoetkanok P, Brady JP, Wawrousek EF, Egwuagu CE, Zigler JS Jr, Vistica BP, Whitcup SM, Gery I.

Immunol Lett. 2003 Oct 31;89(2-3):259-65. Erratum in: Immunol Lett. 2003 Dec 15;90(2-3):229.


A novel inflammatory eye disease induced by lymphocytes from knockout mice sensitized against the deleted ocular antigen.

Gelderman MP, Charukamnoetkanok P, Brady JP, Hung L, Zigler JS, Wawrousek EF, Vistica BP, Fortin E, Chan CC, Gery I.

Clin Exp Immunol. 2003 Aug;133(2):177-81.


Hyperproliferation and p53 status of lens epithelial cells derived from alphaB-crystallin knockout mice.

Bai F, Xi JH, Wawrousek EF, Fleming TP, Andley UP.

J Biol Chem. 2003 Sep 19;278(38):36876-86. Epub 2003 Jun 25.


Upregulation of vascular endothelial growth factor (VEGF) in the retinas of transgenic mice overexpressing interleukin-1beta (IL-1beta) in the lens and mice undergoing retinal degeneration.

Vinores SA, Xiao WH, Zimmerman R, Whitcup SM, Wawrousek EF.

Histol Histopathol. 2003 Jul;18(3):797-810. doi: 10.14670/HH-18.797.


T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form.

Zhang M, Vacchio MS, Vistica BP, Lesage S, Egwuagu CE, Yu CR, Gelderman MP, Kennedy MC, Wawrousek EF, Gery I.

J Immunol. 2003 Apr 15;170(8):3954-62.


Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens.

Boyle DL, Takemoto L, Brady JP, Wawrousek EF.

BMC Ophthalmol. 2003 Jan 24;3:3.


Transketolase haploinsufficiency reduces adipose tissue and female fertility in mice.

Xu ZP, Wawrousek EF, Piatigorsky J.

Mol Cell Biol. 2002 Sep;22(17):6142-7.


Expression and induction of the stress protein alpha-B-crystallin in vascular endothelial cells.

Golenhofen N, Ness W, Wawrousek EF, Drenckhahn D.

Histochem Cell Biol. 2002 Mar;117(3):203-9. Epub 2002 Feb 2.


Experimental models of growth factor-mediated angiogenesis and blood-retinal barrier breakdown.

Vinores SA, Seo MS, Okamoto N, Ash JD, Wawrousek EF, Xiao WH, Hudish T, Derevjanik NL, Campochiaro PA.

Gen Pharmacol. 2000 Nov;35(5):233-9. Review.


Induction of ocular inflammation by T-helper lymphocytes type 2.

Kim SJ, Zhang M, Vistica BP, Chan CC, Shen DF, Wawrousek EF, Gery I.

Invest Ophthalmol Vis Sci. 2002 Mar;43(3):758-65.


Inflammatory mediators in uveitis: differential induction of cytokines and chemokines in Th1- versus Th2-mediated ocular inflammation.

Foxman EF, Zhang M, Hurst SD, Muchamuel T, Shen D, Wawrousek EF, Chan CC, Gery I.

J Immunol. 2002 Mar 1;168(5):2483-92.

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