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Items: 1 to 50 of 122

1.

TRAF1 Signaling in Human Health and Disease.

Edilova MI, Abdul-Sater AA, Watts TH.

Front Immunol. 2018 Dec 18;9:2969. doi: 10.3389/fimmu.2018.02969. eCollection 2018. Review.

2.

GITRL on inflammatory antigen presenting cells in the lung parenchyma provides signal 4 for T-cell accumulation and tissue-resident memory T-cell formation.

Chu KL, Batista NV, Wang KC, Zhou AC, Watts TH.

Mucosal Immunol. 2018 Nov 28. doi: 10.1038/s41385-018-0105-5. [Epub ahead of print]

PMID:
30487647
3.

Fc-Engineered Anti-4-1BB Antibodies Pack a One-Two Punch.

Girard M, Watts TH.

Immunity. 2018 Nov 20;49(5):791-793. doi: 10.1016/j.immuni.2018.11.001.

PMID:
30462993
4.

Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection.

Tsai S, Clemente-Casares X, Zhou AC, Lei H, Ahn JJ, Chan YT, Choi O, Luck H, Woo M, Dunn SE, Engleman EG, Watts TH, Winer S, Winer DA.

Cell Metab. 2018 Dec 4;28(6):922-934.e4. doi: 10.1016/j.cmet.2018.08.003. Epub 2018 Aug 30.

PMID:
30174303
5.

Effect of IL-7 Therapy on Phospho-Ribosomal Protein S6 and TRAF1 Expression in HIV-Specific CD8 T Cells in Patients Receiving Antiretroviral Therapy.

Wang C, Edilova MI, Wagar LE, Mujib S, Singer M, Bernard NF, Croughs T, Lederman MM, Sereti I, Fischl MA, Kremmer E, Ostrowski M, Routy JP, Watts TH.

J Immunol. 2018 Jan 15;200(2):558-564. doi: 10.4049/jimmunol.1601254. Epub 2017 Dec 8.

6.

Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.

Chang YH, Wang KC, Chu KL, Clouthier DL, Tran AT, Torres Perez MS, Zhou AC, Abdul-Sater AA, Watts TH.

Immunity. 2017 Nov 21;47(5):943-958.e9. doi: 10.1016/j.immuni.2017.10.014. Epub 2017 Nov 14.

7.

CD30 Is Dispensable for T-Cell Responses to Influenza Virus and Lymphocytic Choriomeningitis Virus Clone 13 but Contributes to Age-Associated T-Cell Expansion in Mice.

Zhou AC, Snell LM, Wortzman ME, Watts TH.

Front Immunol. 2017 Sep 25;8:1156. doi: 10.3389/fimmu.2017.01156. eCollection 2017.

8.

Constitutive interaction between 4-1BB and 4-1BBL on murine LPS-activated bone marrow dendritic cells masks detection of 4-1BBL by TKS-1 but not 19H3 antibody.

Mbanwi AN, Lin GHY, Wang KC, Watts TH.

J Immunol Methods. 2017 Nov;450:81-89. doi: 10.1016/j.jim.2017.08.001. Epub 2017 Aug 5.

PMID:
28789924
9.

Intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung.

Zhou AC, Wagar LE, Wortzman ME, Watts TH.

Mucosal Immunol. 2017 Sep;10(5):1294-1309. doi: 10.1038/mi.2016.124. Epub 2017 Jan 4.

PMID:
28051085
10.

Editorial: Bone Marrow T Cells at the Center Stage in Immunological Memory.

Di Rosa F, Watts TH.

Front Immunol. 2016 Dec 14;7:596. doi: 10.3389/fimmu.2016.00596. eCollection 2016. No abstract available.

11.

The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease.

Abdul-Sater AA, Edilova MI, Clouthier DL, Mbanwi A, Kremmer E, Watts TH.

Nat Immunol. 2017 Jan;18(1):26-35. doi: 10.1038/ni.3618. Epub 2016 Nov 28.

PMID:
27893701
12.

Irreversible splenic atrophy following chronic LCMV infection is associated with compromised immunity in mice.

Mbanwi AN, Wang C, Geddes K, Philpott DJ, Watts TH.

Eur J Immunol. 2017 Jan;47(1):94-106. doi: 10.1002/eji.201646666. Epub 2016 Nov 3.

13.

Constitutive aryl hydrocarbon receptor signaling constrains type I interferon-mediated antiviral innate defense.

Yamada T, Horimoto H, Kameyama T, Hayakawa S, Yamato H, Dazai M, Takada A, Kida H, Bott D, Zhou AC, Hutin D, Watts TH, Asaka M, Matthews J, Takaoka A.

Nat Immunol. 2016 Jun;17(6):687-94. doi: 10.1038/ni.3422. Epub 2016 Apr 18.

PMID:
27089381
14.

TNFRs and Control of Chronic LCMV Infection: Implications for Therapy.

Clouthier DL, Watts TH.

Trends Immunol. 2015 Nov;36(11):697-708. doi: 10.1016/j.it.2015.09.005. Epub 2015 Oct 17. Review.

PMID:
26481667
15.

GITR intrinsically sustains early type 1 and late follicular helper CD4 T cell accumulation to control a chronic viral infection.

Clouthier DL, Zhou AC, Wortzman ME, Luft O, Levy GA, Watts TH.

PLoS Pathog. 2015 Jan 15;11(1):e1004517. doi: 10.1371/journal.ppat.1004517. eCollection 2015 Jan.

17.

Costimulatory TNFR family members in control of viral infection: outstanding questions.

Mbanwi AN, Watts TH.

Semin Immunol. 2014 Jun;26(3):210-9. doi: 10.1016/j.smim.2014.05.001. Epub 2014 Jun 6.

PMID:
24910294
18.

The human immune system recognizes neopeptides derived from mitochondrial DNA deletions.

Duvvuri B, Duvvuri VR, Wang C, Chen L, Wagar LE, Jamnik V, Wu J, Yeung RS, Grigull J, Watts TH, Wu GE.

J Immunol. 2014 May 15;192(10):4581-91. doi: 10.4049/jimmunol.1300774. Epub 2014 Apr 14.

19.

Cell-specific and context-dependent effects of GITR in cancer, autoimmunity, and infection.

Clouthier DL, Watts TH.

Cytokine Growth Factor Rev. 2014 Apr;25(2):91-106. doi: 10.1016/j.cytogfr.2013.12.003. Epub 2014 Jan 4. Review.

PMID:
24484736
20.

The contextual role of TNFR family members in CD8(+) T-cell control of viral infections.

Wortzman ME, Clouthier DL, McPherson AJ, Lin GH, Watts TH.

Immunol Rev. 2013 Sep;255(1):125-48. doi: 10.1111/imr.12086. Review.

PMID:
23947352
21.

Intrinsic TNF/TNFR2 interactions fine-tune the CD8 T cell response to respiratory influenza virus infection in mice.

Wortzman ME, Lin GH, Watts TH.

PLoS One. 2013 Jul 9;8(7):e68911. doi: 10.1371/journal.pone.0068911. Print 2013.

22.

GITR-dependent regulation of 4-1BB expression: implications for T cell memory and anti-4-1BB-induced pathology.

Lin GH, Snell LM, Wortzman ME, Clouthier DL, Watts TH.

J Immunol. 2013 May 1;190(9):4627-39. doi: 10.4049/jimmunol.1201854. Epub 2013 Mar 27.

23.

Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells.

Sabbagh L, Andreeva D, Laramée GD, Oussa NA, Lew D, Bisson N, Soumounou Y, Pawson T, Watts TH.

J Leukoc Biol. 2013 May;93(5):713-21. doi: 10.1189/jlb.1112579. Epub 2013 Feb 27.

PMID:
23446150
24.

T cell intrinsic NOD2 is dispensable for CD8 T cell immunity.

Lin GH, Wortzman ME, Girardin SE, Philpott DJ, Watts TH.

PLoS One. 2013;8(2):e56014. doi: 10.1371/journal.pone.0056014. Epub 2013 Feb 6.

25.

Contribution of 4-1BBL on radioresistant cells in providing survival signals through 4-1BB expressed on CD8⁺ memory T cells in the bone marrow.

Lin GH, Edele F, Mbanwi AN, Wortzman ME, Snell LM, Vidric M, Roth K, Hauser AE, Watts TH.

Eur J Immunol. 2012 Nov;42(11):2861-74. doi: 10.1002/eji.201242503. Epub 2012 Sep 20.

26.

Maintaining the balance: costimulatory TNFRs and control of HIV.

Wang C, Watts TH.

Cytokine Growth Factor Rev. 2012 Aug-Oct;23(4-5):245-54. doi: 10.1016/j.cytogfr.2012.05.011. Epub 2012 Jun 26. Review.

PMID:
22738932
27.
28.

Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells.

McPherson AJ, Snell LM, Mak TW, Watts TH.

J Biol Chem. 2012 Jun 29;287(27):23010-9. doi: 10.1074/jbc.M112.350538. Epub 2012 May 8.

29.

Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.

Wang C, McPherson AJ, Jones RB, Kawamura KS, Lin GH, Lang PA, Ambagala T, Pellegrini M, Calzascia T, Aidarus N, Elford AR, Yue FY, Kremmer E, Kovacs CM, Benko E, Tremblay C, Routy JP, Bernard NF, Ostrowski MA, Ohashi PS, Watts TH.

J Exp Med. 2012 Jan 16;209(1):77-91. doi: 10.1084/jem.20110675. Epub 2011 Dec 19.

30.

Humoral and cell-mediated immunity to pandemic H1N1 influenza in a Canadian cohort one year post-pandemic: implications for vaccination.

Wagar LE, Rosella L, Crowcroft N, Lowcock B, Drohomyrecky PC, Foisy J, Gubbay J, Rebbapragada A, Winter AL, Achonu C, Ward BJ, Watts TH.

PLoS One. 2011;6(11):e28063. doi: 10.1371/journal.pone.0028063. Epub 2011 Nov 23.

31.

T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy.

Snell LM, Lin GH, McPherson AJ, Moraes TJ, Watts TH.

Immunol Rev. 2011 Nov;244(1):197-217. doi: 10.1111/j.1600-065X.2011.01063.x. Review. Erratum in: Immunol Rev. 2012 Jan;245(1):265.

PMID:
22017440
32.

In vivo accumulation of T cells in response to IL-2/anti-IL-2 mAb complexes is dependent in part on the TNF family ligand 4-1BBL.

Lin GH, Stone JC, Surh CD, Watts TH.

Immunol Cell Biol. 2012 Aug;90(7):743-7. doi: 10.1038/icb.2011.83. Epub 2011 Sep 27.

33.

Influenza-specific T cells from older people are enriched in the late effector subset and their presence inversely correlates with vaccine response.

Wagar LE, Gentleman B, Pircher H, McElhaney JE, Watts TH.

PLoS One. 2011;6(8):e23698. doi: 10.1371/journal.pone.0023698. Epub 2011 Aug 22.

34.
35.

LTβR signaling in dendritic cells induces a type I IFN response that is required for optimal clonal expansion of CD8+ T cells.

Summers deLuca L, Ng D, Gao Y, Wortzman ME, Watts TH, Gommerman JL.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2046-51. doi: 10.1073/pnas.1014188108. Epub 2011 Jan 18.

36.

Role of 4-1BBL and TRAF1 in the CD8 T cell response to influenza virus and HIV.

Watts TH, Lin GH, Wang C, McPherson AJ, Snell LM, Sabbagh L.

Adv Exp Med Biol. 2011;691:177-86. doi: 10.1007/978-1-4419-6612-4_19. Review. No abstract available.

PMID:
21153322
37.

Workshop summary: functions of the TNF family in infectious disease.

Wortzman M, Watts TH.

Adv Exp Med Biol. 2011;691:171-5. doi: 10.1007/978-1-4419-6612-4_18. No abstract available.

PMID:
21153321
38.

CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection.

Snell LM, McPherson AJ, Lin GH, Sakaguchi S, Pandolfi PP, Riccardi C, Watts TH.

J Immunol. 2010 Dec 15;185(12):7223-34. doi: 10.4049/jimmunol.1001912. Epub 2010 Nov 12.

39.

Staying alive: T cell costimulation, CD28, and Bcl-xL.

Watts TH.

J Immunol. 2010 Oct 1;185(7):3785-7. doi: 10.4049/jimmunol.1090085. Review. No abstract available.

40.

Evaluating the cellular targets of anti-4-1BB agonist antibody during immunotherapy of a pre-established tumor in mice.

Lin GH, Liu Y, Ambagala T, Kwon BS, Ohashi PS, Watts TH.

PLoS One. 2010 Jun 8;5(6):e11003. doi: 10.1371/journal.pone.0011003.

41.

Immune regulation by 4-1BB and 4-1BBL: complexities and challenges.

Wang C, Lin GH, McPherson AJ, Watts TH.

Immunol Rev. 2009 May;229(1):192-215. doi: 10.1111/j.1600-065X.2009.00765.x. Review.

PMID:
19426223
42.

Endogenous 4-1BB ligand plays a critical role in protection from influenza-induced disease.

Lin GH, Sedgmen BJ, Moraes TJ, Snell LM, Topham DJ, Watts TH.

J Immunol. 2009 Jan 15;182(2):934-47.

43.

4-1BB enhances proliferation of beryllium-specific T cells in the lung of subjects with chronic beryllium disease.

Mack DG, Lanham AK, Palmer BE, Maier LA, Watts TH, Fontenot AP.

J Immunol. 2008 Sep 15;181(6):4381-8.

44.

ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo.

Sabbagh L, Pulle G, Liu Y, Tsitsikov EN, Watts TH.

J Immunol. 2008 Jun 15;180(12):8093-101.

45.

T cell costimulatory molecules in anti-viral immunity: Potential role in immunotherapeutic vaccines.

Watts TH, Bertram EM, Bukczynski J, Wen T.

Can J Infect Dis. 2003 Jul;14(4):221-9.

47.

TNF family ligands define niches for T cell memory.

Sabbagh L, Snell LM, Watts TH.

Trends Immunol. 2007 Aug;28(8):333-9. Epub 2007 Jun 26. Review.

PMID:
17597006
48.

Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages.

Kang YJ, Kim SO, Shimada S, Otsuka M, Seit-Nebi A, Kwon BS, Watts TH, Han J.

Nat Immunol. 2007 Jun;8(6):601-9. Epub 2007 May 13.

PMID:
17496895
49.

A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival.

Sabbagh L, Srokowski CC, Pulle G, Snell LM, Sedgmen BJ, Liu Y, Tsitsikov EN, Watts TH.

Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18703-8. Epub 2006 Nov 20.

50.

Approaches to studying costimulation of human antiviral T cell responses: prospects for immunotherapeutic vaccines.

Serghides L, Vidric M, Watts TH.

Immunol Res. 2006;35(1-2):137-50. Review.

PMID:
17003516

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