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Remodeling Promotes Proarrhythmic Disruption of Calcium Homeostasis in Failing Atrial Myocytes.

Shiferaw Y, Aistrup GL, Louch WE, Wasserstrom JA.

Biophys J. 2019 Dec 18. pii: S0006-3495(19)34397-8. doi: 10.1016/j.bpj.2019.12.012. [Epub ahead of print]


Region-specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation.

Gussak G, Pfenniger A, Wren L, Gilani M, Zhang W, Yoo S, Johnson DA, Burrell A, Benefield B, Knight G, Knight BP, Passman R, Goldberger JJ, Aistrup G, Wasserstrom JA, Shiferaw Y, Arora R.

JCI Insight. 2019 Oct 17;4(20). pii: 130532. doi: 10.1172/jci.insight.130532.


Oxidative stress creates a unique, CaMKII-mediated substrate for atrial fibrillation in heart failure.

Yoo S, Aistrup G, Shiferaw Y, Ng J, Mohler PJ, Hund TJ, Waugh T, Browne S, Gussak G, Gilani M, Knight BP, Passman R, Goldberger JJ, Wasserstrom JA, Arora R.

JCI Insight. 2018 Nov 2;3(21). pii: 120728. doi: 10.1172/jci.insight.120728.


Synchronization of Triggered Waves in Atrial Tissue.

Shiferaw Y, Aistrup GL, Wasserstrom JA.

Biophys J. 2018 Sep 18;115(6):1130-1141. doi: 10.1016/j.bpj.2018.08.015. Epub 2018 Aug 18.


T-tubule remodeling and increased heterogeneity of calcium release during the progression to heart failure in intact rat ventricle.

Singh JK, Barsegyan V, Bassi N, Marszalec W, Tai S, Mothkur S, Mulla M, Nico E, Shiferaw Y, Aistrup GL, Wasserstrom JA.

Physiol Rep. 2017 Dec;5(24). pii: e13540. doi: 10.14814/phy2.13540. Epub 2017 Dec 26.


Triggered intracellular calcium waves in dog and human left atrial myocytes from normal and failing hearts.

Aistrup GL, Arora R, Grubb S, Yoo S, Toren B, Kumar M, Kunamalla A, Marszalec W, Motiwala T, Tai S, Yamakawa S, Yerrabolu S, Alvarado FJ, Valdivia HH, Cordeiro JM, Shiferaw Y, Wasserstrom JA.

Cardiovasc Res. 2017 Nov 1;113(13):1688-1699. doi: 10.1093/cvr/cvx167.


Mechanism for Triggered Waves in Atrial Myocytes.

Shiferaw Y, Aistrup GL, Wasserstrom JA.

Biophys J. 2017 Aug 8;113(3):656-670. doi: 10.1016/j.bpj.2017.06.026.


Regional distribution of T-tubule density in left and right atria in dogs.

Arora R, Aistrup GL, Supple S, Frank C, Singh J, Tai S, Zhao A, Chicos L, Marszalec W, Guo A, Song LS, Wasserstrom JA.

Heart Rhythm. 2017 Feb;14(2):273-281. doi: 10.1016/j.hrthm.2016.09.022. Epub 2016 Sep 23.


Foxc1 Regulates Early Cardiomyogenesis and Functional Properties of Embryonic Stem Cell Derived Cardiomyocytes.

Lambers E, Arnone B, Fatima A, Qin G, Wasserstrom JA, Kume T.

Stem Cells. 2016 Jun;34(6):1487-500. doi: 10.1002/stem.2301. Epub 2016 Feb 18.


Membrane phospholipid redistribution in cancer micro-particles and implications in the recruitment of cationic protein factors.

Hou S, Grillo D, Williams CL, Wasserstrom JA, Szleifer I, Zhao M.

J Extracell Vesicles. 2014 Jun 11;3. doi: 10.3402/jev.v3.22653. eCollection 2014.


Ultrastructural and cellular basis for the development of abnormal myocardial mechanics during the transition from hypertension to heart failure.

Shah SJ, Aistrup GL, Gupta DK, O'Toole MJ, Nahhas AF, Schuster D, Chirayil N, Bassi N, Ramakrishna S, Beussink L, Misener S, Kane B, Wang D, Randolph B, Ito A, Wu M, Akintilo L, Mongkolrattanothai T, Reddy M, Kumar M, Arora R, Ng J, Wasserstrom JA.

Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H88-100. doi: 10.1152/ajpheart.00642.2013. Epub 2013 Nov 1.


Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat.

Aistrup GL, Gupta DK, Kelly JE, O'Toole MJ, Nahhas A, Chirayil N, Misener S, Beussink L, Singh N, Ng J, Reddy M, Mongkolrattanothai T, El-Bizri N, Rajamani S, Shryock JC, Belardinelli L, Shah SJ, Wasserstrom JA.

Am J Physiol Heart Circ Physiol. 2013 Oct 1;305(7):H1068-79. doi: 10.1152/ajpheart.00401.2013. Epub 2013 Jul 19.


Can triggered arrhythmias arise from propagation of calcium waves between cardiac myocytes?

Nahhas AF, Kumar MS, O'Toole MJ, Aistrup GL, Wasserstrom JA.

Front Biosci (Elite Ed). 2013 Jun 1;5:893-9. Review.


ATP-binding cassette B10 regulates early steps of heme synthesis.

Bayeva M, Khechaduri A, Wu R, Burke MA, Wasserstrom JA, Singh N, Liesa M, Shirihai OS, Langer NB, Paw BH, Ardehali H.

Circ Res. 2013 Jul 19;113(3):279-87. doi: 10.1161/CIRCRESAHA.113.301552. Epub 2013 May 29.


Increased arterial wave reflection magnitude: a novel form of stage B heart failure?

Shah SJ, Wasserstrom JA.

J Am Coll Cardiol. 2012 Nov 20;60(21):2178-81. doi: 10.1016/j.jacc.2012.07.055. Epub 2012 Oct 24. No abstract available.


SERCA2a gene therapy for the prevention of sudden cardiac death: a future theranostic for heart failure?

Shah SJ, Wasserstrom JA.

Circulation. 2012 Oct 23;126(17):2047-50. doi: 10.1161/CIRCULATIONAHA.112.138321. Epub 2012 Sep 27. No abstract available.


Elucidation of a novel pathway through which HDAC1 controls cardiomyocyte differentiation through expression of SOX-17 and BMP2.

Hoxha E, Lambers E, Wasserstrom JA, Mackie A, Ramirez V, Abramova T, Verma SK, Krishnamurthy P, Kishore R.

PLoS One. 2012;7(9):e45046. doi: 10.1371/journal.pone.0045046. Epub 2012 Sep 12.


Histone deacetylase 1 deficiency impairs differentiation and electrophysiological properties of cardiomyocytes derived from induced pluripotent cells.

Hoxha E, Lambers E, Xie H, De Andrade A, Krishnamurthy P, Wasserstrom JA, Ramirez V, Thal M, Verma SK, Soares MB, Kishore R.

Stem Cells. 2012 Nov;30(11):2412-22. doi: 10.1002/stem.1209.


Contribution of fibrosis and the autonomic nervous system to atrial fibrillation electrograms in heart failure.

Koduri H, Ng J, Cokic I, Aistrup GL, Gordon D, Wasserstrom JA, Kadish AH, Lee R, Passman R, Knight BP, Goldberger JJ, Arora R.

Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):640-9. doi: 10.1161/CIRCEP.111.970095. Epub 2012 Jun 21.


Intracellular Ca2+ waves, afterdepolarizations, and triggered arrhythmias.

Shiferaw Y, Aistrup GL, Wasserstrom JA.

Cardiovasc Res. 2012 Aug 1;95(3):265-8. doi: 10.1093/cvr/cvs155. Epub 2012 Apr 27. No abstract available.


Are we ready for a new mechanism of action underlying digitalis toxicity?

Wasserstrom JA.

J Physiol. 2011 Nov 1;589(Pt 21):5015. doi: 10.1113/jphysiol.2011.219774. No abstract available.


Arrhythmia triggers in heart failure: the smoking gun of [Ca2+]i dysregulation.

Aistrup GL, Balke CW, Wasserstrom JA.

Heart Rhythm. 2011 Nov;8(11):1804-8. doi: 10.1016/j.hrthm.2011.06.012. Epub 2011 Jun 12. Review.


Targeted nonviral gene-based inhibition of Gα(i/o)-mediated vagal signaling in the posterior left atrium decreases vagal-induced atrial fibrillation.

Aistrup GL, Cokic I, Ng J, Gordon D, Koduri H, Browne S, Arapi D, Segon Y, Goldstein J, Angulo A, Wasserstrom JA, Goldberger JJ, Kadish AH, Arora R.

Heart Rhythm. 2011 Nov;8(11):1722-9. doi: 10.1016/j.hrthm.2011.06.018. Epub 2011 Aug 25.


Autonomic remodeling in the left atrium and pulmonary veins in heart failure: creation of a dynamic substrate for atrial fibrillation.

Ng J, Villuendas R, Cokic I, Schliamser JE, Gordon D, Koduri H, Benefield B, Simon J, Murthy SN, Lomasney JW, Wasserstrom JA, Goldberger JJ, Aistrup GL, Arora R.

Circ Arrhythm Electrophysiol. 2011 Jun;4(3):388-96. doi: 10.1161/CIRCEP.110.959650. Epub 2011 Mar 18.


A mathematical model of spontaneous calcium release in cardiac myocytes.

Chen W, Aistrup G, Wasserstrom JA, Shiferaw Y.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1794-805. doi: 10.1152/ajpheart.01121.2010. Epub 2011 Feb 25.


Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury.

Wu R, Smeele KM, Wyatt E, Ichikawa Y, Eerbeek O, Sun L, Chawla K, Hollmann MW, Nagpal V, Heikkinen S, Laakso M, Jujo K, Wasserstrom JA, Zuurbier CJ, Ardehali H.

Circ Res. 2011 Jan 7;108(1):60-9. doi: 10.1161/CIRCRESAHA.110.223115. Epub 2010 Nov 11.


Early development of intracellular calcium cycling defects in intact hearts of spontaneously hypertensive rats.

Kapur S, Aistrup GL, Sharma R, Kelly JE, Arora R, Zheng J, Veramasuneni M, Kadish AH, Balke CW, Wasserstrom JA.

Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1843-53. doi: 10.1152/ajpheart.00623.2010. Epub 2010 Oct 1.


Variability in timing of spontaneous calcium release in the intact rat heart is determined by the time course of sarcoplasmic reticulum calcium load.

Wasserstrom JA, Shiferaw Y, Chen W, Ramakrishna S, Patel H, Kelly JE, O'Toole MJ, Pappas A, Chirayil N, Bassi N, Akintilo L, Wu M, Arora R, Aistrup GL.

Circ Res. 2010 Oct 29;107(9):1117-26. doi: 10.1161/CIRCRESAHA.110.229294. Epub 2010 Sep 9.


Changes in intracellular Na+ in heart failure following SERCA knockout--more of a solution or more of a problem?

Wasserstrom JA.

J Physiol. 2010 Apr 1;588(Pt 7):1027. doi: 10.1113/jphysiol.2010.188474. No abstract available.


Embryonic stem cells overexpressing Pitx2c engraft in infarcted myocardium and improve cardiac function.

Guddati AK, Otero JJ, Kessler E, Aistrup G, Wasserstrom JA, Han X, Lomasney JW, Kessler JA.

Int Heart J. 2009 Nov;50(6):783-799.


Multiple defects in intracellular calcium cycling in whole failing rat heart.

Wasserstrom JA, Sharma R, Kapur S, Kelly JE, Kadish AH, Balke CW, Aistrup GL.

Circ Heart Fail. 2009 May;2(3):223-32. doi: 10.1161/CIRCHEARTFAILURE.108.811539. Epub 2009 Mar 30.


Ranolazine antagonizes the effects of increased late sodium current on intracellular calcium cycling in rat isolated intact heart.

Wasserstrom JA, Sharma R, O'Toole MJ, Zheng J, Kelly JE, Shryock J, Belardinelli L, Aistrup GL.

J Pharmacol Exp Ther. 2009 Nov;331(2):382-91. doi: 10.1124/jpet.109.156471. Epub 2009 Aug 12.


Targeted G-protein inhibition as a novel approach to decrease vagal atrial fibrillation by selective parasympathetic attenuation.

Aistrup GL, Villuendas R, Ng J, Gilchrist A, Lynch TW, Gordon D, Cokic I, Mottl S, Zhou R, Dean DA, Wasserstrom JA, Goldberger JJ, Kadish AH, Arora R.

Cardiovasc Res. 2009 Aug 1;83(3):481-92. doi: 10.1093/cvr/cvp148. Epub 2009 May 20.


Role of coupled gating between cardiac ryanodine receptors in the genesis of triggered arrhythmias.

Chen W, Wasserstrom JA, Shiferaw Y.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H171-80. doi: 10.1152/ajpheart.00098.2009. Epub 2009 May 8.


Acidosis and ischemia increase cellular Ca2+ transient alternans and repolarization alternans susceptibility in the intact rat heart.

Kapur S, Wasserstrom JA, Kelly JE, Kadish AH, Aistrup GL.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1491-512. doi: 10.1152/ajpheart.00539.2008. Epub 2009 Mar 13.


Mechanisms underlying the formation and dynamics of subcellular calcium alternans in the intact rat heart.

Aistrup GL, Shiferaw Y, Kapur S, Kadish AH, Wasserstrom JA.

Circ Res. 2009 Mar 13;104(5):639-49. doi: 10.1161/CIRCRESAHA.108.181909. Epub 2009 Jan 15.


Characteristics of intracellular Ca2+ cycling in intact rat heart: a comparison of sex differences.

Wasserstrom JA, Kapur S, Jones S, Faruque T, Sharma R, Kelly JE, Pappas A, Ho W, Kadish AH, Aistrup GL.

Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H1895-904. doi: 10.1152/ajpheart.00469.2008. Epub 2008 Sep 5.


Cellular and subcellular alternans in the canine left ventricle.

Cordeiro JM, Malone JE, Di Diego JM, Scornik FS, Aistrup GL, Antzelevitch C, Wasserstrom JA.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3506-16. Epub 2007 Sep 28.


Pacing-induced heterogeneities in intracellular Ca2+ signaling, cardiac alternans, and ventricular arrhythmias in intact rat heart.

Aistrup GL, Kelly JE, Kapur S, Kowalczyk M, Sysman-Wolpin I, Kadish AH, Wasserstrom JA.

Circ Res. 2006 Sep 29;99(7):e65-73. Epub 2006 Sep 7.


Biphasic changes in cardiac excitation-contraction coupling early in chronic alcohol exposure.

Aistrup GL, Kelly JE, Piano MR, Wasserstrom JA.

Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1047-57. Epub 2006 Apr 28.


Digitalis: new actions for an old drug.

Wasserstrom JA, Aistrup GL.

Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H1781-93. Review.


Defective excitation-contraction coupling in hearts of rats with congestive heart failure.

Sjaastad I, Birkeland JA, Ferrier G, Howlett S, Skomedal T, Bjørnerheim R, Wasserstrom JA, Sejersted OM.

Acta Physiol Scand. 2005 May;184(1):45-58.


Ouabain increases sarcoplasmic reticulum calcium release in cardiac myocytes.

Nishio M, Ruch SW, Kelly JE, Aistrup GL, Sheehan K, Wasserstrom JA.

J Pharmacol Exp Ther. 2004 Mar;308(3):1181-90. Epub 2003 Nov 21.


Localization and function of the Na+/Ca2+-exchanger in normal and detubulated rat cardiomyocytes.

Thomas MJ, Sjaastad I, Andersen K, Helm PJ, Wasserstrom JA, Sejersted OM, Ottersen OP.

J Mol Cell Cardiol. 2003 Nov;35(11):1325-37.


Effect of cardiac glycosides on action potential characteristics and contractility in cat ventricular myocytes: role of calcium overload.

Ruch SR, Nishio M, Wasserstrom JA.

J Pharmacol Exp Ther. 2003 Oct;307(1):419-28. Epub 2003 Sep 3.


Heart failure -- a challenge to our current concepts of excitation-contraction coupling.

Sjaastad I, Wasserstrom JA, Sejersted OM.

J Physiol. 2003 Jan 1;546(Pt 1):33-47. Review.


Positive inotropic effects of ouabain in isolated cat ventricular myocytes in sodium-free conditions.

Nishio M, Ruch SW, Wasserstrom JA.

Am J Physiol Heart Circ Physiol. 2002 Nov;283(5):H2045-53.


Normal contractions triggered by I(Ca,L) in ventricular myocytes from rats with postinfarction CHF.

Sjaastad I, Bøkenes J, Swift F, Wasserstrom JA, Sejersted OM.

Am J Physiol Heart Circ Physiol. 2002 Sep;283(3):H1225-36.


Activation of cardiac ryanodine receptors by the calcium channel agonist FPL-64176.

Wasserstrom JA, Wasserstrom LA, Lokuta AJ, Kelly JE, Reddy ST, Frank AJ.

Am J Physiol Heart Circ Physiol. 2002 Jul;283(1):H331-8.


Subconductance activity induced by quinidine and quinidinium in purified cardiac sarcoplasmic reticulum calcium release channels.

Tsushima RG, Kelly JE, Wasserstrom JA.

J Pharmacol Exp Ther. 2002 May;301(2):729-37.


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