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Items: 1 to 50 of 90

1.

NK cell detachment from target cells is regulated by successful cytotoxicity and influences cytokine production.

Anft M, Netter P, Urlaub D, Prager I, Schaffner S, Watzl C.

Cell Mol Immunol. 2019 Aug 30. doi: 10.1038/s41423-019-0277-2. [Epub ahead of print]

PMID:
31471588
2.

NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing.

Prager I, Liesche C, van Ooijen H, Urlaub D, Verron Q, Sandström N, Fasbender F, Claus M, Eils R, Beaudouin J, Önfelt B, Watzl C.

J Exp Med. 2019 Sep 2;216(9):2113-2127. doi: 10.1084/jem.20181454. Epub 2019 Jul 3.

PMID:
31270246
3.

Mechanisms of natural killer cell-mediated cellular cytotoxicity.

Prager I, Watzl C.

J Leukoc Biol. 2019 Jun;105(6):1319-1329. doi: 10.1002/JLB.MR0718-269R. Epub 2019 May 20. Review.

PMID:
31107565
4.

Circulating growth/differentiation factor 15 is associated with human CD56bright natural killer cell dysfunction and nosocomial infection in severe systemic inflammation.

Kleinertz H, Hepner-Schefczyk M, Ehnert S, Claus M, Halbgebauer R, Boller L, Huber-Lang M, Cinelli P, Kirschning C, Flohé S, Sander A, Waydhas C, Vonderhagen S, Jäger M, Dudda M, Watzl C, Flohé SB.

EBioMedicine. 2019 May;43:380-391. doi: 10.1016/j.ebiom.2019.04.018. Epub 2019 Apr 13.

5.

LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer.

Cadenas C, Vosbeck S, Edlund K, Grgas K, Madjar K, Hellwig B, Adawy A, Glotzbach A, Stewart JD, Lesjak MS, Franckenstein D, Claus M, Hayen H, Schriewer A, Gianmoena K, Thaler S, Schmidt M, Micke P, Pontén F, Mardinoglu A, Zhang C, Käfferlein HU, Watzl C, Frank S, Rahnenführer J, Marchan R, Hengstler JG.

Int J Cancer. 2019 Aug 15;145(4):901-915. doi: 10.1002/ijc.32138. Epub 2019 Feb 7.

6.

SLAM family receptors in natural killer cells - Mediators of adhesion, activation and inhibition via cis and trans interactions.

Claus M, Urlaub D, Fasbender F, Watzl C.

Clin Immunol. 2019 Jul;204:37-42. doi: 10.1016/j.clim.2018.10.011. Epub 2018 Oct 22. Review.

PMID:
30359773
7.

Attention to Emotional Information Is Associated With Cytokine Responses to Psychological Stress.

Maydych V, Claus M, Watzl C, Kleinsorge T.

Front Neurosci. 2018 Oct 2;12:687. doi: 10.3389/fnins.2018.00687. eCollection 2018.

8.

Single-Fluorescent Protein Reporters Allow Parallel Quantification of Natural Killer Cell-Mediated Granzyme and Caspase Activities in Single Target Cells.

Liesche C, Sauer P, Prager I, Urlaub D, Claus M, Eils R, Beaudouin J, Watzl C.

Front Immunol. 2018 Aug 8;9:1840. doi: 10.3389/fimmu.2018.01840. eCollection 2018.

9.

Adaptive responses of innate lymphocytes.

Watzl C.

Nat Immunol. 2018 May;19(5):426-427. doi: 10.1038/s41590-018-0088-0. No abstract available.

PMID:
29670228
10.

Impedance-based analysis of Natural Killer cell stimulation.

Fasbender F, Watzl C.

Sci Rep. 2018 Mar 21;8(1):4938. doi: 10.1038/s41598-018-23368-5.

11.

Impact of chronic and acute academic stress on lymphocyte subsets and monocyte function.

Maydych V, Claus M, Dychus N, Ebel M, Damaschke J, Diestel S, Wolf OT, Kleinsorge T, Watzl C.

PLoS One. 2017 Nov 16;12(11):e0188108. doi: 10.1371/journal.pone.0188108. eCollection 2017.

12.

KIR downregulation by IL-12/15/18 unleashes human NK cells from KIR/HLA-I inhibition and enhances killing of tumor cells.

Ewen EM, Pahl JHW, Miller M, Watzl C, Cerwenka A.

Eur J Immunol. 2018 Feb;48(2):355-365. doi: 10.1002/eji.201747128. Epub 2017 Nov 29.

13.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J.

Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632. No abstract available.

14.

Executive control, ERP and pro-inflammatory activity in emotionally exhausted middle-aged employees. Comparison between subclinical burnout and mild to moderate depression.

Gajewski PD, Boden S, Freude G, Potter GG, Claus M, Bröde P, Watzl C, Getzmann S, Falkenstein M.

Psychoneuroendocrinology. 2017 Dec;86:176-186. doi: 10.1016/j.psyneuen.2017.09.017. Epub 2017 Sep 18.

PMID:
28972891
15.

Termination of the Activating NK Cell Immunological Synapse Is an Active and Regulated Process.

Netter P, Anft M, Watzl C.

J Immunol. 2017 Oct 1;199(7):2528-2535. doi: 10.4049/jimmunol.1700394. Epub 2017 Aug 23.

16.

Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes.

Fasbender F, Claus M, Wingert S, Sandusky M, Watzl C.

Front Immunol. 2017 Jul 7;8:789. doi: 10.3389/fimmu.2017.00789. eCollection 2017.

17.

Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma.

Marchan R, Büttner B, Lambert J, Edlund K, Glaeser I, Blaszkewicz M, Leonhardt G, Marienhoff L, Kaszta D, Anft M, Watzl C, Madjar K, Grinberg M, Rempel E, Hergenröder R, Selinski S, Rahnenführer J, Lesjak MS, Stewart JD, Cadenas C, Hengstler JG.

Cancer Res. 2017 Sep 1;77(17):4589-4601. doi: 10.1158/0008-5472.CAN-16-2065. Epub 2017 Jun 26.

18.

Rituximab and Fcγ Receptors in Granulomatosis With Polyangiitis (Wegener's): Comment on the Article by Cartin-Ceba et al.

Merkt W, Lorenz HM, Watzl C.

Arthritis Rheumatol. 2017 Jul;69(7):1506-1507. doi: 10.1002/art.40119. Epub 2017 May 31. No abstract available.

19.

Altered expression of miR-181a and miR-146a does not change the expression of surface NCRs in human NK cells.

Rady M, Watzl C, Claus M, Khorshid O, Mahran L, Abou-Aisha K.

Sci Rep. 2017 Feb 1;7:41381. doi: 10.1038/srep41381.

20.

Design, Synthesis, and Biological Evaluation of Small, High-Affinity Siglec-7 Ligands: Toward Novel Inhibitors of Cancer Immune Evasion.

Prescher H, Frank M, Gütgemann S, Kuhfeldt E, Schweizer A, Nitschke L, Watzl C, Brossmer R.

J Med Chem. 2017 Feb 9;60(3):941-956. doi: 10.1021/acs.jmedchem.6b01111. Epub 2017 Jan 19.

PMID:
28103033
21.

LFA-1 Activation in NK Cells and Their Subsets: Influence of Receptors, Maturation, and Cytokine Stimulation.

Urlaub D, Höfer K, Müller ML, Watzl C.

J Immunol. 2017 Mar 1;198(5):1944-1951. doi: 10.4049/jimmunol.1601004. Epub 2017 Jan 18.

22.

Co-Activation of Cultured Human Natural Killer Cells: Enhanced Function and Decreased Inhibition.

Urlaub D, Bhat R, Messmer B, Watzl C.

J Toxicol Environ Health A. 2016;79(22-23):1078-1084.

PMID:
27924718
23.

Rituximab induces phenotypical and functional changes of NK cells in a non-malignant experimental setting.

Merkt W, Lorenz HM, Watzl C.

Arthritis Res Ther. 2016 Sep 15;18(1):206. doi: 10.1186/s13075-016-1101-3.

24.

Active but not inactive granulomatosis with polyangiitis is associated with decreased and phenotypically and functionally altered CD56(dim) natural killer cells.

Merkt W, Claus M, Blank N, Hundemer M, Cerwenka A, Lorenz HM, Watzl C.

Arthritis Res Ther. 2016 Sep 13;18(1):204. doi: 10.1186/s13075-016-1098-7.

25.

Measuring the immune system: a comprehensive approach for the analysis of immune functions in humans.

Claus M, Dychus N, Ebel M, Damaschke J, Maydych V, Wolf OT, Kleinsorge T, Watzl C.

Arch Toxicol. 2016 Oct;90(10):2481-95. doi: 10.1007/s00204-016-1809-5. Epub 2016 Aug 13.

PMID:
27522652
26.

Modulation of natural killer cell functions by interactions between 2B4 and CD48 in cis and in trans.

Claus M, Wingert S, Watzl C.

Open Biol. 2016 May;6(5). pii: 160010. doi: 10.1098/rsob.160010. Epub 2016 May 25.

27.

Designed DNA Surfaces for in Vitro Modulation of Natural Killer Cells.

Garrecht R, Meyer R, Duppach J, Reipschläger S, Watzl C, Niemeyer CM.

Chembiochem. 2016 Mar 15;17(6):486-92. doi: 10.1002/cbic.201500629. Epub 2016 Feb 17.

PMID:
26890992
28.

Natural Killer Cells and Liver Fibrosis.

Fasbender F, Widera A, Hengstler JG, Watzl C.

Front Immunol. 2016 Jan 29;7:19. doi: 10.3389/fimmu.2016.00019. eCollection 2016. Review.

29.

Peripheral blood natural killer cell percentages in granulomatosis with polyangiitis correlate with disease inactivity and stage.

Merkt W, Sturm P, Lasitschka F, Tretter T, Watzl C, Saure D, Hundemer M, Schwenger V, Blank N, Lorenz HM, Cerwenka A.

Arthritis Res Ther. 2015 Nov 21;17:337. doi: 10.1186/s13075-015-0851-7.

30.

Synthesis and biological evaluation of 9-N-oxamyl sialosides as Siglec-7 ligands.

Prescher H, Gütgemann S, Frank M, Kuhfeldt E, Watzl C, Brossmer R.

Bioorg Med Chem. 2015 Sep 1;23(17):5915-21. doi: 10.1016/j.bmc.2015.06.069. Epub 2015 Jul 7.

PMID:
26234906
31.

Inhibition of NKp30- and 2B4-mediated NK cell activation by evolutionary different human and bovine CEACAM1 receptors.

Merkt W, Urlaub D, Meinke S, Kammerer R, Watzl C.

Eur J Immunol. 2015 Jul;45(7):2134-42. doi: 10.1002/eji.201445151. Epub 2015 Apr 22.

32.

Recruitment of activating NK-cell receptors 2B4 and NKG2D to membrane microdomains in mammalian cells is dependent on their transmembrane regions.

Gütgemann SA, Sandusky MM, Wingert S, Claus M, Watzl C.

Eur J Immunol. 2015 Apr;45(4):1258-69. doi: 10.1002/eji.201444741. Epub 2015 Jan 21.

33.

Natural killer cell regulation - beyond the receptors.

Watzl C, Urlaub D, Fasbender F, Claus M.

F1000Prime Rep. 2014 Oct 1;6:87. doi: 10.12703/P6-87. eCollection 2014. Review.

34.

How to trigger a killer: modulation of natural killer cell reactivity on many levels.

Watzl C.

Adv Immunol. 2014;124:137-70. doi: 10.1016/B978-0-12-800147-9.00005-4. Review.

PMID:
25175775
35.

WhatSAP - 2B4 sends mixed messages in the absence of SAP.

Watzl C, Claus M.

Eur J Immunol. 2014 May;44(5):1281-4. doi: 10.1002/eji.201444562. Epub 2014 Apr 14.

36.

A unique secreted adenovirus E3 protein binds to the leukocyte common antigen CD45 and modulates leukocyte functions.

Windheim M, Southcombe JH, Kremmer E, Chaplin L, Urlaub D, Falk CS, Claus M, Mihm J, Braithwaite M, Dennehy K, Renz H, Sester M, Watzl C, Burgert HG.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4884-93. doi: 10.1073/pnas.1312420110. Epub 2013 Nov 11.

37.

Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage.

Cohnen A, Chiang SC, Stojanovic A, Schmidt H, Claus M, Saftig P, Janßen O, Cerwenka A, Bryceson YT, Watzl C.

Blood. 2013 Aug 22;122(8):1411-8. doi: 10.1182/blood-2012-07-441832. Epub 2013 Jul 11.

38.

NK cells--versatile tools for viral defense and cancer treatment.

Momburg F, Watzl C, Cerwenka A.

Eur J Immunol. 2013 Apr;43(4):860-3. doi: 10.1002/eji.201370047. No abstract available.

39.

NAB2 and EGR-1 exert opposite roles in regulating TRAIL expression in human Natural Killer cells.

Balzarolo M, Watzl C, Medema JP, Wolkers MC.

Immunol Lett. 2013 Mar;151(1-2):61-7. doi: 10.1016/j.imlet.2013.02.001. Epub 2013 Feb 14.

PMID:
23416169
40.

Activating natural cytotoxicity receptors of natural killer cells in cancer and infection.

Koch J, Steinle A, Watzl C, Mandelboim O.

Trends Immunol. 2013 Apr;34(4):182-91. doi: 10.1016/j.it.2013.01.003. Epub 2013 Feb 13. Review.

PMID:
23414611
41.

NK cell cytotoxicity mediated by 2B4 and NTB-A is dependent on SAP acting downstream of receptor phosphorylation.

Meinke S, Watzl C.

Front Immunol. 2013 Jan 22;4:3. doi: 10.3389/fimmu.2013.00003. eCollection 2013.

42.

Understanding natural killer cell regulation by mathematical approaches.

Watzl C, Sternberg-Simon M, Urlaub D, Mehr R.

Front Immunol. 2012 Dec 12;3:359. doi: 10.3389/fimmu.2012.00359. eCollection 2012.

43.

The stalk domain and the glycosylation status of the activating natural killer cell receptor NKp30 are important for ligand binding.

Hartmann J, Tran TV, Kaudeer J, Oberle K, Herrmann J, Quagliano I, Abel T, Cohnen A, Gatterdam V, Jacobs A, Wollscheid B, Tampé R, Watzl C, Diefenbach A, Koch J.

J Biol Chem. 2012 Sep 7;287(37):31527-39. doi: 10.1074/jbc.M111.304238. Epub 2012 Jul 17.

44.

Enhancement of natural killer cell effector functions against selected lymphoma and leukemia cell lines by dasatinib.

Hassold N, Seystahl K, Kempf K, Urlaub D, Zekl M, Einsele H, Watzl C, Wischhusen J, Seggewiss-Bernhardt R.

Int J Cancer. 2012 Sep 15;131(6):E916-27. doi: 10.1002/ijc.27537. Epub 2012 Apr 4.

45.

Multiple receptors trigger human NK cell-mediated cytotoxicity against porcine chondrocytes.

Sommaggio R, Cohnen A, Watzl C, Costa C.

J Immunol. 2012 Mar 1;188(5):2075-83. doi: 10.4049/jimmunol.1100433. Epub 2012 Jan 27.

46.

Molecular mechanisms of natural killer cell regulation.

Watzl C, Urlaub D.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1418-32. Review.

PMID:
22201812
47.

Modulation of NKp30- and NKp46-mediated natural killer cell responses by poxviral hemagglutinin.

Jarahian M, Fiedler M, Cohnen A, Djandji D, Hämmerling GJ, Gati C, Cerwenka A, Turner PC, Moyer RW, Watzl C, Hengel H, Momburg F.

PLoS Pathog. 2011 Aug;7(8):e1002195. doi: 10.1371/journal.ppat.1002195. Epub 2011 Aug 25.

48.

Integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in immune cells.

Mesecke S, Urlaub D, Busch H, Eils R, Watzl C.

Sci Signal. 2011 May 31;4(175):ra36. doi: 10.1126/scisignal.2001325.

49.

WF10 stimulates NK cell cytotoxicity by increasing LFA-1-mediated adhesion to tumor cells.

Kühne L, Konstandin M, Samstag Y, Meuer S, Giese T, Watzl C.

J Biomed Biotechnol. 2011;2011:436587. doi: 10.1155/2011/436587. Epub 2011 May 3.

50.

Glycosylation affects ligand binding and function of the activating natural killer cell receptor 2B4 (CD244) protein.

Margraf-Schönfeld S, Böhm C, Watzl C.

J Biol Chem. 2011 Jul 8;286(27):24142-9. doi: 10.1074/jbc.M111.225334. Epub 2011 May 23.

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