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Items: 1 to 50 of 65

1.

Human peripheral blood DNAM-1neg NK cells are a terminally differentiated subset with limited effector functions.

Stannard KA, Lemoine S, Waterhouse NJ, Vari F, Chatenoud L, Gandhi MK, Martinet L, Smyth MJ, Guillerey C.

Blood Adv. 2019 Jun 11;3(11):1681-1694. doi: 10.1182/bloodadvances.2018030676.

2.

Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells.

Peters AA, Jamaludin SYN, Yapa KTDS, Chalmers S, Wiegmans AP, Lim HF, Milevskiy MJG, Azimi I, Davis FM, Northwood KS, Pera E, Marcial DL, Dray E, Waterhouse NJ, Cabot PJ, Gonda TJ, Kenny PA, Brown MA, Khanna KK, Roberts-Thomson SJ, Monteith GR.

Oncogene. 2017 Nov 16;36(46):6490-6500. doi: 10.1038/onc.2017.234. Epub 2017 Jul 31.

PMID:
28759041
3.

Dead Cert: Measuring Cell Death.

Crowley LC, Marfell BJ, Scott AP, Boughaba JA, Chojnowski G, Christensen ME, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Dec 1;2016(12). doi: 10.1101/pdb.top070318.

PMID:
27934691
4.

Measuring Mitochondrial Transmembrane Potential by TMRE Staining.

Crowley LC, Christensen ME, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Dec 1;2016(12). doi: 10.1101/pdb.prot087361.

PMID:
27934682
5.

Analysis of Cytochrome c Release by Immunocytochemistry.

Crowley LC, Marfell BJ, Scott AP, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Dec 1;2016(12). doi: 10.1101/pdb.prot087338.

PMID:
27934681
6.

Detecting Cleaved Caspase-3 in Apoptotic Cells by Flow Cytometry.

Crowley LC, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Nov 1;2016(11). doi: 10.1101/pdb.prot087312.

PMID:
27803251
7.

Quantitation of Apoptosis and Necrosis by Annexin V Binding, Propidium Iodide Uptake, and Flow Cytometry.

Crowley LC, Marfell BJ, Scott AP, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Nov 1;2016(11). doi: 10.1101/pdb.prot087288.

PMID:
27803250
8.

Measuring the DNA Content of Cells in Apoptosis and at Different Cell-Cycle Stages by Propidium Iodide Staining and Flow Cytometry.

Crowley LC, Chojnowski G, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Oct 3;2016(10). doi: 10.1101/pdb.prot087247.

PMID:
27698234
9.

Detection of DNA Fragmentation in Apoptotic Cells by TUNEL.

Crowley LC, Marfell BJ, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Oct 3;2016(10). doi: 10.1101/pdb.prot087221.

PMID:
27698233
10.

Analyzing Cell Death by Nuclear Staining with Hoechst 33342.

Crowley LC, Marfell BJ, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.prot087205.

PMID:
27587774
11.

Morphological Analysis of Cell Death by Cytospinning Followed by Rapid Staining.

Crowley LC, Marfell BJ, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.prot087197.

PMID:
27587773
12.

Measuring Survival of Hematopoietic Cancer Cells with the Colony-Forming Assay in Soft Agar.

Crowley LC, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Aug 1;2016(8). doi: 10.1101/pdb.prot087189.

PMID:
27480718
13.

Measuring Survival of Adherent Cells with the Colony-Forming Assay.

Crowley LC, Christensen ME, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Aug 1;2016(8). doi: 10.1101/pdb.prot087171.

PMID:
27480717
14.

Measuring Cell Death by Propidium Iodide Uptake and Flow Cytometry.

Crowley LC, Scott AP, Marfell BJ, Boughaba JA, Chojnowski G, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Jul 1;2016(7). doi: 10.1101/pdb.prot087163.

PMID:
27371595
15.

Measuring Cell Death by Trypan Blue Uptake and Light Microscopy.

Crowley LC, Marfell BJ, Christensen ME, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Jul 1;2016(7). doi: 10.1101/pdb.prot087155.

PMID:
27371594
16.

Triggering Death of Adherent Cells with Ultraviolet Radiation.

Crowley LC, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Jul 1;2016(7). doi: 10.1101/pdb.prot087148.

PMID:
27371593
17.

Triggering Apoptosis in Hematopoietic Cells with Cytotoxic Drugs.

Crowley LC, Marfell BJ, Scott AP, Waterhouse NJ.

Cold Spring Harb Protoc. 2016 Jul 1;2016(7). doi: 10.1101/pdb.prot087130.

PMID:
27371592
18.

A phase I clinical trial of CD1c (BDCA-1)+ dendritic cells pulsed with HLA-A*0201 peptides for immunotherapy of metastatic hormone refractory prostate cancer.

Prue RL, Vari F, Radford KJ, Tong H, Hardy MY, D'Rozario R, Waterhouse NJ, Rossetti T, Coleman R, Tracey C, Goossen H, Gounder V, Crosbie G, Hancock S, Diaz-Guilas S, Mainwaring P, Swindle P, Hart DN.

J Immunother. 2015 Feb-Mar;38(2):71-6. doi: 10.1097/CJI.0000000000000063.

PMID:
25658616
19.

The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress.

Bird CH, Christensen ME, Mangan MS, Prakash MD, Sedelies KA, Smyth MJ, Harper I, Waterhouse NJ, Bird PI.

Cell Death Differ. 2014 Jun;21(6):876-87. doi: 10.1038/cdd.2014.7. Epub 2014 Jan 31.

20.

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis.

Susanto O, Stewart SE, Voskoboinik I, Brasacchio D, Hagn M, Ellis S, Asquith S, Sedelies KA, Bird PI, Waterhouse NJ, Trapani JA.

Cell Death Differ. 2013 Sep;20(9):1183-93. doi: 10.1038/cdd.2013.59. Epub 2013 Jun 7.

21.

Flow cytometry based assays for the measurement of apoptosis-associated mitochondrial membrane depolarisation and cytochrome c release.

Christensen ME, Jansen ES, Sanchez W, Waterhouse NJ.

Methods. 2013 Jun 1;61(2):138-45. doi: 10.1016/j.ymeth.2013.03.020. Epub 2013 Mar 30. Review.

PMID:
23545197
22.

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737.

Sutton VR, Sedelies K, Dewson G, Christensen ME, Bird PI, Johnstone RW, Kluck RM, Trapani JA, Waterhouse NJ.

Cell Death Dis. 2012 Jul 5;3:e344. doi: 10.1038/cddis.2012.73.

23.

Cell death research, on an island girt by sea.

Christensen ME, Wong WW, Waibel M, Johnstone RW, Waterhouse NJ.

Cell Death Differ. 2012 Jun;19(6):1090-1. doi: 10.1038/cdd.2012.32. Epub 2012 Mar 16. No abstract available.

24.

The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2.

Adams MN, Christensen ME, He Y, Waterhouse NJ, Hooper JD.

PLoS One. 2011;6(11):e28018. doi: 10.1371/journal.pone.0028018. Epub 2011 Nov 29.

25.

Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734.

Wortmann A, He Y, Christensen ME, Linn M, Lumley JW, Pollock PM, Waterhouse NJ, Hooper JD.

J Biol Chem. 2011 Dec 9;286(49):42303-15. doi: 10.1074/jbc.M111.227462. Epub 2011 Oct 12.

26.

Environmental conditions are important for establishing and evaluating pre-clinical models of GVHD.

Christensen ME, Sinfield LJ, Cullup H, Waterhouse NJ, Atkinson K, Rice AM.

Bone Marrow Transplant. 2012 Apr;47(4):607-9. doi: 10.1038/bmt.2011.128. Epub 2011 Jun 27. No abstract available.

PMID:
21706062
27.

Mesenchymal stromal cells transiently alter the inflammatory milieu post-transplant to delay graft-versus-host disease.

Christensen ME, Turner BE, Sinfield LJ, Kollar K, Cullup H, Waterhouse NJ, Hart DN, Atkinson K, Rice AM.

Haematologica. 2010 Dec;95(12):2102-10. doi: 10.3324/haematol.2010.028910. Epub 2010 Aug 26.

28.

Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms.

Oliaro J, Van Ham V, Sacirbegovic F, Pasam A, Bomzon Z, Pham K, Ludford-Menting MJ, Waterhouse NJ, Bots M, Hawkins ED, Watt SV, Cluse LA, Clarke CJ, Izon DJ, Chang JT, Thompson N, Gu M, Johnstone RW, Smyth MJ, Humbert PO, Reiner SL, Russell SM.

J Immunol. 2010 Jul 1;185(1):367-75. doi: 10.4049/jimmunol.0903627. Epub 2010 Jun 7.

29.

Mechanisms of CTL cytotoxicity. A reactive response to granzyme B.

Christensen ME, Waterhouse NJ.

Immunol Cell Biol. 2010 Jul;88(5):500-1. doi: 10.1038/icb.2010.23. Epub 2010 Mar 16. No abstract available.

PMID:
20231855
30.

Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing.

Jenkins MR, La Gruta NL, Doherty PC, Trapani JA, Turner SJ, Waterhouse NJ.

Cell Death Differ. 2009 Apr;16(4):537-42. doi: 10.1038/cdd.2008.176. Epub 2009 Jan 9.

31.

Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules.

Sutton VR, Waterhouse NJ, Baran K, Browne K, Voskoboinik I, Trapani JA.

Methods. 2008 Mar;44(3):241-9. doi: 10.1016/j.ymeth.2007.11.011. Review.

PMID:
18314055
32.

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.

Sedelies KA, Ciccone A, Clarke CJ, Oliaro J, Sutton VR, Scott FL, Silke J, Susanto O, Green DR, Johnstone RW, Bird PI, Trapani JA, Waterhouse NJ.

Cell Death Differ. 2008 Apr;15(4):708-17. doi: 10.1038/sj.cdd.4402300. Epub 2008 Jan 18.

33.

H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells.

Waterhouse NJ, Trapani JA.

Trends Immunol. 2007 Sep;28(9):373-5. Epub 2007 Sep 4. Review.

PMID:
17766182
34.

GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation.

Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, Fitzgerald P, Guio-Carrion A, Waterhouse NJ, Li CW, Mari B, Barbry P, Newmeyer DD, Beere HM, Green DR.

Cell. 2007 Jun 1;129(5):983-97. Erratum in: Cell. 2007 Jul 27;130(2):385.

35.

Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis.

Sutton VR, Waterhouse NJ, Browne KA, Sedelies K, Ciccone A, Anthony D, Koskinen A, Mullbacher A, Trapani JA.

J Cell Biol. 2007 Feb 12;176(4):425-33. Epub 2007 Feb 5.

36.

Calreticulin: raising awareness of apoptosis.

Waterhouse NJ, Pinkoski MJ.

Apoptosis. 2007 Apr;12(4):631-4. No abstract available.

PMID:
17278002
37.

Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation.

Oliaro J, Pasam A, Waterhouse NJ, Browne KA, Ludford-Menting MJ, Trapani JA, Russell SM.

Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18685-90. Epub 2006 Nov 20.

38.

A 'polarized' look at alpha-tubulin cleavage by granzyme B.

Waterhouse NJ, Oliaro J, Pinkoski MJ.

Cell Death Differ. 2006 Nov;13(11):1839-41. Epub 2006 Aug 18. No abstract available.

39.

Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.

Waterhouse NJ, Sutton VR, Sedelies KA, Ciccone A, Jenkins M, Turner SJ, Bird PI, Trapani JA.

J Cell Biol. 2006 Apr 10;173(1):133-44.

40.

Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis.

Waterhouse NJ, Sedelies KA, Trapani JA.

Immunol Cell Biol. 2006 Feb;84(1):72-8. Review.

PMID:
16405654
41.

Mitochondria, apoptosis and autoimmunity.

Pinkoski MJ, Waterhouse NJ, Green DR.

Curr Dir Autoimmun. 2006;9:55-73. Review.

PMID:
16394655
42.

Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis.

Waterhouse NJ, Sedelies KA, Sutton VR, Pinkoski MJ, Thia KY, Johnstone R, Bird PI, Green DR, Trapani JA.

Cell Death Differ. 2006 Apr;13(4):607-18.

43.

A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation.

Ludford-Menting MJ, Oliaro J, Sacirbegovic F, Cheah ET, Pedersen N, Thomas SJ, Pasam A, Iazzolino R, Dow LE, Waterhouse NJ, Murphy A, Ellis S, Smyth MJ, Kershaw MH, Darcy PK, Humbert PO, Russell SM.

Immunity. 2005 Jun;22(6):737-48.

44.

A central role for Bid in granzyme B-induced apoptosis.

Waterhouse NJ, Sedelies KA, Browne KA, Wowk ME, Newbold A, Sutton VR, Clarke CJ, Oliaro J, Lindemann RK, Bird PI, Johnstone RW, Trapani JA.

J Biol Chem. 2005 Feb 11;280(6):4476-82. Epub 2004 Dec 1.

45.

Granzyme B; the chalk-mark of a cytotoxic lymphocyte.

Waterhouse NJ, Sedelies KA, Clarke CJ.

J Transl Med. 2004 Oct 25;2(1):36.

46.

Cytotoxic lymphocytes; instigators of dramatic target cell death.

Waterhouse NJ, Clarke CJ, Sedelies KA, Teng MW, Trapani JA.

Biochem Pharmacol. 2004 Sep 15;68(6):1033-40. Review.

PMID:
15313398
47.

Assaying cytochrome C translocation during apoptosis.

Waterhouse NJ, Steel R, Kluck R, Trapani JA.

Methods Mol Biol. 2004;284:307-13.

PMID:
15173625
48.

Granzyme M mediates a novel form of perforin-dependent cell death.

Kelly JM, Waterhouse NJ, Cretney E, Browne KA, Ellis S, Trapani JA, Smyth MJ.

J Biol Chem. 2004 May 21;279(21):22236-42. Epub 2004 Mar 17.

49.

Novel mechanisms of apoptosis induced by histone deacetylase inhibitors.

Peart MJ, Tainton KM, Ruefli AA, Dear AE, Sedelies KA, O'Reilly LA, Waterhouse NJ, Trapani JA, Johnstone RW.

Cancer Res. 2003 Aug 1;63(15):4460-71.

50.

Tumor cell-selective cytotoxicity by targeting cell cycle checkpoints.

Warrener R, Beamish H, Burgess A, Waterhouse NJ, Giles N, Fairlie D, Gabrielli B.

FASEB J. 2003 Aug;17(11):1550-2. Epub 2003 Jun 3.

PMID:
12824307

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