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Items: 1 to 50 of 156

1.

Author Correction: RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.

Cheng JX, Chen L, Li Y, Cloe A, Yue M, Wei J, Watanabe KA, Shammo JM, Anastasi J, Shen QJ, Larson RA, He C, Le Beau MM, Vardiman JW.

Nat Commun. 2018 Jun 6;9(1):2286. doi: 10.1038/s41467-018-04518-9.

2.

RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.

Cheng JX, Chen L, Li Y, Cloe A, Yue M, Wei J, Watanabe KA, Shammo JM, Anastasi J, Shen QJ, Larson RA, He C, Le Beau MM, Vardiman JW.

Nat Commun. 2018 Mar 21;9(1):1163. doi: 10.1038/s41467-018-03513-4. Erratum in: Nat Commun. 2018 Jun 6;9(1):2286.

3.

Transcriptomic analysis of rice aleurone cells identified a novel abscisic acid response element.

Watanabe KA, Homayouni A, Gu L, Huang KY, Ho TD, Shen QJ.

Plant Cell Environ. 2017 Sep;40(9):2004-2016. doi: 10.1111/pce.13006. Epub 2017 Jul 18.

PMID:
28626890
4.

WRKY transcription factor genes in wild rice Oryza nivara.

Xu H, Watanabe KA, Zhang L, Shen QJ.

DNA Res. 2016 Aug;23(4):311-23. doi: 10.1093/dnares/dsw025. Epub 2016 Jun 26.

5.

Transcript structure and domain display: a customizable transcript visualization tool.

Watanabe KA, Ma K, Homayouni A, Rushton PJ, Shen QJ.

Bioinformatics. 2016 Jul 1;32(13):2024-5. doi: 10.1093/bioinformatics/btw095. Epub 2016 Feb 22.

PMID:
27153680
6.

Tiling Assembly: a new tool for reference annotation-independent transcript assembly and novel gene identification by RNA-sequencing.

Watanabe KA, Homayouni A, Tufano T, Lopez J, Ringler P, Rushton P, Shen QJ.

DNA Res. 2015 Oct;22(5):319-29. doi: 10.1093/dnares/dsv015. Epub 2015 Sep 3.

7.

RNA-sequencing reveals previously unannotated protein- and microRNA-coding genes expressed in aleurone cells of rice seeds.

Watanabe KA, Ringler P, Gu L, Shen QJ.

Genomics. 2014 Jan;103(1):122-34. doi: 10.1016/j.ygeno.2013.10.007. Epub 2013 Nov 4.

8.

Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.

Chun BK, Wang P, Hassan A, Du J, Tharnish PM, Murakami E, Stuyver L, Otto MJ, Schinazi RF, Watanabe KA.

Nucleosides Nucleotides Nucleic Acids. 2007;26(1):83-97.

PMID:
17162589
9.

Synthesis and anti-HCV activity of N9,5'-cyclo-3-(beta-D-ribofuranosyl)-8-azapurin-2-one derivatives.

Hassan AE, Wang P, McBrayer T, Tharnish P, Stuyver L, Otto MJ, Watanabe KA, Schinazi RF.

Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1531-42.

PMID:
16438033
10.

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.

Clark JL, Mason JC, Hollecker L, Stuyver LJ, Tharnish PM, McBrayer TR, Otto MJ, Furman PA, Schinazi RF, Watanabe KA.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1712-5. Epub 2005 Dec 20.

PMID:
16368235
11.

N4-hydroxycytosine dioxolane nucleosides and their activity against hepatitis B virus.

Du J, Hollecker L, Shi J, Chun BK, Watanabe KA, Raymond FS, Nachman TY, Lostia S, Stuyver LJ, Otto MJ.

Nucleosides Nucleotides Nucleic Acids. 2005;24(8):1209-14.

PMID:
16270663
12.

Unusual olefin formation by PhSe-F trans-elimination.

Du J, Shi J, Chun BK, Hobbs A, Hollecker L, Watanabe KA.

Nucleosides Nucleotides Nucleic Acids. 2005;24(9):1289-92.

PMID:
16252665
13.

Synthesis and anti-hepatitis C virus activity of nucleoside derivatives of N3, 5'-anhydro-4-(beta-D-ribofuranosyl)-8-aza-purin-2-ones.

Hassan AE, Wang P, McBrayer TR, Tharnish PM, Stuyver LJ, Schinazi RF, Otto MJ, Watanabe KA.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):961-4.

PMID:
16248072
14.

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents.

Wang P, Hollecker L, Pankiewicz KW, Patterson SE, Whitaker T, McBrayer TR, Tharnish PM, Stuyver LJ, Schinazi RF, Otto MJ, Watanabe KA.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):957-60.

PMID:
16248071
15.

Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides.

Shi J, Du J, Ma T, Pankiewicz KW, Patterson SE, Hassan AE, Tharnish PM, McBrayer TR, Lostia S, Stuyver LJ, Watanabe KA, Chu CK, Schinazi RF, Otto MJ.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):875-9.

PMID:
16248053
16.

Synthesis and structure-activity relationships of novel anti-hepatitis C agents: N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one derivatives.

Wang P, Du J, Rachakonda S, Chun BK, Tharnish PM, Stuyver LJ, Otto MJ, Schinazi RF, Watanabe KA.

J Med Chem. 2005 Oct 6;48(20):6454-60.

PMID:
16190771
17.

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

Clark JL, Hollecker L, Mason JC, Stuyver LJ, Tharnish PM, Lostia S, McBrayer TR, Schinazi RF, Watanabe KA, Otto MJ, Furman PA, Stec WJ, Patterson SE, Pankiewicz KW.

J Med Chem. 2005 Aug 25;48(17):5504-8.

PMID:
16107149
18.

Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.

Shi J, Du J, Ma T, Pankiewicz KW, Patterson SE, Tharnish PM, McBrayer TR, Stuyver LJ, Otto MJ, Chu CK, Schinazi RF, Watanabe KA.

Bioorg Med Chem. 2005 Mar 1;13(5):1641-52.

PMID:
15698782
19.

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.

Wang P, Hollecker L, Pankiewicz KW, Patterson SE, Whitaker T, McBrayer TR, Tharnish PM, Sidwell RW, Stuyver LJ, Otto MJ, Schinazi RF, Watanabe KA.

J Med Chem. 2004 Nov 18;47(24):6100-3.

PMID:
15537363
20.

Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors.

Prell GD, Martinelli GP, Holstein GR, Matulić-Adamić J, Watanabe KA, Chan SL, Morgan NG, Haxhiu MA, Ernsberger P.

Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13677-82. Epub 2004 Sep 13.

21.

Synthesis of beta-enantiomers of N4-hydroxy-3'-deoxypyrimidine nucleosides and their evaluation against bovine viral diarrhoea virus and hepatitis C virus in cell culture.

Hollecker L, Choo H, Chong Y, Chu CK, Lostia S, McBrayer TR, Stuyver LJ, Mason JC, Du J, Rachakonda S, Shi J, Schinazi RF, Watanabe KA.

Antivir Chem Chemother. 2004 Jan;15(1):43-55.

PMID:
15074714
22.

Synthesis of 5'-C-methyl-1',3'-dioxolan-4'-yl nucleosides.

Du J, Patterson S, Shi J, Chun BK, Stuyver LJ, Watanabe KA.

Bioorg Med Chem Lett. 2004 Mar 8;14(5):1243-5.

PMID:
14980674
23.

Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.

Stuyver LJ, McBrayer TR, Whitaker T, Tharnish PM, Ramesh M, Lostia S, Cartee L, Shi J, Hobbs A, Schinazi RF, Watanabe KA, Otto MJ.

Antimicrob Agents Chemother. 2004 Feb;48(2):651-4.

24.

Synthesis and antiviral evaluation of 2',3'-dideoxy-2'-fluoro-3'- C-hydroxymethyl-beta-D-arabinofuranosyl pyrimidine nucleosides.

Hassan AE, Pai BS, Lostia S, Stuyver L, Otto MJ, Schinazi RF, Watanabe KA.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):891-4.

PMID:
14565304
25.

Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites.

Stuyver LJ, McBrayer TR, Tharnish PM, Hassan AE, Chu CK, Pankiewicz KW, Watanabe KA, Schinazi RF, Otto MJ.

J Virol. 2003 Oct;77(19):10689-94.

26.

N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity.

Shi J, Mathew JS, Tharnish PM, Rachakonda S, Pai SB, Adams M, Grier JP, Gallagher K, Zhang H, Wu JT, Shi G, Geleziunas R, Erickson-Viitanen S, Stuyver L, Otto MJ, Watanabe KA, Schinazi RF.

Antivir Chem Chemother. 2003 Mar;14(2):81-90.

PMID:
12856919
27.

Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhoea virus agents.

Stuyver LJ, Lostia S, Patterson SE, Clark JL, Watanabe KA, Otto MJ, Pankiewicz KW.

Antivir Chem Chemother. 2002 Nov;13(6):345-52.

PMID:
12718406
28.

Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.

Stuyver LJ, Whitaker T, McBrayer TR, Hernandez-Santiago BI, Lostia S, Tharnish PM, Ramesh M, Chu CK, Jordan R, Shi J, Rachakonda S, Watanabe KA, Otto MJ, Schinazi RF.

Antimicrob Agents Chemother. 2003 Jan;47(1):244-54.

29.

The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside.

Pankiewicz KW, Watanabe KA, Lesiak-Watanabe K, Goldstein BM, Jayaram HN.

Curr Med Chem. 2002 Apr;9(7):733-41.

PMID:
11966436
30.

Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia.

Pankiewicz KW, Lesiak-Watanabe KB, Watanabe KA, Patterson SE, Jayaram HN, Yalowitz JA, Miller MD, Seidman M, Majumdar A, Prehna G, Goldstein BM.

J Med Chem. 2002 Jan 31;45(3):703-12.

PMID:
11806722
31.

Formation and reactivity of 2,4-ditriazolyl pyrimidine C-nucleoside derived from pseudouridine.

Dyatkina N, Khorlin A, Watanabe KA.

Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):585-91.

PMID:
10843494
32.

Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187.

Drohat AC, Xiao G, Tordova M, Jagadeesh J, Pankiewicz KW, Watanabe KA, Gilliland GL, Stivers JT.

Biochemistry. 1999 Sep 14;38(37):11876-86.

PMID:
10508390
33.

Novel mycophenolic adenine bis(phosphonate)s as potential immunosuppressants.

Pankiewicz KW, Lesiak-Watanabe K, Watanabe KA, Malinowski K.

Curr Med Chem. 1999 Jul;6(7):629-34.

PMID:
10390605
34.

Synthesis of a novel C-nucleoside, 2-amino-7-(2-deoxy-beta-D-erythro- pentofuranosyl)-3H,5H-pyrrolo-[3,2-d]pyrimidin-4-one (2'-deoxy-9-deazaguanosine).

Gibson ES, Lesiak K, Watanabe KA, Gudas LJ, Pankiewicz KW.

Nucleosides Nucleotides. 1999 Mar;18(3):363-76.

PMID:
10358941
35.

Kinetic mechanism of damage site recognition and uracil flipping by Escherichia coli uracil DNA glycosylase.

Stivers JT, Pankiewicz KW, Watanabe KA.

Biochemistry. 1999 Jan 19;38(3):952-63.

PMID:
9893991
36.

Targeted gene knockout mediated by triple helix forming oligonucleotides.

Majumdar A, Khorlin A, Dyatkina N, Lin FL, Powell J, Liu J, Fei Z, Khripine Y, Watanabe KA, George J, Glazer PM, Seidman MM.

Nat Genet. 1998 Oct;20(2):212-4.

PMID:
9771719
37.

Substrates of DNA polymerases with planar conformation of sugar: model of substrate transition state?

Krayevsky AA, Watanabe KA.

Nucleosides Nucleotides. 1998 Jul;17(7):1153-62.

PMID:
9708315
38.

Aliphatic and alicyclic diols induce melanogenesis in cultured cells and guinea pig skin.

Brown DA, Ren WY, Khorlin A, Lesiak K, Conklin D, Watanabe KA, Seidman MM, George J.

J Invest Dermatol. 1998 Apr;110(4):428-37.

39.

Synthesis of a methylenebis(phosphonate) analogue of mycophenolic adenine dinucleotide: a glucuronidation-resistant MAD analogue of NAD.

Lesiak K, Watanabe KA, Majumdar A, Powell J, Seidman M, Vanderveen K, Goldstein BM, Pankiewicz KW.

J Med Chem. 1998 Feb 12;41(4):618-22.

PMID:
9484510
41.

The practical synthesis of a methylenebisphosphonate analogue of benzamide adenine dinucleotide: inhibition of human inosine monophosphate dehydrogenase (type I and II).

Pankiewicz KW, Lesiak K, Zatorski A, Goldstein BM, Carr SF, Sochacki M, Majumdar A, Seidman M, Watanabe KA.

J Med Chem. 1997 Apr 11;40(8):1287-91.

PMID:
9111303
42.

Cyclopent[a]anthraquinones as DNA intercalating agents with covalent bond formation potential: synthesis and biological activity.

Kim JY, Su TL, Chou TC, Koehler B, Scarborough A, Ouerfelli O, Watanabe KA.

J Med Chem. 1996 Jul 5;39(14):2812-8.

PMID:
8709111
43.

Chemical synthesis of benzamide adenine dinucleotide: inhibition of inosine monophosphate dehydrogenase (types I and II).

Zatorski A, Watanabe KA, Carr SF, Goldstein BM, Pankiewicz KW.

J Med Chem. 1996 Jun 7;39(12):2422-6.

PMID:
8691436
44.

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.

Lewis W, Levine ES, Griniuviene B, Tankersley KO, Colacino JM, Sommadossi JP, Watanabe KA, Perrino FW.

Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3592-7.

45.

NAD-analogues as potential anticancer agents: conformational restrictions as basis for selectivity.

Pankiewicz KW, Zatorski A, Watanabe KA.

Acta Biochim Pol. 1996;43(1):183-93. Review.

46.

9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships.

Su TL, Chou TC, Kim JY, Huang JT, Ciszewska G, Ren WY, Otter GM, Sirotnak FM, Watanabe KA.

J Med Chem. 1995 Aug 18;38(17):3226-35.

PMID:
7650675
47.
48.

Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes.

Li H, Hallows WH, Punzi JS, Pankiewicz KW, Watanabe KA, Goldstein BM.

Biochemistry. 1994 Oct 4;33(39):11734-44.

PMID:
7918390
49.

Synthesis and biological properties of 5-o-carboranyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil.

Fulcrand-el Kattan G, Goudgaon NM, Ilksoy N, Huang JT, Watanabe KA, Sommadossi JP, Schinazi RF.

J Med Chem. 1994 Aug 5;37(16):2583-8.

PMID:
8057301
50.

CNAD: a potent and specific inhibitor of alcohol dehydrogenase.

Goldstein BM, Li H, Jones JP, Bell JE, Zeidler J, Pankiewicz KW, Watanabe KA.

J Med Chem. 1994 Feb 4;37(3):392-9.

PMID:
8308865

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