Sort by
Items per page

Send to

Choose Destination

Search results

Items: 44


Regeneration-Competent and -Incompetent Murids Differ in Neutrophil Quantity and Function.

Cyr JL, Gawriluk TR, Kimani JM, Rada B, Watford WT, Kiama SG, Seifert AW, Ezenwa VO.

Integr Comp Biol. 2019 Apr 15. pii: icz023. doi: 10.1093/icb/icz023. [Epub ahead of print]


Response by Cui et al to Letter Regarding Article, "RGC-32 (Response Gene to Complement 32) Deficiency Protects Endothelial Cells From Inflammation and Attenuates Atherosclerosis".

Cui XB, Luan JN, Dong K, Chen S, Wang Y, Watford WT, Chen SY.

Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):e97-e98. doi: 10.1161/ATVBAHA.118.311146. No abstract available.


Estrogen receptor α contributes to T cell-mediated autoimmune inflammation by promoting T cell activation and proliferation.

Mohammad I, Starskaia I, Nagy T, Guo J, Yatkin E, Väänänen K, Watford WT, Chen Z.

Sci Signal. 2018 Apr 17;11(526). pii: eaap9415. doi: 10.1126/scisignal.aap9415.


RGC-32 (Response Gene to Complement 32) Deficiency Protects Endothelial Cells From Inflammation and Attenuates Atherosclerosis.

Cui XB, Luan JN, Dong K, Chen S, Wang Y, Watford WT, Chen SY.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):e36-e47. doi: 10.1161/ATVBAHA.117.310656. Epub 2018 Feb 15.


Severe Dermatitis Associated with Spontaneous Staphylococcus xylosus Infection in Rag-/-Tpl2-/- Mice.

Acuff NV, LaGatta M, Nagy T, Watford WT.

Comp Med. 2017 Aug 1;67(4):344-349.


Tpl2 Promotes Innate Cell Recruitment and Effector T Cell Differentiation To Limit Citrobacter rodentium Burden and Dissemination.

Acuff NV, Li X, Latha K, Nagy T, Watford WT.

Infect Immun. 2017 Sep 20;85(10). pii: e00193-17. doi: 10.1128/IAI.00193-17. Print 2017 Oct.


Tpl2 promotes neutrophil trafficking, oxidative burst, and bacterial killing.

Acuff NV, Li X, Elmore J, Rada B, Watford WT.

J Leukoc Biol. 2017 Jun;101(6):1325-1333. doi: 10.1189/jlb.3A0316-146R. Epub 2017 Mar 29.


Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.

Li X, Acuff NV, Peeks AR, Kirkland R, Wyatt KD, Nagy T, Watford WT.

J Biol Chem. 2016 Aug 5;291(32):16802-15. doi: 10.1074/jbc.M116.718783. Epub 2016 Jun 3.


Tumor Progression Locus 2 Promotes Induction of IFNλ, Interferon Stimulated Genes and Antigen-Specific CD8+ T Cell Responses and Protects against Influenza Virus.

Kuriakose T, Tripp RA, Watford WT.

PLoS Pathog. 2015 Aug 4;11(8):e1005038. doi: 10.1371/journal.ppat.1005038. eCollection 2015 Aug.


Tumor progression locus 2 differentially regulates IFNγ and IL-17 production by effector CD4+ T cells in a T cell transfer model of colitis.

Acuff NV, Li X, Kirkland R, Nagy T, Watford WT.

PLoS One. 2015 Mar 17;10(3):e0119885. doi: 10.1371/journal.pone.0119885. eCollection 2015.


Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling.

Kuriakose T, Rada B, Watford WT.

J Biol Chem. 2014 Dec 26;289(52):36089-100. doi: 10.1074/jbc.M114.587121. Epub 2014 Nov 5.


Proprotein convertase FURIN constrains Th2 differentiation and is critical for host resistance against Toxoplasma gondii.

Oksanen A, Aittomäki S, Jankovic D, Ortutay Z, Pulkkinen K, Hämäläinen S, Rokka A, Corthals GL, Watford WT, Junttila I, O'Shea JJ, Pesu M.

J Immunol. 2014 Dec 1;193(11):5470-9. doi: 10.4049/jimmunol.1401629. Epub 2014 Oct 29.


Tumor progression locus 2 (Tpl2) kinase promotes chemokine receptor expression and macrophage migration during acute inflammation.

Rowley SM, Kuriakose T, Dockery LM, Tran-Ngyuen T, Gingerich AD, Wei L, Watford WT.

J Biol Chem. 2014 May 30;289(22):15788-97. doi: 10.1074/jbc.M114.559344. Epub 2014 Apr 8.


Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function.

Gil MP, Ploquin MJ, Watford WT, Lee SH, Kim K, Wang X, Kanno Y, O'Shea JJ, Biron CA.

Blood. 2012 Nov 1;120(18):3718-28. doi: 10.1182/blood-2012-05-428672. Epub 2012 Sep 11.


Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling.

Ghoreschi K, Laurence A, Yang XP, Tato CM, McGeachy MJ, Konkel JE, Ramos HL, Wei L, Davidson TS, Bouladoux N, Grainger JR, Chen Q, Kanno Y, Watford WT, Sun HW, Eberl G, Shevach EM, Belkaid Y, Cua DJ, Chen W, O'Shea JJ.

Nature. 2010 Oct 21;467(7318):967-71. doi: 10.1038/nature09447.


Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation.

Wei L, Vahedi G, Sun HW, Watford WT, Takatori H, Ramos HL, Takahashi H, Liang J, Gutierrez-Cruz G, Zang C, Peng W, O'Shea JJ, Kanno Y.

Immunity. 2010 Jun 25;32(6):840-51. doi: 10.1016/j.immuni.2010.06.003.


Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

Durant L, Watford WT, Ramos HL, Laurence A, Vahedi G, Wei L, Takahashi H, Sun HW, Kanno Y, Powrie F, O'Shea JJ.

Immunity. 2010 May 28;32(5):605-15. doi: 10.1016/j.immuni.2010.05.003. Epub 2010 May 20.


Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice.

Watford WT, Wang CC, Tsatsanis C, Mielke LA, Eliopoulos AG, Daskalakis C, Charles N, Odom S, Rivera J, O'Shea J, Tsichlis PN.

J Immunol. 2010 Jan 1;184(1):105-13. doi: 10.4049/jimmunol.0803730. Epub 2009 Dec 2.


Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.

Mielke LA, Elkins KL, Wei L, Starr R, Tsichlis PN, O'Shea JJ, Watford WT.

J Immunol. 2009 Dec 15;183(12):7984-93. doi: 10.4049/jimmunol.0901336.


Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle DL, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM.

Immunity. 2009 Jun 19;30(6):875-87. doi: 10.1016/j.immuni.2009.05.005. Epub 2009 Jun 4.


Signal transduction and Th17 cell differentiation.

O'Shea JJ, Steward-Tharp SM, Laurence A, Watford WT, Wei L, Adamson AS, Fan S.

Microbes Infect. 2009 Apr;11(5):599-611. doi: 10.1016/j.micinf.2009.04.007. Epub 2009 Apr 18. Review.


Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation.

Charles N, Watford WT, Ramos HL, Hellman L, Oettgen HC, Gomez G, Ryan JJ, O'Shea JJ, Rivera J.

Immunity. 2009 Apr 17;30(4):533-43. doi: 10.1016/j.immuni.2009.02.008. Epub 2009 Apr 9.


Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells.

Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh TY, Watford WT, Schones DE, Peng W, Sun HW, Paul WE, O'Shea JJ, Zhao K.

Immunity. 2009 Jan 16;30(1):155-67. doi: 10.1016/j.immuni.2008.12.009.


Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22.

Takatori H, Kanno Y, Watford WT, Tato CM, Weiss G, Ivanov II, Littman DR, O'Shea JJ.

J Exp Med. 2009 Jan 16;206(1):35-41. doi: 10.1084/jem.20072713. Epub 2008 Dec 29.


Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii.

Watford WT, Hissong BD, Durant LR, Yamane H, Muul LM, Kanno Y, Tato CM, Ramos HL, Berger AE, Mielke L, Pesu M, Solomon B, Frucht DM, Paul WE, Sher A, Jankovic D, Tsichlis PN, O'Shea JJ.

J Exp Med. 2008 Nov 24;205(12):2803-12. doi: 10.1084/jem.20081461. Epub 2008 Nov 10.


The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death.

Feng CG, Zheng L, Jankovic D, Báfica A, Cannons JL, Watford WT, Chaussabel D, Hieny S, Caspar P, Schwartzberg PL, Lenardo MJ, Sher A.

Nat Immunol. 2008 Nov;9(11):1279-87. doi: 10.1038/ni.1653. Epub 2008 Sep 21.


T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.

Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ.

Nature. 2008 Sep 11;455(7210):246-50. doi: 10.1038/nature07210.


Interleukin-22: a sheep in wolf's clothing.

Laurence A, O'Shea JJ, Watford WT.

Nat Med. 2008 Mar;14(3):247-9. doi: 10.1038/nm0308-247. No abstract available.


IFN-gamma mediates the death of Th1 cells in a paracrine manner.

Foulds KE, Rotte MJ, Paley MA, Singh B, Douek DC, Hill BJ, O'Shea JJ, Watford WT, Seder RA, Wu CY.

J Immunol. 2008 Jan 15;180(2):842-9.


STAT5 isoforms: controversies and clarifications.

Ramos HL, O'Shea JJ, Watford WT.

Biochem J. 2007 May 15;404(1):e1-2.


Nonredundant roles for Stat5a/b in directly regulating Foxp3.

Yao Z, Kanno Y, Kerenyi M, Stephens G, Durant L, Watford WT, Laurence A, Robinson GW, Shevach EM, Moriggl R, Hennighausen L, Wu C, O'Shea JJ.

Blood. 2007 May 15;109(10):4368-75. Epub 2007 Jan 16.


Human tyk2 kinase deficiency: another primary immunodeficiency syndrome.

Watford WT, O'Shea JJ.

Immunity. 2006 Nov;25(5):695-7. Review.


Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation.

Watford WT, Li D, Agnello D, Durant L, Yamaoka K, Yao ZJ, Ahn HJ, Cheng TP, Hofmann SR, Cogliati T, Chen A, Hissong BD, Husa MR, Schwartzberg P, O'Shea JJ, Gadina M.

Mol Cell Biol. 2006 Sep;26(17):6623-32.


Stat5a/b are essential for normal lymphoid development and differentiation.

Yao Z, Cui Y, Watford WT, Bream JH, Yamaoka K, Hissong BD, Li D, Durum SK, Jiang Q, Bhandoola A, Hennighausen L, O'Shea JJ.

Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1000-5. Epub 2006 Jan 17.


Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.

Watford WT, Hissong BD, Bream JH, Kanno Y, Muul L, O'Shea JJ.

Immunol Rev. 2004 Dec;202:139-56. Review.


The biology of IL-12: coordinating innate and adaptive immune responses.

Watford WT, Moriguchi M, Morinobu A, O'Shea JJ.

Cytokine Growth Factor Rev. 2003 Oct;14(5):361-8. Review.


Autoimmunity: A case of mistaken identity.

Watford WT, O'Shea JJ.

Nature. 2003 Feb 13;421(6924):706-8. No abstract available.


De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.

Aksentijevich I, Nowak M, Mallah M, Chae JJ, Watford WT, Hofmann SR, Stein L, Russo R, Goldsmith D, Dent P, Rosenberg HF, Austin F, Remmers EF, Balow JE Jr, Rosenzweig S, Komarow H, Shoham NG, Wood G, Jones J, Mangra N, Carrero H, Adams BS, Moore TL, Schikler K, Hoffman H, Lovell DJ, Lipnick R, Barron K, O'Shea JJ, Kastner DL, Goldbach-Mansky R.

Arthritis Rheum. 2002 Dec;46(12):3340-8.


Surfactant protein A enhances the phagocytosis of C1q-coated particles by alveolar macrophages.

Watford WT, Smithers MB, Frank MM, Wright JR.

Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L1011-22.


Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection.

Nguyen KB, Watford WT, Salomon R, Hofmann SR, Pien GC, Morinobu A, Gadina M, O'Shea JJ, Biron CA.

Science. 2002 Sep 20;297(5589):2063-6.


Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity.

Tang P, Cheng TP, Agnello D, Wu CY, Hissong BD, Watford WT, Ahn HJ, Galon J, Moss J, Vaughan M, O'Shea JJ, Gadina M.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2625-9. Epub 2002 Feb 26.


Surfactant protein A regulates complement activation.

Watford WT, Wright JR, Hester CG, Jiang H, Frank MM.

J Immunol. 2001 Dec 1;167(11):6593-600.


Complement-mediated host defense in the lung.

Watford WT, Ghio AJ, Wright JR.

Am J Physiol Lung Cell Mol Physiol. 2000 Nov;279(5):L790-8.


Surfactant protein-A binds group B streptococcus enhancing phagocytosis and clearance from lungs of surfactant protein-A-deficient mice.

LeVine AM, Kurak KE, Wright JR, Watford WT, Bruno MD, Ross GF, Whitsett JA, Korfhagen TR.

Am J Respir Cell Mol Biol. 1999 Feb;20(2):279-86.


Supplemental Content

Loading ...
Support Center