Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 31

1.

Nucleic Acid Therapeutics for Neurological Diseases.

Watts JK, Brown RH, Khvorova A.

Neurotherapeutics. 2019 Apr;16(2):245-247. doi: 10.1007/s13311-019-00736-1. No abstract available.

PMID:
31037650
2.

Next-Generation Peptide Nucleic Acid Chimeras Exhibit High Affinity and Potent Gene Silencing.

Debacker AJ, Sharma VK, Meda Krishnamurthy P, O'Reilly D, Greenhill R, Watts JK.

Biochemistry. 2019 Feb 12;58(6):582-589. doi: 10.1021/acs.biochem.8b00827. Epub 2018 Dec 18.

PMID:
30520300
3.

Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing.

Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ.

Nat Commun. 2018 Jul 6;9(1):2641. doi: 10.1038/s41467-018-05073-z.

4.

Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo.

Sharma VK, Osborn MF, Hassler MR, Echeverria D, Ly S, Ulashchik EA, Martynenko-Makaev YV, Shmanai VV, Zatsepin TS, Khvorova A, Watts JK.

Bioconjug Chem. 2018 Jul 18;29(7):2478-2488. doi: 10.1021/acs.bioconjchem.8b00365. Epub 2018 Jul 2.

PMID:
29898368
5.

Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs.

Osborn MF, Coles AH, Golebiowski D, Echeverria D, Moazami MP, Watts JK, Sena-Esteves M, Khvorova A.

Mol Cancer Ther. 2018 Jun;17(6):1251-1258. doi: 10.1158/1535-7163.MCT-17-1144. Epub 2018 Apr 13.

6.

Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat.

Li L, Shen X, Liu Z, Norrbom M, Prakash TP, O'Reilly D, Sharma VK, Damha MJ, Watts JK, Rigo F, Corey DR.

Nucleic Acid Ther. 2018 Feb;28(1):23-33. doi: 10.1089/nat.2017.0703. Epub 2018 Jan 17.

7.

Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs' dystrophy.

Hu J, Rong Z, Gong X, Zhou Z, Sharma VK, Xing C, Watts JK, Corey DR, Mootha VV.

Hum Mol Genet. 2018 Mar 15;27(6):1015-1026. doi: 10.1093/hmg/ddy018.

8.

Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA.

Pendergraff HM, Krishnamurthy PM, Debacker AJ, Moazami MP, Sharma VK, Niitsoo L, Yu Y, Tan YN, Haitchi HM, Watts JK.

Mol Ther Nucleic Acids. 2017 Sep 15;8:158-168. doi: 10.1016/j.omtn.2017.06.012. Epub 2017 Jun 21.

9.

Synthesis and biological properties of triazole-linked locked nucleic acid.

Sharma VK, Singh SK, Krishnamurthy PM, Alterman JF, Haraszti RA, Khvorova A, Prasad AK, Watts JK.

Chem Commun (Camb). 2017 Aug 3;53(63):8906-8909. doi: 10.1039/c7cc04092j.

PMID:
28736781
10.

The chemical evolution of oligonucleotide therapies of clinical utility.

Khvorova A, Watts JK.

Nat Biotechnol. 2017 Mar;35(3):238-248. doi: 10.1038/nbt.3765. Epub 2017 Feb 27. Review.

11.

Single-Stranded Silencing RNAs: Hit Rate and Chemical Modification.

Pendergraff HM, Debacker AJ, Watts JK.

Nucleic Acid Ther. 2016 Aug;26(4):216-22. doi: 10.1089/nat.2015.0557. Epub 2016 Apr 28.

PMID:
27123752
12.

Oligonucleotide therapeutics: chemistry, delivery and clinical progress.

Sharma VK, Watts JK.

Future Med Chem. 2015;7(16):2221-42. doi: 10.4155/fmc.15.144. Epub 2015 Oct 29. Review.

PMID:
26510815
13.

Improvement of DNA recognition through molecular imprinting: hybrid oligomer imprinted polymeric nanoparticles (oligoMIP NPs).

Brahmbhatt H, Poma A, Pendergraff HM, Watts JK, Turner NW.

Biomater Sci. 2016 Feb;4(2):281-7. doi: 10.1039/c5bm00341e.

PMID:
26509192
14.

Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles.

Poma A, Brahmbhatt H, Pendergraff HM, Watts JK, Turner NW.

Adv Mater. 2015 Jan 27;27(4):750-8. doi: 10.1002/adma.201404235. Epub 2014 Nov 20. Erratum in: Adv Mater. 2015 Mar 4;27(9):1478.

PMID:
25413444
15.

Enhancer RNA facilitates NELF release from immediate early genes.

Schaukowitch K, Joo JY, Liu X, Watts JK, Martinez C, Kim TK.

Mol Cell. 2014 Oct 2;56(1):29-42. doi: 10.1016/j.molcel.2014.08.023. Epub 2014 Sep 25.

16.

Locked nucleic acid: tighter is different.

Watts JK.

Chem Commun (Camb). 2013 Jun 25;49(50):5618-20. doi: 10.1039/c3cc40340h. Epub 2013 May 16.

PMID:
23682352
17.

Silencing disease genes in the laboratory and the clinic.

Watts JK, Corey DR.

J Pathol. 2012 Jan;226(2):365-79. doi: 10.1002/path.2993. Epub 2011 Nov 9. Review.

18.

Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates.

Gagnon KT, Watts JK, Pendergraff HM, Montaillier C, Thai D, Potier P, Corey DR.

J Am Chem Soc. 2011 Jun 8;133(22):8404-7. doi: 10.1021/ja200312y. Epub 2011 May 12.

19.

Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs.

Hu J, Gagnon KT, Liu J, Watts JK, Syeda-Nawaz J, Bennett CF, Swayze EE, Randolph J, Chattopadhyaya J, Corey DR.

Biol Chem. 2011 Apr;392(4):315-25. doi: 10.1515/BC.2011.045. Epub 2011 Feb 7.

20.

Energetically important C-H···F-C pseudohydrogen bonding in water: evidence and application to rational design of oligonucleotides with high binding affinity.

Anzahaee MY, Watts JK, Alla NR, Nicholson AW, Damha MJ.

J Am Chem Soc. 2011 Feb 2;133(4):728-31. doi: 10.1021/ja109817p. Epub 2010 Dec 20.

PMID:
21171597
21.

Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing.

Deleavey GF, Watts JK, Alain T, Robert F, Kalota A, Aishwarya V, Pelletier J, Gewirtz AM, Sonenberg N, Damha MJ.

Nucleic Acids Res. 2010 Jul;38(13):4547-57. doi: 10.1093/nar/gkq181. Epub 2010 Apr 22.

22.

Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters.

Watts JK, Yu D, Charisse K, Montaillier C, Potier P, Manoharan M, Corey DR.

Nucleic Acids Res. 2010 Aug;38(15):5242-59. doi: 10.1093/nar/gkq258. Epub 2010 Apr 19.

23.

Clinical status of duplex RNA.

Watts JK, Corey DR.

Bioorg Med Chem Lett. 2010 Jun 1;20(11):3203-7. doi: 10.1016/j.bmcl.2010.03.109. Epub 2010 Apr 2.

24.

Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility.

Watts JK, Martín-Pintado N, Gómez-Pinto I, Schwartzentruber J, Portella G, Orozco M, González C, Damha MJ.

Nucleic Acids Res. 2010 Apr;38(7):2498-511. doi: 10.1093/nar/gkp1225. Epub 2010 Jan 13.

25.

Chemical modification of siRNA.

Deleavey GF, Watts JK, Damha MJ.

Curr Protoc Nucleic Acid Chem. 2009 Dec;Chapter 16:Unit 16.3. doi: 10.1002/0471142700.nc1603s39. Review.

PMID:
20013783
26.

Studies on the hydrolytic stability of 2'-fluoroarabinonucleic acid (2'F-ANA).

Watts JK, Katolik A, Viladoms J, Damha MJ.

Org Biomol Chem. 2009 May 7;7(9):1904-10. doi: 10.1039/b900443b. Epub 2009 Mar 19.

PMID:
19590787
27.

Chemically modified siRNA: tools and applications.

Watts JK, Deleavey GF, Damha MJ.

Drug Discov Today. 2008 Oct;13(19-20):842-55. doi: 10.1016/j.drudis.2008.05.007. Epub 2008 Jul 7. Review.

PMID:
18614389
28.

Synthesis and biophysical characterization of oligonucleotides containing a 4'-selenonucleotide.

Watts JK, Johnston BD, Jayakanthan K, Wahba AS, Pinto BM, Damha MJ.

J Am Chem Soc. 2008 Jul 9;130(27):8578-9. doi: 10.1021/ja802205u. Epub 2008 Jun 11.

PMID:
18543920
29.

2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity.

Watts JK, Choubdar N, Sadalapure K, Robert F, Wahba AS, Pelletier J, Pinto BM, Damha MJ.

Nucleic Acids Res. 2007;35(5):1441-51. Epub 2007 Feb 6.

30.

Synthesis and conformational analysis of 2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU).

Watts JK, Sadalapure K, Choubdar N, Pinto BM, Damha MJ.

J Org Chem. 2006 Feb 3;71(3):921-5.

PMID:
16438502
31.

Theory of multiplate resonant reflectors.

Watts JK.

Appl Opt. 1968 Aug 1;7(8):1621-3. doi: 10.1364/AO.7.001621.

PMID:
20068848

Supplemental Content

Loading ...
Support Center