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Items: 1 to 50 of 51

1.

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance.

Cirelli KM, Carnathan DG, Nogal B, Martin JT, Rodriguez OL, Upadhyay AA, Enemuo CA, Gebru EH, Choe Y, Viviano F, Nakao C, Pauthner MG, Reiss S, Cottrell CA, Smith ML, Bastidas R, Gibson W, Wolabaugh AN, Melo MB, Cossette B, Kumar V, Patel NB, Tokatlian T, Menis S, Kulp DW, Burton DR, Murrell B, Schief WR, Bosinger SE, Ward AB, Watson CT, Silvestri G, Irvine DJ, Crotty S.

Cell. 2019 May 16;177(5):1153-1171.e28. doi: 10.1016/j.cell.2019.04.012. Epub 2019 May 9.

PMID:
31080066
2.

Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course.

Castro K, Ntranos A, Amatruda M, Petracca M, Kosa P, Chen EY, Morstein J, Trauner D, Watson CT, Kiebish MA, Bielekova B, Inglese M, Katz Sand I, Casaccia P.

EBioMedicine. 2019 May;43:392-410. doi: 10.1016/j.ebiom.2019.03.087. Epub 2019 Apr 10.

3.

Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming.

Ohlin M, Scheepers C, Corcoran M, Lees WD, Busse CE, Bagnara D, Thörnqvist L, Bürckert JP, Jackson KJL, Ralph D, Schramm CA, Marthandan N, Breden F, Scott J, Matsen Iv FA, Greiff V, Yaari G, Kleinstein SH, Christley S, Sherkow JS, Kossida S, Lefranc MP, van Zelm MC, Watson CT, Collins AM.

Front Immunol. 2019 Mar 18;10:435. doi: 10.3389/fimmu.2019.00435. eCollection 2019. Review.

4.

Identification of Subject-Specific Immunoglobulin Alleles From Expressed Repertoire Sequencing Data.

Gadala-Maria D, Gidoni M, Marquez S, Vander Heiden JA, Kos JT, Watson CT, O'Connor KC, Yaari G, Kleinstein SH.

Front Immunol. 2019 Feb 13;10:129. doi: 10.3389/fimmu.2019.00129. eCollection 2019.

5.

Proteomic Analysis Reveals Novel Mechanisms by Which Polychlorinated Biphenyls Compromise the Liver Promoting Diet-Induced Steatohepatitis.

Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Zhou Y, Wilkey DW, Merchant ML, Watson CT, Feng W, Morris AJ, Hennig B, Prough RA, Cave MC.

J Proteome Res. 2019 Apr 5;18(4):1582-1594. doi: 10.1021/acs.jproteome.8b00886. Epub 2019 Mar 15.

PMID:
30807179
6.

Fumarates target the metabolic-epigenetic interplay of brain-homing T cells in multiple sclerosis.

Ntranos A, Ntranos V, Bonnefil V, Liu J, Kim-Schulze S, He Y, Zhu Y, Brandstadter R, Watson CT, Sharp AJ, Katz Sand I, Casaccia P.

Brain. 2019 Mar 1;142(3):647-661. doi: 10.1093/brain/awy344.

PMID:
30698680
7.

Immunoglobulin Light Chain Gene Rearrangements, Receptor Editing and the Development of a Self-Tolerant Antibody Repertoire.

Collins AM, Watson CT.

Front Immunol. 2018 Oct 8;9:2249. doi: 10.3389/fimmu.2018.02249. eCollection 2018. Review.

8.

Identification of rare de novo epigenetic variations in congenital disorders.

Barbosa M, Joshi RS, Garg P, Martin-Trujillo A, Patel N, Jadhav B, Watson CT, Gibson W, Chetnik K, Tessereau C, Mei H, De Rubeis S, Reichert J, Lopes F, Vissers LELM, Kleefstra T, Grice DE, Edelmann L, Soares G, Maciel P, Brunner HG, Buxbaum JD, Gelb BD, Sharp AJ.

Nat Commun. 2018 May 25;9(1):2064. doi: 10.1038/s41467-018-04540-x.

9.

Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions.

Watson CT, Cohain AT, Griffin RS, Chun Y, Grishin A, Hacyznska H, Hoffman GE, Beckmann ND, Shah H, Dawson P, Henning A, Wood R, Burks AW, Jones SM, Leung DYM, Sicherer S, Sampson HA, Sharp AJ, Schadt EE, Bunyavanich S.

Nat Commun. 2017 Dec 5;8(1):1943. doi: 10.1038/s41467-017-02188-7.

10.

Reproducibility and Reuse of Adaptive Immune Receptor Repertoire Data.

Breden F, Luning Prak ET, Peters B, Rubelt F, Schramm CA, Busse CE, Vander Heiden JA, Christley S, Bukhari SAC, Thorogood A, Matsen Iv FA, Wine Y, Laserson U, Klatzmann D, Douek DC, Lefranc MP, Collins AM, Bubela T, Kleinstein SH, Watson CT, Cowell LG, Scott JK, Kepler TB.

Front Immunol. 2017 Nov 1;8:1418. doi: 10.3389/fimmu.2017.01418. eCollection 2017.

11.

Adaptive Immune Receptor Repertoire Community recommendations for sharing immune-repertoire sequencing data.

Rubelt F, Busse CE, Bukhari SAC, Bürckert JP, Mariotti-Ferrandiz E, Cowell LG, Watson CT, Marthandan N, Faison WJ, Hershberg U, Laserson U, Corrie BD, Davis MM, Peters B, Lefranc MP, Scott JK, Breden F; AIRR Community, Luning Prak ET, Kleinstein SH.

Nat Immunol. 2017 Nov 16;18(12):1274-1278. doi: 10.1038/ni.3873. No abstract available.

12.

Genomic Environment Impacts Color Vision Evolution in a Family with Visually Based Sexual Selection.

Sandkam BA, Joy JB, Watson CT, Breden F.

Genome Biol Evol. 2017 Nov 1;9(11):3100-3107. doi: 10.1093/gbe/evx228.

13.

The Individual and Population Genetics of Antibody Immunity.

Watson CT, Glanville J, Marasco WA.

Trends Immunol. 2017 Jul;38(7):459-470. doi: 10.1016/j.it.2017.04.003. Epub 2017 May 20. Review.

14.

Comment on "A Database of Human Immune Receptor Alleles Recovered from Population Sequencing Data".

Watson CT, Matsen FA 4th, Jackson KJL, Bashir A, Smith ML, Glanville J, Breden F, Kleinstein SH, Collins AM, Busse CE.

J Immunol. 2017 May 1;198(9):3371-3373. doi: 10.4049/jimmunol.1700306. No abstract available.

15.

HLBT-100: a highly potent anti-cancer flavanone from Tillandsia recurvata (L.) L.

Lowe HIC, Toyang NJ, Watson CT, Ayeah KN, Bryant J.

Cancer Cell Int. 2017 Mar 7;17:38. doi: 10.1186/s12935-017-0404-z. eCollection 2017.

16.

Using High-Throughput Sequencing to Characterize the Development of the Antibody Repertoire During Infections: A Case Study of HIV-1.

Breden F, Watson CT.

Adv Exp Med Biol. 2017;1053:245-263. doi: 10.1007/978-3-319-72077-7_12. Review.

PMID:
29549643
17.

DNA Methylation Profiling of Uniparental Disomy Subjects Provides a Map of Parental Epigenetic Bias in the Human Genome.

Joshi RS, Garg P, Zaitlen N, Lappalainen T, Watson CT, Azam N, Ho D, Li X, Antonarakis SE, Brunner HG, Buiting K, Cheung SW, Coffee B, Eggermann T, Francis D, Geraedts JP, Gimelli G, Jacobson SG, Le Caignec C, de Leeuw N, Liehr T, Mackay DJ, Montgomery SB, Pagnamenta AT, Papenhausen P, Robinson DO, Ruivenkamp C, Schwartz C, Steiner B, Stevenson DA, Surti U, Wassink T, Sharp AJ.

Am J Hum Genet. 2016 Sep 1;99(3):555-566. doi: 10.1016/j.ajhg.2016.06.032. Epub 2016 Aug 25.

18.

Erratum: IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity.

Avnir Y, Watson CT, Glanville J, Peterson EC, Tallarico AS, Bennett AS, Qin K, Fu Y, Huang CY, Beigel JH, Breden F, Zhu Q, Marasco WA.

Sci Rep. 2016 Apr 29;6:23876. doi: 10.1038/srep23876. No abstract available.

19.

IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity.

Avnir Y, Watson CT, Glanville J, Peterson EC, Tallarico AS, Bennett AS, Qin K, Fu Y, Huang CY, Beigel JH, Breden F, Zhu Q, Marasco WA.

Sci Rep. 2016 Feb 16;6:20842. doi: 10.1038/srep20842. Erratum in: Sci Rep. 2016 Apr 29;6:23876.

20.

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease.

Watson CT, Roussos P, Garg P, Ho DJ, Azam N, Katsel PL, Haroutunian V, Sharp AJ.

Genome Med. 2016 Jan 19;8(1):5. doi: 10.1186/s13073-015-0258-8.

21.

Genome-Wide DNA Methylation Profiling Reveals Epigenetic Changes in the Rat Nucleus Accumbens Associated With Cross-Generational Effects of Adolescent THC Exposure.

Watson CT, Szutorisz H, Garg P, Martin Q, Landry JA, Sharp AJ, Hurd YL.

Neuropsychopharmacology. 2015 Dec;40(13):2993-3005. doi: 10.1038/npp.2015.155. Epub 2015 Jun 5.

22.

Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity.

Watson CT, Steinberg KM, Graves TA, Warren RL, Malig M, Schein J, Wilson RK, Holt RA, Eichler EE, Breden F.

Genes Immun. 2015 Jan-Feb;16(1):24-34. doi: 10.1038/gene.2014.56. Epub 2014 Oct 23.

23.

Synthesis of substituted 1,3-diesters of glycerol using wittig chemistry.

Lowe HI, Toyang NJ, Watson CT, Bryant J.

Nat Prod Commun. 2014 May;9(5):687-9.

PMID:
25026722
24.

Antileukemic activity of Tillandsia recurvata and some of its cycloartanes.

Lowe HI, Toyang NJ, Watson CT, Ayeah KN, Bryant J.

Anticancer Res. 2014 Jul;34(7):3505-9.

25.

The genetics of microdeletion and microduplication syndromes: an update.

Watson CT, Marques-Bonet T, Sharp AJ, Mefford HC.

Annu Rev Genomics Hum Genet. 2014;15:215-244. doi: 10.1146/annurev-genom-091212-153408. Epub 2014 Apr 16. Review.

26.

DNA methylation profiling in X;autosome translocations supports a role for L1 repeats in the spread of X chromosome inactivation.

Bala Tannan N, Brahmachary M, Garg P, Borel C, Alnefaie R, Watson CT, Thomas NS, Sharp AJ.

Hum Mol Genet. 2014 Mar 1;23(5):1224-36. doi: 10.1093/hmg/ddt553. Epub 2013 Nov 1.

27.

DNase hypersensitive sites and association with multiple sclerosis.

Disanto G, Kjetil Sandve G, Ricigliano VA, Pakpoor J, Berlanga-Taylor AJ, Handel AE, Kuhle J, Holden L, Watson CT, Giovannoni G, Handunnetthi L, Ramagopalan SV.

Hum Mol Genet. 2014 Feb 15;23(4):942-8. doi: 10.1093/hmg/ddt489. Epub 2013 Oct 2.

PMID:
24092328
28.

Month of birth and thymic output.

Disanto G, Watson CT, Meier UC, Ebers GC, Giovannoni G, Ramagopalan SV.

JAMA Neurol. 2013 Apr;70(4):527-8. doi: 10.1001/jamaneurol.2013.2116. No abstract available.

PMID:
23568650
29.

Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation.

Watson CT, Steinberg KM, Huddleston J, Warren RL, Malig M, Schein J, Willsey AJ, Joy JB, Scott JK, Graves TA, Wilson RK, Holt RA, Eichler EE, Breden F.

Am J Hum Genet. 2013 Apr 4;92(4):530-46. doi: 10.1016/j.ajhg.2013.03.004. Epub 2013 Mar 28.

30.

Comment on "genomic hypomethylation in the human germline associates with selective structural mutability in the human genome".

Watson CT, Garg P, Sharp AJ.

PLoS Genet. 2013;9(2):e1003332. doi: 10.1371/journal.pgen.1003332. Epub 2013 Feb 28. No abstract available.

31.

Hybridization leads to sensory repertoire expansion in a gynogenetic fish, the Amazon molly (poecilia formosa): a test of the hybrid-sensory expansion hypothesis.

Sandkam BA, Joy JB, Watson CT, Gonzalez-Bendiksen P, Gabor CR, Breden F.

Evolution. 2013 Jan;67(1):120-30. doi: 10.1111/j.1558-5646.2012.01779.x. Epub 2012 Sep 7.

PMID:
23289566
32.

Tuning the electronic absorption of protein-embedded all-trans-retinal.

Wang W, Nossoni Z, Berbasova T, Watson CT, Yapici I, Lee KS, Vasileiou C, Geiger JH, Borhan B.

Science. 2012 Dec 7;338(6112):1340-3. doi: 10.1126/science.1226135.

33.

Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro.

Lowe HI, Watson CT, Badal S, Toyang NJ, Bryant J.

Cancer Cell Int. 2012 Nov 14;12(1):46. doi: 10.1186/1475-2867-12-46.

34.

Estimating the proportion of variation in susceptibility to multiple sclerosis captured by common SNPs.

Watson CT, Disanto G, Breden F, Giovannoni G, Ramagopalan SV.

Sci Rep. 2012;2:770. doi: 10.1038/srep00770. Epub 2012 Oct 25.

35.

Kinase inhibition by the Jamaican ball moss, Tillandsia recurvata L.

Lowe HI, Watson CT, Badal S, Toyang NJ, Bryant J.

Anticancer Res. 2012 Oct;32(10):4419-22.

PMID:
23060567
36.

Age-associated hyper-methylated regions in the human brain overlap with bivalent chromatin domains.

Watson CT, Disanto G, Sandve GK, Breden F, Giovannoni G, Ramagopalan SV.

PLoS One. 2012;7(9):e43840. doi: 10.1371/journal.pone.0043840. Epub 2012 Sep 24.

37.

Vitamin D receptor binding, chromatin states and association with multiple sclerosis.

Disanto G, Sandve GK, Berlanga-Taylor AJ, Ragnedda G, Morahan JM, Watson CT, Giovannoni G, Ebers GC, Ramagopalan SV.

Hum Mol Genet. 2012 Aug 15;21(16):3575-86. doi: 10.1093/hmg/dds189. Epub 2012 May 16.

38.

The immunoglobulin heavy chain locus: genetic variation, missing data, and implications for human disease.

Watson CT, Breden F.

Genes Immun. 2012 Jul;13(5):363-73. doi: 10.1038/gene.2012.12. Epub 2012 May 3. Review.

PMID:
22551722
39.

Regulatory function of conserved sequences upstream of the long-wave sensitive opsin genes in teleost fishes.

Tam KJ, Watson CT, Massah S, Kolybaba AM, Breden F, Prefontaine GG, Beischlag TV.

Vision Res. 2011 Nov;51(21-22):2295-303. doi: 10.1016/j.visres.2011.09.010. Epub 2011 Sep 25.

40.

Phosphatidylinositol synthase is required for lens structural integrity and photoreceptor cell survival in the zebrafish eye.

Murphy TR, Vihtelic TS, Ile KE, Watson CT, Willer GB, Gregg RG, Bankaitis VA, Hyde DR.

Exp Eye Res. 2011 Oct;93(4):460-74. doi: 10.1016/j.exer.2011.06.010. Epub 2011 Jun 23.

41.

Revisiting the T-cell receptor alpha/delta locus and possible associations with multiple sclerosis.

Watson CT, Para AE, Lincoln MR, Ramagopalan SV, Orton SM, Morrison KM, Handunnetthi L, Handel AE, Chao MJ, Morahan J, Sadovnick AD, Breden F, Ebers GC.

Genes Immun. 2011 Mar;12(2):59-66. doi: 10.1038/gene.2010.65. Epub 2011 Jan 27. Review.

PMID:
21270827
42.

Gene duplication and divergence of long wavelength-sensitive opsin genes in the guppy, Poecilia reticulata.

Watson CT, Gray SM, Hoffmann M, Lubieniecki KP, Joy JB, Sandkam BA, Weigel D, Loew E, Dreyer C, Davidson WS, Breden F.

J Mol Evol. 2011 Feb;72(2):240-52. doi: 10.1007/s00239-010-9426-z. Epub 2010 Dec 18.

PMID:
21170644
43.

A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution.

Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, Handunnetthi L, Handel AE, Disanto G, Orton SM, Watson CT, Morahan JM, Giovannoni G, Ponting CP, Ebers GC, Knight JC.

Genome Res. 2010 Oct;20(10):1352-60. doi: 10.1101/gr.107920.110. Epub 2010 Aug 24.

44.

IGHV4-39 deletion polymorphism does not associate with risk or outcome of multiple sclerosis.

Watson CT, Ramagopalan SV, Morrison KM, Ebers GC, Breden F.

J Neuroimmunol. 2010 Aug 25;225(1-2):164-6. doi: 10.1016/j.jneuroim.2010.04.012. Epub 2010 May 15.

PMID:
20471699
45.

The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.

Handel AE, Handunnetthi L, Berlanga AJ, Watson CT, Morahan JM, Ramagopalan SV.

PLoS One. 2010 Apr 13;5(4):e10142. doi: 10.1371/journal.pone.0010142.

46.

Genomic organization of duplicated short wave-sensitive and long wave-sensitive opsin genes in the green swordtail, Xiphophorus helleri.

Watson CT, Lubieniecki KP, Loew E, Davidson WS, Breden F.

BMC Evol Biol. 2010 Mar 30;10:87. doi: 10.1186/1471-2148-10-87.

47.

Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD).

Song Y, Selak MA, Watson CT, Coutts C, Scherer PC, Panzer JA, Gibbs S, Scott MO, Willer G, Gregg RG, Ali DW, Bennett MJ, Balice-Gordon RJ.

PLoS One. 2009 Dec 17;4(12):e8329. doi: 10.1371/journal.pone.0008329.

48.

Elucidating the exact role of engineered CRABPII residues for the formation of a retinal protonated Schiff base.

Vasileiou C, Wang W, Jia X, Lee KS, Watson CT, Geiger JH, Borhan B.

Proteins. 2009 Dec;77(4):812-22. doi: 10.1002/prot.22495.

50.

Models of the bis-histidine-coordinated ferricytochromes: Mössbauer and EPR spectroscopic studies of low-spin iron(III) tetrapyrroles of various electronic ground states and axial ligand orientations.

Benda R, Schünemann V, Trautwein AX, Cai S, Reddy Polam J, Watson CT, Shokhireva TKh, Walker FA.

J Biol Inorg Chem. 2003 Sep;8(7):787-801. Epub 2003 Aug 1.

PMID:
12898323

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