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Clinical features, biochemistry and HLA-DRB1 status in children and adolescents with diabetes in Dhaka, Bangladesh.

Zabeen B, Govender D, Hassan Z, Noble JA, Lane JA, Mack SJ, Atkinson MA, Azad K, Wasserfall CH, Ogle GD.

Diabetes Res Clin Pract. 2019 Oct 24;158:107894. doi: 10.1016/j.diabres.2019.107894. [Epub ahead of print]


Temporal Analysis of Amylase Expression in Control, Autoantibody Positive, and Type 1 Diabetes Pancreatic Tissues.

Kusmartseva I, Beery M, Hiller H, Padilla M, Selman S, Posgai A, Nick HS, Campbell-Thompson M, Schatz DA, Haller MJ, Wasserfall CH, Atkinson MA.

Diabetes. 2019 Oct 9. pii: db190554. doi: 10.2337/db19-0554. [Epub ahead of print]


Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes.

Ma H, Lu Y, Lowe K, van der Meijden-Erkelens L, Wasserfall C, Atkinson MA, Song S.

J Clin Med. 2019 Aug 28;8(9). pii: E1321. doi: 10.3390/jcm8091321.


Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model.

Lewis JS, Stewart JM, Marshall GP, Carstens MR, Zhang Y, Dolgova NV, Xia C, Brusko TM, Wasserfall CH, Clare-Salzler MJ, Atkinson MA, Keselowsky BG.

ACS Biomater Sci Eng. 2019 May 13;5(5):2631-2646. doi: 10.1021/acsbiomaterials.9b00332. Epub 2019 Mar 26.


Untargeted metabolomic analysis in non-fasted diabetic dogs by UHPLC-HRMS.

O'Kell AL, Garrett TJ, Wasserfall C, Atkinson MA.

Metabolomics. 2019 Jan 22;15(2):15. doi: 10.1007/s11306-019-1477-6.


A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry.

Damond N, Engler S, Zanotelli VRT, Schapiro D, Wasserfall CH, Kusmartseva I, Nick HS, Thorel F, Herrera PL, Atkinson MA, Bodenmiller B.

Cell Metab. 2019 Mar 5;29(3):755-768.e5. doi: 10.1016/j.cmet.2018.11.014. Epub 2019 Jan 31.


Epidemiology of childhood-onset type 1 diabetes in Azerbaijan: Incidence, clinical features, biochemistry, and HLA-DRB1 status.

Ahmadov GA, Govender D, Atkinson MA, Sultanova RA, Eubova AA, Wasserfall CH, Mack SJ, Lane JA, Noble JA, Ogle GD.

Diabetes Res Clin Pract. 2018 Oct;144:252-259. doi: 10.1016/j.diabres.2018.09.009. Epub 2018 Sep 13.


Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes.

Tezza S, Ben Nasr M, D'Addio F, Vergani A, Usuelli V, Falzoni S, Bassi R, Dellepiane S, Fotino C, Rossi C, Maestroni A, Solini A, Corradi D, Giani E, Mameli C, Bertuzzi F, Pezzolesi MG, Wasserfall CH, Atkinson MA, Füchtbauer EM, Ricordi C, Folli F, Di Virgilio F, Pileggi A, Dhe-Paganon S, Zuccotti GV, Fiorina P.

Diabetes. 2018 Oct;67(10):2038-2053. doi: 10.2337/db17-1227. Epub 2018 Jul 31.


Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.

Perry DJ, Wasserfall CH, Oram RA, Williams MD, Posgai A, Muir AB, Haller MJ, Schatz DA, Wallet MA, Mathews CE, Atkinson MA, Brusko TM.

Sci Rep. 2018 Mar 14;8(1):4529. doi: 10.1038/s41598-018-22574-5.


Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.

Smith MJ, Rihanek M, Wasserfall C, Mathews CE, Atkinson MA, Gottlieb PA, Cambier JC.

Diabetes. 2018 Apr;67(4):697-703. doi: 10.2337/db17-0937. Epub 2018 Jan 17.


PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes.

Ben Nasr M, Tezza S, D'Addio F, Mameli C, Usuelli V, Maestroni A, Corradi D, Belletti S, Albarello L, Becchi G, Fadini GP, Schuetz C, Markmann J, Wasserfall C, Zon L, Zuccotti GV, Fiorina P.

Sci Transl Med. 2017 Nov 15;9(416). pii: eaam7543. doi: 10.1126/scitranslmed.aam7543.


Hospital time prior to death and pancreas histopathology: implications for future studies.

Kusmartseva I, Beery M, Philips T, Selman S, Jadhav P, Wasserfall C, Muller A, Pugliese A, Longmate JA, Schatz DA, Atkinson MA, Kaddis JS.

Diabetologia. 2018 Apr;61(4):954-958. doi: 10.1007/s00125-017-4494-x. Epub 2017 Nov 11.


Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy.

Wang Q, Racine JJ, Ratiu JJ, Wang S, Ettinger R, Wasserfall C, Atkinson MA, Serreze DV.

J Immunol. 2017 Dec 1;199(11):3757-3770. doi: 10.4049/jimmunol.1700822. Epub 2017 Oct 20.


Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.

Wasserfall C, Nick HS, Campbell-Thompson M, Beachy D, Haataja L, Kusmartseva I, Posgai A, Beery M, Rhodes C, Bonifacio E, Arvan P, Atkinson M.

Cell Metab. 2017 Sep 5;26(3):568-575.e3. doi: 10.1016/j.cmet.2017.08.013.


Proteoliposome-based full-length ZnT8 self-antigen for type 1 diabetes diagnosis on a plasmonic platform.

Wan H, Merriman C, Atkinson MA, Wasserfall CH, Mcgrail KM, Liang Y, Fu D, Dai H.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10196-10201. doi: 10.1073/pnas.1711169114. Epub 2017 Sep 5.


Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes.

O'Kell AL, Garrett TJ, Wasserfall C, Atkinson MA.

Sci Rep. 2017 Aug 25;7(1):9467. doi: 10.1038/s41598-017-09908-5.


High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes.

Jacobsen LM, Haller MJ, Parish A, Gurka MJ, Levine SR, Wasserfall C, Campbell-Thompson M, Kaddis J, Pugliese A, Atkinson MA, Schatz DA.

Diabetes Care. 2017 Sep;40(9):e122-e123. doi: 10.2337/dc17-0996. Epub 2017 Jul 5. No abstract available.


Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults.

Marcial GE, Ford AL, Haller MJ, Gezan SA, Harrison NA, Cai D, Meyer JL, Perry DJ, Atkinson MA, Wasserfall CH, Garrett T, Gonzalez CF, Brusko TM, Dahl WJ, Lorca GL.

Front Immunol. 2017 Jun 12;8:655. doi: 10.3389/fimmu.2017.00655. eCollection 2017.


Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?

O'Kell AL, Wasserfall C, Catchpole B, Davison LJ, Hess RS, Kushner JA, Atkinson MA.

Diabetes. 2017 Jun;66(6):1443-1452. doi: 10.2337/db16-1551.


Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes.

Ratiu JJ, Racine JJ, Hasham MG, Wang Q, Branca JA, Chapman HD, Zhu J, Donghia N, Philip V, Schott WH, Wasserfall C, Atkinson MA, Mills KD, Leeth CM, Serreze DV.

J Immunol. 2017 Jun 1;198(11):4255-4267. doi: 10.4049/jimmunol.1700024. Epub 2017 May 1.


Suppression of islet homeostasis protein thwarts diabetes mellitus progression.

Oh SH, Jorgensen ML, Wasserfall CH, Gjymishka A, Petersen BE.

Lab Invest. 2017 May;97(5):577-590. doi: 10.1038/labinvest.2017.15. Epub 2017 Feb 20.


Plant-based vaccines for oral delivery of type 1 diabetes-related autoantigens: Evaluating oral tolerance mechanisms and disease prevention in NOD mice.

Posgai AL, Wasserfall CH, Kwon KC, Daniell H, Schatz DA, Atkinson MA.

Sci Rep. 2017 Feb 13;7:42372. doi: 10.1038/srep42372.


Serum Trypsinogen Levels in Type 1 Diabetes.

Li X, Campbell-Thompson M, Wasserfall CH, McGrail K, Posgai A, Schultz AR, Brusko TM, Shuster J, Liang F, Muir A, Schatz D, Haller MJ, Atkinson MA.

Diabetes Care. 2017 Apr;40(4):577-582. doi: 10.2337/dc16-1774. Epub 2017 Jan 23.


Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10-Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells.

Takiishi T, Cook DP, Korf H, Sebastiani G, Mancarella F, Cunha JP, Wasserfall C, Casares N, Lasarte JJ, Steidler L, Rottiers P, Dotta F, Gysemans C, Mathieu C.

Diabetes. 2017 Feb;66(2):448-459. doi: 10.2337/db15-1625. Epub 2016 Nov 8.


Factors That Influence the Quality of RNA From the Pancreas of Organ Donors.

Philips T, Kusmartseva I, Gerling IC, Campbell-Thompson M, Wasserfall C, Pugliese A, Longmate JA, Schatz DA, Atkinson MA, Kaddis JS.

Pancreas. 2017 Feb;46(2):252-259. doi: 10.1097/MPA.0000000000000717.


Autoimmune manifestations in aged mice arise from early-life immune dysregulation.

Mahmoud TI, Wang J, Karnell JL, Wang Q, Wang S, Naiman B, Gross P, Brohawn PZ, Morehouse C, Aoyama J, Wasserfall C, Carter L, Atkinson MA, Serreze DV, Braley-Mullen H, Mustelin T, Kolbeck R, Herbst R, Ettinger R.

Sci Transl Med. 2016 Oct 19;8(361):361ra137.


Tracking the Antibody Immunome in Type 1 Diabetes Using Protein Arrays.

Bian X, Wasserfall C, Wallstrom G, Wang J, Wang H, Barker K, Schatz D, Atkinson M, Qiu J, LaBaer J.

J Proteome Res. 2017 Jan 6;16(1):195-203. doi: 10.1021/acs.jproteome.6b00354. Epub 2016 Oct 17.


Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.

Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Perry DJ, Schultz AR, Hulme MA, Shuster JJ, Zou B, Wasserfall CH, Posgai AL, Mathews CE, Brusko TM, Atkinson MA, Schatz DA.

Diabetes. 2016 Dec;65(12):3765-3775. Epub 2016 Sep 26.


Raising Awareness: The Need to Promote Allocation of Pancreata From Rare Nondiabetic Donors With Pancreatic Islet Autoimmunity to Type 1 Diabetes Research.

Burke GW 3rd, Posgai AL, Wasserfall CH, Atkinson MA, Pugliese A.

Am J Transplant. 2017 Jan;17(1):306-307. doi: 10.1111/ajt.13983. Epub 2016 Aug 24. No abstract available.


Validation of a rapid type 1 diabetes autoantibody screening assay for community-based screening of organ donors to identify subjects at increased risk for the disease.

Wasserfall C, Montgomery E, Yu L, Michels A, Gianani R, Pugliese A, Nierras C, Kaddis JS, Schatz DA, Bonifacio E, Atkinson MA.

Clin Exp Immunol. 2016 Jul;185(1):33-41. doi: 10.1111/cei.12797. Epub 2016 May 4.


Identification of tissue-specific cell death using methylation patterns of circulating DNA.

Lehmann-Werman R, Neiman D, Zemmour H, Moss J, Magenheim J, Vaknin-Dembinsky A, Rubertsson S, Nellgård B, Blennow K, Zetterberg H, Spalding K, Haller MJ, Wasserfall CH, Schatz DA, Greenbaum CJ, Dorrell C, Grompe M, Zick A, Hubert A, Maoz M, Fendrich V, Bartsch DK, Golan T, Ben Sasson SA, Zamir G, Razin A, Cedar H, Shapiro AM, Glaser B, Shemer R, Dor Y.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1826-34. doi: 10.1073/pnas.1519286113. Epub 2016 Mar 14.


A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.

Gill RG, Pagni PP, Kupfer T, Wasserfall CH, Deng S, Posgai A, Manenkova Y, Bel Hani A, Straub L, Bernstein P, Atkinson MA, Herold KC, von Herrath M, Staeva T, Ehlers MR, Nepom GT.

Diabetes. 2016 May;65(5):1310-6. doi: 10.2337/db15-0492. Epub 2015 Dec 30.


Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes.

Campbell-Thompson M, Fu A, Kaddis JS, Wasserfall C, Schatz DA, Pugliese A, Atkinson MA.

Diabetes. 2016 Mar;65(3):719-31. doi: 10.2337/db15-0779. Epub 2015 Nov 18.


Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice.

Garrigan E, Belkin NS, Seydel F, Han Z, Carter J, McDuffie M, Morel L, Peck AB, Clare-Salzler MJ, Atkinson M, Wasserfall C, Davoodi-Semiromi A, Shi JD, Haskell-Luevano C, Yang LJ, Alexander JJ, Cdebaca A, Piliant T, Riggs C, Amick M, Litherland SA.

Genet Epigenet. 2015 Oct 11;7:5-17. doi: 10.4137/GEG.S29696. eCollection 2015.


Mobilization without immune depletion fails to restore immunological tolerance or preserve beta cell function in recent onset type 1 diabetes.

Haller MJ, Atkinson MA, Wasserfall CH, Brusko TM, Mathews CE, Hulme M, Cintron M, Shuster J, McGrail K, Posgai A, Schatz D.

Clin Exp Immunol. 2016 Mar;183(3):350-7. doi: 10.1111/cei.12731. Epub 2015 Dec 7.


Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays.

Bian X, Wallstrom G, Davis A, Wang J, Park J, Throop A, Steel J, Yu X, Wasserfall C, Schatz D, Atkinson M, Qiu J, LaBaer J.

Diabetes. 2016 Jan;65(1):285-96. doi: 10.2337/db15-0179. Epub 2015 Oct 8.


The influence of type 1 diabetes on pancreatic weight.

Campbell-Thompson ML, Kaddis JS, Wasserfall C, Haller MJ, Pugliese A, Schatz DA, Shuster JJ, Atkinson MA.

Diabetologia. 2016 Jan;59(1):217-221. doi: 10.1007/s00125-015-3752-z. Epub 2015 Sep 10.


A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice.

Yoon YM, Lewis JS, Carstens MR, Campbell-Thompson M, Wasserfall CH, Atkinson MA, Keselowsky BG.

Sci Rep. 2015 Aug 17;5:13155. doi: 10.1038/srep13155.


Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes.

Mathews CE, Xue S, Posgai A, Lightfoot YL, Li X, Lin A, Wasserfall C, Haller MJ, Schatz D, Atkinson MA.

Diabetes. 2015 Nov;64(11):3885-90. doi: 10.2337/db15-0449. Epub 2015 Jul 27.


Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.

Xue S, Posgai A, Wasserfall C, Myhr C, Campbell-Thompson M, Mathews CE, Brusko T, Rabinovitch A, Savinov A, Battaglia M, Schatz D, Haller M, Atkinson MA.

Diabetes. 2015 Nov;64(11):3873-84. doi: 10.2337/db15-0164. Epub 2015 Jul 16.


Myxoma virus suppresses proliferation of activated T lymphocytes yet permits oncolytic virus transfer to cancer cells.

Villa NY, Wasserfall CH, Meacham AM, Wise E, Chan W, Wingard JR, McFadden G, Cogle CR.

Blood. 2015 Jun 11;125(24):3778-88. doi: 10.1182/blood-2014-07-587329. Epub 2015 Apr 22.


A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice.

Lewis JS, Dolgova NV, Zhang Y, Xia CQ, Wasserfall CH, Atkinson MA, Clare-Salzler MJ, Keselowsky BG.

Clin Immunol. 2015 Sep;160(1):90-102. doi: 10.1016/j.clim.2015.03.023. Epub 2015 Apr 2.


Antiviral antibody profiling by high-density protein arrays.

Bian X, Wiktor P, Kahn P, Brunner A, Khela A, Karthikeyan K, Barker K, Yu X, Magee M, Wasserfall CH, Gibson D, Rooney ME, Qiu J, LaBaer J.

Proteomics. 2015 Jun;15(12):2136-45. doi: 10.1002/pmic.201400612. Epub 2015 May 15.


Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes.

Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Rosenthal SM, Shuster JJ, Zou B, Brusko TM, Hulme MA, Wasserfall CH, Mathews CE, Atkinson MA, Schatz DA.

J Clin Invest. 2015 Jan;125(1):448-55. doi: 10.1172/JCI78492. Epub 2014 Dec 15.


Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia.

Kweh FA, Miller JL, Sulsona CR, Wasserfall C, Atkinson M, Shuster JJ, Goldstone AP, Driscoll DJ.

Am J Med Genet A. 2015 Jan;167A(1):69-79. doi: 10.1002/ajmg.a.36810. Epub 2014 Oct 29.


Interleukin-10+ regulatory B cells arise within antigen-experienced CD40+ B cells to maintain tolerance to islet autoantigens.

Kleffel S, Vergani A, Tezza S, Ben Nasr M, Niewczas MA, Wong S, Bassi R, D'Addio F, Schatton T, Abdi R, Atkinson M, Sayegh MH, Wen L, Wasserfall CH, O'Connor KC, Fiorina P.

Diabetes. 2015 Jan;64(1):158-71. doi: 10.2337/db13-1639. Epub 2014 Sep 3.


Minimal change disease: a dysregulation of the podocyte CD80-CTLA-4 axis?

Cara-Fuentes G, Wasserfall CH, Wang H, Johnson RJ, Garin EH.

Pediatr Nephrol. 2014 Dec;29(12):2333-40. doi: 10.1007/s00467-014-2874-8. Epub 2014 Jul 14.


Nardilysin-dependent proteolysis of cell-associated VTCN1 (B7-H4) marks type 1 diabetes development.

Radichev IA, Maneva-Radicheva LV, Amatya C, Parker C, Ellefson J, Wasserfall C, Atkinson M, Burn P, Savinov AY.

Diabetes. 2014 Oct;63(10):3470-82. doi: 10.2337/db14-0213. Epub 2014 May 21.


Combinatorial delivery of immunosuppressive factors to dendritic cells using dual-sized microspheres.

Lewis JS, Roche C, Zhang Y, Brusko TM, Wasserfall CH, Atkinson M, Clare-Salzler MJ, Keselowsky BG.

J Mater Chem B. 2014 May 7;2(17):2562-2574.


Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice.

Robert S, Gysemans C, Takiishi T, Korf H, Spagnuolo I, Sebastiani G, Van Huynegem K, Steidler L, Caluwaerts S, Demetter P, Wasserfall CH, Atkinson MA, Dotta F, Rottiers P, Van Belle TL, Mathieu C.

Diabetes. 2014 Aug;63(8):2876-87. doi: 10.2337/db13-1236. Epub 2014 Mar 27.

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