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Items: 1 to 50 of 562

1.

Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor.

Krainz T, Lamade AM, Du L, Maskrey TS, Calderon MJ, Watkins SC, Epperly MW, Greenberger JS, Bayır H, Wipf P, Clark RSB.

ACS Chem Biol. 2018 Sep 14. doi: 10.1021/acschembio.8b00423. [Epub ahead of print]

PMID:
30184433
2.

Vertebrate myosin 1d regulates left-right organizer morphogenesis and laterality.

Saydmohammed M, Yagi H, Calderon M, Clark MJ, Feinstein T, Sun M, Stolz DB, Watkins SC, Amack JD, Lo CW, Tsang M.

Nat Commun. 2018 Aug 23;9(1):3381. doi: 10.1038/s41467-018-05866-2.

3.

Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells.

Sannino S, Guerriero CJ, Sabnis AJ, Stolz DB, Wallace CT, Wipf P, Watkins SC, Bivona TG, Brodsky JL.

J Cell Sci. 2018 Sep 5;131(17). pii: jcs217760. doi: 10.1242/jcs.217760.

PMID:
30131440
4.

A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development.

Saydmohammed M, Vollmer LL, Onuoha EO, Maskrey TS, Gibson G, Watkins SC, Wipf P, Vogt A, Tsang M.

Molecules. 2018 Jul 11;23(7). pii: E1691. doi: 10.3390/molecules23071691.

5.

Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice.

Pradhan-Sundd T, Vats R, Russell JM, Singh S, Michael AA, Molina L, Kakar S, Cornuet P, Poddar M, Watkins SC, Nejak-Bowen KN, Monga SP, Sundd P.

Gastroenterology. 2018 Jun 30. pii: S0016-5085(18)34690-0. doi: 10.1053/j.gastro.2018.06.048. [Epub ahead of print]

PMID:
29964040
6.

Pseudomonas PB1-Like Phages: Whole Genomes from Metagenomes Offer Insight into an Abundant Group of Bacteriophages.

Watkins SC, Sible E, Putonti C.

Viruses. 2018 Jun 16;10(6). pii: E331. doi: 10.3390/v10060331.

7.

Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.

Zhao J, Zhang L, Mu X, Doebelin C, Nguyen W, Wallace C, Reay DP, McGowan SJ, Corbo L, Clemens PR, Wilson GM, Watkins SC, Solt LA, Cameron MD, Huard J, Niedernhofer LJ, Kamenecka TM, Robbins PD.

PLoS Biol. 2018 Jun 11;16(6):e2004663. doi: 10.1371/journal.pbio.2004663. eCollection 2018 Jun.

8.

High-Resolution, Three-Dimensional Reconstruction of the Outflow Tract Demonstrates Segmental Differences in Cleared Eyes.

Waxman S, Loewen RT, Dang Y, Watkins SC, Watson AM, Loewen NA.

Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2371-2380. doi: 10.1167/iovs.17-23075.

9.

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.

Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ.

Redox Biol. 2018 Jul;17:259-273. doi: 10.1016/j.redox.2018.04.007. Epub 2018 Apr 13.

10.

Creating a Quality Improvement Course for Undergraduate Medical Education: Practice What You Teach.

Bradham TS, Sponsler KC, Watkins SC, Ehrenfeld JM.

Acad Med. 2018 May 2. doi: 10.1097/ACM.0000000000002253. [Epub ahead of print]

PMID:
29727320
11.

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence.

Choy CH, Saffi G, Gray MA, Wallace C, Dayam RM, Ou ZA, Lenk G, Puertollano R, Watkins SC, Botelho RJ.

J Cell Sci. 2018 May 21;131(10). pii: jcs213587. doi: 10.1242/jcs.213587.

PMID:
29661845
12.

Light sheet imaging comes of age.

Watkins SC, St Croix CM.

J Cell Biol. 2018 May 7;217(5):1567-1569. doi: 10.1083/jcb.201804016. Epub 2018 Apr 13.

PMID:
29653995
13.

Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid.

Ning J, Zhong Z, Fischer DK, Harris G, Watkins SC, Ambrose Z, Zhang P.

J Virol. 2018 Jun 13;92(13). pii: e00368-18. doi: 10.1128/JVI.00368-18. Print 2018 Jul 1.

PMID:
29643241
14.

Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter.

Sorkina T, Ma S, Larsen MB, Watkins SC, Sorkin A.

Elife. 2018 Apr 9;7. pii: e32293. doi: 10.7554/eLife.32293.

15.

4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses.

Menk AV, Scharping NE, Rivadeneira DB, Calderon MJ, Watson MJ, Dunstane D, Watkins SC, Delgoffe GM.

J Exp Med. 2018 Apr 2;215(4):1091-1100. doi: 10.1084/jem.20171068. Epub 2018 Mar 6.

PMID:
29511066
16.

Genetically Targeted Ratiometric and Activated pH Indicator Complexes (TRApHIC) for Receptor Trafficking.

Perkins LA, Yan Q, Schmidt BF, Kolodieznyi D, Saurabh S, Larsen MB, Watkins SC, Kremer L, Bruchez MP.

Biochemistry. 2018 Feb 6;57(5):861-871. doi: 10.1021/acs.biochem.7b01135. Epub 2018 Jan 16.

PMID:
29283245
17.

EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo.

Pinilla-Macua I, Grassart A, Duvvuri U, Watkins SC, Sorkin A.

Elife. 2017 Dec 21;6. pii: e31993. doi: 10.7554/eLife.31993.

18.

Cerebral microcirculatory alterations and the no-reflow phenomenon in vivo after experimental pediatric cardiac arrest.

Li L, Poloyac SM, Watkins SC, St Croix CM, Alexander H, Gibson GA, Loughran PA, Kirisci L, Clark RS, Kochanek PM, Vazquez AL, Manole MD.

J Cereb Blood Flow Metab. 2017 Dec 1:271678X17744717. doi: 10.1177/0271678X17744717. [Epub ahead of print]

PMID:
29192562
19.

14-3-3z sequesters cytosolic T-bet, upregulating IL-13 levels in TC2 and CD8+ lymphocytes from patients with scleroderma.

Cascio S, Medsger TA Jr, Hawse WF, Watkins SC, Milcarek C, Moreland LW, Lafyatis RA, Fuschiotti P.

J Allergy Clin Immunol. 2018 Jul;142(1):109-119.e6. doi: 10.1016/j.jaci.2017.10.029. Epub 2017 Nov 15.

PMID:
29155097
20.

PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1.

Liu L, Kong M, Gassman NR, Freudenthal BD, Prasad R, Zhen S, Watkins SC, Wilson SH, Van Houten B.

Nucleic Acids Res. 2017 Dec 15;45(22):12834-12847. doi: 10.1093/nar/gkx1047.

21.

Interplay between Keratinocytes and Myeloid Cells Drives Dengue Virus Spread in Human Skin.

Duangkhae P, Erdos G, Ryman KD, Watkins SC, Falo LD Jr, Marques ETA Jr, Barratt-Boyes SM.

J Invest Dermatol. 2018 Mar;138(3):618-626. doi: 10.1016/j.jid.2017.10.018. Epub 2017 Oct 26.

PMID:
29106931
22.

Monomer sequence in PLGA microparticles: Effects on acidic microclimates and in vivo inflammatory response.

Washington MA, Balmert SC, Fedorchak MV, Little SR, Watkins SC, Meyer TY.

Acta Biomater. 2018 Jan;65:259-271. doi: 10.1016/j.actbio.2017.10.043. Epub 2017 Oct 31.

PMID:
29101019
23.

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.

Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H, Kagan VE.

Cell. 2017 Oct 19;171(3):628-641.e26. doi: 10.1016/j.cell.2017.09.044.

PMID:
29053969
24.

Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans.

Rudich P, Snoznik C, Watkins SC, Monaghan J, Pandey UB, Lamitina ST.

Hum Mol Genet. 2017 Dec 15;26(24):4916-4928. doi: 10.1093/hmg/ddx372.

25.

A versatile optical tool for studying synaptic GABAA receptor trafficking.

Lorenz-Guertin JM, Wilcox MR, Zhang M, Larsen MB, Pilli J, Schmidt BF, Bruchez MP, Johnson JW, Waggoner AS, Watkins SC, Jacob TC.

J Cell Sci. 2017 Nov 15;130(22):3933-3945. doi: 10.1242/jcs.205286. Epub 2017 Oct 12.

26.

Selective knockout of astrocytic Na+ /H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke.

Begum G, Song S, Wang S, Zhao H, Bhuiyan MIH, Li E, Nepomuceno R, Ye Q, Sun M, Calderon MJ, Stolz DB, St Croix C, Watkins SC, Chen Y, He P, Shull GE, Sun D.

Glia. 2018 Jan;66(1):126-144. doi: 10.1002/glia.23232. Epub 2017 Sep 19.

PMID:
28925083
27.

Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms.

Muller L, Simms P, Hong CS, Nishimura MI, Jackson EK, Watkins SC, Whiteside TL.

Oncoimmunology. 2017 Jul 19;6(8):e1261243. doi: 10.1080/2162402X.2016.1261243. eCollection 2017.

28.

Influence of the Novel ATP-Competitive Dual mTORC1/2 Inhibitor AZD2014 on Immune Cell Populations and Heart Allograft Rejection.

Fantus D, Dai H, Ono Y, Watson A, Yokota S, Mohib K, Yoshida O, Ross MA, Watkins SC, Ramaswami B, Valusjkikh A, Rothstein DM, Thomson AW.

Transplantation. 2017 Dec;101(12):2830-2840. doi: 10.1097/TP.0000000000001933.

PMID:
28885497
29.

Mechanistic Insight into Sonoporation with Ultrasound-Stimulated Polymer Microbubbles.

Helfield BL, Chen X, Qin B, Watkins SC, Villanueva FS.

Ultrasound Med Biol. 2017 Nov;43(11):2678-2689. doi: 10.1016/j.ultrasmedbio.2017.07.017. Epub 2017 Aug 25.

PMID:
28847500
30.

Evaluation of a Simpler Tool to Assess Nontechnical Skills During Simulated Critical Events.

Watkins SC, Roberts DA, Boulet JR, McEvoy MD, Weinger MB.

Simul Healthc. 2017 Apr;12(2):69-75. doi: 10.1097/SIH.0000000000000199.

PMID:
28704284
31.

Ribbon scanning confocal for high-speed high-resolution volume imaging of brain.

Watson AM, Rose AH, Gibson GA, Gardner CL, Sun C, Reed DS, Lam LKM, St Croix CM, Strick PL, Klimstra WB, Watkins SC.

PLoS One. 2017 Jul 7;12(7):e0180486. doi: 10.1371/journal.pone.0180486. eCollection 2017.

32.

Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment.

Weinstein AM, Chen L, Brzana EA, Patil PR, Taylor JL, Fabian KL, Wallace CT, Jones SD, Watkins SC, Lu B, Stroncek DF, Denning TL, Fu YX, Cohen PA, Storkus WJ.

Oncoimmunology. 2017 Apr 28;6(6):e1322238. doi: 10.1080/2162402X.2017.1322238. eCollection 2017.

33.

Assessment Tools for Use During Anesthesia-Centric Pediatric Advanced Life Support Training and Evaluation.

Watkins SC, Nietert PJ, Hughes E, Stickles ET, Wester TE, McEvoy MD.

Am J Med Sci. 2017 Jun;353(6):516-522. doi: 10.1016/j.amjms.2016.09.013. Epub 2016 Oct 3.

34.

HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells.

Kinner-Bibeau LB, Sedlacek AL, Messmer MN, Watkins SC, Binder RJ.

Nat Commun. 2017 May 31;8:15648. doi: 10.1038/ncomms15648.

35.

The use of informativity in the development of robust viromics-based examinations.

Watkins SC, Putonti C.

PeerJ. 2017 May 2;5:e3281. doi: 10.7717/peerj.3281. eCollection 2017.

36.

Tumor-Derived α-Fetoprotein Directly Drives Human Natural Killer-Cell Activation and Subsequent Cell Death.

Vujanovic L, Stahl EC, Pardee AD, Geller DA, Tsung A, Watkins SC, Gibson GA, Storkus WJ, Butterfield LH.

Cancer Immunol Res. 2017 Jun;5(6):493-502. doi: 10.1158/2326-6066.CIR-16-0216. Epub 2017 May 3.

37.

Correlative Fluorescence and Electron Microscopy in 3D-Scanning Electron Microscope Perspective.

Franks J, Wallace CT, Shibata M, Suga M, Erdman N, Stolz DB, Watkins SC.

Curr Protoc Cytom. 2017 Apr 3;80:12.45.1-12.45.15. doi: 10.1002/cpcy.18.

PMID:
28369763
38.

PhagePhisher: a pipeline for the discovery of covert viral sequences in complex genomic datasets.

Hatzopoulos T, Watkins SC, Putonti C.

Microb Genom. 2016 Mar 10;2(3):e000053. doi: 10.1099/mgen.0.000053. eCollection 2016 Mar.

39.

Inducible turnover of optineurin regulates T cell activation.

Montecalvo A, Watkins SC, Orange J, Kane LP.

Mol Immunol. 2017 May;85:9-17. doi: 10.1016/j.molimm.2017.01.027. Epub 2017 Feb 11.

40.

Affibody-targeted fluorogen activating protein for in vivo tumor imaging.

Wang Y, Ballou B, Schmidt BF, Andreko S, St Croix CM, Watkins SC, Bruchez MP.

Chem Commun (Camb). 2017 Feb 7;53(12):2001-2004. doi: 10.1039/c6cc09137g.

41.

Paclitaxel-induced increase in mitochondrial volume mediates dysregulation of intracellular Ca2+ in putative nociceptive glabrous skin neurons from the rat.

Yilmaz E, Watkins SC, Gold MS.

Cell Calcium. 2017 Mar;62:16-28. doi: 10.1016/j.ceca.2017.01.005. Epub 2017 Jan 16.

42.

The Development and Implementation of Cognitive Aids for Critical Events in Pediatric Anesthesia: The Society for Pediatric Anesthesia Critical Events Checklists.

Clebone A, Burian BK, Watkins SC, Gálvez JA, Lockman JL, Heitmiller ES; Members of the Society for Pediatric Anesthesia Quality and Safety Committee (see Acknowledgments).

Anesth Analg. 2017 Mar;124(3):900-907. doi: 10.1213/ANE.0000000000001746. Review.

PMID:
28079584
43.

Mode of Information Delivery Does Not Effect Anesthesia Trainee Performance During Simulated Perioperative Pediatric Critical Events: A Trial of Paper Versus Electronic Cognitive Aids.

Watkins SC, Anders S, Clebone A, Hughes E, Patel V, Zeigler L, Shi Y, Shotwell MS, McEvoy MD, Weinger MB.

Simul Healthc. 2016 Dec;11(6):385-393.

PMID:
27922569
44.

Seven Bacteriophages Isolated from the Female Urinary Microbiota.

Malki K, Sible E, Cooper A, Garretto A, Bruder K, Watkins SC, Putonti C.

Genome Announc. 2016 Nov 23;4(6). pii: e01003-16. doi: 10.1128/genomeA.01003-16.

45.

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres.

Garcia-Exposito L, Bournique E, Bergoglio V, Bose A, Barroso-Gonzalez J, Zhang S, Roncaioli JL, Lee M, Wallace CT, Watkins SC, Opresko PL, Hoffmann JS, O'Sullivan RJ.

Cell Rep. 2016 Nov 8;17(7):1858-1871. doi: 10.1016/j.celrep.2016.10.048.

46.

Fluid resuscitation for acute kidney injury: an empty promise.

Watkins SC, Shaw AD.

Curr Opin Crit Care. 2016 Dec;22(6):527-532. Review.

PMID:
27748663
47.

Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process.

Kong M, Liu L, Chen X, Driscoll KI, Mao P, Böhm S, Kad NM, Watkins SC, Bernstein KA, Wyrick JJ, Min JH, Van Houten B.

Mol Cell. 2016 Oct 20;64(2):376-387. doi: 10.1016/j.molcel.2016.09.005. Epub 2016 Oct 6.

48.

MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage.

Klei LR, Hu D, Panek R, Alfano DN, Bridwell RE, Bailey KM, Oravecz-Wilson KI, Concel VJ, Hess EM, Van Beek M, Delekta PC, Gu S, Watkins SC, Ting AT, Gough PJ, Foley KP, Bertin J, McAllister-Lucas LM, Lucas PC.

Cell Rep. 2016 Sep 27;17(1):221-232. doi: 10.1016/j.celrep.2016.08.080.

49.

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.

Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, Ferris RL, Delgoffe GM.

Immunity. 2016 Sep 20;45(3):701-703. doi: 10.1016/j.immuni.2016.08.009. Epub 2016 Sep 20. No abstract available.

50.

Biophysical insight into mechanisms of sonoporation.

Helfield B, Chen X, Watkins SC, Villanueva FS.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9983-8. doi: 10.1073/pnas.1606915113. Epub 2016 Aug 22.

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