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Items: 42

1.

Antivirals in seasonal and pandemic influenza--future perspectives.

Wathen MW, Barro M, Bright RA.

Influenza Other Respir Viruses. 2013 Jan;7 Suppl 1:76-80. doi: 10.1111/irv.12049.

2.

Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility.

Nieman JA, Nair SK, Heasley SE, Schultz BL, Zerth HM, Nugent RA, Chen K, Stephanski KJ, Hopkins TA, Knechtel ML, Oien NL, Wieber JL, Wathen MW.

Bioorg Med Chem Lett. 2010 May 15;20(10):3039-42. doi: 10.1016/j.bmcl.2010.03.115. Epub 2010 Apr 3.

PMID:
20403696
3.

The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase.

Tanis SP, Strohbach JW, Parker TT, Moon MW, Thaisrivongs S, Perrault WR, Hopkins TA, Knechtel ML, Oien NL, Wieber JL, Stephanski KJ, Wathen MW.

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1994-2000. doi: 10.1016/j.bmcl.2010.01.094. Epub 2010 Jan 25.

PMID:
20167488
4.

Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition.

Schnute ME, Brideau RJ, Collier SA, Cudahy MM, Hopkins TA, Knechtel ML, Oien NL, Sackett RS, Scott A, Stephan ML, Wathen MW, Wieber JL.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):3856-9. doi: 10.1016/j.bmcl.2008.06.060. Epub 2008 Jun 20.

PMID:
18595689
5.

7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase.

Larsen SD, Zhang Z, DiPaolo BA, Manninen PR, Rohrer DC, Hageman MJ, Hopkins TA, Knechtel ML, Oien NL, Rush BD, Schwende FJ, Stefanski KJ, Wieber JL, Wilkinson KF, Zamora KM, Wathen MW, Brideau RJ.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):3840-4. Epub 2007 May 10.

PMID:
17513108
6.

2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases.

Schnute ME, Anderson DJ, Brideau RJ, Ciske FL, Collier SA, Cudahy MM, Eggen M, Genin MJ, Hopkins TA, Judge TM, Kim EJ, Knechtel ML, Nair SK, Nieman JA, Oien NL, Scott A, Tanis SP, Vaillancourt VA, Wathen MW, Wieber JL.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3349-53. Epub 2007 Apr 5.

PMID:
17434304
7.

4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as non-nucleoside inhibitors of human cytomegalovirus and related herpesvirus polymerases.

Schnute ME, Cudahy MM, Brideau RJ, Homa FL, Hopkins TA, Knechtel ML, Oien NL, Pitts TW, Poorman RA, Wathen MW, Wieber JL.

J Med Chem. 2005 Sep 8;48(18):5794-804.

PMID:
16134946
9.

Non-nucleoside inhibitors of herpesviruses.

Wathen MW.

Rev Med Virol. 2002 May-Jun;12(3):167-78. Review.

PMID:
11987142
10.

Broad-spectrum antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses.

Brideau RJ, Knechtel ML, Huang A, Vaillancourt VA, Vera EE, Oien NL, Hopkins TA, Wieber JL, Wilkinson KF, Rush BD, Schwende FJ, Wathen MW.

Antiviral Res. 2002 Apr;54(1):19-28.

PMID:
11888654
11.

Broad-spectrum antiherpes activities of 4-hydroxyquinoline carboxamides, a novel class of herpesvirus polymerase inhibitors.

Oien NL, Brideau RJ, Hopkins TA, Wieber JL, Knechtel ML, Shelly JA, Anstadt RA, Wells PA, Poorman RA, Huang A, Vaillancourt VA, Clayton TL, Tucker JA, Wathen MW.

Antimicrob Agents Chemother. 2002 Mar;46(3):724-30.

12.

Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase.

Vaillancourt VA, Cudahy MM, Staley SA, Brideau RJ, Conrad SJ, Knechtel ML, Oien NL, Wieber JL, Yagi Y, Wathen MW.

Bioorg Med Chem Lett. 2000 Sep 18;10(18):2079-81.

PMID:
10999475
13.

New antiherpetic 1,3-phenylene derivatives, inhibitors of the interaction of the HSV-1 origin binding protein (OBP) with DNA.

Font M, Sanmartín C, Alonso ML, Gracia L, Losa MJ, Marquiegui B, Merino I, Nadal E, Ruiz I, Monge A, Bengoechea MT, Cabodevilla F, Elena S, Martinez-Irujo JJ, Odriozola L, Peñuelas I, Santiago E, Homa F, Wathen MW.

Drug Des Discov. 2000;16(4):295-315.

PMID:
10807035
14.

Assembly of herpes simplex virus capsids using the human cytomegalovirus scaffold protein: critical role of the C terminus.

Oien NL, Thomsen DR, Wathen MW, Newcomb WW, Brown JC, Homa FL.

J Virol. 1997 Feb;71(2):1281-91.

15.

Functional analysis of human cytomegalovirus polymerase accessory protein.

Weiland KL, Oien NL, Homa F, Wathen MW.

Virus Res. 1994 Dec;34(3):191-206.

PMID:
7856311
16.

Purification of a recombinant human respiratory syncytial virus chimeric glycoprotein using reversed-phase chromatography and protein refolding in guanidine hydrochloride.

Wells PA, Garlick RL, Lyle SB, Tuls JL, Poorman RA, Brideau RJ, Wathen MW.

Protein Expr Purif. 1994 Aug;5(4):391-401.

PMID:
7950387
17.
18.

Development of a novel subunit vaccine that protects cotton rats against both human respiratory syncytial virus and human parainfluenza virus type 3.

Homa FL, Brideau RJ, Lehman DJ, Thomsen DR, Olmsted RA, Wathen MW.

J Gen Virol. 1993 Sep;74 ( Pt 9):1995-9.

PMID:
8397289
19.
20.

A human respiratory syncytial virus (RSV) primate model of enhanced pulmonary pathology induced with a formalin-inactivated RSV vaccine but not a recombinant FG subunit vaccine.

Kakuk TJ, Soike K, Brideau RJ, Zaya RM, Cole SL, Zhang JY, Roberts ED, Wells PA, Wathen MW.

J Infect Dis. 1993 Mar;167(3):553-61.

PMID:
8440926
21.

Protection of cotton rats against human parainfluenza virus type 3 by vaccination with a chimeric FHN subunit glycoprotein.

Brideau RJ, Oien NL, Lehman DJ, Homa FL, Wathen MW.

J Gen Virol. 1993 Mar;74 ( Pt 3):471-7.

PMID:
8383179
22.

Comparison of soluble and secreted forms of human parainfluenza virus type 3 glycoproteins expressed from mammalian and insect cells as subunit vaccines.

Lehman DJ, Roof LL, Brideau RJ, Aeed PA, Thomsen DR, Elhammer AP, Wathen MW, Homa FL.

J Gen Virol. 1993 Mar;74 ( Pt 3):459-69.

PMID:
8383178
23.
24.
25.
26.

Vaccination of cotton rats with a chimeric FG glycoprotein of human respiratory syncytial virus induces minimal pulmonary pathology on challenge.

Wathen MW, Kakuk TJ, Brideau RJ, Hausknecht EC, Cole SL, Zaya RM.

J Infect Dis. 1991 Mar;163(3):477-82.

PMID:
1995720
27.

Validation of an immunoradiometric assay to measure plasma levels of active renin.

Wathen LK, Nuorala KW, Wathen MW.

J Clin Lab Anal. 1991;5(4):284-92.

PMID:
1890543
29.

Protection of cotton rats against human respiratory syncytial virus by vaccination with a novel chimeric FG glycoprotein.

Brideau RJ, Walters RR, Stier MA, Wathen MW.

J Gen Virol. 1989 Oct;70 ( Pt 10):2637-44.

PMID:
2677234
30.

Characterization of a novel human respiratory syncytial virus chimeric FG glycoprotein expressed using a baculovirus vector.

Wathen MW, Brideau RJ, Thomsen DR, Murphy BR.

J Gen Virol. 1989 Oct;70 ( Pt 10):2625-35.

PMID:
2477497
31.
32.

Peptides as potential virus inhibitors. Synthesis and bioassay of five respiratory syncytial virus peptide analogs with antimeasles activity.

Lobl TJ, Renis HE, Epand RM, Maggiora LL, Wathen MW.

Int J Pept Protein Res. 1988 Nov;32(5):326-30.

PMID:
2850279
33.

The pseudorabies virus gII gene is closely related to the gB glycoprotein gene of herpes simplex virus.

Robbins AK, Dorney DJ, Wathen MW, Whealy ME, Gold C, Watson RJ, Holland LE, Weed SD, Levine M, Glorioso JC, et al.

J Virol. 1987 Sep;61(9):2691-701.

34.
35.

Production and characterization of monoclonal antibodies directed against pseudorabies virus.

Wathen LM, Platt KB, Wathen MW, Van Deusen RA, Whetstone CA, Pirtle EC.

Virus Res. 1985 Dec;4(1):19-29.

PMID:
3002067
36.

Evaluation of field isolates of pseudorabies (Aujeszky's disease) virus as determined by restriction endonuclease analysis and hybridization.

Pirtle EC, Wathen MW, Paul PS, Mengeling WL, Sacks JM.

Am J Vet Res. 1984 Oct;45(10):1906-12.

PMID:
6093637
37.

Stability of the pseudorabies virus genome after in vivo serial passage.

Wathen MW, Pirtle EC.

J Gen Virol. 1984 Aug;65 ( Pt 8):1401-4.

PMID:
6086823
40.
42.

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