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Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain.

Peng Y, Zhang X, Zhang T, Grace PM, Li H, Wang Y, Li H, Chen H, Watkins LR, Hutchinson MR, Yin H, Wang X.

Brain Behav Immun. 2019 Nov;82:432-444. doi: 10.1016/j.bbi.2019.09.013. Epub 2019 Sep 19.


A multisite, randomized field trial to evaluate the influence of lactoferrin on the morbidity and mortality of dairy calves with diarrhea.

Pempek JA, Watkins LR, Bruner CE, Habing GG.

J Dairy Sci. 2019 Oct;102(10):9259-9267. doi: 10.3168/jds.2019-16476. Epub 2019 Aug 7.


Oxycodone, fentanyl, and morphine amplify established neuropathic pain in male rats.

Green-Fulgham SM, Ball JB, Kwilasz AJ, Fabisiak T, Maier SF, Watkins LR, Grace PM.

Pain. 2019 Nov;160(11):2634-2640. doi: 10.1097/j.pain.0000000000001652.


Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell.

Wang X, Northcutt AL, Cochran TA, Zhang X, Fabisiak TJ, Haas ME, Amat J, Li H, Rice KC, Maier SF, Bachtell RK, Hutchinson MR, Watkins LR.

ACS Chem Neurosci. 2019 Aug 21;10(8):3622-3634. doi: 10.1021/acschemneuro.9b00225. Epub 2019 Jul 17.


TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes.

LaRocca TJ, Mariani A, Watkins LR, Link CD.

Neurobiol Dis. 2019 Dec;132:104514. doi: 10.1016/j.nbd.2019.104514. Epub 2019 Jun 21.


Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.

Zhang X, Peng Y, Grace PM, Metcalf MD, Kwilasz AJ, Wang Y, Zhang T, Wu S, Selfridge BR, Portoghese PS, Rice KC, Watkins LR, Hutchinson MR, Wang X.

FASEB J. 2019 Aug;33(8):9577-9587. doi: 10.1096/fj.201900173RRR. Epub 2019 Jun 4.


Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures.

Frank MG, Annis JL, Watkins LR, Maier SF.

Brain Behav Immun. 2019 Aug;80:678-687. doi: 10.1016/j.bbi.2019.05.014. Epub 2019 May 9.


Microglia: Neuroimmune-sensors of stress.

Frank MG, Fonken LK, Watkins LR, Maier SF.

Semin Cell Dev Biol. 2019 Oct;94:176-185. doi: 10.1016/j.semcdb.2019.01.001. Epub 2019 Jan 9. Review.


Spinal Cord Injury in Rats Disrupts the Circadian System.

Gaudet AD, Fonken LK, Ayala MT, Bateman EM, Schleicher WE, Smith EJ, D'Angelo HM, Maier SF, Watkins LR.

eNeuro. 2018 Dec 21;5(6). pii: ENEURO.0328-18.2018. doi: 10.1523/ENEURO.0328-18.2018. eCollection 2018 Nov-Dec.


Spinal Cord Injury in Rats Dysregulates Diurnal Rhythms of Fecal Output and Liver Metabolic Indicators.

Gaudet AD, Fonken LK, Ayala MT, Dangelo HM, Smith EJ, Bateman EM, Schleicher WE, Maier SF, Watkins LR.

J Neurotrauma. 2019 Jun 15;36(12):1923-1934. doi: 10.1089/neu.2018.6101. Epub 2019 Jan 9.


A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats.

Kwilasz AJ, Green Fulgham SM, Ellis A, Patel HP, Duran-Malle JC, Favret J, Harvey LO Jr, Rieger J, Maier SF, Watkins LR.

Brain Behav Immun. 2019 Feb;76:116-125. doi: 10.1016/j.bbi.2018.11.011. Epub 2018 Nov 16.


Circadian misalignment has differential effects on affective behavior following exposure to controllable or uncontrollable stress.

Daut RA, Hartsock MJ, Tomczik AC, Watkins LR, Spencer RL, Maier SF, Fonken LK.

Behav Brain Res. 2019 Feb 1;359:440-445. doi: 10.1016/j.bbr.2018.10.013. Epub 2018 Oct 9.


Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction.

Fonken LK, Frank MG, D'Angelo HM, Heinze JD, Watkins LR, Lowry CA, Maier SF.

Neurobiol Aging. 2018 Nov;71:105-114. doi: 10.1016/j.neurobiolaging.2018.07.012. Epub 2018 Jul 24.


Could Probiotics Be Used to Mitigate Neuroinflammation?

Frank MG, Fonken LK, Watkins LR, Maier SF, Lowry CA.

ACS Chem Neurosci. 2019 Jan 16;10(1):13-15. doi: 10.1021/acschemneuro.8b00386. Epub 2018 Aug 15.


Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior.

Frank MG, Fonken LK, Dolzani SD, Annis JL, Siebler PH, Schmidt D, Watkins LR, Maier SF, Lowry CA.

Brain Behav Immun. 2018 Oct;73:352-363. doi: 10.1016/j.bbi.2018.05.020. Epub 2018 May 26.


Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury.

Anttila JE, Albert K, Wires ES, Mätlik K, Loram LC, Watkins LR, Rice KC, Wang Y, Harvey BK, Airavaara M.

eNeuro. 2018 Apr 18;5(2). pii: ENEURO.0395-17.2018. doi: 10.1523/ENEURO.0395-17.2018. eCollection 2018 Mar-Apr.


MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats.

Grace PM, Strand KA, Galer EL, Maier SF, Watkins LR.

Brain Res. 2018 Aug 1;1692:9-11. doi: 10.1016/j.brainres.2018.04.038. Epub 2018 May 1.


A novel platform for in vivo detection of cytokine release within discrete brain regions.

Zhang K, Baratta MV, Liu G, Frank MG, Leslie NR, Watkins LR, Maier SF, Hutchinson MR, Goldys EM.

Brain Behav Immun. 2018 Jul;71:18-22. doi: 10.1016/j.bbi.2018.04.011. Epub 2018 Apr 17.


Repeated Morphine Prolongs Postoperative Pain in Male Rats.

Grace PM, Galer EL, Strand KA, Corrigan K, Berkelhammer D, Maier SF, Watkins LR.

Anesth Analg. 2019 Jan;128(1):161-167. doi: 10.1213/ANE.0000000000003345.


DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats.

Grace PM, Wang X, Strand KA, Baratta MV, Zhang Y, Galer EL, Yin H, Maier SF, Watkins LR.

Exp Neurol. 2018 Jun;304:125-131. doi: 10.1016/j.expneurol.2018.03.005. Epub 2018 Mar 9.


Neuroinflammatory priming to stress is differentially regulated in male and female rats.

Fonken LK, Frank MG, Gaudet AD, D'Angelo HM, Daut RA, Hampson EC, Ayala MT, Watkins LR, Maier SF.

Brain Behav Immun. 2018 May;70:257-267. doi: 10.1016/j.bbi.2018.03.005. Epub 2018 Mar 7.


Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists.

Zhang X, Cui F, Chen H, Zhang T, Yang K, Wang Y, Jiang Z, Rice KC, Watkins LR, Hutchinson MR, Li Y, Peng Y, Wang X.

J Chem Inf Model. 2018 Apr 23;58(4):816-825. doi: 10.1021/acs.jcim.7b00717. Epub 2018 Apr 11.


Inhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females.

Dolzani SD, Baratta MV, Moss JM, Leslie NL, Tilden SG, Sørensen AT, Watkins LR, Lin Y, Maier SF.

eNeuro. 2018 Mar 6;5(1). pii: ENEURO.0025-18.2018. doi: 10.1523/ENEURO.0025-18.2018. eCollection 2018 Jan-Feb.


Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A2A receptor agonists.

Kwilasz AJ, Ellis A, Wieseler J, Loram L, Favret J, McFadden A, Springer K, Falci S, Rieger J, Maier SF, Watkins LR.

Brain Behav Immun. 2018 Mar;69:470-479. doi: 10.1016/j.bbi.2018.01.005. Epub 2018 Jan 31.


Behavioural and neural sequelae of stressor exposure are not modulated by controllability in females.

Baratta MV, Leslie NR, Fallon IP, Dolzani SD, Chun LE, Tamalunas AM, Watkins LR, Maier SF.

Eur J Neurosci. 2018 Apr;47(8):959-967. doi: 10.1111/ejn.13833. Epub 2018 Feb 5.


Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming.

Frank MG, Fonken LK, Annis JL, Watkins LR, Maier SF.

Brain Behav Immun. 2018 Mar;69:62-73. doi: 10.1016/j.bbi.2017.11.001. Epub 2017 Nov 2.


Toll-like receptors and their role in persistent pain.

Lacagnina MJ, Watkins LR, Grace PM.

Pharmacol Ther. 2018 Apr;184:145-158. doi: 10.1016/j.pharmthera.2017.10.006. Epub 2017 Oct 4. Review.


Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats.

Grace PM, Strand KA, Galer EL, Rice KC, Maier SF, Watkins LR.

Brain Behav Immun. 2018 Aug;72:45-50. doi: 10.1016/j.bbi.2017.08.018. Epub 2017 Aug 30.


Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking.

Brown KT, Levis SC, O'Neill CE, Northcutt AL, Fabisiak TJ, Watkins LR, Bachtell RK.

Brain Behav Immun. 2018 Jan;67:130-138. doi: 10.1016/j.bbi.2017.08.012. Epub 2017 Aug 13.


MicroRNAs: Roles in Regulating Neuroinflammation.

Gaudet AD, Fonken LK, Watkins LR, Nelson RJ, Popovich PG.

Neuroscientist. 2018 Jun;24(3):221-245. doi: 10.1177/1073858417721150. Epub 2017 Jul 24.


High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory.

Spencer SJ, D'Angelo H, Soch A, Watkins LR, Maier SF, Barrientos RM.

Neurobiol Aging. 2017 Oct;58:88-101. doi: 10.1016/j.neurobiolaging.2017.06.014. Epub 2017 Jun 24.


Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury.

Gaudet AD, Ayala MT, Schleicher WE, Smith EJ, Bateman EM, Maier SF, Watkins LR.

Exp Neurol. 2017 Sep;295:46-54. doi: 10.1016/j.expneurol.2017.05.011. Epub 2017 May 25.


Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats.

Lacagnina MJ, Kopec AM, Cox SS, Hanamsagar R, Wells C, Slade S, Grace PM, Watkins LR, Levin ED, Bilbo SD.

Neuropsychopharmacology. 2017 Oct;42(11):2128-2140. doi: 10.1038/npp.2017.82. Epub 2017 Apr 24.


Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.

Wieseler J, Ellis A, McFadden A, Stone K, Brown K, Cady S, Bastos LF, Sprunger D, Rezvani N, Johnson K, Rice KC, Maier SF, Watkins LR.

Brain Res. 2017 Jun 1;1664:87-94. doi: 10.1016/j.brainres.2017.03.011. Epub 2017 Mar 16.


Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia.

Lewis SS, Grace PM, Hutchinson MR, Maier SF, Watkins LR.

Brain Behav Immun. 2017 Aug;64:59-64. doi: 10.1016/j.bbi.2016.12.004. Epub 2016 Dec 18.


Stress-induced neuroinflammatory priming: A liability factor in the etiology of psychiatric disorders.

Frank MG, Weber MD, Watkins LR, Maier SF.

Neurobiol Stress. 2015 Dec 29;4:62-70. eCollection 2016 Oct. Review.


Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol.

Barrientos RM, Kitt MM, D'Angelo HM, Watkins LR, Rudy JW, Maier SF.

Learn Mem. 2016 Nov 15;23(12):699-702. doi: 10.1101/lm.043489.116. Print 2016 Dec.


Nitroxidative Signaling Mechanisms in Pathological Pain.

Grace PM, Gaudet AD, Staikopoulos V, Maier SF, Hutchinson MR, Salvemini D, Watkins LR.

Trends Neurosci. 2016 Dec;39(12):862-879. doi: 10.1016/j.tins.2016.10.003. Epub 2016 Nov 12. Review.


Activation of a Habenulo-Raphe Circuit Is Critical for the Behavioral and Neurochemical Consequences of Uncontrollable Stress in the Male Rat.

Dolzani SD, Baratta MV, Amat J, Agster KL, Saddoris MP, Watkins LR, Maier SF.

eNeuro. 2016 Oct 17;3(5). pii: ENEURO.0229-16.2016. eCollection 2016 Sep-Oct.


Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization.

Fonken LK, Kitt MM, Gaudet AD, Barrientos RM, Watkins LR, Maier SF.

Neurobiol Aging. 2016 Nov;47:102-112. doi: 10.1016/j.neurobiolaging.2016.07.019. Epub 2016 Aug 1.


HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia.

Das N, Dewan V, Grace PM, Gunn RJ, Tamura R, Tzarum N, Watkins LR, Wilson IA, Yin H.

Cell Rep. 2016 Oct 18;17(4):1128-1140. doi: 10.1016/j.celrep.2016.09.076.


Glial contributions to visceral pain: implications for disease etiology and the female predominance of persistent pain.

Dodds KN, Beckett EA, Evans SF, Grace PM, Watkins LR, Hutchinson MR.

Transl Psychiatry. 2016 Sep 13;6(9):e888. doi: 10.1038/tp.2016.168. Review.


Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1.

Sobesky JL, D'Angelo HM, Weber MD, Anderson ND, Frank MG, Watkins LR, Maier SF, Barrientos RM.

eNeuro. 2016 Aug 30;3(4). pii: ENEURO.0113-16.2016. doi: 10.1523/ENEURO.0113-16.2016. eCollection 2016 Jul-Aug.


Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury.

Ellis A, Grace PM, Wieseler J, Favret J, Springer K, Skarda B, Ayala M, Hutchinson MR, Falci S, Rice KC, Maier SF, Watkins LR.

Brain Behav Immun. 2016 Nov;58:348-356. doi: 10.1016/j.bbi.2016.08.004. Epub 2016 Aug 9.


The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming.

Fonken LK, Frank MG, Kitt MM, D'Angelo HM, Norden DM, Weber MD, Barrientos RM, Godbout JP, Watkins LR, Maier SF.

J Neurosci. 2016 Jul 27;36(30):7946-56. doi: 10.1523/JNEUROSCI.1161-16.2016.


Prior voluntary wheel running attenuates neuropathic pain.

Grace PM, Fabisiak TJ, Green-Fulgham SM, Anderson ND, Strand KA, Kwilasz AJ, Galer EL, Walker FR, Greenwood BN, Maier SF, Fleshner M, Watkins LR.

Pain. 2016 Sep;157(9):2012-23. doi: 10.1097/j.pain.0000000000000607.


Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.

Grace PM, Strand KA, Galer EL, Urban DJ, Wang X, Baratta MV, Fabisiak TJ, Anderson ND, Cheng K, Greene LI, Berkelhammer D, Zhang Y, Ellis AL, Yin HH, Campeau S, Rice KC, Roth BL, Maier SF, Watkins LR.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3441-50. doi: 10.1073/pnas.1602070113. Epub 2016 May 31.


Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy.

Grace PM, Loram LC, Christianson JP, Strand KA, Flyer-Adams JG, Penzkover KR, Forsayeth JR, van Dam AM, Mahoney MJ, Maier SF, Chavez RA, Watkins LR.

Brain Behav Immun. 2017 Jan;59:49-54. doi: 10.1016/j.bbi.2016.05.012. Epub 2016 May 14.


Stress-induced neuroinflammatory priming is time of day dependent.

Fonken LK, Weber MD, Daut RA, Kitt MM, Frank MG, Watkins LR, Maier SF.

Psychoneuroendocrinology. 2016 Apr;66:82-90. doi: 10.1016/j.psyneuen.2016.01.006. Epub 2016 Jan 11.


Previous Ketamine Produces an Enduring Blockade of Neurochemical and Behavioral Effects of Uncontrollable Stress.

Amat J, Dolzani SD, Tilden S, Christianson JP, Kubala KH, Bartholomay K, Sperr K, Ciancio N, Watkins LR, Maier SF.

J Neurosci. 2016 Jan 6;36(1):153-61. doi: 10.1523/JNEUROSCI.3114-15.2016.

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