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Items: 1 to 50 of 170


Legacy data sharing to improve drug safety assessment: the eTOX project.

Sanz F, Pognan F, Steger-Hartmann T, Díaz C; eTOX, Cases M, Pastor M, Marc P, Wichard J, Briggs K, Watson DK, Kleinöder T, Yang C, Amberg A, Beaumont M, Brookes AJ, Brunak S, Cronin MTD, Ecker GF, Escher S, Greene N, Guzmán A, Hersey A, Jacques P, Lammens L, Mestres J, Muster W, Northeved H, Pinches M, Saiz J, Sajot N, Valencia A, van der Lei J, Vermeulen NPE, Vock E, Wolber G, Zamora I.

Nat Rev Drug Discov. 2017 Dec;16(12):811-812. doi: 10.1038/nrd.2017.177. Epub 2017 Oct 13.



Ford ME, Watson DK.

Adv Cancer Res. 2017;133:ix-xi. doi: 10.1016/S0065-230X(16)30092-6. No abstract available.


Complementary feature selection from alternative splicing events and gene expression for phenotype prediction.

Labuzzetta CJ, Antonio ML, Watson PM, Wilson RC, Laboissonniere LA, Trimarchi JM, Genc B, Ozdinler PH, Watson DK, Anderson PE.

Bioinformatics. 2016 Sep 1;32(17):i421-i429. doi: 10.1093/bioinformatics/btw430.


Multivariate models from RNA-Seq SNVs yield candidate molecular targets for biomarker discovery: SNV-DA.

Paul MR, Levitt NP, Moore DE, Watson PM, Wilson RC, Denlinger CE, Watson DK, Anderson PE.

BMC Genomics. 2016 Mar 31;17:263. doi: 10.1186/s12864-016-2542-4.


The CaSm (LSm1) oncogene promotes transformation, chemoresistance and metastasis of pancreatic cancer cells.

Little EC, Camp ER, Wang C, Watson PM, Watson DK, Cole DJ.

Oncogenesis. 2016 Jan 11;5:e182. doi: 10.1038/oncsis.2015.45.


Essential Components of Cancer Education.

Welch DR, Antalis TM, Burnstein K, Vona-Davis L, Jensen RA, Nakshatri H, Riegel AT, Spitz DR, Watson DK, Weiner GJ; Cancer Biology Training Consortium.

Cancer Res. 2015 Dec 15;75(24):5202-5. doi: 10.1158/0008-5472.CAN-15-2077. Epub 2015 Dec 1. Review.


Hematopoietic stem cell-derived cancer-associated fibroblasts are novel contributors to the pro-tumorigenic microenvironment.

McDonald LT, Russell DL, Kelly RR, Xiong Y, Motamarry A, Patel RK, Jones JA, Watson PM, Turner DP, Watson DK, Soloff AC, Findlay VJ, LaRue AC.

Neoplasia. 2015 May;17(5):434-48. doi: 10.1016/j.neo.2015.04.004.


Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2.

Liu F, Li D, Yu YY, Kang I, Cha MJ, Kim JY, Park C, Watson DK, Wang T, Choi K.

EMBO Rep. 2015 May;16(5):654-69. doi: 10.15252/embr.201439939. Epub 2015 Mar 23.


FLI1 expression is correlated with breast cancer cellular growth, migration, and invasion and altered gene expression.

Scheiber MN, Watson PM, Rumboldt T, Stanley C, Wilson RC, Findlay VJ, Anderson PE, Watson DK.

Neoplasia. 2014 Oct 23;16(10):801-13. doi: 10.1016/j.neo.2014.08.007. eCollection 2014 Oct.


SNAI2 modulates colorectal cancer 5-fluorouracil sensitivity through miR145 repression.

Findlay VJ, Wang C, Nogueira LM, Hurst K, Quirk D, Ethier SP, Staveley O'Carroll KF, Watson DK, Camp ER.

Mol Cancer Ther. 2014 Nov;13(11):2713-26. doi: 10.1158/1535-7163.MCT-14-0207. Epub 2014 Sep 23.


Fli-1 controls transcription from the MCP-1 gene promoter, which may provide a novel mechanism for chemokine and cytokine activation.

Lennard Richard ML, Nowling TK, Brandon D, Watson DK, Zhang XK.

Mol Immunol. 2015 Feb;63(2):566-73. doi: 10.1016/j.molimm.2014.07.013. Epub 2014 Aug 6.


Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer.

Findlay VJ, Wang C, Watson DK, Camp ER.

Cancer Gene Ther. 2014 May;21(5):181-7. doi: 10.1038/cgt.2014.15. Epub 2014 May 2. Review.


Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation.

Abedin MJ, Nguyen A, Jiang N, Perry CE, Shelton JM, Watson DK, Ferdous A.

Circ Res. 2014 May 23;114(11):1690-9. doi: 10.1161/CIRCRESAHA.1134303145. Epub 2014 Apr 11.


Slug expression inhibits calcitriol-mediated sensitivity to radiation in colorectal cancer.

Findlay VJ, Moretz RE, Wang C, Vaena SG, Bandurraga SG, Ashenafi M, Marshall DT, Watson DK, Camp ER.

Mol Carcinog. 2014 Feb;53 Suppl 1:E130-9. doi: 10.1002/mc.22054. Epub 2013 Aug 31.


Understanding the role of ETS-mediated gene regulation in complex biological processes.

Findlay VJ, LaRue AC, Turner DP, Watson PM, Watson DK.

Adv Cancer Res. 2013;119:1-61. doi: 10.1016/B978-0-12-407190-2.00001-0. Review.


Transferrin receptor targeting nanomedicine delivering wild-type p53 gene sensitizes pancreatic cancer to gemcitabine therapy.

Camp ER, Wang C, Little EC, Watson PM, Pirollo KF, Rait A, Cole DJ, Chang EH, Watson DK.

Cancer Gene Ther. 2013 Apr;20(4):222-8. doi: 10.1038/cgt.2013.9. Epub 2013 Mar 8.


The transcription factor Fli-1 regulates monocyte, macrophage and dendritic cell development in mice.

Suzuki E, Williams S, Sato S, Gilkeson G, Watson DK, Zhang XK.

Immunology. 2013 Jul;139(3):318-27. doi: 10.1111/imm.12070.


Fli-1 transcription factor affects glomerulonephritis development by regulating expression of monocyte chemoattractant protein-1 in endothelial cells in the kidney.

Suzuki E, Karam E, Williams S, Watson DK, Gilkeson G, Zhang XK.

Clin Immunol. 2012 Dec;145(3):201-8. doi: 10.1016/j.clim.2012.09.006. Epub 2012 Sep 28.


Kaposi's sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection.

Qin Z, Dai L, Defee M, Findlay VJ, Watson DK, Toole BP, Cameron J, Peruzzi F, Kirkwood K, Parsons C.

J Virol. 2013 Jan;87(1):621-35. doi: 10.1128/JVI.01441-12. Epub 2012 Oct 24.


Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion.

Rossa C Jr, Sommer G, Spolidorio LC, Rosenzweig SA, Watson DK, Kirkwood KL.

PLoS One. 2012;7(9):e45197. doi: 10.1371/journal.pone.0045197. Epub 2012 Sep 18.


Inroads to predict in vivo toxicology-an introduction to the eTOX Project.

Briggs K, Cases M, Heard DJ, Pastor M, Pognan F, Sanz F, Schwab CH, Steger-Hartmann T, Sutter A, Watson DK, Wichard JD.

Int J Mol Sci. 2012;13(3):3820-46. doi: 10.3390/ijms13033820. Epub 2012 Mar 21. Review.


Novel immunocompetent murine models representing advanced local and metastatic pancreatic cancer.

Little EC, Wang C, Watson PM, Watson DK, Cole DJ, Camp ER.

J Surg Res. 2012 Aug;176(2):359-66. doi: 10.1016/j.jss.2011.10.025. Epub 2011 Nov 10.


Urinary thromboxane B2 and thromboxane receptors in bladder cancer: opportunity for detection and monitoring.

Moussa O, Ciupek A, Watson DK, Halushka PV.

Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):41-4. doi: 10.1016/j.prostaglandins.2011.09.002. Epub 2011 Sep 29.


Abnormal expression of FLI1 protein is an adverse prognostic factor in acute myeloid leukemia.

Kornblau SM, Qiu YH, Zhang N, Singh N, Faderl S, Ferrajoli A, York H, Qutub AA, Coombes KR, Watson DK.

Blood. 2011 Nov 17;118(20):5604-12. doi: 10.1182/blood-2011-04-348052. Epub 2011 Sep 13.


Prostate-Derived ETS Factor Regulates Epithelial-to-Mesenchymal Transition through Both SLUG-Dependent and Independent Mechanisms.

Findlay VJ, Turner DP, Yordy JS, McCarragher B, Shriver MR, Szalai G, Watson PM, Larue AC, Moussa O, Watson DK.

Genes Cancer. 2011 Feb;2(2):120-9. doi: 10.1177/1947601911410424.


Slug expression enhances tumor formation in a noninvasive rectal cancer model.

Camp ER, Findlay VJ, Vaena SG, Walsh J, Lewin DN, Turner DP, Watson DK.

J Surg Res. 2011 Sep;170(1):56-63. doi: 10.1016/j.jss.2011.02.012. Epub 2011 Mar 23.


Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression.

Turner DP, Findlay VJ, Moussa O, Semenchenko VI, Watson PM, LaRue AC, Desouki MM, Fraig M, Watson DK.

Prostate. 2011 Dec;71(16):1723-35. doi: 10.1002/pros.21389. Epub 2011 Mar 28.


Rearranging the exponential wall for large N-body systems.

Watson DK, Dunn M.

Phys Rev Lett. 2010 Jul 9;105(2):020402. Epub 2010 Jul 7.


Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1.

Moussa O, LaRue AC, Abangan RS Jr, Williams CR, Zhang XK, Masuya M, Gong YZ, Spyropoulos DD, Ogawa M, Gilkeson G, Watson DK.

Mol Cell Biol. 2010 Nov;30(21):5194-206. doi: 10.1128/MCB.01112-09. Epub 2010 Sep 7.


Impact of Fli-1 transcription factor on autoantibody and lupus nephritis in NZM2410 mice.

Mathenia J, Reyes-Cortes E, Williams S, Molano I, Ruiz P, Watson DK, Gilkeson GS, Zhang XK.

Clin Exp Immunol. 2010 Nov;162(2):362-71. doi: 10.1111/j.1365-2249.2010.04245.x. Epub 2010 Aug 20.


Acquired haemophilia in a newly diagnosed elderly diabetic.

Yadava RK, Fernando MU, Watson DK.

Age Ageing. 2010 Sep;39(5):660-1. doi: 10.1093/ageing/afq087. Epub 2010 Jul 15. No abstract available.


Hematopoietic stem cell origin of connective tissues.

Ogawa M, Larue AC, Watson PM, Watson DK.

Exp Hematol. 2010 Jul;38(7):540-7. doi: 10.1016/j.exphem.2010.04.005. Epub 2010 Apr 20. Review.


Hematopoietic stem cell origin of mesenchymal cells: opportunity for novel therapeutic approaches.

Ogawa M, Larue AC, Watson PM, Watson DK.

Int J Hematol. 2010 Apr;91(3):353-9. doi: 10.1007/s12185-010-0554-4. Epub 2010 Mar 26. Review.


Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy.

Asano Y, Stawski L, Hant F, Highland K, Silver R, Szalai G, Watson DK, Trojanowska M.

Am J Pathol. 2010 Apr;176(4):1983-98. doi: 10.2353/ajpath.2010.090593. Epub 2010 Mar 12.


Transcriptional regulation of p21/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progression.

Schaefer JS, Sabherwal Y, Shi HY, Sriraman V, Richards J, Minella A, Turner DP, Watson DK, Zhang M.

J Biol Chem. 2010 Apr 9;285(15):11258-69. doi: 10.1074/jbc.M109.073932. Epub 2010 Feb 5.


PDEF is a negative regulator of colon cancer cell growth and migration.

Moussa O, Turner DP, Feldman RJ, Sementchenko VI, McCarragher BD, Desouki MM, Fraig M, Watson DK.

J Cell Biochem. 2009 Dec 15;108(6):1389-98. doi: 10.1002/jcb.22371.


Hematopoietic stem cell origin of human fibroblasts: cell culture studies of female recipients of gender-mismatched stem cell transplantation and patients with chronic myelogenous leukemia.

Shirai K, Sera Y, Bulkeley W, Mehrotra M, Moussa O, LaRue AC, Watson DK, Stuart RK, Lazarchick J, Ogawa M.

Exp Hematol. 2009 Dec;37(12):1464-71. doi: 10.1016/j.exphem.2009.09.008. Epub 2009 Sep 26.


Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.

Kruse EA, Loughran SJ, Baldwin TM, Josefsson EC, Ellis S, Watson DK, Nurden P, Metcalf D, Hilton DJ, Alexander WS, Kile BT.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13814-9. doi: 10.1073/pnas.0906556106. Epub 2009 Jul 31.


Hematopoietic stem cell origin of adipocytes.

Sera Y, LaRue AC, Moussa O, Mehrotra M, Duncan JD, Williams CR, Nishimoto E, Schulte BA, Watson PM, Watson DK, Ogawa M.

Exp Hematol. 2009 Sep;37(9):1108-20, 1120.e1-4. doi: 10.1016/j.exphem.2009.06.008. Epub 2009 Jul 2.


Osteopathic postdoctoral training institutions: a decentralized model for facilitating accreditation and program quality.

Peska DN, Opipari MI, Watson DK.

Acad Med. 2009 Jun;84(6):729-32. doi: 10.1097/ACM.0b013e3181a43ac3.


Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy.

Elkareh J, Periyasamy SM, Shidyak A, Vetteth S, Schroeder J, Raju V, Hariri IM, El-Okdi N, Gupta S, Fedorova L, Liu J, Fedorova OV, Kahaleh MB, Xie Z, Malhotra D, Watson DK, Bagrov AY, Shapiro JI.

Am J Physiol Renal Physiol. 2009 May;296(5):F1219-26. doi: 10.1152/ajprenal.90710.2008. Epub 2009 Mar 4.


Transcription factor Fli1 regulates collagen fibrillogenesis in mouse skin.

Asano Y, Markiewicz M, Kubo M, Szalai G, Watson DK, Trojanowska M.

Mol Cell Biol. 2009 Jan;29(2):425-34. doi: 10.1128/MCB.01278-08. Epub 2008 Nov 10.


MicroRNA-mediated inhibition of prostate-derived Ets factor messenger RNA translation affects prostate-derived Ets factor regulatory networks in human breast cancer.

Findlay VJ, Turner DP, Moussa O, Watson DK.

Cancer Res. 2008 Oct 15;68(20):8499-506. doi: 10.1158/0008-5472.CAN-08-0907.


The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice.

Zhang XK, Moussa O, LaRue A, Bradshaw S, Molano I, Spyropoulos DD, Gilkeson GS, Watson DK.

J Immunol. 2008 Aug 1;181(3):1644-54.


Global gene expression analysis identifies PDEF transcriptional networks regulating cell migration during cancer progression.

Turner DP, Findlay VJ, Kirven AD, Moussa O, Watson DK.

Mol Biol Cell. 2008 Sep;19(9):3745-57. doi: 10.1091/mbc.E08-02-0154. Epub 2008 Jun 25.


Novel role of thromboxane receptors beta isoform in bladder cancer pathogenesis.

Moussa O, Ashton AW, Fraig M, Garrett-Mayer E, Ghoneim MA, Halushka PV, Watson DK.

Cancer Res. 2008 Jun 1;68(11):4097-104. doi: 10.1158/0008-5472.CAN-07-6560.


Reversible Hodgkin's lymphoma associated with Epstein-Barr virus occurring during azathioprine therapy for SLE.

Evans SJ, Watson DK, O'Sullivan M.

Rheumatology (Oxford). 2008 Jul;47(7):1103-4. doi: 10.1093/rheumatology/ken188. Epub 2008 May 9. No abstract available.


Medical education summits: building a solid foundation for the future of the osteopathic medical profession.

Watson DK, Nichols KJ.

J Am Osteopath Assoc. 2008 Mar;108(3):110-5. Erratum in: J Am Osteopath Assoc. 2008 May;108(5):266.


CaSm (LSm-1) overexpression in lung cancer and mesothelioma is required for transformed phenotypes.

Watson PM, Miller SW, Fraig M, Cole DJ, Watson DK, Boylan AM.

Am J Respir Cell Mol Biol. 2008 Jun;38(6):671-8. doi: 10.1165/rcmb.2007-0205OC. Epub 2008 Jan 24.


ETS transcription factors: oncogenes and tumor suppressor genes as therapeutic targets for prostate cancer.

Turner DP, Watson DK.

Expert Rev Anticancer Ther. 2008 Jan;8(1):33-42. Review.


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