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Items: 1 to 50 of 409

1.

High-throughput platelet spreading analysis: a tool for the diagnosis of platelet- based bleeding disorders.

Khan AO, Maclachlan A, Lowe GC, Nicolson PLR, Al Ghaithi R, Thomas SG, Watson SP, Pike JA, Morgan NV; UK GAPP Study Group.

Haematologica. 2019 Jun 20. pii: haematol.2019.225912. doi: 10.3324/haematol.2019.225912. [Epub ahead of print]

2.

Adenosine and Forskolin Inhibit Platelet Aggregation by Collagen but not the Proximal Signalling Events.

Clark JC, Kavanagh DM, Watson S, Pike JA, Andrews RK, Gardiner EE, Poulter NS, Hill SJ, Watson SP.

Thromb Haemost. 2019 Jul;119(7):1124-1137. doi: 10.1055/s-0039-1688788. Epub 2019 May 26.

PMID:
31129912
3.

LAIR-1 Limits Neutrophilic Airway Inflammation.

Kumawat K, Geerdink RJ, Hennus MP, Roda MA, van Ark I, Leusink-Muis T, Folkerts G, van Oort-Jansen A, Mazharian A, Watson SP, Coenjaerts FE, Bont L, Meyaard L.

Front Immunol. 2019 Apr 26;10:842. doi: 10.3389/fimmu.2019.00842. eCollection 2019.

4.

Comparison of the GPVI inhibitors losartan and honokiol.

Onselaer MB, Nagy M, Pallini C, Pike JA, Perrella G, Quintanilla LG, Eble JA, Poulter NS, Heemskerk JWM, Watson SP.

Platelets. 2019 Mar 8:1-11. doi: 10.1080/09537104.2019.1585526. [Epub ahead of print]

PMID:
30849265
5.

Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice.

Wichaiyo S, Lax S, Montague SJ, Li Z, Grygielska B, Pike JA, Haining EJ, Brill A, Watson SP, Rayes J.

Haematologica. 2019 Aug;104(8):1648-1660. doi: 10.3324/haematol.2018.208363. Epub 2019 Feb 7.

6.

Platelet aggregation induced by polystyrene and platinum nanoparticles is dependent on surface area.

Zia F, Kendall M, Watson SP, Mendes PM.

RSC Adv. 2018 Nov 12;8(66):37789-37794. doi: 10.1039/c8ra07315e.

7.

Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα.

Kardeby C, Fälker K, Haining EJ, Criel M, Lindkvist M, Barroso R, Påhlsson P, Ljungberg LU, Tengdelius M, Rainger GE, Watson S, Eble JA, Hoylaerts MF, Emsley J, Konradsson P, Watson SP, Sun Y, Grenegård M.

Blood Adv. 2019 Feb 12;3(3):275-287. doi: 10.1182/bloodadvances.2018024950.

8.

Functional significance of the platelet immune receptors GPVI and CLEC-2.

Rayes J, Watson SP, Nieswandt B.

J Clin Invest. 2019 Jan 2;129(1):12-23. doi: 10.1172/JCI122955. Epub 2019 Jan 2. Review.

9.

Human Platelet Protein Ubiquitylation and Changes following GPVI Activation.

Unsworth AJ, Bombik I, Pinto-Fernandez A, McGouran JF, Konietzny R, Zahedi RP, Watson SP, Kessler BM, Pears CJ.

Thromb Haemost. 2019 Jan;119(1):104-116. doi: 10.1055/s-0038-1676344. Epub 2018 Dec 31.

10.

Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells.

Noy PJ, Gavin RL, Colombo D, Haining EJ, Reyat JS, Payne H, Thielmann I, Lokman AB, Neag G, Yang J, Lloyd T, Harrison N, Heath VL, Gardiner C, Whitworth KM, Robinson J, Koo CZ, Di Maio A, Harrison P, Lee SP, Michelangeli F, Kalia N, Rainger GE, Nieswandt B, Brill A, Watson SP, Tomlinson MG.

Haematologica. 2018 Dec 20. pii: haematol.2018.194241. doi: 10.3324/haematol.2018.194241. [Epub ahead of print]

11.

Investigation of the contribution of an underlying platelet defect in women with unexplained heavy menstrual bleeding.

Lowe GC, Fickowska R, Al Ghaithi R, Maclachlan A, Harrison P, Lester W, Watson SP, Myers B, Clark J, Morgan NV.

Platelets. 2019;30(1):56-65. doi: 10.1080/09537104.2018.1543865. Epub 2018 Dec 6.

12.

Anagrelide is an anti-megakaryocytic and not an anti-platelet agent.

Watson SP, Dalby A.

Platelets. 2019;30(1):136-137. doi: 10.1080/09537104.2018.1542124. Epub 2018 Nov 7. No abstract available.

PMID:
30404556
13.

Salmonella-induced thrombi in mice develop asynchronously in the spleen and liver and are not effective bacterial traps.

Beristain-Covarrubias N, Perez-Toledo M, Flores-Langarica A, Zuidscherwoude M, Hitchcock JR, Channell WM, King LDW, Thomas MR, Henderson IR, Rayes J, Watson SP, Cunningham AF.

Blood. 2019 Feb 7;133(6):600-604. doi: 10.1182/blood-2018-08-867267. Epub 2018 Nov 6.

14.

Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?

Slater A, Perrella G, Onselaer MB, Martin EM, Gauer JS, Xu RG, Heemskerk JW, Ariëns RAS, Watson SP.

Platelets. 2019;30(3):281-289. doi: 10.1080/09537104.2018.1508649. Epub 2018 Aug 15.

PMID:
30110193
15.

Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI.

Nicolson PLR, Hughes CE, Watson S, Nock SH, Hardy AT, Watson CN, Montague SJ, Clifford H, Huissoon AP, Malcor JD, Thomas MR, Pollitt AY, Tomlinson MG, Pratt G, Watson SP.

Haematologica. 2018 Dec;103(12):2097-2108. doi: 10.3324/haematol.2018.193391. Epub 2018 Jul 19.

16.

Signalling through Src family kinase isoforms is not redundant in models of thrombo-inflammatory vascular disease.

Harrison MJ, Chimen M, Hussain M, Iqbal AJ, Senis YA, Nash GB, Watson SP, Rainger GE.

J Cell Mol Med. 2018 Sep;22(9):4317-4327. doi: 10.1111/jcmm.13721. Epub 2018 Jul 4.

17.

Mutation in GNE is associated with severe congenital thrombocytopenia.

Futterer J, Dalby A, Lowe GC, Johnson B, Simpson MA, Motwani J, Williams M, Watson SP, Morgan NV; UK GAPP Study Group.

Blood. 2018 Oct 25;132(17):1855-1858. doi: 10.1182/blood-2018-04-847798. Epub 2018 Jun 25. No abstract available.

18.

Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry.

Chan MV, Leadbeater PD, Watson SP, Warner TD.

Platelets. 2018 Nov;29(7):686-689. doi: 10.1080/09537104.2018.1466388. Epub 2018 May 1.

19.

Significant Hypo-Responsiveness to GPVI and CLEC-2 Agonists in Pre-Term and Full-Term Neonatal Platelets and following Immune Thrombocytopenia.

Hardy AT, Palma-Barqueros V, Watson SK, Malcor JD, Eble JA, Gardiner EE, Blanco JE, Guijarro-Campillo R, Delgado JL, Lozano ML, Teruel-Montoya R, Vicente V, Watson SP, Rivera J, Ferrer-Marín F.

Thromb Haemost. 2018 Jun;118(6):1009-1020. doi: 10.1055/s-0038-1646924. Epub 2018 Apr 25.

20.

Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation.

Borgognone A, Shantsila E, Worrall SM, Prompunt E, Loka T, Loudon BL, Chimen M, Ed Rainger G, Lord JM, Turner A, Nightingale P, Feelisch M, Kirchhof P, Lip GYH, Watson SP, Frenneaux MP, Madhani M.

Cardiovasc Res. 2018 Aug 1;114(10):1313-1323. doi: 10.1093/cvr/cvy087.

21.

Origin-Specific Adhesive Interactions of Mesenchymal Stem Cells with Platelets Influence Their Behavior After Infusion.

Sheriff L, Alanazi A, Ward LSC, Ward C, Munir H, Rayes J, Alassiri M, Watson SP, Newsome PN, Rainger GE, Kalia N, Frampton J, McGettrick HM, Nash GB.

Stem Cells. 2018 Jul;36(7):1062-1074. doi: 10.1002/stem.2811. Epub 2018 Mar 23.

22.

Immobilized fibrinogen activates human platelets through glycoprotein VI.

Mangin PH, Onselaer MB, Receveur N, Le Lay N, Hardy AT, Wilson C, Sanchez X, Loyau S, Dupuis A, Babar AK, Miller JL, Philippou H, Hughes CE, Herr AB, Ariëns RA, Mezzano D, Jandrot-Perrus M, Gachet C, Watson SP.

Haematologica. 2018 May;103(5):898-907. doi: 10.3324/haematol.2017.182972. Epub 2018 Feb 22.

23.

P2X1 Receptors Amplify FcγRIIa-Induced Ca2+ Increases and Functional Responses in Human Platelets.

Ilkan Z, Watson S, Watson SP, Mahaut-Smith MP.

Thromb Haemost. 2018 Feb;118(2):369-380. doi: 10.1160/TH17-07-0530. Epub 2018 Jan 29.

24.

Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI.

Montague SJ, Delierneux C, Lecut C, Layios N, Dinsdale RJ, Lee CS, Poulter NS, Andrews RK, Hampson P, Wearn CM, Maes N, Bishop J, Bamford A, Gardiner C, Lee WM, Iqbal T, Moiemen N, Watson SP, Oury C, Harrison P, Gardiner EE.

Blood Adv. 2018 Feb 13;2(3):240-251. doi: 10.1182/bloodadvances.2017011171.

25.

Effect of anti-podoplanin antibody administration during lipopolysaccharide-induced lung injury in mice.

Lax S, Rayes J, Thickett DR, Watson SP.

BMJ Open Respir Res. 2017 Nov 8;4(1):e000257. doi: 10.1136/bmjresp-2017-000257. eCollection 2017.

26.

The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent.

Rayes J, Jadoui S, Lax S, Gros A, Wichaiyo S, Ollivier V, Denis CV, Ware J, Nieswandt B, Jandrot-Perrus M, Watson SP, Ho-Tin-Noé B.

Haematologica. 2018 Jun;103(6):e256-e258. doi: 10.3324/haematol.2017.182162. Epub 2018 Feb 1. No abstract available.

27.

Mucor circinelloides induces platelet aggregation through integrin αIIbβ3 and FcγRIIA.

Ghuman H, Shepherd-Roberts A, Watson S, Zuidscherwoude M, Watson SP, Voelz K.

Platelets. 2019;30(2):256-263. doi: 10.1080/09537104.2017.1420152. Epub 2018 Jan 3.

PMID:
29297721
28.

Fibrin and D-dimer bind to monomeric GPVI.

Onselaer MB, Hardy AT, Wilson C, Sanchez X, Babar AK, Miller JLC, Watson CN, Watson SK, Bonna A, Philippou H, Herr AB, Mezzano D, Ariëns RAS, Watson SP.

Blood Adv. 2017 Aug 15;1(19):1495-1504. doi: 10.1182/bloodadvances.2017007732. eCollection 2017 Aug 22.

29.

Fluorescence Approaches Unravel Spatial and Temporal Aspects of GPCR Organisation, Location, and Intracellular Signalling.

Hill SJ, Watson SP.

Trends Pharmacol Sci. 2018 Feb;39(2):91-92. doi: 10.1016/j.tips.2017.12.001. Epub 2017 Dec 21. No abstract available.

PMID:
29276072
30.

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis.

Rayes J, Lax S, Wichaiyo S, Watson SK, Di Y, Lombard S, Grygielska B, Smith SW, Skordilis K, Watson SP.

Nat Commun. 2017 Dec 21;8(1):2239. doi: 10.1038/s41467-017-02402-6.

31.

Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect.

Messaoudi K, Ali A, Ishaq R, Palazzo A, Sliwa D, Bluteau O, Souquère S, Muller D, Diop KM, Rameau P, Lapierre V, Marolleau JP, Matthias P, Godin I, Pierron G, Thomas SG, Watson SP, Droin N, Vainchenker W, Plo I, Raslova H, Debili N.

Nat Commun. 2017 Nov 27;8(1):1786. doi: 10.1038/s41467-017-01690-2.

32.

Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis.

Lombard SE, Pollitt AY, Hughes CE, Di Y, Mckinnon T, O'callaghan CA, Watson SP.

Platelets. 2018 Nov;29(7):716-722. doi: 10.1080/09537104.2017.1356919. Epub 2017 Nov 1.

PMID:
29090616
33.

Introducing high-throughput sequencing into mainstream genetic diagnosis practice in inherited platelet disorders.

Bastida JM, Lozano ML, Benito R, Janusz K, Palma-Barqueros V, Del Rey M, Hernández-Sánchez JM, Riesco S, Bermejo N, González-García H, Rodriguez-Alén A, Aguilar C, Sevivas T, López-Fernández MF, Marneth AE, van der Reijden BA, Morgan NV, Watson SP, Vicente V, Hernández-Rivas JM, Rivera J, González-Porras JR.

Haematologica. 2018 Jan;103(1):148-162. doi: 10.3324/haematol.2017.171132. Epub 2017 Oct 5.

34.

Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse.

Lax S, Rayes J, Wichaiyo S, Haining EJ, Lowe K, Grygielska B, Laloo R, Flodby P, Borok Z, Crandall ED, Thickett DR, Watson SP.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1016-L1029. doi: 10.1152/ajplung.00023.2017. Epub 2017 Aug 24.

35.

CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice.

Haining EJ, Cherpokova D, Wolf K, Becker IC, Beck S, Eble JA, Stegner D, Watson SP, Nieswandt B.

Blood. 2017 Nov 16;130(20):2224-2228. doi: 10.1182/blood-2017-03-771907. Epub 2017 Aug 23.

36.

The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors.

Smith GP, Badolo L, Chell V, Chen IJ, Christensen KV, David L, Daechsel JA, Hentzer M, Herzig MC, Mikkelsen GK, Watson SP, Williamson DS.

Bioorg Med Chem Lett. 2017 Sep 15;27(18):4500-4505. doi: 10.1016/j.bmcl.2017.07.072. Epub 2017 Aug 1.

PMID:
28802631
37.

Comparison of multiple electrode aggregometry with lumi-aggregometry for the diagnosis of patients with mild bleeding disorders.

Al Ghaithi R, Drake S, Watson SP, Morgan NV, Harrison P.

J Thromb Haemost. 2017 Oct;15(10):2045-2052. doi: 10.1111/jth.13784. Epub 2017 Sep 13.

PMID:
28762630
38.

Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis.

Sevivas T, Bastida JM, Paul DS, Caparros E, Palma-Barqueros V, Coucelo M, Marques D, Ferrer-Marín F, González-Porras JR, Vicente V, Hernández-Rivas JM, Watson SP, Lozano ML, Bergmeier W, Rivera J.

Platelets. 2018 Mar;29(2):192-195. doi: 10.1080/09537104.2017.1336214. Epub 2017 Aug 1.

39.

Modulation of VEGF-induced migration and network formation by lymphatic endothelial cells: Roles of platelets and podoplanin.

Langan SA, Navarro-Núñez L, Watson SP, Nash GB.

Platelets. 2018 Jul;29(5):486-495. doi: 10.1080/09537104.2017.1336210. Epub 2017 Jul 20.

40.

The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin.

Andersen JL, Lindberg S, Langgård M, Maltas PJ, Rønn LCB, Bundgaard C, Strandbygaard D, Thirup S, Watson SP.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2629-2633. doi: 10.1016/j.bmcl.2017.02.028. Epub 2017 Feb 20.

PMID:
28462834
41.

Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets.

Smith CW, Thomas SG, Raslan Z, Patel P, Byrne M, Lordkipanidzé M, Bem D, Meyaard L, Senis YA, Watson SP, Mazharian A.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):823-835. doi: 10.1161/ATVBAHA.117.309253. Epub 2017 Mar 23.

PMID:
28336561
42.

Whole exome sequencing identifies a mutation in thrombomodulin as the genetic cause of a suspected platelet disorder in a family with normal platelet function.

Maclachlan A, Dolan G, Grimley C, Watson SP, Morgan NV, On Behalf Of The Uk Gapp Study Group.

Platelets. 2017 Sep;28(6):611-613. doi: 10.1080/09537104.2017.1283011. Epub 2017 Mar 7.

43.

Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis.

Payne H, Ponomaryov T, Watson SP, Brill A.

Blood. 2017 Apr 6;129(14):2013-2020. doi: 10.1182/blood-2016-09-742999. Epub 2017 Jan 19.

44.

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets.

Poulter NS, Pollitt AY, Owen DM, Gardiner EE, Andrews RK, Shimizu H, Ishikawa D, Bihan D, Farndale RW, Moroi M, Watson SP, Jung SM.

J Thromb Haemost. 2017 Mar;15(3):549-564. doi: 10.1111/jth.13613. Epub 2017 Feb 16.

45.

Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation.

Haining EJ, Matthews AL, Noy PJ, Romanska HM, Harris HJ, Pike J, Morowski M, Gavin RL, Yang J, Milhiet PE, Berditchevski F, Nieswandt B, Poulter NS, Watson SP, Tomlinson MG.

Platelets. 2017 Nov;28(7):629-642. doi: 10.1080/09537104.2016.1254175. Epub 2016 Dec 29.

46.

ISTH Advanced Training Course on platelet bleeding disorders: How should they be investigated?St. Anne's College, Oxford, 6-9th September 2016.

Watson SP, Daly ME, Harrison P, Lowe GC, Paterson A, Rivera J, Warner TD, Morgan NV.

Platelets. 2016 Dec;27(8):719-721. Epub 2016 Nov 14. No abstract available.

PMID:
27841701
47.

Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph Nodes.

Bianchi R, Russo E, Bachmann SB, Proulx ST, Sesartic M, Smaadahl N, Watson SP, Buckley CD, Halin C, Detmar M.

Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):108-117. doi: 10.1161/ATVBAHA.116.308020. Epub 2016 Nov 3.

PMID:
27810998
48.

The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation.

Thomas SG, Poulter NS, Bem D, Finney B, Machesky LM, Watson SP.

Platelets. 2017 Jun;28(4):372-379. doi: 10.1080/09537104.2016.1235688. Epub 2016 Oct 25.

49.

Platelets: No longer bystanders in liver disease.

Chauhan A, Adams DH, Watson SP, Lalor PF.

Hepatology. 2016 Nov;64(5):1774-1784. doi: 10.1002/hep.28526. Epub 2016 Apr 7. Review.

50.

Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects.

Johnson B, Lowe GC, Futterer J, Lordkipanidzé M, MacDonald D, Simpson MA, Sanchez-Guiú I, Drake S, Bem D, Leo V, Fletcher SJ, Dawood B, Rivera J, Allsup D, Biss T, Bolton-Maggs PH, Collins P, Curry N, Grimley C, James B, Makris M, Motwani J, Pavord S, Talks K, Thachil J, Wilde J, Williams M, Harrison P, Gissen P, Mundell S, Mumford A, Daly ME, Watson SP, Morgan NV; UK GAPP Study Group.

Haematologica. 2016 Oct;101(10):1170-1179. Epub 2016 Jun 16.

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