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The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses.

Sin JH, Zuckerman C, Cortez JT, Eckalbar WL, Erle DJ, Anderson MS, Waterfield MR.

J Exp Med. 2019 Sep 2;216(9):2024-2037. doi: 10.1084/jem.20182316. Epub 2019 Jun 19.


Analysis of pulmonary features and treatment approaches in the COPA syndrome.

Tsui JL, Estrada OA, Deng Z, Wang KM, Law CS, Elicker BM, Jones KD, Dell SD, Gudmundsson G, Hansdottir S, Helfgott SM, Volpi S, Gattorno M, Waterfield MR, Chan AY, Chung SA, Ley B, Shum AK.

ERJ Open Res. 2018 Jun 27;4(2). pii: 00017-2018. doi: 10.1183/23120541.00017-2018. eCollection 2018 Apr.


Identification of a novel cis-regulatory element essential for immune tolerance.

LaFlam TN, Seumois G, Miller CN, Lwin W, Fasano KJ, Waterfield M, Proekt I, Vijayanand P, Anderson MS.

J Exp Med. 2015 Nov 16;212(12):1993-2002. doi: 10.1084/jem.20151069. Epub 2015 Nov 2.


COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.

Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C; Baylor-Hopkins Center for Mendelian Genomics, Boerwinkle E, Eissa NT, Gibbs RA, Lupski JR, Orange JS, Shum AK.

Nat Genet. 2015 Jun;47(6):654-60. doi: 10.1038/ng.3279. Epub 2015 Apr 20.


Prevention of postpartum stress incontinence in primigravidae with increased bladder neck mobility: a randomised controlled trial of antenatal pelvic floor exercises.

Reilly ET, Freeman RM, Waterfield MR, Waterfield AE, Steggles P, Pedlar F.

BJOG. 2014 Dec;121 Suppl 7:58-66. doi: 10.1111/1471-0528.13213.


The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.

Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS.

Nat Immunol. 2014 Mar;15(3):258-65. doi: 10.1038/ni.2820. Epub 2014 Jan 26. Erratum in: Nat Immunol. 2014 Sep;15(9):894.


A randomised controlled trial of abdominal versus laparoscopic sacrocolpopexy for the treatment of post-hysterectomy vaginal vault prolapse: LAS study. Reply to comment.

Freeman RM, Pantazis K, Thomson A, Frappell J, Bombieri L, Moran P, Slack M, Scott P, Waterfield M.

Int Urogynecol J. 2014 Mar;25(3):437-8. doi: 10.1007/s00192-013-2305-6. No abstract available.


Is anatomical failure following anterior vaginal repair associated with weak native vaginal tissues? A biomechanical and immunohistochemical study.

Khaja A, Winlove P, Waterfield M, Oriolowo A, Adekanmi OA, Freeman RM.

Int Urogynecol J. 2014 Feb;25(2):181-7. doi: 10.1007/s00192-013-2237-1. Epub 2013 Oct 15.


Is rheumatoid factor useful in primary care? A retrospective cross-sectional study.

Miller A, Mahtani KR, Waterfield MA, Timms A, Misbah SA, Luqmani RA.

Clin Rheumatol. 2013 Jul;32(7):1089-93. doi: 10.1007/s10067-013-2236-0. Epub 2013 Mar 21.


Functional proteomic analysis of long-term growth factor stimulation and receptor tyrosine kinase coactivation in Swiss 3T3 fibroblasts.

Nagano K, Akpan A, Warnasuriya G, Corless S, Totty N, Yang A, Stein R, Zvelebil M, Stensballe A, Burlingame A, Waterfield M, Cramer R, Timms JF, Naaby-Hansen S.

Mol Cell Proteomics. 2012 Dec;11(12):1690-708. doi: 10.1074/mcp.M112.019778. Epub 2012 Sep 6.


A randomised controlled trial of abdominal versus laparoscopic sacrocolpopexy for the treatment of post-hysterectomy vaginal vault prolapse: LAS study.

Freeman RM, Pantazis K, Thomson A, Frappell J, Bombieri L, Moran P, Slack M, Scott P, Waterfield M.

Int Urogynecol J. 2013 Mar;24(3):377-84. doi: 10.1007/s00192-012-1885-x. Epub 2012 Aug 3.


Targeting PI3KC2β impairs proliferation and survival in acute leukemia, brain tumours and neuroendocrine tumours.

Boller D, Doepfner KT, De Laurentiis A, Guerreiro AS, Marinov M, Shalaby T, Depledge P, Robson A, Saghir N, Hayakawa M, Kaizawa H, Koizumi T, Ohishi T, Fattet S, Delattre O, Schweri-Olac A, Höland K, Grotzer MA, Frei K, Spertini O, Waterfield MD, Arcaro A.

Anticancer Res. 2012 Aug;32(8):3015-27.


Autoimmunity's collateral damage: Immunodeficiency hints at autoreactivity to cytokines.

Waterfield M, Anderson MS.

Nat Med. 2011 Sep 7;17(9):1054-5. doi: 10.1038/nm0911-1054. No abstract available.


Hands on or hands off the perineum: a survey of care of the perineum in labour (HOOPS).

Trochez R, Waterfield M, Freeman RM.

Int Urogynecol J. 2011 Oct;22(10):1279-85. doi: 10.1007/s00192-011-1454-8. Epub 2011 May 25.


Clues to immune tolerance: the monogenic autoimmune syndromes.

Waterfield M, Anderson MS.

Ann N Y Acad Sci. 2010 Dec;1214:138-55. doi: 10.1111/j.1749-6632.2010.05818.x. Epub 2010 Oct 22. Review.


Do the anatomical defects associated with cystocele affect the outcome of the anterior repair? A clinical and radiological study.

Adekanmi OA, Freeman RM, Jackson SA, Puckett M, Bombieri L, Waterfield MR.

Int Urogynecol J Pelvic Floor Dysfunct. 2009 Nov;20(11):1369-77. No abstract available.


Major role of epidermal growth factor receptor and Src kinases in promoting oxidative stress-dependent loss of adhesion and apoptosis in epithelial cells.

Chan HL, Chou HC, Duran M, Gruenewald J, Waterfield MD, Ridley A, Timms JF.

J Biol Chem. 2010 Feb 12;285(7):4307-18. doi: 10.1074/jbc.M109.047027. Epub 2009 Dec 7.


mTORbeta splicing isoform promotes cell proliferation and tumorigenesis.

Panasyuk G, Nemazanyy I, Zhyvoloup A, Filonenko V, Davies D, Robson M, Pedley RB, Waterfield M, Gout I.

J Biol Chem. 2009 Nov 6;284(45):30807-14. doi: 10.1074/jbc.M109.056085. Epub 2009 Sep 2.


The long-term effectiveness of antenatal pelvic floor muscle training: eight-year follow up of a randomised controlled trial.

Agur WI, Steggles P, Waterfield M, Freeman RM.

BJOG. 2008 Jul;115(8):985-90. doi: 10.1111/j.1471-0528.2008.01742.x.


Structural analysis of PI3-kinase isoforms: identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors.

Zvelebil MJ, Waterfield MD, Shuttleworth SJ.

Arch Biochem Biophys. 2008 Sep 15;477(2):404-10. doi: 10.1016/ Epub 2008 Jul 8.


Moderate weight loss in obese women with urinary incontinence: a prospective longitudinal study.

Auwad W, Steggles P, Bombieri L, Waterfield M, Wilkin T, Freeman R.

Int Urogynecol J Pelvic Floor Dysfunct. 2008 Sep;19(9):1251-9. doi: 10.1007/s00192-008-0616-9. Epub 2008 Apr 18.


A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.

Jefferies HB, Cooke FT, Jat P, Boucheron C, Koizumi T, Hayakawa M, Kaizawa H, Ohishi T, Workman P, Waterfield MD, Parker PJ.

EMBO Rep. 2008 Feb;9(2):164-70. doi: 10.1038/sj.embor.7401155. Epub 2008 Jan 11.


Serum peptide profiling using MALDI mass spectrometry: avoiding the pitfalls of coated magnetic beads using well-established ZipTip technology.

Tiss A, Smith C, Camuzeaux S, Kabir M, Gayther S, Menon U, Waterfield M, Timms J, Jacobs I, Cramer R.

Proteomics. 2007 Sep;7 Suppl 1:77-89. Review.


Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.

Hayakawa M, Kawaguchi K, Kaizawa H, Koizumi T, Ohishi T, Yamano M, Okada M, Ohta M, Tsukamoto S, Raynaud FI, Parker P, Workman P, Waterfield MD.

Bioorg Med Chem. 2007 Sep 1;15(17):5837-44. Epub 2007 Jun 6.


Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

Raynaud FI, Eccles S, Clarke PA, Hayes A, Nutley B, Alix S, Henley A, Di-Stefano F, Ahmad Z, Guillard S, Bjerke LM, Kelland L, Valenti M, Patterson L, Gowan S, de Haven Brandon A, Hayakawa M, Kaizawa H, Koizumi T, Ohishi T, Patel S, Saghir N, Parker P, Waterfield M, Workman P.

Cancer Res. 2007 Jun 15;67(12):5840-50.


Does antenatal pelvic floor muscle training affect the outcome of labour? A randomised controlled trial.

Agur W, Steggles P, Waterfield M, Freeman R.

Int Urogynecol J Pelvic Floor Dysfunct. 2008 Jan;19(1):85-8. Epub 2007 May 26.


Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis.

Jovceva E, Larsen MR, Waterfield MD, Baum B, Timms JF.

J Cell Sci. 2007 Jun 1;120(Pt 11):1888-97. Epub 2007 May 15.


Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.

Maloney A, Clarke PA, Naaby-Hansen S, Stein R, Koopman JO, Akpan A, Yang A, Zvelebil M, Cramer R, Stimson L, Aherne W, Banerji U, Judson I, Sharp S, Powers M, deBilly E, Salmons J, Walton M, Burlingame A, Waterfield M, Workman P.

Cancer Res. 2007 Apr 1;67(7):3239-53.


Synthesis and biological evaluation of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors.

Hayakawa M, Kaizawa H, Moritomo H, Koizumi T, Ohishi T, Yamano M, Okada M, Ohta M, Tsukamoto S, Raynaud FI, Workman P, Waterfield MD, Parker P.

Bioorg Med Chem Lett. 2007 May 1;17(9):2438-42. Epub 2007 Feb 15.


Exploring the specificity of the PI3K family inhibitor LY294002.

Gharbi SI, Zvelebil MJ, Shuttleworth SJ, Hancox T, Saghir N, Timms JF, Waterfield MD.

Biochem J. 2007 May 15;404(1):15-21.


Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors.

Hayakawa M, Kaizawa H, Kawaguchi K, Ishikawa N, Koizumi T, Ohishi T, Yamano M, Okada M, Ohta M, Tsukamoto S, Raynaud FI, Waterfield MD, Parker P, Workman P.

Bioorg Med Chem. 2007 Jan 1;15(1):403-12. Epub 2006 Oct 16.


Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.

Stahelin RV, Karathanassis D, Bruzik KS, Waterfield MD, Bravo J, Williams RL, Cho W.

J Biol Chem. 2006 Dec 22;281(51):39396-406. Epub 2006 Oct 12.


Proteomic response of Schizosaccharomyces pombe to static and oscillating extremely low-frequency electromagnetic fields.

Sinclair J, Weeks M, Butt A, Worthington JL, Akpan A, Jones N, Waterfield M, Allanand D, Timms JF.

Proteomics. 2006 Sep;6(17):4755-64.


Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors.

Hayakawa M, Kaizawa H, Moritomo H, Koizumi T, Ohishi T, Okada M, Ohta M, Tsukamoto S, Parker P, Workman P, Waterfield M.

Bioorg Med Chem. 2006 Oct 15;14(20):6847-58. Epub 2006 Jul 11.


Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms.

Katso RM, Pardo OE, Palamidessi A, Franz CM, Marinov M, De Laurentiis A, Downward J, Scita G, Ridley AJ, Waterfield MD, Arcaro A.

Mol Biol Cell. 2006 Sep;17(9):3729-44. Epub 2006 Jun 14.


Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry.

Cutillas PR, Khwaja A, Graupera M, Pearce W, Gharbi S, Waterfield M, Vanhaesebroeck B.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):8959-64. Epub 2006 Jun 2.


Proteomic analysis of UVC irradiation-induced damage of plasma proteins: Serum amyloid P component as a major target of photolysis.

Chan HL, Gaffney PR, Waterfield MD, Anderle H, Peter Matthiessen H, Schwarz HP, Turecek PL, Timms JF.

FEBS Lett. 2006 May 29;580(13):3229-36. Epub 2006 May 6.


Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells.

Babu G, Waterfield M, Chang M, Wu X, Sun SC.

J Biol Chem. 2006 May 19;281(20):14041-7. Epub 2006 Mar 24.


The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS).

Freeman RM, Adekanmi O, Waterfield MR, Waterfield AE, Wright D, Zajicek J.

Int Urogynecol J Pelvic Floor Dysfunct. 2006 Nov;17(6):636-41. Epub 2006 Mar 22.


A parallel proteomic and metabolomic analysis of the hydrogen peroxide- and Sty1p-dependent stress response in Schizosaccharomyces pombe.

Weeks ME, Sinclair J, Butt A, Chung YL, Worthington JL, Wilkinson CR, Griffiths J, Jones N, Waterfield MD, Timms JF.

Proteomics. 2006 May;6(9):2772-96.


Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation.

Babu GR, Jin W, Norman L, Waterfield M, Chang M, Wu X, Zhang M, Sun SC.

Biochim Biophys Acta. 2006 Feb;1763(2):174-81. Epub 2006 Jan 13.


Enhanced phosphopeptide isolation by Fe(III)-IMAC using 1,1,1,3,3,3-hexafluoroisopropanol.

Barnouin KN, Hart SR, Thompson AJ, Okuyama M, Waterfield M, Cramer R.

Proteomics. 2005 Nov;5(17):4376-88.


The development of pelvic organ prolapse after colposuspension: a prospective, long-term follow-up study on the prevalence and predisposing factors.

Auwad W, Bombieri L, Adekanmi O, Waterfield M, Freeman R.

Int Urogynecol J Pelvic Floor Dysfunct. 2006 Jun;17(4):389-94. Epub 2005 Oct 26.


Pulmonary arteriovenous malformation: an unusual case of hypoxemia in an infant.

Geskey JM, Waterfield M, Weber HS, Graff GR.

Clin Pediatr (Phila). 2005 Apr;44(3):263-6. No abstract available.


Stress-induced changes in the Schizosaccharomyces pombe proteome using two-dimensional difference gel electrophoresis, mass spectrometry and a novel integrated robotics platform.

Weeks ME, Sinclair J, Jacob RJ, Saxton MJ, Kirby S, Jones J, Waterfield MD, Cramer R, Timms JF.

Proteomics. 2005 Apr;5(6):1669-85.


Proteomic analysis of plasma membrane vesicles isolated from the rat renal cortex.

Cutillas PR, Biber J, Marks J, Jacob R, Stieger B, Cramer R, Waterfield M, Burlingame AL, Unwin RJ.

Proteomics. 2005 Jan;5(1):101-12.


Gene targeting: attention to detail.

Vanhaesebroeck B, Rohn JL, Waterfield MD.

Cell. 2004 Aug 6;118(3):274-6.

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