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Items: 1 to 50 of 679

1.

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy.

Jones EJ, Matthews ZJ, Gul L, Sudhakar P, Treveil A, Divekar D, Buck J, Wrzesinski T, Jefferson M, Armstrong SD, Hall LJ, Watson AJM, Carding SR, Haerty W, Di Palma F, Mayer U, Powell PP, Hautefort I, Wileman T, Korcsmaros T.

Dis Model Mech. 2019 Mar 18;12(3). pii: dmm037069. doi: 10.1242/dmm.037069.

2.

Real-world effectiveness and safety of Vedolizumab for the treatment of Inflammatory Bowel Disease: The Scottish Vedolizumab Cohort.

Plevris N, Chuah CS, Allen RM, Arnott ID, Brennan PN, Chaudhary S, Churchhouse AMD, Din S, Donoghue E, Gaya DR, Groome M, Jafferbhoy HM, Jenkinson PW, Lam WL, Lyons M, Macdonald JC, MacMaster M, Mowat C, Naismith GD, Potts LF, Saffouri E, Seenan JP, Sengupta A, Shasi P, Sutherland DI, Todd JA, Veryan J, Watson AJM, Watts DA, Jones GR, Lees CW.

J Crohns Colitis. 2019 Feb 14. pii: jjz042. doi: 10.1093/ecco-jcc/jjz042. [Epub ahead of print]

PMID:
30768123
3.

Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation.

Parker A, Vaux L, Patterson AM, Modasia A, Muraro D, Fletcher AG, Byrne HM, Maini PK, Watson AJM, Pin C.

Cell Death Dis. 2019 Feb 6;10(2):108. doi: 10.1038/s41419-018-1275-5.

4.

A validated severity score for haemorrhoids as an essential prerequisite for future haemorrhoid trials.

Lee MJ, Morgan J, Watson AJM, Jones GL, Brown SR.

Tech Coloproctol. 2019 Jan;23(1):33-41. doi: 10.1007/s10151-019-01936-9. Epub 2019 Feb 6.

5.

N-Alkyl-α-amino acids in Nature and their biocatalytic preparation.

Hyslop JF, Lovelock SL, Watson AJB, Sutton PW, Roiban GD.

J Biotechnol. 2019 Mar 10;293:56-65. doi: 10.1016/j.jbiotec.2019.01.006. Epub 2019 Jan 26.

PMID:
30690098
6.

High Mucosal Plasma Cell Numbers and Low Serum TREM-1 Levels May Predict Nonresponsiveness to Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease.

Biancheri P, Watson AJM.

Gastroenterology. 2019 Jan;156(1):279-281. doi: 10.1053/j.gastro.2018.11.043. Epub 2018 Nov 22. No abstract available.

PMID:
30472227
7.

A pilot primary school active break program (ACTI-BREAK): Effects on academic and physical activity outcomes for students in Years 3 and 4.

Watson AJL, Timperio A, Brown H, Hesketh KD.

J Sci Med Sport. 2019 Apr;22(4):438-443. doi: 10.1016/j.jsams.2018.09.232. Epub 2018 Sep 28.

PMID:
30314856
8.

Intraepithelial Lymphocytes Are the First Line of Defense Against Enteric Infection.

Patterson AM, Watson AJM.

Gastroenterology. 2018 Nov;155(5):1640-1642. doi: 10.1053/j.gastro.2018.10.015. Epub 2018 Oct 8. No abstract available.

PMID:
30308193
9.

A flow platform for degradation-free CuAAC bioconjugation.

Hatit MZC, Reichenbach LF, Tobin JM, Vilela F, Burley GA, Watson AJB.

Nat Commun. 2018 Oct 1;9(1):4021. doi: 10.1038/s41467-018-06551-0.

10.

Biocatalytic Synthesis of Chiral N-Functionalized Amino Acids.

Hyslop JF, Lovelock SL, Sutton PW, Brown KK, Watson AJB, Roiban GD.

Angew Chem Int Ed Engl. 2018 Oct 15;57(42):13821-13824. doi: 10.1002/anie.201806893. Epub 2018 Sep 21.

PMID:
30138551
11.

Knockdown of p66Shc Alters Lineage-Associated Transcription Factor Expression in Mouse Blastocysts.

Edwards NA, Watson AJ, Betts DH.

Stem Cells Dev. 2018 Nov 1;27(21):1479-1493. doi: 10.1089/scd.2018.0131. Epub 2018 Sep 6.

12.

Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium.

Muraro D, Parker A, Vaux L, Filippi S, Almet AA, Fletcher AG, Watson AJM, Pin C, Maini PK, Byrne HM.

J R Soc Interface. 2018 Aug;15(145). pii: 20180037. doi: 10.1098/rsif.2018.0037.

13.

Catalytic Enantioselective Synthesis of α-Chiral Azaheteroaryl Ethylamines by Asymmetric Protonation.

Xu C, Muir CW, Leach AG, Kennedy AR, Watson AJB.

Angew Chem Int Ed Engl. 2018 Aug 27;57(35):11374-11377. doi: 10.1002/anie.201806956. Epub 2018 Aug 1.

PMID:
29956430
14.

Long-Term Planetary Habitability and the Carbonate-Silicate Cycle.

Rushby AJ, Johnson M, Mills BJW, Watson AJ, Claire MW.

Astrobiology. 2018 May;18(5):469-480. doi: 10.1089/ast.2017.1693.

PMID:
29791235
15.

Reoptimization of the Organocatalyzed Double Aldol Domino Process to a Key Enal Intermediate and Its Application to the Total Synthesis of Δ12 -Prostaglandin J3.

Pelšs A, Gandhamsetty N, Smith JR, Mailhol D, Silvi M, Watson AJA, Perez-Powell I, Prévost S, Schützenmeister N, Moore PR, Aggarwal VK.

Chemistry. 2018 Jul 5;24(38):9542-9545. doi: 10.1002/chem.201802498. Epub 2018 Jun 6.

16.

Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain.

Law RP, Atkinson SJ, Bamborough P, Chung CW, Demont EH, Gordon LJ, Lindon M, Prinjha RK, Watson AJB, Hirst DJ.

J Med Chem. 2018 May 24;61(10):4317-4334. doi: 10.1021/acs.jmedchem.7b01666. Epub 2018 May 3.

PMID:
29656650
17.

Cyrene as a bio-based solvent for HATU mediated amide coupling.

Wilson KL, Murray J, Jamieson C, Watson AJB.

Org Biomol Chem. 2018 Apr 25;16(16):2851-2854. doi: 10.1039/c8ob00653a.

PMID:
29630081
18.

Cost Effectiveness of Stapled Haemorrhoidopexy and Traditional Excisional Surgery for the Treatment of Haemorrhoidal Disease.

Kilonzo MM, Brown SR, Bruhn H, Cook JA, Hudson J, Norrie J, Watson AJM, Wood J.

Pharmacoecon Open. 2018 Sep;2(3):271-280. doi: 10.1007/s41669-017-0052-1.

19.

Could Fecal Transplantation Become Part of PD-1-Based Immunotherapy, Due to Effects of the Intestinal Microbiome?

Biancheri P, Divekar D, Watson AJM.

Gastroenterology. 2018 May;154(6):1845-1847. doi: 10.1053/j.gastro.2018.03.060. Epub 2018 Apr 1. No abstract available.

PMID:
29614305
20.

Scalable total synthesis and comprehensive structure-activity relationship studies of the phytotoxin coronatine.

Littleson MM, Baker CM, Dalençon AJ, Frye EC, Jamieson C, Kennedy AR, Ling KB, McLachlan MM, Montgomery MG, Russell CJ, Watson AJB.

Nat Commun. 2018 Mar 16;9(1):1105. doi: 10.1038/s41467-018-03443-1.

21.

Association of Patient Satisfaction With Medical Scribe Use in an Academic Dermatology Practice.

Nambudiri VE, Watson AJ, Rubenstein MH, Kupper TS, Yang FC.

JAMA Dermatol. 2018 Apr 1;154(4):480-482. doi: 10.1001/jamadermatol.2017.6139. No abstract available.

22.

Cost-Effectiveness of Haemorrhoidal Artery Ligation versus Rubber Band Ligation for the Treatment of Grade II-III Haemorrhoids: Analysis Using Evidence from the HubBLe Trial.

Alshreef A, Wailoo AJ, Brown SR, Tiernan JP, Watson AJM, Biggs K, Bradburn M, Hind D.

Pharmacoecon Open. 2017 Sep;1(3):175-184. doi: 10.1007/s41669-017-0023-6.

23.

Contra-Thermodynamic, Photocatalytic E→Z Isomerization of Styrenyl Boron Species: Vectors to Facilitate Exploration of Two-Dimensional Chemical Space.

Molloy JJ, Metternich JB, Daniliuc CG, Watson AJB, Gilmour R.

Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3168-3172. doi: 10.1002/anie.201800286. Epub 2018 Feb 21.

PMID:
29393569
24.

Calcium-Responsive Liposomes via a Synthetic Lipid Switch.

Lou J, Carr AJ, Watson AJ, Mattern-Schain SI, Best MD.

Chemistry. 2018 Mar 7;24(14):3599-3607. doi: 10.1002/chem.201705810. Epub 2018 Feb 8.

PMID:
29323763
25.

CD-1 mouse fertility rapidly declines and is accompanied with early pregnancy loss under conventional housing conditions.

Crocker K, Calder MD, Edwards NA, Betts DH, Watson AJ.

Theriogenology. 2018 Mar 1;108:245-254. doi: 10.1016/j.theriogenology.2017.12.018. Epub 2017 Dec 14.

PMID:
29258041
26.

Interrogating Pd(II) Anion Metathesis Using a Bifunctional Chemical Probe: A Transmetalation Switch.

Molloy JJ, Seath CP, West MJ, McLaughlin C, Fazakerley NJ, Kennedy AR, Nelson DJ, Watson AJB.

J Am Chem Soc. 2018 Jan 10;140(1):126-130. doi: 10.1021/jacs.7b11180. Epub 2017 Dec 22.

27.

Exploring Tandem Ruthenium-Catalyzed Hydrogen Transfer and SNAr Chemistry.

Polidano K, Reed-Berendt BG, Basset A, Watson AJA, Williams JMJ, Morrill LC.

Org Lett. 2017 Dec 15;19(24):6716-6719. doi: 10.1021/acs.orglett.7b03441. Epub 2017 Dec 6.

28.

A pragmatic multicentre randomised controlled trial comparing stapled haemorrhoidopexy with traditional excisional surgery for haemorrhoidal disease: the eTHoS study.

Watson AJ, Cook J, Hudson J, Kilonzo M, Wood J, Bruhn H, Brown S, Buckley B, Curran F, Jayne D, Loudon M, Rajagopal R, McDonald A, Norrie J.

Health Technol Assess. 2017 Nov;21(70):1-224. doi: 10.3310/hta21700.

29.

A Multicomponent Route to Functionalized Amides and Oxazolidinones.

McPherson CG, Cooper AK, Bubliauskas A, Mulrainey P, Jamieson C, Watson AJB.

Org Lett. 2017 Dec 15;19(24):6736-6739. doi: 10.1021/acs.orglett.7b03470. Epub 2017 Dec 1.

30.

Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character.

Campbell PS, Jamieson C, Simpson I, Watson AJB.

Chem Commun (Camb). 2017 Dec 19;54(1):46-49. doi: 10.1039/c7cc08670a.

31.

Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware.

Clohessy TA, Roberts A, Manas ES, Patel VK, Anderson NA, Watson AJB.

Org Lett. 2017 Dec 1;19(23):6368-6371. doi: 10.1021/acs.orglett.7b03214. Epub 2017 Nov 14.

PMID:
29135268
32.

Medical Scribes in an Academic Dermatology Practice.

Nambudiri VE, Watson AJ, Buzney EA, Kupper TS, Rubenstein MH, Yang FC.

JAMA Dermatol. 2018 Jan 1;154(1):101-103. doi: 10.1001/jamadermatol.2017.3658. No abstract available.

33.

Treatment with AICAR inhibits blastocyst development, trophectoderm differentiation and tight junction formation and function in mice.

Calder MD, Edwards NA, Betts DH, Watson AJ.

Mol Hum Reprod. 2017 Nov 1;23(11):771-785. doi: 10.1093/molehr/gax050.

34.

More haste less speed: A meta-analysis of thinking latencies during planning in people with psychosis.

Watson AJ, Joyce EM, Fugard AJB, Leeson VC, Barnes TRE, Huddy V.

Psychiatry Res. 2017 Dec;258:576-582. doi: 10.1016/j.psychres.2017.09.003. Epub 2017 Sep 5. Review.

PMID:
28918863
35.

Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity.

Lampert TJ, Kamprad N, Edwards M, Borleis J, Watson AJ, Tarantola M, Devreotes PN.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7727-E7736. doi: 10.1073/pnas.1616600114. Epub 2017 Aug 28. Erratum in: Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6670.

36.

Ocean deoxygenation, the global phosphorus cycle and the possibility of human-caused large-scale ocean anoxia.

Watson AJ, Lenton TM, Mills BJW.

Philos Trans A Math Phys Eng Sci. 2017 Sep 13;375(2102). pii: 20160318. doi: 10.1098/rsta.2016.0318.

37.

Ocean ventilation and deoxygenation in a warming world: posters.

Shepherd JG, Brewer PG, Oschlies A, Watson AJ.

Philos Trans A Math Phys Eng Sci. 2017 Sep 13;375(2102). pii: 20170241. doi: 10.1098/rsta.2017.0241. No abstract available.

PMID:
28784708
38.

Ocean ventilation and deoxygenation in a warming world: introduction and overview.

Shepherd JG, Brewer PG, Oschlies A, Watson AJ.

Philos Trans A Math Phys Eng Sci. 2017 Sep 13;375(2102). pii: 20170240. doi: 10.1098/rsta.2017.0240.

39.

Deciphering the Complex Signaling Systems That Regulate Intestinal Epithelial Cell Death Processes and Shedding.

Patterson AM, Watson AJM.

Front Immunol. 2017 Jul 18;8:841. doi: 10.3389/fimmu.2017.00841. eCollection 2017. Review.

40.

Correction to "Modular, Step-Efficient Palladium-Catalyzed Cross-Coupling Strategy To Access C6-Heteroaryl 2-Aminopurine Ribonucleosides".

Buchanan HS, Pauff SM, Kosmidis TD, Taladriz-Sender A, Rutherford OI, Hatit MZC, Fenner S, Watson AJB, Burley GA.

Org Lett. 2017 Aug 18;19(16):4411. doi: 10.1021/acs.orglett.7b02273. Epub 2017 Aug 2. No abstract available.

41.

A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system.

Xu C, Fyfe JWB, Seath CP, Bennett SH, Watson AJB.

Chem Commun (Camb). 2017 Aug 10;53(65):9139-9142. doi: 10.1039/c7cc05416e.

42.

A hierarchical Bayesian model for understanding the spatiotemporal dynamics of the intestinal epithelium.

Maclaren OJ, Parker A, Pin C, Carding SR, Watson AJM, Fletcher AG, Byrne HM, Maini PK.

PLoS Comput Biol. 2017 Jul 28;13(7):e1005688. doi: 10.1371/journal.pcbi.1005688. eCollection 2017 Jul.

43.

Modular, Step-Efficient Palladium-Catalyzed Cross-Coupling Strategy To Access C6-Heteroaryl 2-Aminopurine Ribonucleosides.

Buchanan HS, Pauff SM, Kosmidis TD, Taladriz-Sender A, Rutherford OI, Hatit MZC, Fenner S, Watson AJB, Burley GA.

Org Lett. 2017 Jul 21;19(14):3759-3762. doi: 10.1021/acs.orglett.7b01602. Epub 2017 Jul 6. Erratum in: Org Lett. 2017 Aug 18;19(16):4411.

44.

Chemoselective oxidation of aryl organoboron systems enabled by boronic acid-selective phase transfer.

Molloy JJ, Clohessy TA, Irving C, Anderson NA, Lloyd-Jones GC, Watson AJB.

Chem Sci. 2017 Feb 1;8(2):1551-1559. doi: 10.1039/c6sc04014d. Epub 2016 Oct 27.

45.

The Relative Contributions of the Gut Microbiome, Host Genetics, and Environment to Cytokine Responses to Microbial Stimulation.

Biancheri P, Watson AJM.

Gastroenterology. 2017 Jun;152(8):2068-2070. doi: 10.1053/j.gastro.2017.04.037. Epub 2017 Apr 29. No abstract available.

PMID:
28463688
46.

Strategy for Conditional Orthogonal Sequential CuAAC Reactions Using a Protected Aromatic Ynamine.

Hatit MZC, Seath CP, Watson AJB, Burley GA.

J Org Chem. 2017 May 19;82(10):5461-5468. doi: 10.1021/acs.joc.7b00545. Epub 2017 May 5.

47.

Amidation of unactivated ester derivatives mediated by trifluoroethanol.

McPherson CG, Caldwell N, Jamieson C, Simpson I, Watson AJB.

Org Biomol Chem. 2017 Apr 18;15(16):3507-3518. doi: 10.1039/c7ob00593h.

48.

Spectroscopic Studies of the Chan-Lam Amination: A Mechanism-Inspired Solution to Boronic Ester Reactivity.

Vantourout JC, Miras HN, Isidro-Llobet A, Sproules S, Watson AJ.

J Am Chem Soc. 2017 Apr 5;139(13):4769-4779. doi: 10.1021/jacs.6b12800. Epub 2017 Mar 24.

49.

Correction: The Feasibility and Impact of Delivering a Mind-Body Intervention in a Virtual World.

Hoch DB, Watson AJ, Linton DA, Bello HE, Senelly M, Milik MT, Baim MA, Jethwani K, Fricchione GL, Benson H, Kvedar JC.

PLoS One. 2017 Feb 21;12(2):e0172863. doi: 10.1371/journal.pone.0172863. eCollection 2017.

50.

Determining the Origin of Rate-Independent Chemoselectivity in CuAAC Reactions: An Alkyne-Specific Shift in Rate-Determining Step.

Seath CP, Burley GA, Watson AJ.

Angew Chem Int Ed Engl. 2017 Mar 13;56(12):3314-3318. doi: 10.1002/anie.201612288. Epub 2017 Feb 16.

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