Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 86

1.

VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites.

Czogalla KJ, Liphardt K, Höning K, Hornung V, Biswas A, Watzka M, Oldenburg J.

Blood Adv. 2018 Mar 27;2(6):691-702. doi: 10.1182/bloodadvances.2017006775.

2.

Food supply and size class depending variations in phytodetritus intake in the benthic foraminifer Ammonia tepida.

Wukovits J, Bukenberger P, Enge AJ, Gerg M, Wanek W, Watzka M, Heinz P.

Biol Open. 2018 Apr 13;7(4). pii: bio030056. doi: 10.1242/bio.030056.

3.

Decoupling of microbial carbon, nitrogen, and phosphorus cycling in response to extreme temperature events.

Mooshammer M, Hofhansl F, Frank AH, Wanek W, Hämmerle I, Leitner S, Schnecker J, Wild B, Watzka M, Keiblinger KM, Zechmeister-Boltenstern S, Richter A.

Sci Adv. 2017 May 3;3(5):e1602781. doi: 10.1126/sciadv.1602781. eCollection 2017 May.

4.

Warfarin and vitamin K compete for binding to Phe55 in human VKOR.

Czogalla KJ, Biswas A, Höning K, Hornung V, Liphardt K, Watzka M, Oldenburg J.

Nat Struct Mol Biol. 2017 Jan;24(1):77-85. doi: 10.1038/nsmb.3338. Epub 2016 Dec 12.

PMID:
27941861
5.

VKCFD2 - from clinical phenotype to molecular mechanism.

Czogalla KJ, Watzka M, Oldenburg J.

Hamostaseologie. 2016 Nov 8;36(Suppl. 2):S13-S20. Review.

PMID:
27824210
6.

Drought history affects grassland plant and microbial carbon turnover during and after a subsequent drought event.

Fuchslueger L, Bahn M, Hasibeder R, Kienzl S, Fritz K, Schmitt M, Watzka M, Richter A.

J Ecol. 2016 Sep;104(5):1453-1465. Epub 2016 May 24.

7.

Plant-derived compounds stimulate the decomposition of organic matter in arctic permafrost soils.

Wild B, Gentsch N, Čapek P, Diáková K, Alves RJ, Bárta J, Gittel A, Hugelius G, Knoltsch A, Kuhry P, Lashchinskiy N, Mikutta R, Palmtag J, Schleper C, Schnecker J, Shibistova O, Takriti M, Torsvik VL, Urich T, Watzka M, Šantrůčková H, Guggenberger G, Richter A.

Sci Rep. 2016 May 9;6:25607. doi: 10.1038/srep25607.

8.

Carbon and Nitrogen Uptake of Calcareous Benthic Foraminifera along a Depth-Related Oxygen Gradient in the OMZ of the Arabian Sea.

Enge AJ, Wukovits J, Wanek W, Watzka M, Witte UF, Hunter WR, Heinz P.

Front Microbiol. 2016 Feb 11;7:71. doi: 10.3389/fmicb.2016.00071. eCollection 2016.

9.

Structural Modeling Insights into Human VKORC1 Phenotypes.

Czogalla KJ, Watzka M, Oldenburg J.

Nutrients. 2015 Aug 14;7(8):6837-51. doi: 10.3390/nu7085313. Review.

10.

VKORC1 and VKORC1L1: Why do Vertebrates Have Two Vitamin K 2,3-Epoxide Reductases?

Oldenburg J, Watzka M, Bevans CG.

Nutrients. 2015 Jul 30;7(8):6250-80. doi: 10.3390/nu7085280. Review.

11.

Phylogeny of the Vitamin K 2,3-Epoxide Reductase (VKOR) Family and Evolutionary Relationship to the Disulfide Bond Formation Protein B (DsbB) Family.

Bevans CG, Krettler C, Reinhart C, Watzka M, Oldenburg J.

Nutrients. 2015 Jul 29;7(8):6224-49. doi: 10.3390/nu7085281.

12.

Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain.

Caspers M, Czogalla KJ, Liphardt K, Müller J, Westhofen P, Watzka M, Oldenburg J.

Thromb Res. 2015 May;135(5):977-83. doi: 10.1016/j.thromres.2015.01.025. Epub 2015 Jan 26.

13.

Capture of algae promotes growth and propagation in aquatic Utricularia.

Koller-Peroutka M, Lendl T, Watzka M, Adlassnig W.

Ann Bot. 2015 Feb;115(2):227-36. doi: 10.1093/aob/mcu236. Epub 2014 Dec 18.

14.

Tris(3-hydroxypropyl)phosphine is superior to dithiothreitol for in vitro assessment of vitamin K 2,3-epoxide reductase activity.

Krettler C, Bevans CG, Reinhart C, Watzka M, Oldenburg J.

Anal Biochem. 2015 Apr 1;474:89-94. doi: 10.1016/j.ab.2014.12.004. Epub 2014 Dec 15.

PMID:
25524619
15.

Genetic variants of the vitamin K dependent coagulation system and intraventricular hemorrhage in preterm infants.

Schreiner C, Suter S, Watzka M, Hertfelder HJ, Schreiner F, Oldenburg J, Bartmann P, Heep A.

BMC Pediatr. 2014 Sep 1;14:219. doi: 10.1186/1471-2431-14-219.

16.

Bleeding and non-bleeding phenotypes in patients with GGCX gene mutations.

Watzka M, Geisen C, Scheer M, Wieland R, Wiegering V, Dörner T, Laws HJ, Gümrük F, Hanalioglu S, Unal S, Albayrak D, Oldenburg J.

Thromb Res. 2014 Oct;134(4):856-65. doi: 10.1016/j.thromres.2014.07.004. Epub 2014 Jul 12.

PMID:
25151188
17.

Input of easily available organic C and N stimulates microbial decomposition of soil organic matter in arctic permafrost soil.

Wild B, Schnecker J, Alves RJ, Barsukov P, Bárta J, Capek P, Gentsch N, Gittel A, Guggenberger G, Lashchinskiy N, Mikutta R, Rusalimova O, Santrůčková H, Shibistova O, Urich T, Watzka M, Zrazhevskaya G, Richter A.

Soil Biol Biochem. 2014 Aug;75(100):143-151.

18.

The Arg98Trp mutation in human VKORC1 causing VKCFD2 disrupts a di-arginine-based ER retention motif.

Czogalla KJ, Biswas A, Rost S, Watzka M, Oldenburg J.

Blood. 2014 Aug 21;124(8):1354-62. doi: 10.1182/blood-2013-12-545988. Epub 2014 Jun 24.

19.

Adjustment of microbial nitrogen use efficiency to carbon:nitrogen imbalances regulates soil nitrogen cycling.

Mooshammer M, Wanek W, Hämmerle I, Fuchslueger L, Hofhansl F, Knoltsch A, Schnecker J, Takriti M, Watzka M, Wild B, Keiblinger KM, Zechmeister-Boltenstern S, Richter A.

Nat Commun. 2014 Apr 16;5:3694. doi: 10.1038/ncomms4694.

20.

Comparative genetics of warfarin resistance.

Oldenburg J, Müller CR, Rost S, Watzka M, Bevans CG.

Hamostaseologie. 2014;34(2):143-59. doi: 10.5482/HAMO-13-09-0047. Epub 2013 Nov 29. Review.

PMID:
24287886
21.

Human VKORC1 mutations cause variable degrees of 4-hydroxycoumarin resistance and affect putative warfarin binding interfaces.

Czogalla KJ, Biswas A, Wendeln AC, Westhofen P, Müller CR, Watzka M, Oldenburg J.

Blood. 2013 Oct 10;122(15):2743-50. doi: 10.1182/blood-2013-05-501692. Epub 2013 Aug 27.

22.

Metabolic features of Protochlamydia amoebophila elementary bodies--a link between activity and infectivity in Chlamydiae.

Sixt BS, Siegl A, Müller C, Watzka M, Wultsch A, Tziotis D, Montanaro J, Richter A, Schmitt-Kopplin P, Horn M.

PLoS Pathog. 2013;9(8):e1003553. doi: 10.1371/journal.ppat.1003553. Epub 2013 Aug 8.

23.

Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay.

Bevans CG, Krettler C, Reinhart C, Tran H, Koßmann K, Watzka M, Oldenburg J.

Biochim Biophys Acta. 2013 Aug;1830(8):4202-10. doi: 10.1016/j.bbagen.2013.04.018. Epub 2013 Apr 22. Erratum in: Biochim Biophys Acta. 2014 Jul;1840(7):2382-4.

24.

A new cell culture-based assay quantifies vitamin K 2,3-epoxide reductase complex subunit 1 function and reveals warfarin resistance phenotypes not shown by the dithiothreitol-driven VKOR assay.

Fregin A, Czogalla KJ, Gansler J, Rost S, Taverna M, Watzka M, Bevans CG, Müller CR, Oldenburg J.

J Thromb Haemost. 2013 May;11(5):872-80. doi: 10.1111/jth.12185.

25.

An analysis of diet quality, how it controls fatty acid profiles, isotope signatures and stoichiometry in the malaria mosquito Anopheles arabiensis.

Hood-Nowotny R, Schwarzinger B, Schwarzinger C, Soliban S, Madakacherry O, Aigner M, Watzka M, Gilles J.

PLoS One. 2012;7(10):e45222. doi: 10.1371/journal.pone.0045222. Epub 2012 Oct 25.

26.

Rate of belowground carbon allocation differs with successional habit of two afromontane trees.

Shibistova O, Yohannes Y, Boy J, Richter A, Wild B, Watzka M, Guggenberger G.

PLoS One. 2012;7(9):e45540. doi: 10.1371/journal.pone.0045540. Epub 2012 Sep 26.

27.

VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation.

Marinova M, Lütjohann D, Breuer O, Kölsch H, Westhofen P, Watzka M, Mengel M, Stoffel-Wagner B, Hartmann G, Coch C, Oldenburg J.

Eur J Clin Pharmacol. 2013 Mar;69(3):467-75. doi: 10.1007/s00228-012-1362-y. Epub 2012 Aug 5.

28.

Intrinsic and synthetic stable isotope marking of tsetse flies.

Hood-Nowotny R, Watzka M, Mayr L, Mekonnen S, Kapitano B, Parker A.

J Insect Sci. 2011;11:79. doi: 10.1673/031.011.7901.

29.

Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function.

Westhofen P, Watzka M, Marinova M, Hass M, Kirfel G, Müller J, Bevans CG, Müller CR, Oldenburg J.

J Biol Chem. 2011 Apr 29;286(17):15085-94. doi: 10.1074/jbc.M110.210971. Epub 2011 Mar 2.

30.

Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles.

El-Maarri O, Walier M, Behne F, van Üüm J, Singer H, Diaz-Lacava A, Nüsgen N, Niemann B, Watzka M, Reinsberg J, van der Ven H, Wienker T, Stoffel-Wagner B, Schwaab R, Oldenburg J.

PLoS One. 2011 Jan 19;6(1):e16252. doi: 10.1371/journal.pone.0016252. Erratum in: PLoS One. 2015;10(3):e0119057.

31.

Prediction of phenprocoumon maintenance dose and phenprocoumon plasma concentration by genetic and non-genetic parameters.

Geisen C, Luxembourg B, Watzka M, Toennes SW, Sittinger K, Marinova M, von Ahsen N, Lindhoff-Last E, Seifried E, Oldenburg J.

Eur J Clin Pharmacol. 2011 Apr;67(4):371-381. doi: 10.1007/s00228-010-0950-y. Epub 2010 Nov 26.

32.

Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment.

Watzka M, Geisen C, Bevans CG, Sittinger K, Spohn G, Rost S, Seifried E, Müller CR, Oldenburg J.

J Thromb Haemost. 2011 Jan;9(1):109-18. doi: 10.1111/j.1538-7836.2010.04095.x.

33.

Polymorphisms in VKORC1 and GGCX are not major genetic determinants of vitamin K-dependent coagulation factor activity in Western Germans.

Watzka M, Westhofen P, Hass M, Marinova M, Pötzsch B, Oldenburg J.

Thromb Haemost. 2009 Aug;102(2):418-20. doi: 10.1160/TH09-04-0217. No abstract available.

PMID:
19652895
34.

Vitamin K-dependent coagulation factors deficiency.

Brenner B, Kuperman AA, Watzka M, Oldenburg J.

Semin Thromb Hemost. 2009 Jun;35(4):439-46. doi: 10.1055/s-0029-1225766. Epub 2009 Jul 13. Review.

PMID:
19598072
35.

VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding.

Spohn G, Kleinridders A, Wunderlich FT, Watzka M, Zaucke F, Blumbach K, Geisen C, Seifried E, Müller C, Paulsson M, Brüning JC, Oldenburg J.

Thromb Haemost. 2009 Jun;101(6):1044-50.

PMID:
19492146
36.

The first case of combined coagulation factor V and coagulation factor VIII deficiency in Poland due to a novel p.Tyr135Asn missense mutation in the MCFD2 gene.

Ivaskevicius V, Windyga J, Baran B, Bykowska K, Daugela L, Watzka M, Seifried E, Oldenburg J.

Blood Coagul Fibrinolysis. 2008 Sep;19(6):531-534. doi: 10.1097/MBC.0b013e3283061103.

PMID:
18685427
37.

The vitamin K cycle.

Oldenburg J, Marinova M, Müller-Reible C, Watzka M.

Vitam Horm. 2008;78:35-62. doi: 10.1016/S0083-6729(07)00003-9. Review.

PMID:
18374189
38.

[New insight in therapeutic anticoagulation by Coumarin derivatives].

Oldenburg J, Seidel H, Pötzsch B, Watzka M.

Hamostaseologie. 2008 Feb;28(1-2):44-50. Review. German.

PMID:
18278162
39.

Current pharmacogenetic developments in oral anticoagulation therapy: the influence of variant VKORC1 and CYP2C9 alleles.

Oldenburg J, Bevans CG, Fregin A, Geisen C, Müller-Reible C, Watzka M.

Thromb Haemost. 2007 Sep;98(3):570-8. Review.

PMID:
17849045
40.

VKORC1: molecular target of coumarins.

Oldenburg J, Watzka M, Rost S, Müller CR.

J Thromb Haemost. 2007 Jul;5 Suppl 1:1-6. Review.

41.

Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans.

Watzka M, Nebel A, El Mokhtari NE, Ivandic B, Müller J, Schreiber S, Oldenburg J.

Thromb Haemost. 2007 Jun;97(6):998-1002.

PMID:
17549303
42.

Detection of heterozygous large deletions in the antithrombin gene using multiplex polymerase chain reaction and denatured high performance liquid chromatography.

Pavlova A, El-Maarri O, Luxembourg B, Lindhoff-Last E, Kochhan L, Bruhn HD, Delev D, Watzka M, Seifried E, Oldenburg J.

Haematologica. 2006 Sep;91(9):1264-7.

43.

Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle.

Oldenburg J, Bevans CG, Müller CR, Watzka M.

Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):347-53. Review.

PMID:
16677080
44.

Lack of F8 mRNA: a novel mechanism leading to hemophilia A.

El-Maarri O, Singer H, Klein C, Watzka M, Herbiniaux U, Brackmann HH, Schröder J, Graw J, Müller CR, Schramm W, Schwaab R, Haaf T, Hanfland P, Oldenburg J.

Blood. 2006 Apr 1;107(7):2759-65. Epub 2005 Dec 8.

45.

VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation.

Geisen C, Watzka M, Sittinger K, Steffens M, Daugela L, Seifried E, Müller CR, Wienker TF, Oldenburg J.

Thromb Haemost. 2005 Oct;94(4):773-9.

PMID:
16270629
46.

Analysis of mRNA in hemophilia A patients with undetectable mutations reveals normal splicing in the factor VIII gene.

El-Maarri O, Herbiniaux U, Graw J, Schröder J, Terzic A, Watzka M, Brackmann HH, Schramm W, Hanfland P, Schwaab R, Müller CR, Oldenburg J.

J Thromb Haemost. 2005 Feb;3(2):332-9.

47.

Steroid sulfatase (STS) expression in the human temporal lobe: enzyme activity, mRNA expression and immunohistochemistry study.

Steckelbroeck S, Nassen A, Ugele B, Ludwig M, Watzka M, Reissinger A, Clusmann H, Lütjohann D, Siekmann L, Klingmüller D, Hans VH.

J Neurochem. 2004 Apr;89(2):403-17.

48.

Sequence of the rat factor VIII cDNA.

Watzka M, Geisen C, Seifried E, Oldenburg J.

Thromb Haemost. 2004 Jan;91(1):38-42.

PMID:
14691566
49.

Characterisation of estrogenic 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity in the human brain.

Steckelbroeck S, Watzka M, Reissinger A, Wegener-Toper P, Bidlingmaier F, Bliesener N, Hans VH, Clusmann H, Ludwig M, Siekmann L, Klingmüller D.

J Steroid Biochem Mol Biol. 2003 Jul;86(1):79-92.

PMID:
12943747
50.

Calcium prevents loss of glutathione and reduces oxidative stress upon reperfusion in the perfused liver.

Dutkowski P, Wahl W, Winkelbach V, Watzka M, Krysiak M, Junginger T.

Int J Surg Investig. 2000;2(1):1-7.

PMID:
12774332

Supplemental Content

Loading ...
Support Center