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Items: 50

1.

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle.

Neelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HL, McHardy SF, Papaconstantinou J, Fry CS, Watowich SJ.

Biochem Pharmacol. 2019 May;163:481-492. doi: 10.1016/j.bcp.2019.02.008. Epub 2019 Feb 10.

PMID:
30753815
2.

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.

Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ.

Biochem Pharmacol. 2018 Jan;147:141-152. doi: 10.1016/j.bcp.2017.11.007. Epub 2017 Nov 15.

3.

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase.

Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ.

J Med Chem. 2017 Jun 22;60(12):5015-5028. doi: 10.1021/acs.jmedchem.7b00389. Epub 2017 Jun 12.

PMID:
28548833
4.

Host oxidative folding pathways offer novel anti-chikungunya virus drug targets with broad spectrum potential.

Langsjoen RM, Auguste AJ, Rossi SL, Roundy CM, Penate HN, Kastis M, Schnizlein MK, Le KC, Haller SL, Chen R, Watowich SJ, Weaver SC.

Antiviral Res. 2017 Jul;143:246-251. doi: 10.1016/j.antiviral.2017.04.014. Epub 2017 Apr 28.

PMID:
28461071
5.

Noncoupled Fluorescent Assay for Direct Real-Time Monitoring of Nicotinamide N-Methyltransferase Activity.

Neelakantan H, Vance V, Wang HL, McHardy SF, Watowich SJ.

Biochemistry. 2017 Feb 14;56(6):824-832. doi: 10.1021/acs.biochem.6b01215. Epub 2017 Jan 30.

PMID:
28121423
6.

Drug search for leishmaniasis: a virtual screening approach by grid computing.

Ochoa R, Watowich SJ, Flórez A, Mesa CV, Robledo SM, Muskus C.

J Comput Aided Mol Des. 2016 Jul;30(7):541-52. doi: 10.1007/s10822-016-9921-4. Epub 2016 Jul 20.

PMID:
27438595
7.

Identification of a novel inhibitor of dengue virus protease through use of a virtual screening drug discovery Web portal.

Viswanathan U, Tomlinson SM, Fonner JM, Mock SA, Watowich SJ.

J Chem Inf Model. 2014 Oct 27;54(10):2816-25. doi: 10.1021/ci500531r. Epub 2014 Oct 10.

PMID:
25263519
8.

Intrinsic flexibility of West Nile virus protease in solution characterized using small-angle X-ray scattering.

Garces AP, Watowich SJ.

Biochemistry. 2013 Oct 1;52(39):6856-65. doi: 10.1021/bi400782w. Epub 2013 Sep 20.

PMID:
24015950
9.

An assembly model of rift valley Fever virus.

Rusu M, Bonneau R, Holbrook MR, Watowich SJ, Birmanns S, Wriggers W, Freiberg AN.

Front Microbiol. 2012 Jul 19;3:254. doi: 10.3389/fmicb.2012.00254. eCollection 2012.

10.

Use of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors.

Tomlinson SM, Watowich SJ.

Antiviral Res. 2012 Feb;93(2):245-252. doi: 10.1016/j.antiviral.2011.12.003. Epub 2011 Dec 13.

11.

Using free energy of binding calculations to improve the accuracy of virtual screening predictions.

Malmstrom RD, Watowich SJ.

J Chem Inf Model. 2011 Jul 25;51(7):1648-55. doi: 10.1021/ci200126v. Epub 2011 Jul 11.

12.

Anthracene-based inhibitors of dengue virus NS2B-NS3 protease.

Tomlinson SM, Watowich SJ.

Antiviral Res. 2011 Feb;89(2):127-35. doi: 10.1016/j.antiviral.2010.12.006. Epub 2010 Dec 23.

13.

Structural basis for substrate specificity of alphavirus nsP2 proteases.

Russo AT, Malmstrom RD, White MA, Watowich SJ.

J Mol Graph Model. 2010 Aug 24;29(1):46-53. doi: 10.1016/j.jmgm.2010.04.005. Epub 2010 Apr 24.

14.

Hark back: passive immunotherapy for influenza and other serious infections.

Luke TC, Casadevall A, Watowich SJ, Hoffman SL, Beigel JH, Burgess TH.

Crit Care Med. 2010 Apr;38(4 Suppl):e66-73. doi: 10.1097/CCM.0b013e3181d44c1e. Review.

PMID:
20154602
15.

A Unique BSL-3 Cryo-Electron Microscopy Laboratory at UTMB.

Sherman MB, Freiberg AN, Razmus D, Yazuka S, Koht C, Hilser VJ, Lemon SM, Brocard AS, Zimmerman D, Chiu W, Watowich SJ, Weaver SC.

Appl Biosaf. 2010;15(3):130-136.

16.

New approaches to structure-based discovery of dengue protease inhibitors.

Tomlinson SM, Malmstrom RD, Watowich SJ.

Infect Disord Drug Targets. 2009 Jun;9(3):327-43. Review.

PMID:
19519486
17.

Structure-based discovery of dengue virus protease inhibitors.

Tomlinson SM, Malmstrom RD, Russo A, Mueller N, Pang YP, Watowich SJ.

Antiviral Res. 2009 Jun;82(3):110-4. doi: 10.1016/j.antiviral.2009.02.190. Epub 2009 Feb 21. Review.

18.

Chapter 20 Effects of hepatitis C core protein on mitochondrial electron transport and production of reactive oxygen species.

Campbell RV, Yang Y, Wang T, Rachamallu A, Li Y, Watowich SJ, Weinman SA.

Methods Enzymol. 2009;456:363-80. doi: 10.1016/S0076-6879(08)04420-0.

19.

Single-particle cryo-electron microscopy of Rift Valley fever virus.

Sherman MB, Freiberg AN, Holbrook MR, Watowich SJ.

Virology. 2009 Apr 25;387(1):11-5. doi: 10.1016/j.virol.2009.02.038. Epub 2009 Mar 21.

20.

Substrate inhibition kinetic model for West Nile virus NS2B-NS3 protease.

Tomlinson SM, Watowich SJ.

Biochemistry. 2008 Nov 11;47(45):11763-70. doi: 10.1021/bi801034f. Epub 2008 Oct 15.

21.

Three-dimensional organization of Rift Valley fever virus revealed by cryoelectron tomography.

Freiberg AN, Sherman MB, Morais MC, Holbrook MR, Watowich SJ.

J Virol. 2008 Nov;82(21):10341-8. doi: 10.1128/JVI.01191-08. Epub 2008 Aug 20.

22.

Alphavirus production is inhibited in neurofibromin 1-deficient cells through activated RAS signalling.

Kolokoltsova OA, Domina AM, Kolokoltsov AA, Davey RA, Weaver SC, Watowich SJ.

Virology. 2008 Jul 20;377(1):133-42. doi: 10.1016/j.virol.2008.03.025. Epub 2008 May 15.

23.

Biochemical basis for the functional switch that regulates hepatocyte growth factor receptor tyrosine kinase activation.

Sheth PR, Hays JL, Elferink LA, Watowich SJ.

Biochemistry. 2008 Apr 1;47(13):4028-38. doi: 10.1021/bi701892f. Epub 2008 Mar 7.

24.

Combinatorial selection of a RNA thioaptamer that binds to Venezuelan equine encephalitis virus capsid protein.

Kang J, Lee MS, Watowich SJ, Gorenstein DG.

FEBS Lett. 2007 May 29;581(13):2497-502. Epub 2007 May 4.

25.

The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease.

Russo AT, White MA, Watowich SJ.

Structure. 2006 Sep;14(9):1449-58.

26.

Purification, crystallization and X-ray diffraction analysis of the C-terminal protease domain of Venezuelan equine encephalitis virus nsP2.

Russo AT, Watowich SJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jun 1;62(Pt 6):514-7. Epub 2006 May 5.

27.

Structure of a glutathione conjugate bound to the active site of aldose reductase.

Singh R, White MA, Ramana KV, Petrash JM, Watowich SJ, Bhatnagar A, Srivastava SK.

Proteins. 2006 Jul 1;64(1):101-10.

PMID:
16639747
28.

Chemiluminescence-based electrophoretic mobility shift assay of RNA-protein interactions: application to binding of viral capsid proteins to RNA.

Kang J, Lee MS, Watowich SJ, Gorenstein DG.

J Virol Methods. 2006 Feb;131(2):155-9. Epub 2005 Sep 22.

PMID:
16182384
29.

Oligomerization-induced differential dephosphorylation of c-Met receptor tyrosine kinase.

Sheth PR, Watowich SJ.

Biochemistry. 2005 Aug 23;44(33):10984-93.

PMID:
16101282
30.
31.
32.

Oligomerization-induced modulation of TPR-MET tyrosine kinase activity.

Hays JL, Watowich SJ.

J Biol Chem. 2003 Jul 25;278(30):27456-63. Epub 2003 Apr 23.

33.
34.
35.

Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase.

Wooll JO, Friesen RH, White MA, Watowich SJ, Fox RO, Lee JC, Czerwinski EW.

J Mol Biol. 2001 Sep 21;312(3):525-40.

PMID:
11563914
36.

Venezuelan equine encephalomyelitis virus structure and its divergence from old world alphaviruses.

Paredes A, Alwell-Warda K, Weaver SC, Chiu W, Watowich SJ.

J Virol. 2001 Oct;75(19):9532-7.

37.

Characterization of the glutathione binding site of aldose reductase.

Ramana KV, Dixit BL, Srivastava S, Bhatnagar A, Balendiran GK, Watowich SJ, Petrash JM, Srivastava SK.

Chem Biol Interact. 2001 Jan 30;130-132(1-3):537-48.

PMID:
11306073
38.
39.

Self-assembly of nucleocapsid-like particles from recombinant hepatitis C virus core protein.

Kunkel M, Lorinczi M, Rijnbrand R, Lemon SM, Watowich SJ.

J Virol. 2001 Mar;75(5):2119-29.

40.

Kinetic and structural characterization of the glutathione-binding site of aldose reductase.

Dixit BL, Balendiran GK, Watowich SJ, Srivastava S, Ramana KV, Petrash JM, Bhatnagar A, Srivastava SK.

J Biol Chem. 2000 Jul 14;275(28):21587-95.

41.

Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses.

Wang E, Ni H, Xu R, Barrett AD, Watowich SJ, Gubler DJ, Weaver SC.

J Virol. 2000 Apr;74(7):3227-34.

42.

Interaction of yellow fever virus French neurotropic vaccine strain with monkey brain: characterization of monkey brain membrane receptor escape variants.

Ni H, Ryman KD, Wang H, Saeed MF, Hull R, Wood D, Minor PD, Watowich SJ, Barrett AD.

J Virol. 2000 Mar;74(6):2903-6.

43.

Molecular and biological changes associated with HeLa cell attenuation of wild-type yellow fever virus.

Dunster LM, Wang H, Ryman KD, Miller BR, Watowich SJ, Minor PD, Barrett AD.

Virology. 1999 Sep 1;261(2):309-18.

44.

Structural and kinetic determinants of aldehyde reduction by aldose reductase.

Srivastava S, Watowich SJ, Petrash JM, Srivastava SK, Bhatnagar A.

Biochemistry. 1999 Jan 5;38(1):42-54.

PMID:
9890881
45.

Mutation in a 17D-204 vaccine substrain-specific envelope protein epitope alters the pathogenesis of yellow fever virus in mice.

Ryman KD, Ledger TN, Campbell GA, Watowich SJ, Barrett AD.

Virology. 1998 Apr 25;244(1):59-65.

46.
47.

Cryocrystallography of influenza virus hemagglutinin crystals.

Watowich SJ, Skehel JJ, Wiley DC.

Acta Crystallogr D Biol Crystallogr. 1995 Jan 1;51(Pt 1):7-12.

PMID:
15299330
48.

Crystal structures of influenza virus hemagglutinin in complex with high-affinity receptor analogs.

Watowich SJ, Skehel JJ, Wiley DC.

Structure. 1994 Aug 15;2(8):719-31.

PMID:
7994572
49.
50.

Intermolecular contacts within sickle hemoglobin fibers.

Watowich SJ, Gross LJ, Josephs R.

J Mol Biol. 1989 Oct 20;209(4):821-8.

PMID:
2585512

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