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Items: 1 to 50 of 93

1.

Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization.

Li Y, Yang JY, Xie X, Jie Z, Zhang L, Shi J, Lin D, Gu M, Zhou X, Li HS, Watowich SS, Jain A, Yun Jung S, Qin J, Cheng X, Sun SC.

Cell Res. 2019 Jun;29(6):474-485. doi: 10.1038/s41422-019-0174-3. Epub 2019 May 13.

PMID:
31086255
2.

CXCR5+CD8+ T cells are a distinct functional subset with an antitumor activity.

Chu F, Li HS, Liu X, Cao J, Ma W, Ma Y, Weng J, Zhu Z, Cheng X, Wang Z, Liu J, Jiang ZY, Luong AU, Peng W, Wang J, Balakrishnan K, Yee C, Dong C, Davis RE, Watowich SS, Neelapu SS.

Leukemia. 2019 Apr 25. doi: 10.1038/s41375-019-0464-2. [Epub ahead of print]

PMID:
31028278
3.

PPARD and Interferon Gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice.

Zuo X, Deguchi Y, Xu W, Liu Y, Li HS, Wei D, Tian R, Chen W, Xu M, Yang Y, Gao S, Jaoude JC, Liu F, Chrieki SP, Moussalli MJ, Gagea M, Sebastian MM, Zheng X, Tan D, Broaddus R, Wang J, Ajami NJ, Swennes AG, Watowich SS, Shureiqi I.

Gastroenterology. 2019 Jul;157(1):163-178. doi: 10.1053/j.gastro.2019.03.018. Epub 2019 Mar 15.

PMID:
30885780
4.

Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer.

Kettner NM, Vijayaraghavan S, Durak MG, Bui T, Kohansal M, Ha MJ, Liu B, Rao X, Wang J, Yi M, Carey JPW, Chen X, Eckols TK, Raghavendra AS, Ibrahim NK, Karuturi MS, Watowich SS, Sahin A, Tweardy DJ, Hunt KK, Tripathy D, Keyomarsi K.

Clin Cancer Res. 2019 Jul 1;25(13):3996-4013. doi: 10.1158/1078-0432.CCR-18-3274. Epub 2019 Mar 13.

PMID:
30867218
5.

Author Correction: FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation.

Yan J, Zhao Q, Gabrusiewicz K, Kong LY, Xia X, Wang J, Ott M, Xu J, Davis RE, Huo L, Rao G, Sun SC, Watowich SS, Heimberger AB, Li S.

Nat Commun. 2019 Feb 15;10(1):862. doi: 10.1038/s41467-019-08770-5.

6.

FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation.

Yan J, Zhao Q, Gabrusiewicz K, Kong LY, Xia X, Wang J, Ott M, Xu J, Davis RE, Huo L, Rao G, Sun SC, Watowich SS, Heimberger AB, Li S.

Nat Commun. 2019 Jan 25;10(1):448. doi: 10.1038/s41467-018-08271-x. Erratum in: Nat Commun. 2019 Feb 15;10(1):862.

7.

Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer.

Caetano MS, Hassane M, Van HT, Bugarin E, Cumpian AM, McDowell CL, Cavazos CG, Zhang H, Deng S, Diao L, Wang J, Evans SE, Behrens C, Wistuba II, Fuqua SAW, Lin H, Stabile LP, Watowich SS, Kadara H, Moghaddam SJ.

Nat Commun. 2018 Nov 2;9(1):4589. doi: 10.1038/s41467-018-07042-y.

8.

Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant.

Cardona SM, Kim SV, Church KA, Torres VO, Cleary IA, Mendiola AS, Saville SP, Watowich SS, Parker-Thornburg J, Soto-Ospina A, Araque P, Ransohoff RM, Cardona AE.

Front Cell Neurosci. 2018 Oct 17;12:365. doi: 10.3389/fncel.2018.00365. eCollection 2018.

9.

Introduction to the Special Issue: The tumor microenvironment and molecular regulation of innate immune cells.

Nicholson SE, Watowich SS.

Mol Immunol. 2019 Jun;110:1-2. doi: 10.1016/j.molimm.2018.10.009. Epub 2018 Oct 11. No abstract available.

PMID:
30318379
10.

Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer.

Chrisikos TT, Zhou Y, Slone N, Babcock R, Watowich SS, Li HS.

Mol Immunol. 2019 Jun;110:24-39. doi: 10.1016/j.molimm.2018.01.014. Epub 2018 Mar 15.

PMID:
29549977
11.

Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis.

Zhang H, Li HS, Hillmer EJ, Zhao Y, Chrisikos TT, Hu H, Wu X, Thompson EJ, Clise-Dwyer K, Millerchip KA, Wei Y, Puebla-Osorio N, Kaushik S, Santos MA, Wang B, Garcia-Manero G, Wang J, Sun SC, Watowich SS.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2311-E2319. doi: 10.1073/pnas.1713889115. Epub 2018 Feb 20.

12.

Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway.

Fan F, Wang R, Boulbes DR, Zhang H, Watowich SS, Xia L, Ye X, Bhattacharya R, Ellis LM.

PLoS One. 2018 Jan 2;13(1):e0190070. doi: 10.1371/journal.pone.0190070. eCollection 2018.

13.

MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice.

Kadmon CS, Landers CT, Li HS, Watowich SS, Rodriguez A, King KY.

Exp Hematol. 2017 Dec;56:7-15. doi: 10.1016/j.exphem.2017.09.001. Epub 2017 Sep 11.

14.

The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity.

Xiao Y, Zou Q, Xie X, Liu T, Li HS, Jie Z, Jin J, Hu H, Manyam G, Zhang L, Cheng X, Wang H, Marie I, Levy DE, Watowich SS, Sun SC.

J Exp Med. 2017 May 1;214(5):1493-1507. doi: 10.1084/jem.20161524. Epub 2017 Mar 29.

15.

The histone deacetylase inhibitor valproic acid inhibits NKG2D expression in natural killer cells through suppression of STAT3 and HDAC3.

Ni L, Wang L, Yao C, Ni Z, Liu F, Gong C, Zhu X, Yan X, Watowich SS, Lee DA, Zhu S.

Sci Rep. 2017 Mar 24;7:45266. doi: 10.1038/srep45266.

16.

Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells.

Li HS, Liu C, Xiao Y, Chu F, Liang X, Peng W, Hu J, Neelapu SS, Sun SC, Hwu P, Watowich SS.

Sci Signal. 2016 Sep 27;9(447):ra94. doi: 10.1126/scisignal.aaf3957.

17.

IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer.

Caetano MS, Zhang H, Cumpian AM, Gong L, Unver N, Ostrin EJ, Daliri S, Chang SH, Ochoa CE, Hanash S, Behrens C, Wistuba II, Sternberg C, Kadara H, Ferreira CG, Watowich SS, Moghaddam SJ.

Cancer Res. 2016 Jun 1;76(11):3189-99. doi: 10.1158/0008-5472.CAN-15-2840. Epub 2016 Apr 1.

18.

STAT3 signaling in immunity.

Hillmer EJ, Zhang H, Li HS, Watowich SS.

Cytokine Growth Factor Rev. 2016 Oct;31:1-15. doi: 10.1016/j.cytogfr.2016.05.001. Epub 2016 May 9. Review.

19.

Loss of c-Kit and bone marrow failure upon conditional removal of the GATA-2 C-terminal zinc finger domain in adult mice.

Li HS, Jin J, Liang X, Matatall KA, Ma Y, Zhang H, Ullrich SE, King KY, Sun SC, Watowich SS.

Eur J Haematol. 2016 Sep;97(3):261-70. doi: 10.1111/ejh.12719. Epub 2016 Jan 14.

20.

Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species.

Huang X, Li J, Dorta-Estremera S, Di Domizio J, Anthony SM, Watowich SS, Popkin D, Liu Z, Brohawn P, Yao Y, Schluns KS, Lanier LL, Cao W.

Cell Rep. 2015 Aug 18;12(7):1120-32. doi: 10.1016/j.celrep.2015.07.021. Epub 2015 Aug 6.

21.

15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway.

Mao F, Xu M, Zuo X, Yu J, Xu W, Moussalli MJ, Elias E, Li HS, Watowich SS, Shureiqi I.

FASEB J. 2015 Jun;29(6):2359-70. doi: 10.1096/fj.14-264515. Epub 2015 Feb 24.

22.

STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13.

Zhang H, Hu H, Greeley N, Jin J, Matthews AJ, Ohashi E, Caetano MS, Li HS, Wu X, Mandal PK, McMurray JS, Moghaddam SJ, Sun SC, Watowich SS.

Nat Commun. 2014 Dec 15;5:5798. doi: 10.1038/ncomms6798.

23.

Microbial messaging to the marrow.

Watowich SS.

Blood. 2014 Aug 28;124(9):1379-80. doi: 10.1182/blood-2014-07-587345. No abstract available.

24.

Innate immune regulation by STAT-mediated transcriptional mechanisms.

Li HS, Watowich SS.

Immunol Rev. 2014 Sep;261(1):84-101. doi: 10.1111/imr.12198. Review.

25.

Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation.

Zhu S, Phatarpekar PV, Denman CJ, Senyukov VV, Somanchi SS, Nguyen-Jackson HT, Mace EM, Freeman AF, Watowich SS, Orange JS, Holland SM, Lee DA.

Blood. 2014 Jul 17;124(3):403-11. doi: 10.1182/blood-2013-05-499707. Epub 2014 Jun 2.

26.

USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses.

Zou Q, Jin J, Hu H, Li HS, Romano S, Xiao Y, Nakaya M, Zhou X, Cheng X, Yang P, Lozano G, Zhu C, Watowich SS, Ullrich SE, Sun SC.

Nat Immunol. 2014 Jun;15(6):562-70. doi: 10.1038/ni.2885. Epub 2014 Apr 28.

27.

STAT3 inhibitors: finding a home in lymphoma and leukemia.

Munoz J, Dhillon N, Janku F, Watowich SS, Hong DS.

Oncologist. 2014 May;19(5):536-44. doi: 10.1634/theoncologist.2013-0407. Epub 2014 Apr 4. Review.

29.

Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity.

Jin J, Hu H, Li HS, Yu J, Xiao Y, Brittain GC, Zou Q, Cheng X, Mallette FA, Watowich SS, Sun SC.

Immunity. 2014 Mar 20;40(3):342-54. doi: 10.1016/j.immuni.2014.02.006.

30.

Diversification of dendritic cell subsets: Emerging roles for STAT proteins.

Li HS, Watowich SS.

JAKSTAT. 2013 Oct 1;2(4):e25112. doi: 10.4161/jkst.25112. Epub 2013 May 21. Review.

31.

The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation.

Yang XO, Zhang H, Kim BS, Niu X, Peng J, Chen Y, Kerketta R, Lee YH, Chang SH, Corry DB, Wang D, Watowich SS, Dong C.

Nat Immunol. 2013 Jul;14(7):732-40. doi: 10.1038/ni.2633. Epub 2013 Jun 2.

32.

miR-22 controls Irf8 mRNA abundance and murine dendritic cell development.

Li HS, Greeley N, Sugimoto N, Liu YJ, Watowich SS.

PLoS One. 2012;7(12):e52341. doi: 10.1371/journal.pone.0052341. Epub 2012 Dec 14.

33.

BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice.

Liu C, Peng W, Xu C, Lou Y, Zhang M, Wargo JA, Chen JQ, Li HS, Watowich SS, Yang Y, Tompers Frederick D, Cooper ZA, Mbofung RM, Whittington M, Flaherty KT, Woodman SE, Davies MA, Radvanyi LG, Overwijk WW, Lizée G, Hwu P.

Clin Cancer Res. 2013 Jan 15;19(2):393-403. doi: 10.1158/1078-0432.CCR-12-1626. Epub 2012 Nov 30.

34.

The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development.

Li HS, Yang CY, Nallaparaju KC, Zhang H, Liu YJ, Goldrath AW, Watowich SS.

Blood. 2012 Nov 22;120(22):4363-73. doi: 10.1182/blood-2012-07-441311. Epub 2012 Oct 1.

35.

G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils.

Nguyen-Jackson HT, Li HS, Zhang H, Ohashi E, Watowich SS.

J Leukoc Biol. 2012 Dec;92(6):1215-25. doi: 10.1189/jlb.0312126. Epub 2012 Sep 27.

36.

A STATus report on DC development.

Li HS, Watowich SS.

J Leukoc Biol. 2012 Sep;92(3):445-59. doi: 10.1189/jlb.0212052. Epub 2012 May 1. Review.

37.

STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function.

Nurieva RI, Podd A, Chen Y, Alekseev AM, Yu M, Qi X, Huang H, Wen R, Wang J, Li HS, Watowich SS, Qi H, Dong C, Wang D.

J Biol Chem. 2012 Mar 30;287(14):11234-9. doi: 10.1074/jbc.M111.324046. Epub 2012 Feb 8.

38.

The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.

Yang CY, Best JA, Knell J, Yang E, Sheridan AD, Jesionek AK, Li HS, Rivera RR, Lind KC, D'Cruz LM, Watowich SS, Murre C, Goldrath AW.

Nat Immunol. 2011 Nov 6;12(12):1221-9. doi: 10.1038/ni.2158.

39.

Cell-intrinsic role for IFN-α-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response.

Li HS, Gelbard A, Martinez GJ, Esashi E, Zhang H, Nguyen-Jackson H, Liu YJ, Overwijk WW, Watowich SS.

Blood. 2011 Oct 6;118(14):3879-89. doi: 10.1182/blood-2011-04-349761. Epub 2011 Aug 9.

40.

The erythropoietin receptor: molecular structure and hematopoietic signaling pathways.

Watowich SS.

J Investig Med. 2011 Oct;59(7):1067-72. doi: 10.2310/JIM.0b013e31820fb28c. Review.

41.

Mechanisms regulating dendritic cell specification and development.

Watowich SS, Liu YJ.

Immunol Rev. 2010 Nov;238(1):76-92. doi: 10.1111/j.1600-065X.2010.00949.x. Review.

42.

Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling.

Qualls JE, Neale G, Smith AM, Koo MS, DeFreitas AA, Zhang H, Kaplan G, Watowich SS, Murray PJ.

Sci Signal. 2010 Aug 17;3(135):ra62. doi: 10.1126/scisignal.2000955.

43.

STAT3 controls myeloid progenitor growth during emergency granulopoiesis.

Zhang H, Nguyen-Jackson H, Panopoulos AD, Li HS, Murray PJ, Watowich SS.

Blood. 2010 Oct 7;116(14):2462-71. doi: 10.1182/blood-2009-12-259630. Epub 2010 Jun 25.

44.

STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction.

Nguyen-Jackson H, Panopoulos AD, Zhang H, Li HS, Watowich SS.

Blood. 2010 Apr 22;115(16):3354-63. doi: 10.1182/blood-2009-08-240317. Epub 2010 Feb 25.

45.

Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation.

Hegde S, Ni S, He S, Yoon D, Feng GS, Watowich SS, Paulson RF, Hankey PA.

Oncogene. 2009 Sep 24;28(38):3349-59. doi: 10.1038/onc.2009.202. Epub 2009 Jul 6.

46.

Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.

Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS, Ma L, Watowich SS, Jetten AM, Tian Q, Dong C.

Immunity. 2009 Apr 17;30(4):576-87. doi: 10.1016/j.immuni.2009.02.007. Epub 2009 Apr 9.

47.

Endogenous suppression of mast cell development and survival by IL-4 and IL-10.

Speiran K, Bailey DP, Fernando J, Macey M, Barnstein B, Kolawole M, Curley D, Watowich SS, Murray PJ, Oskeritzian C, Ryan JJ.

J Leukoc Biol. 2009 May;85(5):826-36. doi: 10.1189/jlb.0708448. Epub 2009 Feb 19.

48.

CCR6 regulates the migration of inflammatory and regulatory T cells.

Yamazaki T, Yang XO, Chung Y, Fukunaga A, Nurieva R, Pappu B, Martin-Orozco N, Kang HS, Ma L, Panopoulos AD, Craig S, Watowich SS, Jetten AM, Tian Q, Dong C.

J Immunol. 2008 Dec 15;181(12):8391-401.

49.

Dendritic cells: transcriptional control of plasmacytoid dendritic cell development by E2-2.

Esashi E, Watowich SS.

Immunol Cell Biol. 2009 Jan;87(1):1-2. doi: 10.1038/icb.2008.93. Epub 2008 Dec 2. No abstract available.

PMID:
19048021
50.

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.

Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C.

Immunity. 2008 Jul 18;29(1):138-49. doi: 10.1016/j.immuni.2008.05.009. Epub 2008 Jul 3.

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