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Transendothelial Insulin Transport is Impaired in Skeletal Muscle Capillaries of Obese Male Mice.

Williams IM, McClatchey PM, Bracy DP, Bonner JS, Valenzuela FA, Wasserman DH.

Obesity (Silver Spring). 2020 Jan 5. doi: 10.1002/oby.22683. [Epub ahead of print]


Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.

Williams AS, Koves TR, Davidson MT, Crown SB, Fisher-Wellman KH, Torres MJ, Draper JA, Narowski TM, Slentz DH, Lantier L, Wasserman DH, Grimsrud PA, Muoio DM.

Cell Metab. 2020 Jan 7;31(1):131-147.e11. doi: 10.1016/j.cmet.2019.11.003. Epub 2019 Dec 5.


Whole Body Irradiation Induces Diabetes and Adipose Insulin Resistance in Nonhuman Primates.

Bacarella N, Ruggiero A, Davis AT, Uberseder B, Davis MA, Bracy DP, Wasserman DH, Cline JM, Sherrill C, Kavanagh K.

Int J Radiat Oncol Biol Phys. 2019 Dec 2. pii: S0360-3016(19)34079-9. doi: 10.1016/j.ijrobp.2019.11.034. [Epub ahead of print]


CD44 contributes to hyaluronan-mediated insulin resistance in skeletal muscle of high-fat-fed C57BL/6 mice.

Hasib A, Hennayake CK, Bracy DP, Bugler-Lamb AR, Lantier L, Khan F, Ashford MLJ, McCrimmon RJ, Wasserman DH, Kang L.

Am J Physiol Endocrinol Metab. 2019 Dec 1;317(6):E973-E983. doi: 10.1152/ajpendo.00215.2019. Epub 2019 Sep 24.


Perfusion controls muscle glucose uptake by altering the rate of glucose dispersion in vivo.

McClatchey PM, Williams IM, Xu Z, Mignemi NA, Hughey CC, McGuinness OP, Beckman JA, Wasserman DH.

Am J Physiol Endocrinol Metab. 2019 Dec 1;317(6):E1022-E1036. doi: 10.1152/ajpendo.00260.2019. Epub 2019 Sep 17.


Fibrotic Encapsulation Is the Dominant Source of Continuous Glucose Monitor Delays.

McClatchey PM, McClain ES, Williams IM, Malabanan CM, James FD, Lord PC, Gregory JM, Cliffel DE, Wasserman DH.

Diabetes. 2019 Oct;68(10):1892-1901. doi: 10.2337/db19-0229. Epub 2019 Aug 9.


Microvascular Disease, Peripheral Artery Disease, and Amputation.

Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, Bedimo RJ, Butt AA, Marconi VC, Sico JJ, Tindle HA, Bonaca MP, Aday AW, Freiberg MS.

Circulation. 2019 Aug 6;140(6):449-458. doi: 10.1161/CIRCULATIONAHA.119.040672. Epub 2019 Jul 8.


Rapid changes in the microvascular circulation of skeletal muscle impair insulin delivery during sepsis.

Mignemi NA, McClatchey PM, Kilchrist KV, Williams IM, Millis BA, Syring KE, Duvall CL, Wasserman DH, McGuinness OP.

Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1012-E1023. doi: 10.1152/ajpendo.00501.2018. Epub 2019 Mar 12.


Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.

Hughey CC, James FD, Wang Z, Goelzer M, Wasserman DH.

Mol Metab. 2019 May;23:1-13. doi: 10.1016/j.molmet.2019.02.006. Epub 2019 Feb 25.


Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner.

Trefts E, Hughey CC, Lantier L, Lark DS, Boyd KL, Pozzi A, Zent R, Wasserman DH.

Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1118-E1135. doi: 10.1152/ajpendo.00496.2018. Epub 2019 Mar 5.


SIRT2 knockout exacerbates insulin resistance in high fat-fed mice.

Lantier L, Williams AS, Hughey CC, Bracy DP, James FD, Ansari MA, Gius D, Wasserman DH.

PLoS One. 2018 Dec 11;13(12):e0208634. doi: 10.1371/journal.pone.0208634. eCollection 2018.


CETP Inhibition Improves HDL Function but Leads to Fatty Liver and Insulin Resistance in CETP-Expressing Transgenic Mice on a High-Fat Diet.

Zhu L, Luu T, Emfinger CH, Parks BA, Shi J, Trefts E, Zeng F, Kuklenyik Z, Harris RC, Wasserman DH, Fazio S, Stafford JM.

Diabetes. 2018 Dec;67(12):2494-2506. doi: 10.2337/db18-0474. Epub 2018 Sep 13.


Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.

Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K.

Nat Med. 2018 Sep;24(9):1395-1406. doi: 10.1038/s41591-018-0159-7. Epub 2018 Aug 27.


Acute Nitric Oxide Synthase Inhibition Accelerates Transendothelial Insulin Efflux In Vivo.

Williams IM, McClatchey PM, Bracy DP, Valenzuela FA, Wasserman DH.

Diabetes. 2018 Oct;67(10):1962-1975. doi: 10.2337/db18-0288. Epub 2018 Jul 12.


Automated quantification of microvascular perfusion.

McClatchey PM, Mignemi NA, Xu Z, Williams IM, Reusch JEB, McGuinness OP, Wasserman DH.

Microcirculation. 2018 Aug;25(6):e12482. doi: 10.1111/micc.12482. Epub 2018 Jul 15.


Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates.

Hughey CC, Trefts E, Bracy DP, James FD, Donahue EP, Wasserman DH.

J Biol Chem. 2018 Jul 27;293(30):11944-11954. doi: 10.1074/jbc.RA118.002568. Epub 2018 Jun 11.


The Vasculature in Prediabetes.

Wasserman DH, Wang TJ, Brown NJ.

Circ Res. 2018 Apr 13;122(8):1135-1150. doi: 10.1161/CIRCRESAHA.118.311912. Review.


Reduced Nonexercise Activity Attenuates Negative Energy Balance in Mice Engaged in Voluntary Exercise.

Lark DS, Kwan JR, McClatchey PM, James MN, James FD, Lighton JRB, Lantier L, Wasserman DH.

Diabetes. 2018 May;67(5):831-840. doi: 10.2337/db17-1293. Epub 2018 Mar 6.


Point: Counterpoint Glucose Phosphorylation is/ is not a Significant Barrier to Muscle Glucose Uptake By the Working Muscle.

Wasserman DH, Fueger P, Ploug T, Vinten J.

J Appl Physiol (1985). 2017 Nov 14:8172006. doi: 10.1152/japplphysiol.00817.2006. [Epub ahead of print] No abstract available.


Hepatocyte estrogen receptor alpha mediates estrogen action to promote reverse cholesterol transport during Western-type diet feeding.

Zhu L, Shi J, Luu TN, Neuman JC, Trefts E, Yu S, Palmisano BT, Wasserman DH, Linton MF, Stafford JM.

Mol Metab. 2018 Feb;8:106-116. doi: 10.1016/j.molmet.2017.12.012. Epub 2017 Dec 29.


Insulin exits skeletal muscle capillaries by fluid-phase transport.

Williams IM, Valenzuela FA, Kahl SD, Ramkrishna D, Mezo AR, Young JD, Wells KS, Wasserman DH.

J Clin Invest. 2018 Feb 1;128(2):699-714. doi: 10.1172/JCI94053. Epub 2018 Jan 8.


The liver.

Trefts E, Gannon M, Wasserman DH.

Curr Biol. 2017 Nov 6;27(21):R1147-R1151. doi: 10.1016/j.cub.2017.09.019.


Meta-fibrosis links positive energy balance and mitochondrial metabolism to insulin resistance.

Lark DS, Wasserman DH.

F1000Res. 2017 Sep 27;6:1758. doi: 10.12688/f1000research.11653.1. eCollection 2017. Review.


Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice.

Hughey CC, James FD, Bracy DP, Donahue EP, Young JD, Viollet B, Foretz M, Wasserman DH.

J Biol Chem. 2017 Dec 8;292(49):20125-20140. doi: 10.1074/jbc.M117.811547. Epub 2017 Oct 16.


Correction: Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation.

Hasenour CM, Wall ML, Ridley DE, James FD, Hughey CC, Donahue EP, Viollet B, Foretz M, Young JD, Wasserman DH.

PLoS One. 2017 Aug 16;12(8):e0183601. doi: 10.1371/journal.pone.0183601. eCollection 2017.


Changes in microvascular density differentiate metabolic health outcomes in monkeys with prior radiation exposure and subsequent skeletal muscle ECM remodeling.

Fanning KM, Pfisterer B, Davis AT, Presley TD, Williams IM, Wasserman DH, Cline JM, Kavanagh K.

Am J Physiol Regul Integr Comp Physiol. 2017 Sep 1;313(3):R290-R297. doi: 10.1152/ajpregu.00108.2017. Epub 2017 Jul 12.


Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans.

Gangadhariah MH, Dieckmann BW, Lantier L, Kang L, Wasserman DH, Chiusa M, Caskey CF, Dickerson J, Luo P, Gamboa JL, Capdevila JH, Imig JD, Yu C, Pozzi A, Luther JM.

Diabetologia. 2017 Jun;60(6):1066-1075. doi: 10.1007/s00125-017-4260-0. Epub 2017 Mar 28.


Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation.

Hasenour CM, Ridley DE, James FD, Hughey CC, Donahue EP, Viollet B, Foretz M, Young JD, Wasserman DH.

PLoS One. 2017 Jan 20;12(1):e0170382. doi: 10.1371/journal.pone.0170382. eCollection 2017. Erratum in: PLoS One. 2017 Aug 16;12 (8):e0183601.


Integrin-Linked Kinase Is Necessary for the Development of Diet-Induced Hepatic Insulin Resistance.

Williams AS, Trefts E, Lantier L, Grueter CA, Bracy DP, James FD, Pozzi A, Zent R, Wasserman DH.

Diabetes. 2017 Feb;66(2):325-334. doi: 10.2337/db16-0484. Epub 2016 Nov 29.


Statement of Retraction. Hepatic Glucagon Action Is Essential for Exercise-Induced Reversal of Mouse Fatty Liver. Diabetes 2011;60:2720-2729. DOI: 10.2337/db11-0455.

Berglund ED, Lustig DG, Baheza RA, Hasenour CM, Lee-Young RS, Donahue EP, Lynes SE, Swift LL, Charron MJ, Damon BM, Wasserman DH.

Diabetes. 2016 Aug;65(8):2463. doi: 10.2337/db16-rt08. No abstract available.


Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.

Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW.

Nat Med. 2016 Jul;22(7):800-6. doi: 10.1038/nm.4101. Epub 2016 May 23.


Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice.

Kang L, Mokshagundam S, Reuter B, Lark DS, Sneddon CC, Hennayake C, Williams AS, Bracy DP, James FD, Pozzi A, Zent R, Wasserman DH.

Diabetes. 2016 Jun;65(6):1590-600. doi: 10.2337/db15-1434. Epub 2016 Apr 5.


VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications.

Robciuc MR, Kivelä R, Williams IM, de Boer JF, van Dijk TH, Elamaa H, Tigistu-Sahle F, Molotkov D, Leppänen VM, Käkelä R, Eklund L, Wasserman DH, Groen AK, Alitalo K.

Cell Metab. 2016 Apr 12;23(4):712-24. doi: 10.1016/j.cmet.2016.03.004.


Chronic Angiotensin-(1-7) Improves Insulin Sensitivity in High-Fat Fed Mice Independent of Blood Pressure.

Williams IM, Otero YF, Bracy DP, Wasserman DH, Biaggioni I, Arnold AC.

Hypertension. 2016 May;67(5):983-91. doi: 10.1161/HYPERTENSIONAHA.115.06935. Epub 2016 Mar 14.


Enhanced Glucose Transport, but not Phosphorylation Capacity, Ameliorates Lipopolysaccharide-Induced Impairments in Insulin-Stimulated Muscle Glucose Uptake.

Otero YF, Mulligan KX, Barnes TM, Ford EA, Malabanan CM, Zong H, Pessin JE, Wasserman DH, McGuinness OP.

Shock. 2016 Jun;45(6):677-85. doi: 10.1097/SHK.0000000000000550.


Exercise and the Regulation of Hepatic Metabolism.

Trefts E, Williams AS, Wasserman DH.

Prog Mol Biol Transl Sci. 2015;135:203-25. doi: 10.1016/bs.pmbts.2015.07.010. Epub 2015 Aug 5. Review.


CETP Expression Protects Female Mice from Obesity-Induced Decline in Exercise Capacity.

Cappel DA, Lantier L, Palmisano BT, Wasserman DH, Stafford JM.

PLoS One. 2015 Aug 27;10(8):e0136915. doi: 10.1371/journal.pone.0136915. eCollection 2015.


Erratum: FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization.

O-Sullivan I, Zhang W, Wasserman DH, Liew CW, Liu J, Paik J, DePinho RA, Stolz DB, Kahn CR, Schwartz MW, Unterman TG.

Nat Commun. 2015 Jul 24;6:7861. doi: 10.1038/ncomms8861. No abstract available.


Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery.

Flynn CR, Albaugh VL, Cai S, Cheung-Flynn J, Williams PE, Brucker RM, Bordenstein SR, Guo Y, Wasserman DH, Abumrad NN.

Nat Commun. 2015 Jul 21;6:7715. doi: 10.1038/ncomms8715.


The extracellular matrix and insulin resistance.

Williams AS, Kang L, Wasserman DH.

Trends Endocrinol Metab. 2015 Jul;26(7):357-66. doi: 10.1016/j.tem.2015.05.006. Epub 2015 Jun 6. Review.


Enhanced mitochondrial superoxide scavenging does not improve muscle insulin action in the high fat-fed mouse.

Lark DS, Kang L, Lustig ME, Bonner JS, James FD, Neufer PD, Wasserman DH.

PLoS One. 2015 May 19;10(5):e0126732. doi: 10.1371/journal.pone.0126732. eCollection 2015.


Mass spectrometry-based microassay of (2)H and (13)C plasma glucose labeling to quantify liver metabolic fluxes in vivo.

Hasenour CM, Wall ML, Ridley DE, Hughey CC, James FD, Wasserman DH, Young JD.

Am J Physiol Endocrinol Metab. 2015 Jul 15;309(2):E191-203. doi: 10.1152/ajpendo.00003.2015. Epub 2015 May 19.


FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization.

O-Sullivan I, Zhang W, Wasserman DH, Liew CW, Liu J, Paik J, DePinho RA, Stolz DB, Kahn CR, Schwartz MW, Unterman TG.

Nat Commun. 2015 May 12;6:7079. doi: 10.1038/ncomms8079. Erratum in: Nat Commun. 2015;6:7861.


SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat-Fed Mice.

Lantier L, Williams AS, Williams IM, Yang KK, Bracy DP, Goelzer M, James FD, Gius D, Wasserman DH.

Diabetes. 2015 Sep;64(9):3081-92. doi: 10.2337/db14-1810. Epub 2015 May 6.


Integrin α1-null mice exhibit improved fatty liver when fed a high fat diet despite severe hepatic insulin resistance.

Williams AS, Kang L, Zheng J, Grueter C, Bracy DP, James FD, Pozzi A, Wasserman DH.

J Biol Chem. 2015 Mar 6;290(10):6546-57. doi: 10.1074/jbc.M114.615716. Epub 2015 Jan 15.


Approach to assessing determinants of glucose homeostasis in the conscious mouse.

Hughey CC, Wasserman DH, Lee-Young RS, Lantier L.

Mamm Genome. 2014 Oct;25(9-10):522-38. doi: 10.1007/s00335-014-9533-z. Epub 2014 Jul 30. Review.


Striatal dopamine homeostasis is altered in mice following Roux-en-Y gastric bypass surgery.

Reddy IA, Wasserman DH, Ayala JE, Hasty AH, Abumrad NN, Galli A.

ACS Chem Neurosci. 2014 Oct 15;5(10):943-51. doi: 10.1021/cn500137d. Epub 2014 Aug 5.


Heterozygous SOD2 deletion impairs glucose-stimulated insulin secretion, but not insulin action, in high-fat-fed mice.

Kang L, Dai C, Lustig ME, Bonner JS, Mayes WH, Mokshagundam S, James FD, Thompson CS, Lin CT, Perry CG, Anderson EJ, Neufer PD, Wasserman DH, Powers AC.

Diabetes. 2014 Nov;63(11):3699-710. doi: 10.2337/db13-1845. Epub 2014 Jun 19.


5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo.

Hasenour CM, Ridley DE, Hughey CC, James FD, Donahue EP, Shearer J, Viollet B, Foretz M, Wasserman DH.

J Biol Chem. 2014 Feb 28;289(9):5950-9. doi: 10.1074/jbc.M113.528232. Epub 2014 Jan 8.


Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice.

Kang L, Mayes WH, James FD, Bracy DP, Wasserman DH.

Diabetologia. 2014 Mar;57(3):603-13. doi: 10.1007/s00125-013-3128-1. Epub 2013 Dec 4.

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