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Association Between Maternal Fluoride Exposure and Child IQ.

Waugh D.

JAMA Pediatr. 2019 Dec 30. doi: 10.1001/jamapediatrics.2019.5233. [Epub ahead of print] No abstract available.


Crystal structure of UDP-glucose pyrophosphorylase from Yersinia pestis, a potential therapeutic target against plague.

Gibbs ME, Lountos GT, Gumpena R, Waugh DS.

Acta Crystallogr F Struct Biol Commun. 2019 Sep 1;75(Pt 9):608-615. doi: 10.1107/S2053230X19011154. Epub 2019 Aug 28.


On the Droplet Size and Application of Wettability Analysis for the Development of Ink and Printing Substrates.

Grüßer M, Waugh DG, Lawrence J, Langer N, Scholz D.

Langmuir. 2019 Sep 24;35(38):12356-12365. doi: 10.1021/acs.langmuir.9b01674. Epub 2019 Sep 12.


Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer.

Di Mitri D, Mirenda M, Vasilevska J, Calcinotto A, Delaleu N, Revandkar A, Gil V, Boysen G, Losa M, Mosole S, Pasquini E, D'Antuono R, Masetti M, Zagato E, Chiorino G, Ostano P, Rinaldi A, Gnetti L, Graupera M, Martins Figueiredo Fonseca AR, Pereira Mestre R, Waugh D, Barry S, De Bono J, Alimonti A.

Cell Rep. 2019 Aug 20;28(8):2156-2168.e5. doi: 10.1016/j.celrep.2019.07.068.


Cancer and Other Outcomes After Surgery With Fluoridated Anesthesia.

Waugh DT.

JAMA Surg. 2019 Jun 26. doi: 10.1001/jamasurg.2019.1747. [Epub ahead of print] No abstract available.


Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening.

Lountos GT, Zhao XZ, Kiselev E, Tropea JE, Needle D, Pommier Y, Burke TR, Waugh DS.

Nucleic Acids Res. 2019 Nov 4;47(19):10134-10150. doi: 10.1093/nar/gkz515.


Consensus Statement on Circulating Biomarkers for Advanced Prostate Cancer.

Sumanasuriya S, Omlin A, Armstrong A, Attard G, Chi KN, Bevan CL, Shibakawa A, IJzerman MJ, De Laere B, Lolkema M, Lorente D, Luo J, Mehra N, Olmos D, Scher H, Soule H, Stoecklein NH, Terstappen LWMM, Waugh D, de Bono JS.

Eur Urol Oncol. 2018 Jun;1(2):151-159. doi: 10.1016/j.euo.2018.02.009. Epub 2018 May 15. Review.


The molecular mechanism of dsRNA processing by a bacterial Dicer.

Jin L, Song H, Tropea JE, Needle D, Waugh DS, Gu S, Ji X.

Nucleic Acids Res. 2019 May 21;47(9):4707-4720. doi: 10.1093/nar/gkz208.


The Contribution of Fluoride to the Pathogenesis of Eye Diseases: Molecular Mechanisms and Implications for Public Health.

Waugh DT.

Int J Environ Res Public Health. 2019 Mar 8;16(5). pii: E856. doi: 10.3390/ijerph16050856. Review.


ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA.

Gilmore AR, Alderdice M, Savage KI, O'Reilly PG, Roddy AC, Dunne PD, Lawler M, McDade SS, Waugh DJ, McArt DG.

Cancer Res. 2019 Apr 15;79(8):2072-2075. doi: 10.1158/0008-5472.CAN-18-1976. Epub 2019 Feb 13.


Targeting Protein-Protein Interactions of Tyrosine Phosphatases with Microarrayed Fragment Libraries Displayed on Phosphopeptide Substrate Scaffolds.

Hogan M, Bahta M, Tsuji K, Nguyen TX, Cherry S, Lountos GT, Tropea JE, Zhao BM, Zhao XZ, Waugh DS, Burke TR Jr, Ulrich RG.

ACS Comb Sci. 2019 Mar 11;21(3):158-170. doi: 10.1021/acscombsci.8b00122. Epub 2019 Jan 31.


A new zygodactylid species indicates the persistence of stem passerines into the early Oligocene in North America.

Hieronymus TL, Waugh DA, Clarke JA.

BMC Evol Biol. 2019 Jan 5;19(1):3. doi: 10.1186/s12862-018-1319-6.


Author Correction: Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen.

Olson MA, Lee MS, Kissner TL, Alam S, Waugh DS, Saikh KU.

Sci Rep. 2018 Nov 19;8(1):17074. doi: 10.1038/s41598-018-35538-6.


Treatment strategy of end stage renal disease-related hyperparathyroidism before, during, and after the era of calcimimetics.

van der Plas WY, Engelsman AF, Umakanthan M, Mather A, Sidhu SB, Delbridge LW, Pollock C, Waugh D, Sywak MS, Kruijff S.

Surgery. 2019 Jan;165(1):135-141. doi: 10.1016/j.surg.2018.04.092. Epub 2018 Nov 6.


Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists.

McCann C, Crawford N, Majkut J, Holohan C, Armstrong CWD, Maxwell PJ, Ong CW, LaBonte MJ, McDade SS, Waugh DJ, Longley DB.

Cell Death Dis. 2018 Oct 22;9(11):1081. doi: 10.1038/s41419-018-1125-5.


High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design.

Lountos GT, Raran-Kurussi S, Zhao BM, Dyas BK, Burke TR Jr, Ulrich RG, Waugh DS.

Acta Crystallogr D Struct Biol. 2018 Oct 1;74(Pt 10):1015-1026. doi: 10.1107/S2059798318011919. Epub 2018 Oct 2.


Reduced Urban Heat Island intensity under warmer conditions.

Scott AA, Waugh DW, Zaitchik BF.

Environ Res Lett. 2018 Jun;13(6). pii: 064003. doi: 10.1088/1748-9326/aabd6c. Epub 2018 May 18.


MBP-binding DARPins facilitate the crystallization of an MBP fusion protein.

Gumpena R, Lountos GT, Waugh DS.

Acta Crystallogr F Struct Biol Commun. 2018 Sep 1;74(Pt 9):549-557. doi: 10.1107/S2053230X18009901. Epub 2018 Aug 29.


Influence of Diabetes Mellitus on the Recovery Trajectories of Function, Strength, and Self-Report Measures After Total Knee Arthroplasty.

Cheuy VA, Loyd BJ, Hafner W, Kittelson AJ, Waugh D, Stevens-Lapsley JE.

Arthritis Care Res (Hoboken). 2019 Aug;71(8):1059-1067. doi: 10.1002/acr.23741. Epub 2019 Jul 8.


Protocols for Studies on Genetically Engineered Mouse Models in Prostate Cancer.

Armstrong CWD, Lyubomska O, LaBonte MJ, Waugh DJJ.

Methods Mol Biol. 2018;1786:195-206. doi: 10.1007/978-1-4939-7845-8_11.


A gene signature associated with PTEN activation defines good prognosis intermediate risk prostate cancer cases.

Ong CW, Maxwell P, Alvi MA, McQuaid S, Waugh D, Mills I, Salto-Tellez M.

J Pathol Clin Res. 2018 Apr;4(2):103-113. doi: 10.1002/cjp2.94. Epub 2018 Feb 28.


Validation of Growth Layer Group (GLG) depositional rate using daily incremental growth lines in the dentin of beluga (Delphinapterus leucas (Pallas, 1776)) teeth.

Waugh DA, Suydam RS, Ortiz JD, Thewissen JGM.

PLoS One. 2018 Jan 16;13(1):e0190498. doi: 10.1371/journal.pone.0190498. eCollection 2018.


Temperature and heat in informal settlements in Nairobi.

Scott AA, Misiani H, Okoth J, Jordan A, Gohlke J, Ouma G, Arrighi J, Zaitchik BF, Jjemba E, Verjee S, Waugh DW.

PLoS One. 2017 Nov 6;12(11):e0187300. doi: 10.1371/journal.pone.0187300. eCollection 2017.


Crystal structure of the human dual specificity phosphatase 1 catalytic domain.

Gumpena R, Lountos GT, Raran-Kurussi S, Tropea JE, Cherry S, Waugh DS.

Protein Sci. 2018 Feb;27(2):561-567. doi: 10.1002/pro.3328. Epub 2017 Nov 21.


Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy.

Jain S, Lyons CA, Walker SM, McQuaid S, Hynes SO, Mitchell DM, Pang B, Logan GE, McCavigan AM, O'Rourke D, McArt DG, McDade SS, Mills IG, Prise KM, Knight LA, Steele CJ, Medlow PW, Berge V, Katz B, Loblaw DA, Harkin DP, James JA, O'Sullivan JM, Kennedy RD, Waugh DJ.

Ann Oncol. 2018 Jan 1;29(1):215-222. doi: 10.1093/annonc/mdx637.


Fluoride exposure and indicators of thyroid functioning: study design and data analysis considerations.

Waugh DT.

J Epidemiol Community Health. 2017 Dec;71(12):1226. doi: 10.1136/jech-2017-209956. Epub 2017 Oct 9. No abstract available.


Black Tea Source, Production, and Consumption: Assessment of Health Risks of Fluoride Intake in New Zealand.

Waugh DT, Godfrey M, Limeback H, Potter W.

J Environ Public Health. 2017;2017:5120504. doi: 10.1155/2017/5120504. Epub 2017 Jun 21.


Combining field experiments and predictive models to assess potential for increased plant diversity to climate-proof intensive agriculture.

Mason NWH, Palmer DJ, Romera A, Waugh D, Mudge PL.

Ecol Evol. 2017 May 30;7(13):4907-4918. doi: 10.1002/ece3.3028. eCollection 2017 Jul.


Expression and Purification of Recombinant Proteins in Escherichia coli with a His6 or Dual His6-MBP Tag.

Raran-Kurussi S, Waugh DS.

Methods Mol Biol. 2017;1607:1-15. doi: 10.1007/978-1-4939-7000-1_1.


Removal of Affinity Tags with TEV Protease.

Raran-Kurussi S, Cherry S, Zhang D, Waugh DS.

Methods Mol Biol. 2017;1586:221-230. doi: 10.1007/978-1-4939-6887-9_14.


Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology.

Walker SM, Knight LA, McCavigan AM, Logan GE, Berge V, Sherif A, Pandha H, Warren AY, Davidson C, Uprichard A, Blayney JK, Price B, Jellema GL, Steele CJ, Svindland A, McDade SS, Eden CG, Foster C, Mills IG, Neal DE, Mason MD, Kay EW, Waugh DJ, Harkin DP, Watson RW, Clarke NW, Kennedy RD.

Eur Urol. 2017 Oct;72(4):509-518. doi: 10.1016/j.eururo.2017.03.027. Epub 2017 Apr 10.


A Small-Molecule Microarray Approach for the Identification of E2 Enzyme Inhibitors in Ubiquitin-Like Conjugation Pathways.

Zlotkowski K, Hewitt WM, Sinniah RS, Tropea JE, Needle D, Lountos GT, Barchi JJ Jr, Waugh DS, Schneekloth JS Jr.

SLAS Discov. 2017 Jul;22(6):760-766. doi: 10.1177/2472555216683937. Epub 2017 Jan 6.


Respiratory Effects of Indoor Heat and the Interaction with Air Pollution in Chronic Obstructive Pulmonary Disease.

McCormack MC, Belli AJ, Waugh D, Matsui EC, Peng RD, Williams DL, Paulin L, Saha A, Aloe CM, Diette GB, Breysse PN, Hansel NN.

Ann Am Thorac Soc. 2016 Dec;13(12):2125-2131.


Isolating the roles of different forcing agents in global stratospheric temperature changes using model integrations with incrementally added single forcings.

Aquila V, Swartz WH, Waugh DW, Colarco PR, Pawson S, Polvani LM, Stolarski RS.

J Geophys Res Atmos. 2016 Jul 16;121(13):8067-8082. doi: 10.1002/2015JD023841. Epub 2016 Apr 1.


In vitro mesenchymal stem cell response to a CO2 laser modified polymeric material.

Waugh DG, Hussain I, Lawrence J, Smith GC, Cosgrove D, Toccaceli C.

Mater Sci Eng C Mater Biol Appl. 2016 Oct 1;67:727-736. doi: 10.1016/j.msec.2016.05.055. Epub 2016 May 16.


Expanding the Armamentarium for Castrate-resistant Prostate Cancer.

Waugh DJ.

Eur Urol. 2017 Mar;71(3):328-329. doi: 10.1016/j.eururo.2016.05.022. Epub 2016 May 24. No abstract available.


Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.

Dunne PD, McArt DG, Bradley CA, O'Reilly PG, Barrett HL, Cummins R, O'Grady T, Arthur K, Loughrey MB, Allen WL, McDade SS, Waugh DJ, Hamilton PW, Longley DB, Kay EW, Johnston PG, Lawler M, Salto-Tellez M, Van Schaeybroeck S.

Clin Cancer Res. 2016 Aug 15;22(16):4095-104. doi: 10.1158/1078-0432.CCR-16-0032. Epub 2016 May 5.


A dual protease approach for expression and affinity purification of recombinant proteins.

Raran-Kurussi S, Waugh DS.

Anal Biochem. 2016 Jul 1;504:30-7. doi: 10.1016/j.ab.2016.04.006. Epub 2016 Apr 19.


Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9.

Hewitt WM, Lountos GT, Zlotkowski K, Dahlhauser SD, Saunders LB, Needle D, Tropea JE, Zhan C, Wei G, Ma B, Nussinov R, Waugh DS, Schneekloth JS Jr.

Angew Chem Int Ed Engl. 2016 May 4;55(19):5703-7. doi: 10.1002/anie.201511351. Epub 2016 Apr 1.


Risk Assessment of Fluoride Intake from Tea in the Republic of Ireland and its Implications for Public Health and Water Fluoridation.

Waugh DT, Potter W, Limeback H, Godfrey M.

Int J Environ Res Public Health. 2016 Feb 26;13(3). pii: E259. doi: 10.3390/ijerph13030259.


PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy.

Armstrong CW, Maxwell PJ, Ong CW, Redmond KM, McCann C, Neisen J, Ward GA, Chessari G, Johnson C, Crawford NT, LaBonte MJ, Prise KM, Robson T, Salto-Tellez M, Longley DB, Waugh DJ.

Oncotarget. 2016 Feb 16;7(7):7885-98. doi: 10.18632/oncotarget.6955.


Delivering a research-enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program.

Lawler M, Gavin A, Salto-Tellez M, Kennedy RD, Van Schaeybroeck S, Wilson RH, Harkin DP, Grayson M, Boyd RE, Hamilton PW, McArt DG, James J, Robson T, Ladner RD, Prise KM, O'Sullivan JM, Harrison T, Murray L, Johnston PG, Waugh DJ.

Cancer. 2016 Mar 1;122(5):664-73. doi: 10.1002/cncr.29814. Epub 2015 Dec 22. No abstract available.


Crystal structures of MBP fusion proteins.

Waugh DS.

Protein Sci. 2016 Mar;25(3):559-71. doi: 10.1002/pro.2863. Epub 2016 Jan 9. Review.


PTEN mRNA detection by chromogenic, RNA in situ technologies: a reliable alternative to PTEN immunohistochemistry.

Bingham V, Ong CW, James J, Maxwell P, Waugh D, Salto-Tellez M, McQuaid S.

Hum Pathol. 2016 Jan;47(1):95-103. doi: 10.1016/j.humpath.2015.09.009. Epub 2015 Sep 25.


CD44-mediated activation of α5β1-integrin, cortactin and paxillin signaling underpins adhesion of basal-like breast cancer cells to endothelium and fibronectin-enriched matrices.

McFarlane S, McFarlane C, Montgomery N, Hill A, Waugh DJ.

Oncotarget. 2015 Nov 3;6(34):36762-73. doi: 10.18632/oncotarget.5461.


Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen.

Olson MA, Lee MS, Kissner TL, Alam S, Waugh DS, Saikh KU.

Sci Rep. 2015 Sep 18;5:14246. doi: 10.1038/srep14246. Erratum in: Sci Rep. 2018 Nov 19;8(1):17074.

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