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Items: 1 to 50 of 53

1.

Structures of Hepatitis B Virus Core- and e-Antigen Immune Complexes Suggest Multi-point Inhibition.

Eren E, Watts NR, Dearborn AD, Palmer IW, Kaufman JD, Steven AC, Wingfield PT.

Structure. 2018 Oct 2;26(10):1314-1326.e4. doi: 10.1016/j.str.2018.06.012. Epub 2018 Aug 9.

PMID:
30100358
2.

Structure of an RNA Aptamer that Can Inhibit HIV-1 by Blocking Rev-Cognate RNA (RRE) Binding and Rev-Rev Association.

Dearborn AD, Eren E, Watts NR, Palmer IW, Kaufman JD, Steven AC, Wingfield PT.

Structure. 2018 Sep 4;26(9):1187-1195.e4. doi: 10.1016/j.str.2018.06.001. Epub 2018 Jul 12.

PMID:
30017564
3.

A new HIV-1 Rev structure optimizes interaction with target RNA (RRE) for nuclear export.

Watts NR, Eren E, Zhuang X, Wang YX, Steven AC, Wingfield PT.

J Struct Biol. 2018 Aug;203(2):102-108. doi: 10.1016/j.jsb.2018.03.011. Epub 2018 Mar 29.

4.

Chimeric rabbit/human Fab antibodies against the hepatitis Be-antigen and their potential applications in assays, characterization, and therapy.

Zhuang X, Watts NR, Palmer IW, Kaufman JD, Dearborn AD, Trenbeath JL, Eren E, Steven AC, Rader C, Wingfield PT.

J Biol Chem. 2017 Oct 6;292(40):16760-16772. doi: 10.1074/jbc.M117.802272. Epub 2017 Aug 23.

5.

Evidence for newly generated interneurons in the basolateral amygdala of adult mice.

Jhaveri DJ, Tedoldi A, Hunt S, Sullivan R, Watts NR, Power JM, Bartlett PF, Sah P.

Mol Psychiatry. 2018 Mar;23(3):521-532. doi: 10.1038/mp.2017.134. Epub 2017 Aug 15.

6.

Secretion clearance strategies in Australian and New Zealand Intensive Care Units.

Ntoumenopoulos G, Hammond N, Watts NR, Thompson K, Hanlon G, Paratz JD, Thomas P; George Institute for Global Health and the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Aust Crit Care. 2018 Jul;31(4):191-196. doi: 10.1016/j.aucc.2017.06.002. Epub 2017 Jun 27.

PMID:
28662942
7.

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

Afzali B, Grönholm J, Vandrovcova J, O'Brien C, Sun HW, Vanderleyden I, Davis FP, Khoder A, Zhang Y, Hegazy AN, Villarino AV, Palmer IW, Kaufman J, Watts NR, Kazemian M, Kamenyeva O, Keith J, Sayed A, Kasperaviciute D, Mueller M, Hughes JD, Fuss IJ, Sadiyah MF, Montgomery-Recht K, McElwee J, Restifo NP, Strober W, Linterman MA, Wingfield PT, Uhlig HH, Roychoudhuri R, Aitman TJ, Kelleher P, Lenardo MJ, O'Shea JJ, Cooper N, Laurence ADJ.

Nat Immunol. 2017 Jul;18(7):813-823. doi: 10.1038/ni.3753. Epub 2017 May 22.

8.

Patterns of intravenous fluid resuscitation use in adult intensive care patients between 2007 and 2014: An international cross-sectional study.

Hammond NE, Taylor C, Finfer S, Machado FR, An Y, Billot L, Bloos F, Bozza F, Cavalcanti AB, Correa M, Du B, Hjortrup PB, Li Y, McIntryre L, Saxena M, Schortgen F, Watts NR, Myburgh J; Fluid-TRIPS and Fluidos Investigators; George Institute for Global Health, The ANZICS Clinical Trials Group, BRICNet, and the REVA research Network.

PLoS One. 2017 May 12;12(5):e0176292. doi: 10.1371/journal.pone.0176292. eCollection 2017.

9.

Expression and Purification of ZASP Subdomains and Clinically Important Isoforms: High-Affinity Binding to G-Actin.

Watts NR, Zhuang X, Kaufman JD, Palmer IW, Dearborn AD, Coscia S, Blech-Hermoni Y, Alfano C, Pastore A, Mankodi A, Wingfield PT.

Biochemistry. 2017 Apr 11;56(14):2061-2070. doi: 10.1021/acs.biochem.7b00067. Epub 2017 Apr 3.

PMID:
28349680
10.

Core Domains in Evaluating Patient Outcomes After Acute Respiratory Failure: International Multidisciplinary Clinician Consultation.

Hodgson CL, Turnbull AE, Iwashyna TJ, Parker A, Davis W, Bingham CO, Watts NR, Finfer S, Needham DM.

Phys Ther. 2017 Feb 1;97(2):168-174. doi: 10.2522/ptj.20160196. No abstract available.

11.

Can transcutaneous near infrared spectroscopy detect severe hepatic ischemia: a juvenile porcine model.

Skowno JJ, Karpelowsky JS, Watts NR, Little DG.

Paediatr Anaesth. 2016 Dec;26(12):1188-1196. doi: 10.1111/pan.13004. Epub 2016 Sep 24.

PMID:
27663858
12.

The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly.

DiMattia MA, Watts NR, Cheng N, Huang R, Heymann JB, Grimes JM, Wingfield PT, Stuart DI, Steven AC.

Structure. 2016 Jul 6;24(7):1068-80. doi: 10.1016/j.str.2016.04.015. Epub 2016 Jun 2.

13.

Maintenance fluid practices in intensive care units in Australia and New Zealand.

Bihari S, Watts NR, Seppelt I, Thompson K, Myburgh A, Prakash S, Bersten A; George Institute for Global Health and the Australian and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Resusc. 2016 Jun;18(2):89-94.

PMID:
27242106
14.

A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behçet's disease in HLA-B*51 carriers.

Takeuchi M, Ombrello MJ, Kirino Y, Erer B, Tugal-Tutkun I, Seyahi E, Özyazgan Y, Watts NR, Gül A, Kastner DL, Remmers EF.

Ann Rheum Dis. 2016 Dec;75(12):2208-2211. doi: 10.1136/annrheumdis-2015-209059. Epub 2016 May 23.

15.

Extinguished second-order conditioned fear responses are renewed but not reinstated.

Holmes NM, Cai SY, Lay BP, Watts NR, Westbrook RF.

J Exp Psychol Anim Learn Cogn. 2014 Oct;40(4):440-56. doi: 10.1037/xan0000036. Epub 2014 Jul 7.

PMID:
25546102
16.

A cell-penetrating antibody fragment against HIV-1 Rev has high antiviral activity: characterization of the paratope.

Zhuang X, Stahl SJ, Watts NR, DiMattia MA, Steven AC, Wingfield PT.

J Biol Chem. 2014 Jul 18;289(29):20222-33. doi: 10.1074/jbc.M114.581090. Epub 2014 May 30.

17.

Assessment of differences in the conformational flexibility of hepatitis B virus core-antigen and e-antigen by hydrogen deuterium exchange-mass spectrometry.

Bereszczak JZ, Watts NR, Wingfield PT, Steven AC, Heck AJ.

Protein Sci. 2014 Jul;23(7):884-96. doi: 10.1002/pro.2470. Epub 2014 Apr 17.

18.

Generation and use of antibody fragments for structural studies of proteins refractory to crystallization.

Stahl SJ, Watts NR, Wingfield PT.

Methods Mol Biol. 2014;1131:549-61. doi: 10.1007/978-1-62703-992-5_35.

19.

Sizing up large protein complexes by electrospray ionisation-based electrophoretic mobility and native mass spectrometry: morphology selective binding of Fabs to hepatitis B virus capsids.

Bereszczak JZ, Havlik M, Weiss VU, Marchetti-Deschmann M, van Duijn E, Watts NR, Wingfield PT, Allmaier G, Steven AC, Heck AJ.

Anal Bioanal Chem. 2014 Feb;406(5):1437-46. doi: 10.1007/s00216-013-7548-z. Epub 2013 Dec 20.

20.

Exploiting radiation damage to map proteins in nucleoprotein complexes: the internal structure of bacteriophage T7.

Cheng N, Wu W, Watts NR, Steven AC.

J Struct Biol. 2014 Mar;185(3):250-6. doi: 10.1016/j.jsb.2013.12.004. Epub 2013 Dec 15.

21.

An unusual topological structure of the HIV-1 Rev response element.

Fang X, Wang J, O'Carroll IP, Mitchell M, Zuo X, Wang Y, Yu P, Liu Y, Rausch JW, Dyba MA, Kjems J, Schwieters CD, Seifert S, Winans RE, Watts NR, Stahl SJ, Wingfield PT, Byrd RA, Le Grice SF, Rein A, Wang YX.

Cell. 2013 Oct 24;155(3):594-605. doi: 10.1016/j.cell.2013.10.008. Epub 2013 Oct 24.

22.

Epitope-distal effects accompany the binding of two distinct antibodies to hepatitis B virus capsids.

Bereszczak JZ, Rose RJ, van Duijn E, Watts NR, Wingfield PT, Steven AC, Heck AJ.

J Am Chem Soc. 2013 May 1;135(17):6504-12. doi: 10.1021/ja402023x. Epub 2013 Apr 18.

23.

Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.

DiMattia MA, Watts NR, Stahl SJ, Grimes JM, Steven AC, Stuart DI, Wingfield PT.

Structure. 2013 Jan 8;21(1):133-142. doi: 10.1016/j.str.2012.10.017. Epub 2012 Dec 6.

24.

Specificity of an anti-capsid antibody associated with Hepatitis B Virus-related acute liver failure.

Wu W, Chen Z, Cheng N, Watts NR, Stahl SJ, Farci P, Purcell RH, Wingfield PT, Steven AC.

J Struct Biol. 2013 Jan;181(1):53-60. doi: 10.1016/j.jsb.2012.10.004. Epub 2012 Oct 16.

25.

Cryo-EM study of Hepatitis B virus core antigen capsids decorated with antibodies from a human patient.

Kandiah E, Watts NR, Cheng N, Cardone G, Stahl SJ, Heller T, Liang TJ, Wingfield PT, Steven AC.

J Struct Biol. 2012 Jan;177(1):145-51. doi: 10.1016/j.jsb.2011.10.003. Epub 2011 Oct 25.

26.

Role of the propeptide in controlling conformation and assembly state of hepatitis B virus e-antigen.

Watts NR, Conway JF, Cheng N, Stahl SJ, Steven AC, Wingfield PT.

J Mol Biol. 2011 Jun 3;409(2):202-13. doi: 10.1016/j.jmb.2011.03.049. Epub 2011 Apr 2.

27.

Doctors talk climate change--students take action.

Duvivier RJ, Watts NR, Rukavina S, Kaduru CJ.

Lancet. 2011 Mar 19;377(9770):995. doi: 10.1016/S0140-6736(11)60384-X. No abstract available.

PMID:
21420551
28.

Squeezing protein shells: how continuum elastic models, molecular dynamics simulations, and experiments coalesce at the nanoscale.

Roos WH, Gibbons MM, Arkhipov A, Uetrecht C, Watts NR, Wingfield PT, Steven AC, Heck AJ, Schulten K, Klug WS, Wuite GJ.

Biophys J. 2010 Aug 9;99(4):1175-81. doi: 10.1016/j.bpj.2010.05.033.

29.

Subunit exchange rates in Hepatitis B virus capsids are geometry- and temperature-dependent.

Uetrecht C, Watts NR, Stahl SJ, Wingfield PT, Steven AC, Heck AJ.

Phys Chem Chem Phys. 2010 Nov 7;12(41):13368-71. doi: 10.1039/c0cp00692k. Epub 2010 Jul 30.

30.

Molecular basis for the high degree of antigenic cross-reactivity between hepatitis B virus capsids (HBcAg) and dimeric capsid-related protein (HBeAg): insights into the enigmatic nature of the e-antigen.

Watts NR, Vethanayagam JG, Ferns RB, Tedder RS, Harris A, Stahl SJ, Steven AC, Wingfield PT.

J Mol Biol. 2010 May 14;398(4):530-41. doi: 10.1016/j.jmb.2010.03.026. Epub 2010 Mar 20.

31.

Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element.

DiMattia MA, Watts NR, Stahl SJ, Rader C, Wingfield PT, Stuart DI, Steven AC, Grimes JM.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5810-4. doi: 10.1073/pnas.0914946107. Epub 2010 Mar 15.

32.

Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev.

Stahl SJ, Watts NR, Rader C, DiMattia MA, Mage RG, Palmer I, Kaufman JD, Grimes JM, Stuart DI, Steven AC, Wingfield PT.

J Mol Biol. 2010 Apr 2;397(3):697-708. doi: 10.1016/j.jmb.2010.01.061. Epub 2010 Feb 4.

33.

Stability and shape of hepatitis B virus capsids in vacuo.

Uetrecht C, Versluis C, Watts NR, Wingfield PT, Steven AC, Heck AJ.

Angew Chem Int Ed Engl. 2008;47(33):6247-51. doi: 10.1002/anie.200802410. No abstract available.

34.

High-resolution mass spectrometry of viral assemblies: molecular composition and stability of dimorphic hepatitis B virus capsids.

Uetrecht C, Versluis C, Watts NR, Roos WH, Wuite GJ, Wingfield PT, Steven AC, Heck AJ.

Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9216-20. doi: 10.1073/pnas.0800406105. Epub 2008 Jun 27.

35.

Non-canonical binding of an antibody resembling a naïve B cell receptor immunoglobulin to hepatitis B virus capsids.

Watts NR, Cardone G, Vethanayagam JG, Cheng N, Hultgren C, Stahl SJ, Steven AC, Sällberg M, Wingfield PT.

J Mol Biol. 2008 Jun 20;379(5):1119-29. doi: 10.1016/j.jmb.2008.04.009. Epub 2008 Apr 9.

36.

Epitope diversity of hepatitis B virus capsids: quasi-equivalent variations in spike epitopes and binding of different antibodies to the same epitope.

Harris A, Belnap DM, Watts NR, Conway JF, Cheng N, Stahl SJ, Vethanayagam JG, Wingfield PT, Steven AC.

J Mol Biol. 2006 Jan 20;355(3):562-76. Epub 2005 Nov 8.

PMID:
16309704
37.

Structure, assembly, and antigenicity of hepatitis B virus capsid proteins.

Steven AC, Conway JF, Cheng N, Watts NR, Belnap DM, Harris A, Stahl SJ, Wingfield PT.

Adv Virus Res. 2005;64:125-64. No abstract available.

PMID:
16139594
38.

Diversity of core antigen epitopes of hepatitis B virus.

Belnap DM, Watts NR, Conway JF, Cheng N, Stahl SJ, Wingfield PT, Steven AC.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10884-9. Epub 2003 Sep 3.

39.

Characterization of a conformational epitope on hepatitis B virus core antigen and quasiequivalent variations in antibody binding.

Conway JF, Watts NR, Belnap DM, Cheng N, Stahl SJ, Wingfield PT, Steven AC.

J Virol. 2003 Jun;77(11):6466-73.

40.

The cryptophycin-tubulin ring structure indicates two points of curvature in the tubulin dimer.

Watts NR, Cheng N, West W, Steven AC, Sackett DL.

Biochemistry. 2002 Oct 22;41(42):12662-9.

PMID:
12379108
41.

Cryo-electron microscopy of trichocyte (hard alpha-keratin) intermediate filaments reveals a low-density core.

Watts NR, Jones LN, Cheng N, Wall JS, Parry DA, Steven AC.

J Struct Biol. 2002 Jan-Feb;137(1-2):109-18.

PMID:
12064938
42.

The morphogenic linker peptide of HBV capsid protein forms a mobile array on the interior surface.

Watts NR, Conway JF, Cheng N, Stahl SJ, Belnap DM, Steven AC, Wingfield PT.

EMBO J. 2002 Mar 1;21(5):876-84.

43.

HIV-1 rev depolymerizes microtubules to form stable bilayered rings.

Watts NR, Sackett DL, Ward RD, Miller MW, Wingfield PT, Stahl SS, Steven AC.

J Cell Biol. 2000 Jul 24;150(2):349-60.

44.

Tetrairidium, a four-atom cluster, is readily visible as a density label in three-dimensional cryo-EM maps of proteins at 10-25 A resolution.

Cheng N, Conway JF, Watts NR, Hainfeld JF, Joshi V, Powell RD, Stahl SJ, Wingfield PE, Steven AC.

J Struct Biol. 1999 Sep;127(2):169-76.

PMID:
10527906
45.

Intermediate filament structure: hard alpha-keratin.

Jones LN, Simon M, Watts NR, Booy FP, Steven AC, Parry DA.

Exp Dermatol. 1999 Aug;8(4):310. No abstract available.

PMID:
10439240
46.

Three-dimensional structure of HIV-1 Rev protein filaments.

Watts NR, Misra M, Wingfield PT, Stahl SJ, Cheng N, Trus BL, Steven AC, Williams RW.

J Struct Biol. 1998 Jan;121(1):41-52.

PMID:
9573619
47.

Intermediate filament structure: hard alpha-keratin.

Jones LN, Simon M, Watts NR, Booy FP, Steven AC, Parry DA.

Biophys Chem. 1997 Oct;68(1-3):83-93.

PMID:
9468612
48.

Peptides as standards for denaturing isoelectric focusing.

Watts NR, Singh RP.

Electrophoresis. 1995 Jan;16(1):22-7.

PMID:
7537658
49.
50.

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