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LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells.

Morgan RG, Ridsdale J, Payne M, Heesom KJ, Wilson MC, Davidson A, Greenhough A, Davies S, Williams AC, Blair A, Waterman ML, Tonks A, Darley RL.

Haematologica. 2019 Jul;104(7):1365-1377. doi: 10.3324/haematol.2018.202846. Epub 2019 Jan 10.


TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency.

Sierra RA, Hoverter NP, Ramirez RN, Vuong LM, Mortazavi A, Merrill BJ, Waterman ML, Donovan PJ.

Development. 2018 Feb 23;145(4). pii: dev161075. doi: 10.1242/dev.161075.


Inhibition of nuclear Wnt signalling: challenges of an elusive target for cancer therapy.

Lyou Y, Habowski AN, Chen GT, Waterman ML.

Br J Pharmacol. 2017 Dec;174(24):4589-4599. doi: 10.1111/bph.13963. Epub 2017 Aug 24. Review.


Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer.

Lee M, Chen GT, Puttock E, Wang K, Edwards RA, Waterman ML, Lowengrub J.

Mol Syst Biol. 2017 Feb 9;13(2):912. doi: 10.15252/msb.20167386.


Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer.

Sprowl-Tanio S, Habowski AN, Pate KT, McQuade MM, Wang K, Edwards RA, Grun F, Lyou Y, Waterman ML.

Cancer Metab. 2016 Oct 3;4:20. eCollection 2016.


Cancer: leaping the E-cadherin hurdle.

Chen GT, Waterman ML.

EMBO J. 2015 Sep 14;34(18):2307-9. doi: 10.15252/embj.201592757. Epub 2015 Aug 17. No abstract available.


Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells.

Vuong LM, Chellappa K, Dhahbi JM, Deans JR, Fang B, Bolotin E, Titova NV, Hoverter NP, Spindler SR, Waterman ML, Sladek FM.

Mol Cell Biol. 2015 Oct;35(20):3471-90. doi: 10.1128/MCB.00030-15. Epub 2015 Aug 3.


The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition.

Hoverter NP, Zeller MD, McQuade MM, Garibaldi A, Busch A, Selwan EM, Hertel KJ, Baldi P, Waterman ML.

Nucleic Acids Res. 2014 Dec 16;42(22):13615-32. doi: 10.1093/nar/gku1186. Epub 2014 Nov 20.


A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1.

Tsai BP, Jimenez J, Lim S, Fitzgerald KD, Zhang M, Chuah CT, Axelrod H, Wilson L, Ong ST, Semler BL, Waterman ML.

Open Biol. 2014 Nov;4(11):140180. doi: 10.1098/rsob.140180.


Predicting mechanism of biphasic growth factor action on tumor growth using a multi-species model with feedback control.

Konstorum A, Sprowl SA, Waterman ML, Lander AD, Lowengrub JS.

J Coupled Syst Multiscale Dyn. 2013 Dec 1;1(4):459-467.


Disulfide bond requirements for active Wnt ligands.

MacDonald BT, Hien A, Zhang X, Iranloye O, Virshup DM, Waterman ML, He X.

J Biol Chem. 2014 Jun 27;289(26):18122-36. doi: 10.1074/jbc.M114.575027. Epub 2014 May 19.


Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer.

Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML.

EMBO J. 2014 Jul 1;33(13):1454-73. doi: 10.15252/embj.201488598. Epub 2014 May 13.


A three-dimensional in vitro model of tumor cell intravasation.

Ehsan SM, Welch-Reardon KM, Waterman ML, Hughes CC, George SC.

Integr Biol (Camb). 2014 Jun;6(6):603-10. doi: 10.1039/c3ib40170g.


Molecular functions of the TLE tetramerization domain in Wnt target gene repression.

Chodaparambil JV, Pate KT, Hepler MR, Tsai BP, Muthurajan UM, Luger K, Waterman ML, Weis WI.

EMBO J. 2014 Apr 1;33(7):719-31. doi: 10.1002/embj.201387188. Epub 2014 Mar 3.


Physiological β-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma.

Cheng Y, Cheung AK, Ko JM, Phoon YP, Chiu PM, Lo PH, Waterman ML, Lung ML.

BMC Cell Biol. 2013 Sep 27;14:44. doi: 10.1186/1471-2121-14-44.


Past visits present: TCF/LEFs partner with ATFs for β-catenin-independent activity.

Sprowl S, Waterman ML.

PLoS Genet. 2013;9(8):e1003745. doi: 10.1371/journal.pgen.1003745. Epub 2013 Aug 15. No abstract available.


Ring Finger Protein 14 is a new regulator of TCF/β-catenin-mediated transcription and colon cancer cell survival.

Wu B, Piloto S, Zeng W, Hoverter NP, Schilling TF, Waterman ML.

EMBO Rep. 2013 Apr;14(4):347-55. doi: 10.1038/embor.2013.19. Epub 2013 Mar 1.


Blending hippo and WNT: sharing messengers and regulation.

Tsai BP, Hoverter NP, Waterman ML.

Cell. 2012 Dec 21;151(7):1401-3. doi: 10.1016/j.cell.2012.12.007.


TCF/LEFs and Wnt signaling in the nucleus.

Cadigan KM, Waterman ML.

Cold Spring Harb Perspect Biol. 2012 Nov 1;4(11). pii: a007906. doi: 10.1101/cshperspect.a007906. Review.


Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH.

Stringari C, Edwards RA, Pate KT, Waterman ML, Donovan PJ, Gratton E.

Sci Rep. 2012;2:568. doi: 10.1038/srep00568. Epub 2012 Aug 10.


A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities.

Najdi R, Proffitt K, Sprowl S, Kaur S, Yu J, Covey TM, Virshup DM, Waterman ML.

Differentiation. 2012 Sep;84(2):203-13. doi: 10.1016/j.diff.2012.06.004. Epub 2012 Jul 9.


A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs.

Hoverter NP, Ting JH, Sundaresh S, Baldi P, Waterman ML.

Mol Cell Biol. 2012 Sep;32(18):3648-62. doi: 10.1128/MCB.06769-11. Epub 2012 Jul 9.


Wnt signaling and colon carcinogenesis: beyond APC.

Najdi R, Holcombe RF, Waterman ML.

J Carcinog. 2011 Mar 17;10:5. doi: 10.4103/1477-3163.78111.


Quantitative profiling of in vivo-assembled RNA-protein complexes using a novel integrated proteomic approach.

Tsai BP, Wang X, Huang L, Waterman ML.

Mol Cell Proteomics. 2011 Apr;10(4):M110.007385. doi: 10.1074/mcp.M110.007385. Epub 2011 Feb 1. Erratum in: Mol Cell Proteomics. 2011 Sep;10(9) doi:10.1074/mcp.A110.007385.


A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer.

Yokoyama NN, Pate KT, Sprowl S, Waterman ML.

Nucleic Acids Res. 2010 Oct;38(19):6375-88. doi: 10.1093/nar/gkq492. Epub 2010 Jun 4.


Microdevice to capture colon crypts for in vitro studies.

Wang Y, Dhopeshwarkar R, Najdi R, Waterman ML, Sims CE, Allbritton N.

Lab Chip. 2010 Jun 21;10(12):1596-603. doi: 10.1039/b927316f. Epub 2010 Apr 7.


NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer.

Sikandar SS, Pate KT, Anderson S, Dizon D, Edwards RA, Waterman ML, Lipkin SM.

Cancer Res. 2010 Feb 15;70(4):1469-78. doi: 10.1158/0008-5472.CAN-09-2557. Epub 2010 Feb 9.


Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2.

Crampton SP, Wu B, Park EJ, Kim JH, Solomon C, Waterman ML, Hughes CC.

PLoS One. 2009 Nov 16;4(11):e7841. doi: 10.1371/journal.pone.0007841.


A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer.

Najdi R, Syed A, Arce L, Theisen H, Ting JH, Atcha F, Nguyen AV, Martinez M, Holcombe RF, Edwards RA, Marsh JL, Waterman ML.

Oncogene. 2009 Nov 26;28(47):4133-46. doi: 10.1038/onc.2009.271. Epub 2009 Sep 14.


T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma.

Yu Q, Sharma A, Oh SY, Moon HG, Hossain MZ, Salay TM, Leeds KE, Du H, Wu B, Waterman ML, Zhu Z, Sen JM.

Nat Immunol. 2009 Sep;10(9):992-9. doi: 10.1038/ni.1762. Epub 2009 Aug 2.


Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling.

Ciznadija D, Tothill R, Waterman ML, Zhao L, Huynh D, Yu RM, Ernst M, Ishii S, Mantamadiotis T, Gonda TJ, Ramsay RG, Malaterre J.

Cell Death Differ. 2009 Nov;16(11):1530-8. doi: 10.1038/cdd.2009.94. Epub 2009 Jul 17.


Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression.

Arce L, Pate KT, Waterman ML.

BMC Cancer. 2009 May 21;9:159. doi: 10.1186/1471-2407-9-159.


A Wnt-fall for gene regulation: repression.

Hoverter NP, Waterman ML.

Sci Signal. 2008 Sep 30;1(39):pe43. doi: 10.1126/scisignal.139pe43.


IRES-mediated pathways to polysomes: nuclear versus cytoplasmic routes.

Semler BL, Waterman ML.

Trends Microbiol. 2008 Jan;16(1):1-5.


hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of beta-catenin.

Yang M, Waterman ML, Brachmann RK.

Cancer Biol Ther. 2008 Jan;7(1):120-8. Epub 2007 Oct 19.


A unique DNA binding domain converts T-cell factors into strong Wnt effectors.

Atcha FA, Syed A, Wu B, Hoverter NP, Yokoyama NN, Ting JH, Munguia JE, Mangalam HJ, Marsh JL, Waterman ML.

Mol Cell Biol. 2007 Dec;27(23):8352-63. Epub 2007 Sep 24.


Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2.

Li B, Rhéaume C, Teng A, Bilanchone V, Munguia JE, Hu M, Jessen S, Piccolo S, Waterman ML, Dai X.

Genesis. 2007 May;45(5):318-25.


Wingless directly represses DPP morphogen expression via an armadillo/TCF/Brinker complex.

Theisen H, Syed A, Nguyen BT, Lukacsovich T, Purcell J, Srivastava GP, Iron D, Gaudenz K, Nie Q, Wan FY, Waterman ML, Marsh JL.

PLoS One. 2007 Jan 3;2(1):e142.


Diversity of LEF/TCF action in development and disease.

Arce L, Yokoyama NN, Waterman ML.

Oncogene. 2006 Dec 4;25(57):7492-504. Review.


Expression of lymphoid enhancer factor/T-cell factor proteins in colon cancer.

Waterman ML.

Curr Opin Gastroenterol. 2002 Jan;18(1):53-9.


Wnt activation and alternative promoter repression of LEF1 in colon cancer.

Li TW, Ting JH, Yokoyama NN, Bernstein A, van de Wetering M, Waterman ML.

Mol Cell Biol. 2006 Jul;26(14):5284-99.


An internal ribosome entry site mediates translation of lymphoid enhancer factor-1.

Jimenez J, Jang GM, Semler BL, Waterman ML.

RNA. 2005 Sep;11(9):1385-99.


Lymphoid enhancer factor/T cell factor expression in colorectal cancer.

Waterman ML.

Cancer Metastasis Rev. 2004 Jan-Jun;23(1-2):41-52. Review.


A new beta-catenin-dependent activation domain in T cell factor.

Atcha FA, Munguia JE, Li TW, Hovanes K, Waterman ML.

J Biol Chem. 2003 May 2;278(18):16169-75. Epub 2003 Feb 11.


Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma.

Holcombe RF, Marsh JL, Waterman ML, Lin F, Milovanovic T, Truong T.

Mol Pathol. 2002 Aug;55(4):220-6.


The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation.

Li B, Mackay DR, Dai Q, Li TW, Nair M, Fallahi M, Schonbaum CP, Fantes J, Mahowald AP, Waterman ML, Fuchs E, Dai X.

Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6064-9.


Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer.

Hovanes K, Li TW, Munguia JE, Truong T, Milovanovic T, Lawrence Marsh J, Holcombe RF, Waterman ML.

Nat Genet. 2001 May;28(1):53-7.


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