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Items: 35


Two-dimensional NMR lineshape analysis of single, multiple, zero and double quantum correlation experiments.

Waudby CA, Ouvry M, Davis B, Christodoulou J.

J Biomol NMR. 2020 Jan 8. doi: 10.1007/s10858-019-00297-7. [Epub ahead of print]


Probing the dynamic stalk region of the ribosome using solution NMR.

Wang X, Kirkpatrick JP, Launay HMM, de Simone A, Häussinger D, Dobson CM, Vendruscolo M, Cabrita LD, Waudby CA, Christodoulou J.

Sci Rep. 2019 Sep 19;9(1):13528. doi: 10.1038/s41598-019-49190-1.


Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes.

Corazza A, Verona G, Waudby CA, Mangione PP, Bingham R, Uings I, Canetti D, Nocerino P, Taylor GW, Pepys MB, Christodoulou J, Bellotti V.

J Med Chem. 2019 Sep 12;62(17):8274-8283. doi: 10.1021/acs.jmedchem.9b01037. Epub 2019 Aug 22.


Nature and Regulation of Protein Folding on the Ribosome.

Waudby CA, Dobson CM, Christodoulou J.

Trends Biochem Sci. 2019 Nov;44(11):914-926. doi: 10.1016/j.tibs.2019.06.008. Epub 2019 Jul 10. Review.


Cross-Peaks in Simple Two-Dimensional NMR Experiments from Chemical Exchange of Transverse Magnetisation.

Waudby CA, Frenkiel T, Christodoulou J.

Angew Chem Int Ed Engl. 2019 Jun 24;58(26):8784-8788. doi: 10.1002/anie.201903245. Epub 2019 May 24.


Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis.

Waudby CA, Wlodarski T, Karyadi ME, Cassaignau AME, Chan SHS, Wentink AS, Schmidt-Engler JM, Camilloni C, Vendruscolo M, Cabrita LD, Christodoulou J.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9744-9749. doi: 10.1073/pnas.1716252115. Epub 2018 Sep 10.


Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation.

Ahn M, Waudby CA, Bernardo-Gancedo A, De Genst E, Dhulesia A, Salvatella X, Christodoulou J, Dobson CM, Kumita JR.

Sci Rep. 2017 Nov 3;7(1):15018. doi: 10.1038/s41598-017-14739-5.


A strategy for co-translational folding studies of ribosome-bound nascent chain complexes using NMR spectroscopy.

Cassaignau AM, Launay HM, Karyadi ME, Wang X, Waudby CA, Deckert A, Robertson AL, Christodoulou J, Cabrita LD.

Nat Protoc. 2016 Aug;11(8):1492-507. doi: 10.1038/nprot.2016.101. Epub 2016 Jul 28.


Two-Dimensional NMR Lineshape Analysis.

Waudby CA, Ramos A, Cabrita LD, Christodoulou J.

Sci Rep. 2016 Apr 25;6:24826. doi: 10.1038/srep24826.


Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor.

Deckert A, Waudby CA, Wlodarski T, Wentink AS, Wang X, Kirkpatrick JP, Paton JF, Camilloni C, Kukic P, Dobson CM, Vendruscolo M, Cabrita LD, Christodoulou J.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):5012-7. doi: 10.1073/pnas.1519124113. Epub 2016 Apr 18.


A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding.

Cabrita LD, Cassaignau AME, Launay HMM, Waudby CA, Wlodarski T, Camilloni C, Karyadi ME, Robertson AL, Wang X, Wentink AS, Goodsell L, Woolhead CA, Vendruscolo M, Dobson CM, Christodoulou J.

Nat Struct Mol Biol. 2016 Apr;23(4):278-285. doi: 10.1038/nsmb.3182. Epub 2016 Feb 29.


D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile.

Valleix S, Verona G, Jourde-Chiche N, Nédelec B, Mangione PP, Bridoux F, Mangé A, Dogan A, Goujon JM, Lhomme M, Dauteuille C, Chabert M, Porcari R, Waudby CA, Relini A, Talmud PJ, Kovrov O, Olivecrona G, Stoppini M, Christodoulou J, Hawkins PN, Grateau G, Delpech M, Kontush A, Gillmore JD, Kalopissis AD, Bellotti V.

Nat Commun. 2016 Jan 21;7:10353. doi: 10.1038/ncomms10353.


Increasing the sensitivity of NMR diffusion measurements by paramagnetic longitudinal relaxation enhancement, with application to ribosome-nascent chain complexes.

Chan SHS, Waudby CA, Cassaignau AME, Cabrita LD, Christodoulou J.

J Biomol NMR. 2015 Oct;63(2):151-163. doi: 10.1007/s10858-015-9968-x. Epub 2015 Aug 8.


The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.

Porcari R, Proukakis C, Waudby CA, Bolognesi B, Mangione PP, Paton JF, Mullin S, Cabrita LD, Penco A, Relini A, Verona G, Vendruscolo M, Stoppini M, Tartaglia GG, Camilloni C, Christodoulou J, Schapira AH, Bellotti V.

J Biol Chem. 2015 Jan 23;290(4):2395-404. doi: 10.1074/jbc.M114.610527. Epub 2014 Dec 10.


Protein folding on the ribosome studied using NMR spectroscopy.

Waudby CA, Launay H, Cabrita LD, Christodoulou J.

Prog Nucl Magn Reson Spectrosc. 2013 Oct;74:57-75. doi: 10.1016/j.pnmrs.2013.07.003. Epub 2013 Jul 27. Review.


In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells.

Waudby CA, Camilloni C, Fitzpatrick AW, Cabrita LD, Dobson CM, Vendruscolo M, Christodoulou J.

PLoS One. 2013 Aug 26;8(8):e72286. doi: 10.1371/journal.pone.0072286. eCollection 2013.


Hsp90 inhibits α-synuclein aggregation by interacting with soluble oligomers.

Daturpalli S, Waudby CA, Meehan S, Jackson SE.

J Mol Biol. 2013 Nov 15;425(22):4614-28. doi: 10.1016/j.jmb.2013.08.006. Epub 2013 Aug 13.


Atomic structure and hierarchical assembly of a cross-β amyloid fibril.

Fitzpatrick AW, Debelouchina GT, Bayro MJ, Clare DK, Caporini MA, Bajaj VS, Jaroniec CP, Wang L, Ladizhansky V, Müller SA, MacPhee CE, Waudby CA, Mott HR, De Simone A, Knowles TP, Saibil HR, Vendruscolo M, Orlova EV, Griffin RG, Dobson CM.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5468-73. doi: 10.1073/pnas.1219476110. Epub 2013 Mar 19.


Rapid distinction of intracellular and extracellular proteins using NMR diffusion measurements.

Waudby CA, Mantle MD, Cabrita LD, Gladden LF, Dobson CM, Christodoulou J.

J Am Chem Soc. 2012 Jul 18;134(28):11312-5. doi: 10.1021/ja304912c. Epub 2012 Jul 10.


An analysis of NMR sensitivity enhancements obtained using non-uniform weighted sampling, and the application to protein NMR.

Waudby CA, Christodoulou J.

J Magn Reson. 2012 Jun;219:46-52. doi: 10.1016/j.jmr.2012.04.013. Epub 2012 May 1.


Structural dynamics associated with intermediate formation in an archetypal conformational disease.

Nyon MP, Segu L, Cabrita LD, Lévy GR, Kirkpatrick J, Roussel BD, Patschull AO, Barrett TE, Ekeowa UI, Kerr R, Waudby CA, Kalsheker N, Hill M, Thalassinos K, Lomas DA, Christodoulou J, Gooptu B.

Structure. 2012 Mar 7;20(3):504-12. doi: 10.1016/j.str.2012.01.012.


Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation.

Fitzpatrick AW, Knowles TP, Waudby CA, Vendruscolo M, Dobson CM.

PLoS Comput Biol. 2011 Oct;7(10):e1002169. doi: 10.1371/journal.pcbi.1002169. Epub 2011 Oct 13.


Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation.

Shammas SL, Waudby CA, Wang S, Buell AK, Knowles TP, Ecroyd H, Welland ME, Carver JA, Dobson CM, Meehan S.

Biophys J. 2011 Oct 5;101(7):1681-9. doi: 10.1016/j.bpj.2011.07.056.


Solution-state nuclear magnetic resonance spectroscopy and protein folding.

Cabrita LD, Waudby CA, Dobson CM, Christodoulou J.

Methods Mol Biol. 2011;752:97-120. doi: 10.1007/978-1-60327-223-0_7.


Metastability of native proteins and the phenomenon of amyloid formation.

Baldwin AJ, Knowles TP, Tartaglia GG, Fitzpatrick AW, Devlin GL, Shammas SL, Waudby CA, Mossuto MF, Meehan S, Gras SL, Christodoulou J, Anthony-Cahill SJ, Barker PD, Vendruscolo M, Dobson CM.

J Am Chem Soc. 2011 Sep 14;133(36):14160-3. doi: 10.1021/ja2017703. Epub 2011 Aug 19.


GPU accelerated Monte Carlo simulation of pulsed-field gradient NMR experiments.

Waudby CA, Christodoulou J.

J Magn Reson. 2011 Jul;211(1):67-73. doi: 10.1016/j.jmr.2011.04.004. Epub 2011 Apr 23.


Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants.

Roodveldt C, Labrador-Garrido A, Gonzalez-Rey E, Fernandez-Montesinos R, Caro M, Lachaud CC, Waudby CA, Delgado M, Dobson CM, Pozo D.

PLoS One. 2010 Oct 26;5(10):e13481. doi: 10.1371/journal.pone.0013481.


Structure and properties of a complex of α-synuclein and a single-domain camelid antibody.

De Genst EJ, Guilliams T, Wellens J, O'Day EM, Waudby CA, Meehan S, Dumoulin M, Hsu ST, Cremades N, Verschueren KH, Pardon E, Wyns L, Steyaert J, Christodoulou J, Dobson CM.

J Mol Biol. 2010 Sep 17;402(2):326-43. doi: 10.1016/j.jmb.2010.07.001. Epub 2010 Jul 8.


Mechanosensitive self-replication driven by self-organization.

Carnall JM, Waudby CA, Belenguer AM, Stuart MC, Peyralans JJ, Otto S.

Science. 2010 Mar 19;327(5972):1502-6. doi: 10.1126/science.1182767.


The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation.

Waudby CA, Knowles TP, Devlin GL, Skepper JN, Ecroyd H, Carver JA, Welland ME, Christodoulou J, Dobson CM, Meehan S.

Biophys J. 2010 Mar 3;98(5):843-51. doi: 10.1016/j.bpj.2009.10.056.


An analytical solution to the kinetics of breakable filament assembly.

Knowles TP, Waudby CA, Devlin GL, Cohen SI, Aguzzi A, Vendruscolo M, Terentjev EM, Welland ME, Dobson CM.

Science. 2009 Dec 11;326(5959):1533-7. doi: 10.1126/science.1178250.


On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid.

Lendel C, Bertoncini CW, Cremades N, Waudby CA, Vendruscolo M, Dobson CM, Schenk D, Christodoulou J, Toth G.

Biochemistry. 2009 Sep 8;48(35):8322-34. doi: 10.1021/bi901285x.


Position-dependent electrostatic protection against protein aggregation.

Buell AK, Tartaglia GG, Birkett NR, Waudby CA, Vendruscolo M, Salvatella X, Welland ME, Dobson CM, Knowles TP.

Chembiochem. 2009 May 25;10(8):1309-12. doi: 10.1002/cbic.200900144.


Chemical documents: machine understanding and automated information extraction.

Townsend JA, Adams SE, Waudby CA, de Souza VK, Goodman JM, Murray-Rust P.

Org Biomol Chem. 2004 Nov 21;2(22):3294-300. Epub 2004 Oct 20.


Experimental data checker: better information for organic chemists.

Adams SE, Goodman JM, Kidd RJ, McNaught AD, Murray-Rust P, Norton FR, Townsend JA, Waudby CA.

Org Biomol Chem. 2004 Nov 7;2(21):3067-70. Epub 2004 Sep 30.


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