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Items: 1 to 50 of 341

1.

Delta-like 1-mediated cis-inhibition of Jagged1/2 signalling inhibits differentiation of human epidermal cells in culture.

Negri VA, Logtenberg MEW, Renz LM, Oules B, Walko G, Watt FM.

Sci Rep. 2019 Jul 25;9(1):10825. doi: 10.1038/s41598-019-47232-2.

2.

The role of keratins in modulating carcinogenesis via communication with cells of the immune system.

Sequeira I, Watt FM.

Cell Stress. 2019 Mar 23;3(4):136-138. doi: 10.15698/cst2019.04.184.

3.

Mechanisms, Hallmarks, and Implications of Stem Cell Quiescence.

Cho IJ, Lui PP, Obajdin J, Riccio F, Stroukov W, Willis TL, Spagnoli F, Watt FM.

Stem Cell Reports. 2019 Jun 11;12(6):1190-1200. doi: 10.1016/j.stemcr.2019.05.012. Review.

4.

Mutant Lef1 controls Gata6 in sebaceous gland development and cancer.

Oulès B, Rognoni E, Hoste E, Goss G, Fiehler R, Natsuga K, Quist S, Mentink R, Donati G, Watt FM.

EMBO J. 2019 May 2;38(9). pii: e100526. doi: 10.15252/embj.2018100526. Epub 2019 Mar 18.

5.

Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02.

Tziotzios C, Petridis C, Dand N, Ainali C, Saklatvala JR, Pullabhatla V, Onoufriadis A, Pramanik R, Baudry D, Lee SH, Wood K, Liu L, Seegobin S, Michelotti GA, Lwin SM, Christou EAA, Curtis CJ, de Rinaldis E, Saxena A, Holmes S, Harries M, Palamaras I, Cunningham F, Parkins G, Kaur M, Farrant P, McDonagh A, Messenger A, Jones J, Jolliffe V, Ali I, Ardern-Jones M, Mitchell C, Burrows N, Atkar R, Banfield C, Alexandroff A, Champagne C, Cooper HL, Vañó-Galván S, Molina-Ruiz AM, Perez NO, Patel GK, Macbeth A, Page M, Bryden A, Mowbray M, Wahie S, Armstrong K, Cooke N, Goodfield M, Man I, de Berker D, Dunnill G, Takwale A, Rao A, Siah TW, Sinclair R, Wade MS, Dlova NC, Setterfield J, Lewis F, Bhargava K, Kirkpatrick N, Estivill X, Stefanato CM, Flohr C, Spector T, Watt FM, Smith CH, Barker JN, Fenton DA, Simpson MA, McGrath JA.

Nat Commun. 2019 Mar 8;10(1):1150. doi: 10.1038/s41467-019-09117-w.

6.

Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors.

Vigilante A, Laddach A, Moens N, Meleckyte R, Leha A, Ghahramani A, Culley OJ, Kathuria A, Hurling C, Vickers A, Wiseman E, Tewary M, Zandstra PW; HipSci Consortium, Durbin R, Fraternali F, Stegle O, Birney E, Luscombe NM, Danovi D, Watt FM.

Cell Rep. 2019 Feb 19;26(8):2078-2087.e3. doi: 10.1016/j.celrep.2019.01.094.

7.

Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness.

Mobasseri SA, Zijl S, Salameti V, Walko G, Stannard A, Garcia-Manyes S, Watt FM.

Acta Biomater. 2019 Mar 15;87:256-264. doi: 10.1016/j.actbio.2019.01.063. Epub 2019 Jan 30.

8.

Micro-scaled topographies direct differentiation of human epidermal stem cells.

Zijl S, Vasilevich AS, Viswanathan P, Helling AL, Beijer NRM, Walko G, Chiappini C, de Boer J, Watt FM.

Acta Biomater. 2019 Jan 15;84:133-145. doi: 10.1016/j.actbio.2018.12.003. Epub 2018 Dec 5.

9.

Hair follicle epidermal stem cells define a niche for tactile sensation.

Cheng CC, Tsutsui K, Taguchi T, Sanzen N, Nakagawa A, Kakiguchi K, Yonemura S, Tanegashima C, Keeley SD, Kiyonari H, Furuta Y, Tomono Y, Watt FM, Fujiwara H.

Elife. 2018 Oct 25;7. pii: e38883. doi: 10.7554/eLife.38883.

10.

Lrig1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro.

Schweiger PJ, Clement DL, Page ME, Schepeler T, Zou X, Sirokmány G, Watt FM, Jensen KB.

Sci Rep. 2018 Oct 15;8(1):15255. doi: 10.1038/s41598-018-33578-6.

11.

Dynamic Culture Substrates That Mimic the Topography of the Epidermal-Dermal Junction.

Helling AL, Viswanathan P, Cheliotis KS, Mobasseri SA, Yang Y, El Haj AJ, Watt FM.

Tissue Eng Part A. 2019 Feb;25(3-4):214-223. doi: 10.1089/ten.TEA.2018.0125. Epub 2018 Dec 28.

12.

Fibroblast state switching orchestrates dermal maturation and wound healing.

Rognoni E, Pisco AO, Hiratsuka T, Sipilä KH, Belmonte JM, Mobasseri SA, Philippeos C, Dilão R, Watt FM.

Mol Syst Biol. 2018 Aug 29;14(8):e8174. doi: 10.15252/msb.20178174.

13.

The reward of great collaborations.

Watt FM.

Nat Cell Biol. 2018 Sep;20(9):1011. doi: 10.1038/s41556-018-0157-5. No abstract available.

PMID:
30154564
14.

Immunomodulatory role of Keratin 76 in oral and gastric cancer.

Sequeira I, Neves JF, Carrero D, Peng Q, Palasz N, Liakath-Ali K, Lord GM, Morgan PR, Lombardi G, Watt FM.

Nat Commun. 2018 Aug 24;9(1):3437. doi: 10.1038/s41467-018-05872-4.

15.

Bench to bedside: Current advances in regenerative medicine.

Clarke G, Harley P, Hubber EL, Manea T, Manuelli L, Read E, Watt FM.

Curr Opin Cell Biol. 2018 Dec;55:59-66. doi: 10.1016/j.ceb.2018.05.006. Epub 2018 Jul 11. Review.

PMID:
30007127
16.

Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.

Kober KI, Cano A, Géraud C, Sipilä K, Mobasseri SA, Philippeos C, Pisco AO, Stannard A, Martin A, Salvador F, Santos V, Boutros M, Rognoni E, Watt FM.

PLoS One. 2018 Jun 28;13(6):e0199679. doi: 10.1371/journal.pone.0199679. eCollection 2018.

17.

Homeostasis, regeneration and tumour formation in the mammalian epidermis.

Belokhvostova D, Berzanskyte I, Cujba AM, Jowett G, Marshall L, Prueller J, Watt FM.

Int J Dev Biol. 2018;62(6-7-8):571-582. doi: 10.1387/ijdb.170341fw. Review.

18.

Skin Cell Heterogeneity in Development, Wound Healing, and Cancer.

Rognoni E, Watt FM.

Trends Cell Biol. 2018 Sep;28(9):709-722. doi: 10.1016/j.tcb.2018.05.002. Epub 2018 May 25. Review.

19.

Diverse mechanisms for endogenous regeneration and repair in mammalian organs.

Wells JM, Watt FM.

Nature. 2018 May;557(7705):322-328. doi: 10.1038/s41586-018-0073-7. Epub 2018 May 16. Review.

PMID:
29769669
20.

An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis.

Liakath-Ali K, Mills EW, Sequeira I, Lichtenberger BM, Pisco AO, Sipilä KH, Mishra A, Yoshikawa H, Wu CC, Ly T, Lamond AI, Adham IM, Green R, Watt FM.

Nature. 2018 Apr;556(7701):376-380. doi: 10.1038/s41586-018-0032-3. Epub 2018 Apr 11.

PMID:
29643507
21.

(More) women in science.

Watt FM.

Nat Rev Mol Cell Biol. 2018 Jul;19(7):413-414. doi: 10.1038/s41580-018-0006-1. No abstract available.

PMID:
29599526
22.

Myosin 10 is involved in murine pigmentation.

Liakath-Ali K, Vancollie VE, Sequeira I, Lelliott CJ, Watt FM.

Exp Dermatol. 2019 Apr;28(4):391-394. doi: 10.1111/exd.13528. Epub 2018 Apr 24.

23.

Defining Adult Stem Cells by Function, not by Phenotype.

Clevers H, Watt FM.

Annu Rev Biochem. 2018 Jun 20;87:1015-1027. doi: 10.1146/annurev-biochem-062917-012341. Epub 2018 Mar 1. Review.

PMID:
29494240
24.

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations.

Philippeos C, Telerman SB, Oulès B, Pisco AO, Shaw TJ, Elgueta R, Lombardi G, Driskell RR, Soldin M, Lynch MD, Watt FM.

J Invest Dermatol. 2018 Apr;138(4):811-825. doi: 10.1016/j.jid.2018.01.016. Epub 2018 Jan 31.

25.

Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells.

Ghahramani A, Donati G, Luscombe NM, Watt FM.

Genome Biol. 2018 Jan 15;19(1):3. doi: 10.1186/s13059-017-1384-y.

26.

The adaptive immune response to cardiac injury-the true roadblock to effective regenerative therapies?

Sattler S, Fairchild P, Watt FM, Rosenthal N, Harding SE.

NPJ Regen Med. 2017 Jun 19;2:19. doi: 10.1038/s41536-017-0022-3. eCollection 2017. Review.

27.

Fibroblast heterogeneity: implications for human disease.

Lynch MD, Watt FM.

J Clin Invest. 2018 Jan 2;128(1):26-35. doi: 10.1172/JCI93555. Epub 2018 Jan 2. Review.

28.

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation.

Galleu A, Riffo-Vasquez Y, Trento C, Lomas C, Dolcetti L, Cheung TS, von Bonin M, Barbieri L, Halai K, Ward S, Weng L, Chakraverty R, Lombardi G, Watt FM, Orchard K, Marks DI, Apperley J, Bornhauser M, Walczak H, Bennett C, Dazzi F.

Sci Transl Med. 2017 Nov 15;9(416). pii: eaam7828. doi: 10.1126/scitranslmed.aam7828.

29.

Spatial constraints govern competition of mutant clones in human epidermis.

Lynch MD, Lynch CNS, Craythorne E, Liakath-Ali K, Mallipeddi R, Barker JN, Watt FM.

Nat Commun. 2017 Oct 24;8(1):1119. doi: 10.1038/s41467-017-00993-8.

30.

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis.

Mishra A, Oulès B, Pisco AO, Ly T, Liakath-Ali K, Walko G, Viswanathan P, Tihy M, Nijjher J, Dunn SJ, Lamond AI, Watt FM.

Elife. 2017 Oct 18;6. pii: e27356. doi: 10.7554/eLife.27356.

31.

Type XVII collagen coordinates proliferation in the interfollicular epidermis.

Watanabe M, Natsuga K, Nishie W, Kobayashi Y, Donati G, Suzuki S, Fujimura Y, Tsukiyama T, Ujiie H, Shinkuma S, Nakamura H, Murakami M, Ozaki M, Nagayama M, Watt FM, Shimizu H.

Elife. 2017 Jul 11;6. pii: e26635. doi: 10.7554/eLife.26635.

32.

Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth.

Telerman SB, Rognoni E, Sequeira I, Pisco AO, Lichtenberger BM, Culley OJ, Viswanathan P, Driskell RR, Watt FM.

J Invest Dermatol. 2017 Nov;137(11):2270-2281. doi: 10.1016/j.jid.2017.06.015. Epub 2017 Jun 28.

33.

Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs.

Kilpinen H, Goncalves A, Leha A, Afzal V, Alasoo K, Ashford S, Bala S, Bensaddek D, Casale FP, Culley OJ, Danecek P, Faulconbridge A, Harrison PW, Kathuria A, McCarthy D, McCarthy SA, Meleckyte R, Memari Y, Moens N, Soares F, Mann A, Streeter I, Agu CA, Alderton A, Nelson R, Harper S, Patel M, White A, Patel SR, Clarke L, Halai R, Kirton CM, Kolb-Kokocinski A, Beales P, Birney E, Danovi D, Lamond AI, Ouwehand WH, Vallier L, Watt FM, Durbin R, Stegle O, Gaffney DJ.

Nature. 2017 Jun 29;546(7660):686. doi: 10.1038/nature23012. Epub 2017 Jun 14.

PMID:
28614302
34.

Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties.

Donati G, Rognoni E, Hiratsuka T, Liakath-Ali K, Hoste E, Kar G, Kayikci M, Russell R, Kretzschmar K, Mulder KW, Teichmann SA, Watt FM.

Nat Cell Biol. 2017 Jun;19(6):603-613. doi: 10.1038/ncb3532. Epub 2017 May 15.

35.

Common genetic variation drives molecular heterogeneity in human iPSCs.

Kilpinen H, Goncalves A, Leha A, Afzal V, Alasoo K, Ashford S, Bala S, Bensaddek D, Casale FP, Culley OJ, Danecek P, Faulconbridge A, Harrison PW, Kathuria A, McCarthy D, McCarthy SA, Meleckyte R, Memari Y, Moens N, Soares F, Mann A, Streeter I, Agu CA, Alderton A, Nelson R, Harper S, Patel M, White A, Patel SR, Clarke L, Halai R, Kirton CM, Kolb-Kokocinski A, Beales P, Birney E, Danovi D, Lamond AI, Ouwehand WH, Vallier L, Watt FM, Durbin R, Stegle O, Gaffney DJ.

Nature. 2017 Jun 15;546(7658):370-375. doi: 10.1038/nature22403. Epub 2017 May 10. Erratum in: Nature. 2017 Jun 29;546(7660):686.

36.

A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells.

Walko G, Woodhouse S, Pisco AO, Rognoni E, Liakath-Ali K, Lichtenberger BM, Mishra A, Telerman SB, Viswanathan P, Logtenberg M, Renz LM, Donati G, Quist SR, Watt FM.

Nat Commun. 2017 Mar 23;8:14744. doi: 10.1038/ncomms14744.

37.

Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.

Boardman DA, Philippeos C, Fruhwirth GO, Ibrahim MA, Hannen RF, Cooper D, Marelli-Berg FM, Watt FM, Lechler RI, Maher J, Smyth LA, Lombardi G.

Am J Transplant. 2017 Apr;17(4):931-943. doi: 10.1111/ajt.14185. Epub 2017 Feb 1.

38.

Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.

Hayes TF, Benaich N, Goldie SJ, Sipilä K, Ames-Draycott A, Cai W, Yin G, Watt FM.

Cancer Lett. 2016 Dec 1;383(1):106-114. doi: 10.1016/j.canlet.2016.09.014. Epub 2016 Sep 28.

39.

Engineered Microenvironments to Direct Epidermal Stem Cell Behavior at Single-Cell Resolution.

Watt FM.

Dev Cell. 2016 Sep 26;38(6):601-9. doi: 10.1016/j.devcel.2016.08.010. Review.

40.

Reply to Chi et al.

Kaushal G, Rognoni E, Lichtenberger BM, Driskell RR, Kretzschmar K, Hoste E, Watt FM.

J Invest Dermatol. 2017 Jan;137(1):247-248. doi: 10.1016/j.jid.2016.08.026. Epub 2016 Sep 13. No abstract available.

41.

Galectin-6 is a novel skin anti-microbial peptide that is modulated by the skin barrier and microbiome.

Natsuga K, Watt FM.

J Dermatol Sci. 2016 Oct;84(1):97-99. doi: 10.1016/j.jdermsci.2016.06.008. Epub 2016 Jun 23. No abstract available.

42.

CIRM and UKRMP: Different Ways to Invest in Regenerative Medicine.

Weissman IL, Watt FM.

Cell Stem Cell. 2016 Jul 7;19(1):19-22. doi: 10.1016/j.stem.2016.05.011.

43.

Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.

Rognoni E, Gomez C, Pisco AO, Rawlins EL, Simons BD, Watt FM, Driskell RR.

Development. 2016 Jul 15;143(14):2522-35. doi: 10.1242/dev.131797. Epub 2016 Jun 10.

44.

A Novel Automated High-Content Analysis Workflow Capturing Cell Population Dynamics from Induced Pluripotent Stem Cell Live Imaging Data.

Kerz M, Folarin A, Meleckyte R, Watt FM, Dobson RJ, Danovi D.

J Biomol Screen. 2016 Oct;21(9):887-96. doi: 10.1177/1087057116652064. Epub 2016 Jun 2.

45.

Pelota Regulates Epidermal Differentiation by Modulating BMP and PI3K/AKT Signaling Pathways.

Elkenani M, Nyamsuren G, Raju P, Liakath-Ali K, Hamdaoui A, Kata A, Dressel R, Klonisch T, Watt FM, Engel W, Thliveris JA, Krishna Pantakani DV, Adham IM.

J Invest Dermatol. 2016 Aug;136(8):1664-1671. doi: 10.1016/j.jid.2016.04.020. Epub 2016 May 7.

46.

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure.

Liakath-Ali K, Vancollie VE, Lelliott CJ, Speak AO, Lafont D, Protheroe HJ, Ingvorsen C, Galli A, Green A, Gleeson D, Ryder E, Glover L, Vizcay-Barrena G, Karp NA, Arends MJ, Brenn T, Spiegel S, Adams DJ, Watt FM, van der Weyden L.

J Pathol. 2016 Jul;239(3):374-83. doi: 10.1002/path.4737. Epub 2016 May 30.

47.

Professor Sir Henry Harris (1925-2014).

Watt FM.

J Cell Sci. 2015 Dec 1;128(23):4253. No abstract available.

48.

β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis.

Mastrogiannaki M, Lichtenberger BM, Reimer A, Collins CA, Driskell RR, Watt FM.

J Invest Dermatol. 2016 Jun;136(6):1130-1142. doi: 10.1016/j.jid.2016.01.036. Epub 2016 Feb 20.

49.

Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.

Lichtenberger BM, Mastrogiannaki M, Watt FM.

Nat Commun. 2016 Feb 3;7:10537. doi: 10.1038/ncomms10537.

50.

Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity.

Kretzschmar K, Weber C, Driskell RR, Calonje E, Watt FM.

Cell Rep. 2016 Jan 12;14(2):269-81. doi: 10.1016/j.celrep.2015.12.041. Epub 2016 Jan 7.

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