Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 112

1.

Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases.

McCabe MJ, Pinese M, Chan CL, Sheriff N, Thompson TJ, Grady J, Wong M, Gauthier MA, Puttick C, Gayevskiy V, Hajdu E, Wong SQ, Barrett W, Earls P, Lukeis R, Cheng YY, Lin RCY, Thomas DM, Watkins DN, Dinger ME, McCormack AI, Cowley MJ.

Cold Spring Harb Mol Case Stud. 2019 Apr 1;5(2). pii: a003764. doi: 10.1101/mcs.a003764. Print 2019 Apr.

2.

Chiral DNA sequences as commutable controls for clinical genomics.

Deveson IW, Madala BS, Blackburn J, Barker C, Wong T, Barton KM, Smith MA, Watkins DN, Mercer TR.

Nat Commun. 2019 Mar 22;10(1):1342. doi: 10.1038/s41467-019-09272-0.

3.

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

Kennedy SP, Han JZR, Portman N, Nobis M, Hastings JF, Murphy KJ, Latham SL, Cadell AL, Miladinovic D, Marriott GR, O'Donnell YEI, Shearer RF, Williams JT, Munoz AG, Cox TR, Watkins DN, Saunders DN, Timpson P, Lim E, Kolch W, Croucher DR.

Breast Cancer Res. 2019 Mar 21;21(1):43. doi: 10.1186/s13058-019-1127-y.

4.

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.

Saad MI, Alhayyani S, McLeod L, Yu L, Alanazi M, Deswaerte V, Tang K, Jarde T, Smith JA, Prodanovic Z, Tate MD, Balic JJ, Watkins DN, Cain JE, Bozinovski S, Algar E, Kohmoto T, Ebi H, Ferlin W, Garbers C, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ.

EMBO Mol Med. 2019 Apr;11(4). pii: e9976. doi: 10.15252/emmm.201809976.

5.

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing.

Lim CH, Sun Q, Ratti K, Lee SH, Zheng Y, Takeo M, Lee W, Rabbani P, Plikus MV, Cain JE, Wang DH, Watkins DN, Millar S, Taketo MM, Myung P, Cotsarelis G, Ito M.

Nat Commun. 2018 Nov 21;9(1):4903. doi: 10.1038/s41467-018-07142-9.

6.

Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer.

Leong TL, Gayevskiy V, Steinfort DP, De Massy MR, Gonzalez-Rajal A, Marini KD, Stone E, Chin V, Havryk A, Plit M, Irving LB, Jennings BR, McCloy RA, Jayasekara WSN, Alamgeer M, Boolell V, Field A, Russell PA, Kumar B, Gough DJ, Szczepny A, Ganju V, Rossello FJ, Cain JE, Papenfuss AT, Asselin-Labat ML, Cowley MJ, Watkins DN.

Oncogene. 2019 Mar;38(10):1661-1675. doi: 10.1038/s41388-018-0536-1. Epub 2018 Oct 22.

PMID:
30348992
7.

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy.

Marini KD, Croucher DR, McCloy RA, Vaghjiani V, Gonzalez-Rajal A, Hastings JF, Chin V, Szczepny A, Kostyrko K, Marquez C, Jayasekara WSN, Alamgeer M, Boolell V, Han JZR, Waugh T, Lee HC, Oakes SR, Kumar B, Harrison CA, Hedger MP, Lorensuhewa N, Kita B, Barrow R, Robinson BW, de Kretser DM, Wu J, Ganju V, Sweet-Cordero EA, Burgess A, Martelotto LG, Rossello FJ, Cain JE, Watkins DN.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaat3504. doi: 10.1126/scitranslmed.aat3504.

PMID:
30045976
8.

Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer.

Cazet AS, Hui MN, Elsworth BL, Wu SZ, Roden D, Chan CL, Skhinas JN, Collot R, Yang J, Harvey K, Johan MZ, Cooper C, Nair R, Herrmann D, McFarland A, Deng N, Ruiz-Borrego M, Rojo F, Trigo JM, Bezares S, Caballero R, Lim E, Timpson P, O'Toole S, Watkins DN, Cox TR, Samuel MS, Martín M, Swarbrick A.

Nat Commun. 2018 Jul 24;9(1):2897. doi: 10.1038/s41467-018-05220-6.

9.

MASTL overexpression promotes chromosome instability and metastasis in breast cancer.

Rogers S, McCloy RA, Parker BL, Gallego-Ortega D, Law AMK, Chin VT, Conway JRW, Fey D, Millar EKA, O'Toole S, Deng N, Swarbrick A, Chastain PD, Cesare AJ, Timpson P, Caldon CE, Croucher DR, James DE, Watkins DN, Burgess A.

Oncogene. 2018 Aug;37(33):4518-4533. doi: 10.1038/s41388-018-0295-z. Epub 2018 May 10.

10.

The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.

Szczepny A, Carey K, McKenzie L, Jayasekara WSN, Rossello F, Gonzalez-Rajal A, McCaw AS, Popovski D, Wang D, Sadler AJ, Mahar A, Russell PA, Wright G, McCloy RA, Garama DJ, Gough DJ, Baylin SB, Burgess A, Cain JE, Watkins DN.

Oncogene. 2018 Apr;37(14):1939-1948. doi: 10.1038/s41388-017-0022-1. Epub 2018 Jan 25.

11.

In vivo evidence that RBM5 is a tumour suppressor in the lung.

Jamsai D, Watkins DN, O'Connor AE, Merriner DJ, Gursoy S, Bird AD, Kumar B, Miller A, Cole TJ, Jenkins BJ, O'Bryan MK.

Sci Rep. 2017 Nov 24;7(1):16323. doi: 10.1038/s41598-017-15874-9.

12.

Positive regulatory interactions between YAP and Hedgehog signalling in skin homeostasis and BCC development in mouse skin in vivo.

Akladios B, Mendoza Reinoso V, Cain JE, Wang T, Lambie DL, Watkins DN, Beverdam A.

PLoS One. 2017 Aug 18;12(8):e0183178. doi: 10.1371/journal.pone.0183178. eCollection 2017.

13.

A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.

Conduit SE, Ramaswamy V, Remke M, Watkins DN, Wainwright BJ, Taylor MD, Mitchell CA, Dyson JM.

Oncogene. 2017 Oct 26;36(43):5969-5984. doi: 10.1038/onc.2017.208. Epub 2017 Jun 26.

PMID:
28650469
14.

MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway.

Tripathi SC, Fahrmann JF, Celiktas M, Aguilar M, Marini KD, Jolly MK, Katayama H, Wang H, Murage EN, Dennison JB, Watkins DN, Levine H, Ostrin EJ, Taguchi A, Hanash SM.

Cancer Res. 2017 Aug 15;77(16):4414-4425. doi: 10.1158/0008-5472.CAN-16-2874. Epub 2017 Jun 23.

15.

The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer.

Szczepny A, Rogers S, Jayasekara WSN, Park K, McCloy RA, Cochrane CR, Ganju V, Cooper WA, Sage J, Peacock CD, Cain JE, Burgess A, Watkins DN.

Oncogene. 2017 Sep 28;36(39):5544-5550. doi: 10.1038/onc.2017.173. Epub 2017 Jun 5.

16.

The Immune Microenvironment, Genome-wide Copy Number Aberrations, and Survival in Mesothelioma.

Thapa B, Salcedo A, Lin X, Walkiewicz M, Murone C, Ameratunga M, Asadi K, Deb S, Barnett SA, Knight S, Mitchell P, Watkins DN, Boutros PC, John T.

J Thorac Oncol. 2017 May;12(5):850-859. doi: 10.1016/j.jtho.2017.02.013. Epub 2017 Feb 28.

17.

Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease.

Grzelak CA, Sigglekow ND, Tirnitz-Parker JE, Hamson EJ, Warren A, Maneck B, Chen J, Patkunanathan B, Boland J, Cheng R, Shackel NA, Seth D, Bowen DG, Martelotto LG, Watkins DN, McCaughan GW.

PLoS One. 2017 Feb 10;12(2):e0171480. doi: 10.1371/journal.pone.0171480. eCollection 2017.

18.

MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib.

Young AI, Law AM, Castillo L, Chong S, Cullen HD, Koehler M, Herzog S, Brummer T, Lee EF, Fairlie WD, Lucas MC, Herrmann D, Allam A, Timpson P, Watkins DN, Millar EK, O'Toole SA, Gallego-Ortega D, Ormandy CJ, Oakes SR.

Breast Cancer Res. 2016 Dec 8;18(1):125.

19.

Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma.

Miller A, McLeod L, Alhayyani S, Szczepny A, Watkins DN, Chen W, Enriori P, Ferlin W, Ruwanpura S, Jenkins BJ.

Oncogene. 2017 May 25;36(21):3059-3066. doi: 10.1038/onc.2016.437. Epub 2016 Nov 28.

PMID:
27893707
20.

Calretinin but not caveolin-1 correlates with tumour histology and survival in malignant mesothelioma.

Thapa B, Walkiewicz M, Murone C, Asadi K, Deb S, Barnett S, Knight S, Mitchell P, Liew D, Watkins DN, John T.

Pathology. 2016 Dec;48(7):660-665. doi: 10.1016/j.pathol.2016.08.003. Epub 2016 Oct 22.

PMID:
27780599
21.

Immunotherapy for malignant mesothelioma: reality check.

Thapa B, Watkins DN, John T.

Expert Rev Anticancer Ther. 2016 Nov;16(11):1167-1176. doi: 10.1080/14737140.2016.1241149. Epub 2016 Oct 6.

PMID:
27669108
22.

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis.

Lee WT, Cain JE, Cuddihy A, Johnson J, Dickinson A, Yeung KY, Kumar B, Johns TG, Watkins DN, Spencer A, St John JC.

Cell Death Discov. 2016 Apr 4;2:16016. doi: 10.1038/cddiscovery.2016.16. eCollection 2016.

23.

Mechanisms regulating phosphatase specificity and the removal of individual phosphorylation sites during mitotic exit.

Rogers S, McCloy R, Watkins DN, Burgess A.

Bioessays. 2016 Jul;38 Suppl 1:S24-32. doi: 10.1002/bies.201670905. Review.

PMID:
27417119
24.

Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumor Growth Arrest and Multi-Lineage Differentiation of Malignant Rhabdoid Tumors.

Muscat A, Popovski D, Jayasekara WS, Rossello FJ, Ferguson M, Marini KD, Alamgeer M, Algar EM, Downie P, Watkins DN, Cain JE, Ashley DM.

Clin Cancer Res. 2016 Jul 15;22(14):3560-70. doi: 10.1158/1078-0432.CCR-15-2260. Epub 2016 Feb 26.

25.

PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells.

Rogers S, Fey D, McCloy RA, Parker BL, Mitchell NJ, Payne RJ, Daly RJ, James DE, Caldon CE, Watkins DN, Croucher DR, Burgess A.

J Cell Sci. 2016 Apr 1;129(7):1340-54. doi: 10.1242/jcs.179754. Epub 2016 Feb 12.

26.

The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase.

Deane JA, Ong YR, Cain JE, Jayasekara WS, Tiwari A, Carlone DL, Watkins DN, Breault DT, Gargett CE.

Mol Hum Reprod. 2016 Apr;22(4):272-84. doi: 10.1093/molehr/gav076. Epub 2016 Jan 5.

27.

Dataset from the global phosphoproteomic mapping of early mitotic exit in human cells.

Rogers S, McCloy RA, Parker BL, Chaudhuri R, Gayevskiy V, Hoffman NJ, Watkins DN, Daly RJ, James DE, Burgess A.

Data Brief. 2015 Aug 24;5:45-52. doi: 10.1016/j.dib.2015.08.010. eCollection 2015 Dec.

28.

The Evolution of Therapies in Non-Small Cell Lung Cancer.

Boolell V, Alamgeer M, Watkins DN, Ganju V.

Cancers (Basel). 2015 Sep 9;7(3):1815-46. doi: 10.3390/cancers7030864. Review.

29.

Hedgehog Signaling in the Maintenance of Cancer Stem Cells.

Cochrane CR, Szczepny A, Watkins DN, Cain JE.

Cancers (Basel). 2015 Aug 11;7(3):1554-85. doi: 10.3390/cancers7030851. Review.

30.

Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia.

Lim Y, Gondek L, Li L, Wang Q, Ma H, Chang E, Huso DL, Foerster S, Marchionni L, McGovern K, Watkins DN, Peacock CD, Levis M, Smith BD, Merchant AA, Small D, Matsui W.

Sci Transl Med. 2015 Jun 10;7(291):291ra96. doi: 10.1126/scitranslmed.aaa5731. Erratum in: Sci Transl Med. 2015 Jul 8;7(295):295er6. Ma, Haley [corrected to Ma, Hayley].

31.

Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs.

McCloy RA, Parker BL, Rogers S, Chaudhuri R, Gayevskiy V, Hoffman NJ, Ali N, Watkins DN, Daly RJ, James DE, Lorca T, Castro A, Burgess A.

Mol Cell Proteomics. 2015 Aug;14(8):2194-212. doi: 10.1074/mcp.M114.046938. Epub 2015 Jun 8.

32.

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs.

Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liaskos M, Gantier MP, Ying H, Yim HC, Hartland EL, Notini AJ, de Boer S, White SJ, Mansell A, Liu JP, Watkins DN, Gerondakis S, Williams BR, Xu D.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1535-40. doi: 10.1073/pnas.1409728112. Epub 2015 Jan 20.

33.

Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis.

Lim CB, Prêle CM, Baltic S, Arthur PG, Creaney J, Watkins DN, Thompson PJ, Mutsaers SE.

Oncotarget. 2015 Jan 30;6(3):1519-30.

34.

Genomic characterisation of small cell lung cancer patient-derived xenografts generated from endobronchial ultrasound-guided transbronchial needle aspiration specimens.

Leong TL, Marini KD, Rossello FJ, Jayasekara SN, Russell PA, Prodanovic Z, Kumar B, Ganju V, Alamgeer M, Irving LB, Steinfort DP, Peacock CD, Cain JE, Szczepny A, Watkins DN.

PLoS One. 2014 Sep 5;9(9):e106862. doi: 10.1371/journal.pone.0106862. eCollection 2014.

35.

Reply to: "The many faces of Hedgehog signalling in the liver: recent progress reveals striking cellular diversity and the importance of microenvironments".

Grzelak CA, Sigglekow ND, Watkins DN, McCaughan GW.

J Hepatol. 2014 Dec;61(6):1451-2. doi: 10.1016/j.jhep.2014.08.019. Epub 2014 Aug 23. No abstract available.

36.

Peptide receptor chemoradionuclide therapy in small cell carcinoma: from bench to bedside.

Lewin J, Cullinane C, Akhurst T, Waldeck K, Watkins DN, Rao A, Eu P, Mileshkin L, Hicks RJ.

Eur J Nucl Med Mol Imaging. 2015 Jan;42(1):25-32. doi: 10.1007/s00259-014-2888-2. Epub 2014 Aug 16.

PMID:
25125202
37.

Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett's metaplasia.

Wang DH, Tiwari A, Kim ME, Clemons NJ, Regmi NL, Hodges WA, Berman DM, Montgomery EA, Watkins DN, Zhang X, Zhang Q, Jie C, Spechler SJ, Souza RF.

J Clin Invest. 2014 Sep;124(9):3767-80. doi: 10.1172/JCI66603. Epub 2014 Aug 1.

38.

Seminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines.

van der Zwan YG, Rijlaarsdam MA, Rossello FJ, Notini AJ, de Boer S, Watkins DN, Gillis AJ, Dorssers LC, White SJ, Looijenga LH.

PLoS One. 2014 Jun 2;9(6):e98330. doi: 10.1371/journal.pone.0098330. eCollection 2014.

39.

Changes in aldehyde dehydrogenase-1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer.

Alamgeer M, Ganju V, Kumar B, Fox J, Hart S, White M, Harris M, Stuckey J, Prodanovic Z, Schneider-Kolsky ME, Watkins DN.

Breast Cancer Res. 2014 Apr 24;16(2):R44. doi: 10.1186/bcr3648.

40.

The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts.

Bandopadhayay P, Jabbour AM, Riffkin C, Salmanidis M, Gordon L, Popovski D, Rigby L, Ashley DM, Watkins DN, Thomas DM, Algar E, Ekert PG.

BMC Cancer. 2013 Dec 9;13:585. doi: 10.1186/1471-2407-13-585.

41.

Next-generation sequence analysis of cancer xenograft models.

Rossello FJ, Tothill RW, Britt K, Marini KD, Falzon J, Thomas DM, Peacock CD, Marchionni L, Li J, Bennett S, Tantoso E, Brown T, Chan P, Martelotto LG, Watkins DN.

PLoS One. 2013 Sep 26;8(9):e74432. doi: 10.1371/journal.pone.0074432. eCollection 2013.

42.

The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury.

Grzelak CA, Martelotto LG, Sigglekow ND, Patkunanathan B, Ajami K, Calabro SR, Dwyer BJ, Tirnitz-Parker JE, Watkins DN, Warner FJ, Shackel NA, McCaughan GW.

J Hepatol. 2014 Jan;60(1):143-51. doi: 10.1016/j.jhep.2013.08.012. Epub 2013 Aug 23.

PMID:
23978713
43.

The prognostic significance of aldehyde dehydrogenase 1A1 (ALDH1A1) and CD133 expression in early stage non-small cell lung cancer.

Alamgeer M, Ganju V, Szczepny A, Russell PA, Prodanovic Z, Kumar B, Wainer Z, Brown T, Schneider-Kolsky M, Conron M, Wright G, Watkins DN.

Thorax. 2013 Dec;68(12):1095-104. doi: 10.1136/thoraxjnl-2012-203021. Epub 2013 Jul 22.

44.

Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling.

Barakat B, Yu L, Lo C, Vu D, De Luca E, Cain JE, Martelotto LG, Dedhar S, Sadler AJ, Wang D, Watkins DN, Hannigan GE.

EMBO Rep. 2013 Sep;14(9):837-44. doi: 10.1038/embor.2013.110. Epub 2013 Jul 23. Erratum in: EMBO Rep. 2013 Oct;14(10):945. Martellotto, Luciano G [corrected to Martelotto, Luciano G].

45.

Mutational analysis of hedgehog signaling pathway genes in human malignant mesothelioma.

Lim CB, Prêle CM, Cheah HM, Cheng YY, Klebe S, Reid G, Watkins DN, Baltic S, Thompson PJ, Mutsaers SE.

PLoS One. 2013 Jun 24;8(6):e66685. doi: 10.1371/journal.pone.0066685. Print 2013.

46.

Novel therapeutic targets in non-small cell lung cancer.

Alamgeer M, Ganju V, Watkins DN.

Curr Opin Pharmacol. 2013 Jun;13(3):394-401. doi: 10.1016/j.coph.2013.03.010. Epub 2013 Apr 20. Review.

PMID:
23608109
47.

Cancer stem cells in lung cancer: Evidence and controversies.

Alamgeer M, Peacock CD, Matsui W, Ganju V, Watkins DN.

Respirology. 2013 Jul;18(5):757-64. doi: 10.1111/resp.12094. Review.

48.

The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy.

Hui M, Cazet A, Nair R, Watkins DN, O'Toole SA, Swarbrick A.

Breast Cancer Res. 2013 Mar 28;15(2):203. doi: 10.1186/bcr3401. Review.

49.

Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells.

Cain JE, McCaw A, Jayasekara WS, Rossello FJ, Marini KD, Irving AT, Kansara M, Thomas DM, Ashley DM, Watkins DN.

Sarcoma. 2013;2013:608964. doi: 10.1155/2013/608964. Epub 2013 Feb 28.

50.

Visualizing renal primary cilia.

Deane JA, Verghese E, Martelotto LG, Cain JE, Galtseva A, Rosenblum ND, Watkins DN, Ricardo SD.

Nephrology (Carlton). 2013 Mar;18(3):161-8. doi: 10.1111/nep.12022. Review.

PMID:
23240784

Supplemental Content

Loading ...
Support Center