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Items: 1 to 50 of 155

1.

Cine balanced fast field echo magnetic resonance imaging of canine spinal arachnoid diverticulae pulsation.

Shivapour SK, Volk HA, Watts V, De Decker S.

Vet J. 2019 Jun;248:86-90. doi: 10.1016/j.tvjl.2019.04.014. Epub 2019 May 2.

PMID:
31113570
2.

Challenges of investigating a large food-borne norovirus outbreak across all branches of a restaurant group in the United Kingdom, October 2016.

Morgan M, Watts V, Allen D, Curtis D, Kirolos A, Macdonald N, Maslen E, Morgan D, Saei A, Sedgwick J, Stevenson J, Turbitt D, Vivancos R, Waugh C, Williams C, Decraene V.

Euro Surveill. 2019 May;24(18). doi: 10.2807/1560-7917.ES.2019.24.18.1800511.

3.

Functional characterization of AC5 gain-of-function variants: Impact on the molecular basis of ADCY5-related dyskinesia.

Doyle TB, Hayes MP, Chen DH, Raskind WH, Watts VJ.

Biochem Pharmacol. 2019 May;163:169-177. doi: 10.1016/j.bcp.2019.02.005. Epub 2019 Feb 14.

PMID:
30772269
4.

Insights into the Regulatory Properties of Human Adenylyl Cyclase Type 9.

Baldwin TA, Li Y, Brand CS, Watts VJ, Dessauer CW.

Mol Pharmacol. 2019 Apr;95(4):349-360. doi: 10.1124/mol.118.114595. Epub 2019 Jan 29.

PMID:
30696718
5.

Increased Risk for Invasive Group A Streptococcus Disease for Household Contacts of Scarlet Fever Cases, England, 2011-2016.

Watts V, Balasegaram S, Brown CS, Mathew S, Mearkle R, Ready D, Saliba V, Lamagni T.

Emerg Infect Dis. 2019 Mar;25(3):529-537. doi: 10.3201/eid2503.181518. Epub 2019 Mar 17.

6.

Genomics, GPCRs and new targets for the control of insect pests and vectors.

Hill CA, Sharan S, Watts VJ.

Curr Opin Insect Sci. 2018 Dec;30:99-106. doi: 10.1016/j.cois.2018.08.010. Epub 2018 Aug 30. Review.

PMID:
30553493
7.

Optimization of a 1,3,4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain.

Kaur J, Soto-Velasquez M, Ding Z, Ghanbarpour A, Lill MA, van Rijn RM, Watts VJ, Flaherty DP.

Eur J Med Chem. 2019 Jan 15;162:568-585. doi: 10.1016/j.ejmech.2018.11.036. Epub 2018 Nov 16.

PMID:
30472604
8.

Reconstruction of Complex Full-Thickness Scalp Defects After Dog-Bite Injuries Using Dermal Regeneration Template (Integra): Case Report and Literature Review.

Watts V, Attie MD, McClure S.

J Oral Maxillofac Surg. 2019 Feb;77(2):338-351. doi: 10.1016/j.joms.2018.08.022. Epub 2018 Sep 4.

PMID:
30267703
9.

A Large, Refractory Nosocomial Outbreak of Klebsiella pneumoniae Carbapenemase-Producing Escherichia coli Demonstrates Carbapenemase Gene Outbreaks Involving Sink Sites Require Novel Approaches to Infection Control.

Decraene V, Phan HTT, George R, Wyllie DH, Akinremi O, Aiken Z, Cleary P, Dodgson A, Pankhurst L, Crook DW, Lenney C, Walker AS, Woodford N, Sebra R, Fath-Ordoubadi F, Mathers AJ, Seale AC, Guiver M, McEwan A, Watts V, Welfare W, Stoesser N, Cawthorne J; TRACE Investigators’ Group.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e01689-18. doi: 10.1128/AAC.01689-18. Print 2018 Dec.

10.

Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis.

Česnek M, Skácel J, Jansa P, Dračínský M, Šmídková M, Mertlíková-Kaiserová H, Soto-Velasquez MP, Watts VJ, Janeba Z.

ChemMedChem. 2018 Sep 6;13(17):1779-1796. doi: 10.1002/cmdc.201800332. Epub 2018 Jul 31.

11.

A Novel CRISPR/Cas9-Based Cellular Model to Explore Adenylyl Cyclase and cAMP Signaling.

Soto-Velasquez M, Hayes MP, Alpsoy A, Dykhuizen EC, Watts VJ.

Mol Pharmacol. 2018 Sep;94(3):963-972. doi: 10.1124/mol.118.111849. Epub 2018 Jun 27.

12.

Synthesis of α-Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases.

Frydrych J, Skácel J, Šmídková M, Mertlíková-Kaiserová H, Dračínský M, Gnanasekaran R, Lepšík M, Soto-Velasquez M, Watts VJ, Janeba Z.

ChemMedChem. 2018 Jan 22;13(2):199-206. doi: 10.1002/cmdc.201700715. Epub 2018 Jan 8.

PMID:
29235265
13.

Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain.

Watts VJ.

Neuropsychopharmacology. 2018 Jan;43(1):215-216. doi: 10.1038/npp.2017.190. No abstract available.

14.

Identification of FDA-Approved Small Molecules Capable of Disrupting the Calmodulin-Adenylyl Cyclase 8 Interaction through Direct Binding to Calmodulin.

Hayes MP, Soto-Velasquez M, Fowler CA, Watts VJ, Roman DL.

ACS Chem Neurosci. 2018 Feb 21;9(2):346-357. doi: 10.1021/acschemneuro.7b00349. Epub 2017 Oct 16.

15.

Posttreatment Imaging in Orthopedic Oncology.

Watts V GJ, Zoga AC, Abraham JA.

Semin Roentgenol. 2017 Oct;52(4):291-300. doi: 10.1053/j.ro.2017.04.001. Epub 2017 Apr 14. Review. No abstract available.

PMID:
28965548
16.

Dynamic Lumbosacral Magnetic Resonance Imaging in a Dog with Tethered Cord Syndrome with a Tight Filum Terminale.

De Decker S, Watts V, Neilson DM.

Front Vet Sci. 2017 Aug 18;4:134. doi: 10.3389/fvets.2017.00134. eCollection 2017.

17.

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.

Dessauer CW, Watts VJ, Ostrom RS, Conti M, Dove S, Seifert R.

Pharmacol Rev. 2017 Apr;69(2):93-139. doi: 10.1124/pr.116.013078. Review.

18.

Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.

Brust TF, Alongkronrusmee D, Soto-Velasquez M, Baldwin TA, Ye Z, Dai M, Dessauer CW, van Rijn RM, Watts VJ.

Sci Signal. 2017 Feb 21;10(467). pii: eaah5381. doi: 10.1126/scisignal.aah5381.

19.

Molecular Modeling Evaluation of the Enantiomers of a Novel Adenylyl Cyclase 2 Inhibitor.

Rana N, Conley JM, Soto-Velasquez M, León F, Cutler SJ, Watts VJ, Lill MA.

J Chem Inf Model. 2017 Feb 27;57(2):322-334. doi: 10.1021/acs.jcim.6b00454. Epub 2017 Jan 26.

PMID:
28068084
20.

Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases.

Břehová P, Šmídková M, Skácel J, Dračínský M, Mertlíková-Kaiserová H, Velasquez MP, Watts VJ, Janeba Z.

ChemMedChem. 2016 Nov 21;11(22):2534-2546. doi: 10.1002/cmdc.201600439. Epub 2016 Oct 24.

21.

[Research progress of Gα(i/o)-coupled receptor-mediated supersensitization of adenylyl cyclase].

Xu RQ, Watts VJ.

Yao Xue Xue Bao. 2016 Sep;51(9):1349-55. Review. Chinese.

PMID:
29924508
22.
23.

Assessment of mitral regurgitation in dogs: comparison of results of echocardiography with magnetic resonance imaging.

Sargent J, Connolly DJ, Watts V, Mõtsküla P, Volk HA, Lamb CR, Fuentes VL.

J Small Anim Pract. 2015 Nov;56(11):641-50. doi: 10.1111/jsap.12410. Epub 2015 Oct 16.

PMID:
26473746
24.

Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.

Česnek M, Jansa P, Šmídková M, Mertlíková-Kaiserová H, Dračínský M, Brust TF, Pávek P, Trejtnar F, Watts VJ, Janeba Z.

ChemMedChem. 2015 Aug;10(8):1351-64. doi: 10.1002/cmdc.201500183. Epub 2015 Jul 1.

PMID:
26136378
25.

Gα(i/o)-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years later.

Brust TF, Conley JM, Watts VJ.

Eur J Pharmacol. 2015 Sep 15;763(Pt B):223-32. doi: 10.1016/j.ejphar.2015.05.014. Epub 2015 May 14. Review.

26.

Dopamine receptor antagonists as new mode-of-action insecticide leads for control of Aedes and Culex mosquito vectors.

Nuss AB, Ejendal KF, Doyle TB, Meyer JM, Lang EG, Watts VJ, Hill CA.

PLoS Negl Trop Dis. 2015 Mar 20;9(3):e0003515. doi: 10.1371/journal.pntd.0003515. eCollection 2015 Mar.

27.

Palladium-catalyzed regio- and stereoselective γ-arylation of tertiary allylic amines: identification of potent adenylyl cyclase inhibitors.

Ye Z, Brust TF, Watts VJ, Dai M.

Org Lett. 2015 Feb 20;17(4):892-5. doi: 10.1021/ol503748t. Epub 2015 Feb 10.

28.

Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways.

Brust TF, Hayes MP, Roman DL, Burris KD, Watts VJ.

J Pharmacol Exp Ther. 2015 Mar;352(3):480-93. doi: 10.1124/jpet.114.220293. Epub 2014 Dec 24.

29.

New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling.

Brust TF, Hayes MP, Roman DL, Watts VJ.

Biochem Pharmacol. 2015 Jan 1;93(1):85-91. doi: 10.1016/j.bcp.2014.10.014. Epub 2014 Nov 7.

30.

Engaging youth in bullying prevention through community-based participatory research.

Gibson JE, Flaspohler PD, Watts V.

Fam Community Health. 2015 Jan-Mar;38(1):120-30. doi: 10.1097/FCH.0000000000000048.

PMID:
25423250
31.

Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.

Conley JM, Meyer JM, Nuss AB, Doyle TB, Savinov SN, Hill CA, Watts VJ.

J Pharmacol Exp Ther. 2015 Jan;352(1):53-60. doi: 10.1124/jpet.114.219717. Epub 2014 Oct 20.

32.

(-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling.

Meade JA, Free RB, Miller NR, Chun LS, Doyle TB, Moritz AE, Conroy JL, Watts VJ, Sibley DR.

Psychopharmacology (Berl). 2015 Mar;232(5):917-30. doi: 10.1007/s00213-014-3726-8. Epub 2014 Sep 18.

33.

Polydopamine-based simple and versatile surface modification of polymeric nano drug carriers.

Park J, Brust TF, Lee HJ, Lee SC, Watts VJ, Yeo Y.

ACS Nano. 2014 Apr 22;8(4):3347-56. doi: 10.1021/nn405809c. Epub 2014 Mar 19.

34.

Drug-induced sensitization of adenylyl cyclase: assay streamlining and miniaturization for small molecule and siRNA screening applications.

Conley JM, Brust TF, Xu R, Burris KD, Watts VJ.

J Vis Exp. 2014 Jan 27;(83):e51218. doi: 10.3791/51218.

35.

Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.

Conley JM, Brand CS, Bogard AS, Pratt EP, Xu R, Hockerman GH, Ostrom RS, Dessauer CW, Watts VJ.

J Pharmacol Exp Ther. 2013 Nov;347(2):276-87. doi: 10.1124/jpet.113.207449. Epub 2013 Sep 5.

36.

Cell-type specific increases in female hamster nucleus accumbens spine density following female sexual experience.

Staffend NA, Hedges VL, Chemel BR, Watts VJ, Meisel RL.

Brain Struct Funct. 2014 Nov;219(6):2071-81. doi: 10.1007/s00429-013-0624-5. Epub 2013 Aug 11.

37.

Assessment of cerebellar pulsation in dogs with and without Chiari-like malformation and syringomyelia using cardiac-gated cine magnetic resonance imaging.

Driver CJ, Watts V, Bunck AC, Van Ham LM, Volk HA.

Vet J. 2013 Oct;198(1):88-91. doi: 10.1016/j.tvjl.2013.05.017. Epub 2013 Jun 14.

PMID:
23770398
38.

Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation.

Watts VL, Sepulveda FM, Cingolani OH, Ho AS, Niu X, Kim R, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Rameau G, O'Rourke B, Kass DA, Barouch LA.

J Mol Cell Cardiol. 2013 Sep;62:8-17. doi: 10.1016/j.yjmcc.2013.04.025. Epub 2013 May 2.

39.

Differential effects of AGS3 expression on D(2L) dopamine receptor-mediated adenylyl cyclase signaling.

Conley JM, Watts VJ.

Cell Mol Neurobiol. 2013 May;33(4):551-8. doi: 10.1007/s10571-013-9925-8. Epub 2013 Mar 17.

40.

Beneficial cardiac effects of caloric restriction are lost with age in a murine model of obesity.

AlGhatrif M, Watts VL, Niu X, Halushka M, Miller KL, Vandegaer K, Bedja D, Fox-Talbot K, Bielawska A, Gabrielson KL, Barouch LA.

J Cardiovasc Transl Res. 2013 Jun;6(3):436-45. doi: 10.1007/s12265-013-9453-4. Epub 2013 Mar 2.

PMID:
23456569
41.

Bimolecular fluorescence complementation analysis of G protein-coupled receptor dimerization in living cells.

Ejendal KF, Conley JM, Hu CD, Watts VJ.

Methods Enzymol. 2013;521:259-79. doi: 10.1016/B978-0-12-391862-8.00014-4.

PMID:
23351744
42.

Discovery of antagonists of tick dopamine receptors via chemical library screening and comparative pharmacological analyses.

Ejendal KF, Meyer JM, Brust TF, Avramova LV, Hill CA, Watts VJ.

Insect Biochem Mol Biol. 2012 Nov;42(11):846-53.

PMID:
23213654
43.

Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand.

Clark AH, McCorvy JD, Conley JM, Williams WK, Bekkam M, Watts VJ, Nichols DE.

Bioorg Med Chem. 2012 Nov 1;20(21):6366-74. doi: 10.1016/j.bmc.2012.08.058. Epub 2012 Sep 8.

44.

Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase.

Niu X, Watts VL, Cingolani OH, Sivakumaran V, Leyton-Mange JS, Ellis CL, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Paolocci N, Kass DA, Barouch LA.

J Am Coll Cardiol. 2012 May 29;59(22):1979-87. doi: 10.1016/j.jacc.2011.12.046. Erratum in: J Am Coll Cardiol. 2012 Jul 31;60(5):481.

45.

Dopamine D(2) Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly.

Ejendal KF, Dessauer CW, Hébert TE, Watts VJ.

J Signal Transduct. 2012;2012:210324. doi: 10.1155/2012/210324. Epub 2012 Mar 12.

46.

Ligand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D(1) receptor catechol agonists.

Chemel BR, Bonner LA, Watts VJ, Nichols DE.

Mol Pharmacol. 2012 May;81(5):729-38. doi: 10.1124/mol.111.077339. Epub 2012 Feb 14.

47.

A "genome-to-lead" approach for insecticide discovery: pharmacological characterization and screening of Aedes aegypti D(1)-like dopamine receptors.

Meyer JM, Ejendal KF, Avramova LV, Garland-Kuntz EE, Giraldo-Calderón GI, Brust TF, Watts VJ, Hill CA.

PLoS Negl Trop Dis. 2012 Jan;6(1):e1478. doi: 10.1371/journal.pntd.0001478. Epub 2012 Jan 24.

48.

Comparison of the D₁ dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease.

McCorvy JD, Watts VJ, Nichols DE.

Psychopharmacology (Berl). 2012 Jul;222(1):81-7. doi: 10.1007/s00213-011-2625-5. Epub 2012 Jan 6.

PMID:
22222862
49.

Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines.

Cueva JP, Chemel BR, Juncosa JI Jr, Lill MA, Watts VJ, Nichols DE.

Eur J Med Chem. 2012 Feb;48:97-107. doi: 10.1016/j.ejmech.2011.11.039. Epub 2011 Dec 3.

50.

Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393.

Clark AH, McCorvy JD, Watts VJ, Nichols DE.

Bioorg Med Chem. 2011 Sep 15;19(18):5420-31. doi: 10.1016/j.bmc.2011.07.057. Epub 2011 Aug 3.

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