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Items: 43

1.

Pharmacokinetics, safety and efficacy of an allometric miltefosine regimen for the treatment of visceral leishmaniasis in Eastern African children: an open-label, phase-II clinical trial.

Mbui J, Olobo J, Omollo R, Solomos A, Kip AE, Kirigi G, Sagaki P, Kimutai R, Were L, Omollo T, Egondi TW, Wasunna M, Alvar J, Dorlo TPC, Alves F.

Clin Infect Dis. 2018 Sep 5. doi: 10.1093/cid/ciy747. [Epub ahead of print]

PMID:
30188978
2.

Recent Development of Visceral Leishmaniasis Treatments: Successes, Pitfalls, and Perspectives.

Alves F, Bilbe G, Blesson S, Goyal V, Monnerat S, Mowbray C, Muthoni Ouattara G, Pécoul B, Rijal S, Rode J, Solomos A, Strub-Wourgaft N, Wasunna M, Wells S, Zijlstra EE, Arana B, Alvar J.

Clin Microbiol Rev. 2018 Aug 29;31(4). pii: e00048-18. doi: 10.1128/CMR.00048-18. Print 2018 Oct. Review.

PMID:
30158301
3.

Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis.

Kip AE, Wasunna M, Alves F, Schellens JHM, Beijnen JH, Musa AM, Khalil EAG, Dorlo TPC.

Front Cell Infect Microbiol. 2018 Jun 1;8:181. doi: 10.3389/fcimb.2018.00181. eCollection 2018.

4.

Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study.

Dorlo TPC, Kip AE, Younis BM, Ellis SJ, Alves F, Beijnen JH, Njenga S, Kirigi G, Hailu A, Olobo J, Musa AM, Balasegaram M, Wasunna M, Karlsson MO, Khalil EAG.

J Antimicrob Chemother. 2017 Nov 1;72(11):3131-3140. doi: 10.1093/jac/dkx283.

5.

Systematic review of clinical trials assessing the therapeutic efficacy of visceral leishmaniasis treatments: A first step to assess the feasibility of establishing an individual patient data sharing platform.

Bush JT, Wasunna M, Alves F, Alvar J, Olliaro PL, Otieno M, Sibley CH, Strub Wourgaft N, Guerin PJ.

PLoS Negl Trop Dis. 2017 Sep 5;11(9):e0005781. doi: 10.1371/journal.pntd.0005781. eCollection 2017 Sep. Review.

6.

Safety and Effectiveness of Sodium Stibogluconate and Paromomycin Combination for the Treatment of Visceral Leishmaniasis in Eastern Africa: Results from a Pharmacovigilance Programme.

Kimutai R, Musa AM, Njoroge S, Omollo R, Alves F, Hailu A, Khalil EA, Diro E, Soipei P, Musa B, Salman K, Ritmeijer K, Chappuis F, Rashid J, Mohammed R, Jameneh A, Makonnen E, Olobo J, Okello L, Sagaki P, Strub N, Ellis S, Alvar J, Balasegaram M, Alirol E, Wasunna M.

Clin Drug Investig. 2017 Mar;37(3):259-272. doi: 10.1007/s40261-016-0481-0.

7.

Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial.

Wasunna M, Njenga S, Balasegaram M, Alexander N, Omollo R, Edwards T, Dorlo TP, Musa B, Ali MH, Elamin MY, Kirigi G, Juma R, Kip AE, Schoone GJ, Hailu A, Olobo J, Ellis S, Kimutai R, Wells S, Khalil EA, Strub Wourgaft N, Alves F, Musa A.

PLoS Negl Trop Dis. 2016 Sep 14;10(9):e0004880. doi: 10.1371/journal.pntd.0004880. eCollection 2016 Sep.

8.

The Leishmaniasis East Africa Platform (LEAP): strengthening clinical trial capacity in resource-limited countries to deliver new treatments for visceral leishmaniasis.

Wasunna M, Musa A, Hailu A, Khalil EA, Olobo J, Juma R, Wells S, Alvar J, Balasegaram M.

Trans R Soc Trop Med Hyg. 2016 Jun;110(6):321-3. doi: 10.1093/trstmh/trw031. Epub 2016 Jun 7.

9.

The Number and Complexity of Pure and Recombinant HIV-1 Strains Observed within Incident Infections during the HIV and Malaria Cohort Study Conducted in Kericho, Kenya, from 2003 to 2006.

Billings E, Sanders-Buell E, Bose M, Bradfield A, Lei E, Kijak GH, Arroyo MA, Kibaya RM, Scott PT, Wasunna MK, Sawe FK, Shaffer DN, Birx DL, McCutchan FE, Michael NL, Robb ML, Kim JH, Tovanabutra S.

PLoS One. 2015 Aug 19;10(8):e0135124. doi: 10.1371/journal.pone.0135124. eCollection 2015.

10.

Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi-country randomised clinical trials in African adults.

Sagara I, Oduro AR, Mulenga M, Dieng Y, Ogutu B, Tiono AB, Mugyenyi P, Sie A, Wasunna M, Kain KC, Djimdé AA, Sarkar S, Chandra R, Robbins J, Dunne MW.

Malar J. 2014 Nov 25;13:458. doi: 10.1186/1475-2875-13-458.

11.

Innovative approaches to clinical data management in resource limited settings using open-source technologies.

Omollo R, Ochieng M, Mutinda B, Omollo T, Owiti R, Okeyo S, Wasunna M, Edwards T.

PLoS Negl Trop Dis. 2014 Sep 11;8(9):e3134. doi: 10.1371/journal.pntd.0003134. eCollection 2014 Sep. No abstract available.

12.

Safety and efficacy of single dose versus multiple doses of AmBisome for treatment of visceral leishmaniasis in eastern Africa: a randomised trial.

Khalil EA, Weldegebreal T, Younis BM, Omollo R, Musa AM, Hailu W, Abuzaid AA, Dorlo TP, Hurissa Z, Yifru S, Haleke W, Smith PG, Ellis S, Balasegaram M, EL-Hassan AM, Schoone GJ, Wasunna M, Kimutai R, Edwards T, Hailu A.

PLoS Negl Trop Dis. 2014 Jan 16;8(1):e2613. doi: 10.1371/journal.pntd.0002613. eCollection 2014.

13.

Validation of two rapid diagnostic tests for visceral leishmaniasis in Kenya.

Mbui J, Wasunna M, Balasegaram M, Laussermayer A, Juma R, Njenga SN, Kirigi G, Riongoita M, de la Tour R, van Peteghem J, Omollo R, Chappuis F.

PLoS Negl Trop Dis. 2013 Sep 26;7(9):e2441. doi: 10.1371/journal.pntd.0002441. eCollection 2013.

14.

Identification of Leishmania tropica from micro-foci of cutaneous leishmaniasis in the Kenyan Rift Valley.

Odiwuor S, Muia A, Magiri C, Maes I, Kirigi G, Dujardin JC, Wasunna M, Mbuchi M, Auwera GV.

Pathog Glob Health. 2012 Jul;106(3):159-65. doi: 10.1179/2047773212Y.0000000015.

15.

Antiretroviral therapy, labor productivity, and sex: a longitudinal cohort study of tea pluckers in Kenya.

Larson BA, Fox MP, Bii M, Rosen S, Rohr J, Shaffer D, Sawe F, Wasunna M, Simon JL.

AIDS. 2013 Jan 2;27(1):115-23. doi: 10.1097/QAD.0b013e32835a5b12.

16.

A global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis.

Cunningham J, Hasker E, Das P, El Safi S, Goto H, Mondal D, Mbuchi M, Mukhtar M, Rabello A, Rijal S, Sundar S, Wasunna M, Adams E, Menten J, Peeling R, Boelaert M; WHO/TDR Visceral Leishmaniasis Laboratory Network.

Clin Infect Dis. 2012 Nov 15;55(10):1312-9. doi: 10.1093/cid/cis716. Epub 2012 Aug 31.

17.

Sodium stibogluconate (SSG) & paromomycin combination compared to SSG for visceral leishmaniasis in East Africa: a randomised controlled trial.

Musa A, Khalil E, Hailu A, Olobo J, Balasegaram M, Omollo R, Edwards T, Rashid J, Mbui J, Musa B, Abuzaid AA, Ahmed O, Fadlalla A, El-Hassan A, Mueller M, Mucee G, Njoroge S, Manduku V, Mutuma G, Apadet L, Lodenyo H, Mutea D, Kirigi G, Yifru S, Mengistu G, Hurissa Z, Hailu W, Weldegebreal T, Tafes H, Mekonnen Y, Makonnen E, Ndegwa S, Sagaki P, Kimutai R, Kesusu J, Owiti R, Ellis S, Wasunna M.

PLoS Negl Trop Dis. 2012;6(6):e1674. doi: 10.1371/journal.pntd.0001674. Epub 2012 Jun 19.

18.

Safety and efficacy of miltefosine alone and in combination with sodium stibogluconate and liposomal amphotericin B for the treatment of primary visceral leishmaniasis in East Africa: study protocol for a randomized controlled trial.

Omollo R, Alexander N, Edwards T, Khalil EA, Younis BM, Abuzaid AA, Wasunna M, Njoroge N, Kinoti D, Kirigi G, Dorlo TP, Ellis S, Balasegaram M, Musa AM.

Trials. 2011 Jun 30;12:166. doi: 10.1186/1745-6215-12-166.

19.

Single-dose liposomal amphotericin B (AmBisome®) for the treatment of visceral leishmaniasis in East Africa: study protocol for a randomized controlled trial.

Edwards T, Omollo R, Khalil EA, Yifru S, Musa B, Musa A, Wasunna M, Smith PG, Royce C, Ellis S, Balasegaram M, Hailu A.

Trials. 2011 Mar 6;12:66. doi: 10.1186/1745-6215-12-66.

20.

Comparison of short-term and long-term protocols for stabilization and preservation of RNA and DNA of Leishmania, Trypanosoma, and Plasmodium.

Basiye FL, Schoone GJ, Beld M, Minnaar R, Ngeranwa JN, Wasunna MK, Schallig HD.

Diagn Microbiol Infect Dis. 2011 Jan;69(1):66-73. doi: 10.1016/j.diagmicrobio.2010.08.018.

PMID:
21146716
21.

A successful treatment of a Kenyan case of unresponsive cutaneous leishmaniasis with a combination of pentostam and oral allopurinol: case report.

Kirigi G, Mbuchi MW, Mbui JK, Rashid JR, Kinoti DM, Njoroge SN, Basiye F, Magiri C, Wasunna MK.

East Afr Med J. 2010 Dec;87(12):521-4.

PMID:
23457863
22.

Paromomycin for the treatment of visceral leishmaniasis in Sudan: a randomized, open-label, dose-finding study.

Musa AM, Younis B, Fadlalla A, Royce C, Balasegaram M, Wasunna M, Hailu A, Edwards T, Omollo R, Mudawi M, Kokwaro G, El-Hassan A, Khalil E.

PLoS Negl Trop Dis. 2010 Oct 26;4(10):e855. doi: 10.1371/journal.pntd.0000855.

23.

Geographical variation in the response of visceral leishmaniasis to paromomycin in East Africa: a multicentre, open-label, randomized trial.

Hailu A, Musa A, Wasunna M, Balasegaram M, Yifru S, Mengistu G, Hurissa Z, Hailu W, Weldegebreal T, Tesfaye S, Makonnen E, Khalil E, Ahmed O, Fadlalla A, El-Hassan A, Raheem M, Mueller M, Koummuki Y, Rashid J, Mbui J, Mucee G, Njoroge S, Manduku V, Musibi A, Mutuma G, Kirui F, Lodenyo H, Mutea D, Kirigi G, Edwards T, Smith P, Muthami L, Royce C, Ellis S, Alobo M, Omollo R, Kesusu J, Owiti R, Kinuthia J; Leishmaniasis East Africa Platform (LEAP) group.

PLoS Negl Trop Dis. 2010 Oct 26;4(10):e709. doi: 10.1371/journal.pntd.0000709.

24.

Sensitivity and specificity of the Leishmania OligoC-TesT and NASBA-oligochromatography for diagnosis of visceral leishmaniasis in Kenya.

Basiye FL, Mbuchi M, Magiri C, Kirigi G, Deborggraeve S, Schoone GJ, Saad AA, El-Safi S, Matovu E, Wasunna MK.

Trop Med Int Health. 2010 Jul;15(7):806-10. doi: 10.1111/j.1365-3156.2010.02548.x. Epub 2010 May 14.

25.

Improvements in physical wellbeing over the first two years on antiretroviral therapy in western Kenya.

Fox MP, McCoy K, Larson BA, Rosen S, Bii M, Sigei C, Shaffer D, Sawe F, Wasunna M, Simon JL.

AIDS Care. 2010 Feb;22(2):137-45. doi: 10.1080/09540120903038366.

26.

Short communication: HIV type 1 genetic diversity among tea plantation workers in Kericho, Kenya.

Arroyo MA, Sateren WB, Foglia G, Kibaya R, Langat L, Wasunna M, Bautista CT, Scott PT, Shaffer DN, Robb ML, Michael NL, Birx DL, McCutchan FE.

AIDS Res Hum Retroviruses. 2009 Nov;25(11):1061-4. doi: 10.1089/aid.2009.0092.

PMID:
19943788
27.

HIV-1 incidence rates and risk factors in agricultural workers and dependents in rural Kenya: 36-month follow-up of the Kericho HIV cohort study.

Shaffer DN, Ngetich IK, Bautista CT, Sawe FK, Renzullo PO, Scott PT, Kibaya RM, Imbuki KO, Michael NL, Birx DL, Wasunna MK, Robb ML.

J Acquir Immune Defic Syndr. 2010 Apr 1;53(4):514-21. doi: 10.1097/QAI.0b013e3181bcdae0.

PMID:
19855286
28.

Do the socioeconomic impacts of antiretroviral therapy vary by gender? A longitudinal study of Kenyan agricultural worker employment outcomes.

Larson BA, Fox MP, Rosen S, Bii M, Sigei C, Shaffer D, Sawe F, McCoy K, Wasunna M, Simon JL.

BMC Public Health. 2009 Jul 15;9:240. doi: 10.1186/1471-2458-9-240.

29.

A simplified and standardized polymerase chain reaction format for the diagnosis of leishmaniasis.

Deborggraeve S, Laurent T, Espinosa D, Van der Auwera G, Mbuchi M, Wasunna M, El-Safi S, Al-Basheer AA, Arévalo J, Miranda-Verástegui C, Leclipteux T, Mertens P, Dujardin JC, Herdewijn P, Büscher P.

J Infect Dis. 2008 Nov 15;198(10):1565-72. doi: 10.1086/592509.

PMID:
18816188
30.

Early effects of antiretroviral therapy on work performance: preliminary results from a cohort study of Kenyan agricultural workers.

Larson BA, Fox MP, Rosen S, Bii M, Sigei C, Shaffer D, Sawe F, Wasunna M, Simon JL.

AIDS. 2008 Jan 30;22(3):421-5. doi: 10.1097/QAD.0b013e3282f3cc0c.

PMID:
18195569
31.

Diagnostic tests for kala-azar: a multi-centre study of the freeze-dried DAT, rK39 strip test and KAtex in East Africa and the Indian subcontinent.

Boelaert M, El-Safi S, Hailu A, Mukhtar M, Rijal S, Sundar S, Wasunna M, Aseffa A, Mbui J, Menten J, Desjeux P, Peeling RW.

Trans R Soc Trop Med Hyg. 2008 Jan;102(1):32-40. Epub 2007 Oct 22.

PMID:
17942129
32.

High prevalence of HIV infection among rural tea plantation residents in Kericho, Kenya.

Foglia G, Sateren WB, Renzullo PO, Bautista CT, Langat L, Wasunna MK, Singer DE, Scott PT, Robb ML, Birx DL.

Epidemiol Infect. 2008 May;136(5):694-702. Epub 2007 Jun 29.

33.

Epidemiology of HIV-1 infection in agricultural plantation residents in Kericho, Kenya: preparation for vaccine feasibility studies.

Sateren WB, Foglia G, Renzullo PO, Elson L, Wasunna M, Bautista CT, Birx DL.

J Acquir Immune Defic Syndr. 2006 Sep;43(1):102-6.

PMID:
16885773
34.

Circulating and unique recombinant forms of HIV type 1 containing subsubtype A2.

Visawapoka U, Tovanabutra S, Currier JR, Cox JH, Mason CJ, Wasunna M, Ponglikitmongkol M, Dowling WE, Robb ML, Birx DL, McCutchan FE.

AIDS Res Hum Retroviruses. 2006 Jul;22(7):695-702.

PMID:
16831094
35.

Spatial clustering and epidemiological aspects of visceral leishmaniasis in two endemic villages, Baringo District, Kenya.

Ryan JR, Mbui J, Rashid JR, Wasunna MK, Kirigi G, Magiri C, Kinoti D, Ngumbi PM, Martin SK, Odera SO, Hochberg LP, Bautista CT, Chan AS.

Am J Trop Med Hyg. 2006 Feb;74(2):308-17.

PMID:
16474089
36.

A phase II dose-increasing study of sitamaquine for the treatment of visceral leishmaniasis in Kenya.

Wasunna MK, Rashid JR, Mbui J, Kirigi G, Kinoti D, Lodenyo H, Felton JM, Sabin AJ, Albert MJ, Horton J.

Am J Trop Med Hyg. 2005 Nov;73(5):871-6. Erratum in: Am J Trop Med Hyg. 2006 Jan;74(1):185. Albert, M John [added].

PMID:
16282296
37.

Visceral leishmaniasis: new health tools are needed.

Hailu A, Musa AM, Royce C, Wasunna M.

PLoS Med. 2005 Jul;2(7):e211. Epub 2005 Jul 26. Review. No abstract available.

38.

The impact of HIV/AIDS on labour productivity in Kenya.

Fox MP, Rosen S, MacLeod WB, Wasunna M, Bii M, Foglia G, Simon JL.

Trop Med Int Health. 2004 Mar;9(3):318-24.

PMID:
14996359
39.

Visceral leishmaniasis with concomittant post kala-azar dermal leishmaniasis responds to oral sitamaquine: case report.

Mbui J, Rashid R, Lodenyo H, Nyakundi P, Kipmutai R, Mutuma G, Kirigi G, Kinoti D, Wasunna M.

East Afr Med J. 2003 Aug;80(8):440-2.

PMID:
14601788
40.

Compassionate use of sitamaquine in an HIV-positive patient with visceral leishmaniasis.

Rashid JR, Nyakundi PM, Kirigi G, Kinoti D, Wasunna MK.

Trans R Soc Trop Med Hyg. 2002 Sep-Oct;96(5):533-4. No abstract available.

PMID:
12474482
41.

Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda.

Guerin PJ, Olliaro P, Sundar S, Boelaert M, Croft SL, Desjeux P, Wasunna MK, Bryceson AD.

Lancet Infect Dis. 2002 Aug;2(8):494-501. Review.

PMID:
12150849
42.

A simple and inexpensive medium for culture of splenic aspirates in visceral leishmaniasis.

Mbui J, Wasunna M, Martin K.

East Afr Med J. 1999 Jun;76(6):358. No abstract available.

PMID:
10750528
43.

Plasmodium falciparum: purification of the various gametocyte developmental stages from in vitro-cultivated parasites.

Kariuki MM, Kiaira JK, Mulaa FK, Mwangi JK, Wasunna MK, Martin SK.

Am J Trop Med Hyg. 1998 Oct;59(4):505-8.

PMID:
9790418

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