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Items: 25

1.

Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes.

Lee MB, Dowsett IT, Carr DT, Wasko BM, Stanton SG, Chung MS, Ghodsian N, Bode A, Kiflezghi MG, Uppal PA, Grayden KA, Elala YC, Tang TT, Tran NHB, Tran THB, Diep AB, Hope M, Promislow DEL, Kennedy SR, Kaeberlein M, Herr AJ.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3062-3071. doi: 10.1073/pnas.1815966116. Epub 2019 Feb 4.

2.

Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.

Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9586-9591. doi: 10.1073/pnas.1804264115. Epub 2018 Sep 5.

3.

Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.

Bennett CF, Kwon JJ, Chen C, Russell J, Acosta K, Burnaevskiy N, Crane MM, Bitto A, Vander Wende H, Simko M, Pineda V, Rossner R, Wasko BM, Choi H, Chen S, Park S, Jafari G, Sands B, Perez Olsen C, Mendenhall AR, Morgan PG, Kaeberlein M.

PLoS Genet. 2017 Mar 29;13(3):e1006695. doi: 10.1371/journal.pgen.1006695. eCollection 2017 Mar.

4.

CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes.

Beaupere C, Wasko BM, Lorusso J, Kennedy BK, Kaeberlein M, Labunskyy VM.

Cell Rep. 2017 Feb 21;18(8):1884-1892. doi: 10.1016/j.celrep.2017.01.077.

5.

New functional and biophysical insights into the mitochondrial Rieske iron-sulfur protein from genetic suppressor analysis in C. elegans.

Jafari G, Wasko BM, Kaeberlein M, Crofts AR.

Worm. 2016 Apr 11;5(2):e1174803. doi: 10.1080/21624054.2016.1174803. eCollection 2016 Apr-Jun.

6.

Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae.

Sunshine AB, Ong GT, Nickerson DP, Carr D, Murakami CJ, Wasko BM, Shemorry A, Merz AJ, Kaeberlein M, Dunham MJ.

Aging Cell. 2016 Apr;15(2):317-24. doi: 10.1111/acel.12443. Epub 2016 Jan 13.

7.

Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein.

Jafari G, Wasko BM, Tonge A, Schurman N, Dong C, Li Z, Peters R, Kayser EB, Pitt JN, Morgan PG, Sedensky MM, Crofts AR, Kaeberlein M.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6148-57. doi: 10.1073/pnas.1509416112. Epub 2015 Oct 26.

8.

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.

McCormick MA, Delaney JR, Tsuchiya M, Tsuchiyama S, Shemorry A, Sim S, Chou AC, Ahmed U, Carr D, Murakami CJ, Schleit J, Sutphin GL, Wasko BM, Bennett CF, Wang AM, Olsen B, Beyer RP, Bammler TK, Prunkard D, Johnson SC, Pennypacker JK, An E, Anies A, Castanza AS, Choi E, Dang N, Enerio S, Fletcher M, Fox L, Goswami S, Higgins SA, Holmberg MA, Hu D, Hui J, Jelic M, Jeong KS, Johnston E, Kerr EO, Kim J, Kim D, Kirkland K, Klum S, Kotireddy S, Liao E, Lim M, Lin MS, Lo WC, Lockshon D, Miller HA, Moller RM, Muller B, Oakes J, Pak DN, Peng ZJ, Pham KM, Pollard TG, Pradeep P, Pruett D, Rai D, Robison B, Rodriguez AA, Ros B, Sage M, Singh MK, Smith ED, Snead K, Solanky A, Spector BL, Steffen KK, Tchao BN, Ting MK, Vander Wende H, Wang D, Welton KL, Westman EA, Brem RB, Liu XG, Suh Y, Zhou Z, Kaeberlein M, Kennedy BK.

Cell Metab. 2015 Nov 3;22(5):895-906. doi: 10.1016/j.cmet.2015.09.008. Epub 2015 Oct 8.

9.

H3K36 methylation promotes longevity by enhancing transcriptional fidelity.

Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL.

Genes Dev. 2015 Jul 1;29(13):1362-76. doi: 10.1101/gad.263707.115.

10.

PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae.

Cui HJ, Liu XG, McCormick M, Wasko BM, Zhao W, He X, Yuan Y, Fang BX, Sun XR, Kennedy BK, Suh Y, Zhou ZJ, Kaeberlein M, Feng WL.

Age (Dordr). 2015 Jun;37(3):9788. doi: 10.1007/s11357-015-9788-7. Epub 2015 May 4.

11.

Buffering the pH of the culture medium does not extend yeast replicative lifespan.

Wasko BM, Carr DT, Tung H, Doan H, Schurman N, Neault JR, Feng J, Lee J, Zipkin B, Mouser J, Oudanonh E, Nguyen T, Stetina T, Shemorry A, Lemma M, Kaeberlein M.

F1000Res. 2013 Oct 15;2:216. doi: 10.12688/f1000research.2-216.v1. eCollection 2013.

12.

Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase.

Zhao W, Fang BX, Niu YJ, Liu YN, Liu B, Peng Q, Li JB, Wasko BM, Delaney JR, Kennedy BK, Suh Y, Zhou ZJ, Kaeberlein M, Liu XG.

Mech Ageing Dev. 2014 Jun;138:53-8. doi: 10.1016/j.mad.2014.01.007. Epub 2014 Jan 31.

PMID:
24486555
13.

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.

Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko BM, Ramos FJ, Palmiter RD, Rabinovitch PS, Morgan PG, Sedensky MM, Kaeberlein M.

Science. 2013 Dec 20;342(6165):1524-8. doi: 10.1126/science.1244360. Epub 2013 Nov 14.

14.

Yeast replicative aging: a paradigm for defining conserved longevity interventions.

Wasko BM, Kaeberlein M.

FEMS Yeast Res. 2014 Feb;14(1):148-59. doi: 10.1111/1567-1364.12104. Epub 2013 Oct 30. Review.

15.

Molecular mechanisms underlying genotype-dependent responses to dietary restriction.

Schleit J, Johnson SC, Bennett CF, Simko M, Trongtham N, Castanza A, Hsieh EJ, Moller RM, Wasko BM, Delaney JR, Sutphin GL, Carr D, Murakami CJ, Tocchi A, Xian B, Chen W, Yu T, Goswami S, Higgins S, Holmberg M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Olsen B, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Singh M, Spector BL, Vander Wende H, An EH, Fletcher M, Jelic M, Rabinovitch PS, MacCoss MJ, Han JD, Kennedy BK, Kaeberlein M.

Aging Cell. 2013 Dec;12(6):1050-61. doi: 10.1111/acel.12130. Epub 2013 Aug 11.

16.

End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging.

Delaney JR, Chou A, Olsen B, Carr D, Murakami C, Ahmed U, Sim S, An EH, Castanza AS, Fletcher M, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schleit J, Schuster A, Singh M, Spector BL, Sutphin GL, Wang AM, Wasko BM, Vander Wende H, Kennedy BK, Kaeberlein M.

FEMS Yeast Res. 2013 May;13(3):267-76. doi: 10.1111/1567-1364.12030. Epub 2013 Feb 20.

17.

Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae.

Delaney JR, Murakami C, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Goswami S, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schuster A, Singh M, Spector BL, Wende HV, Wang AM, Wasko BM, Olsen B, Kaeberlein M.

Exp Gerontol. 2013 Oct;48(10):1006-13. doi: 10.1016/j.exger.2012.12.001. Epub 2012 Dec 9.

18.

Quantitative determination of isopentenyl diphosphate in cultured mammalian cells.

Tong H, Kuder CH, Wasko BM, Hohl RJ.

Anal Biochem. 2013 Feb 1;433(1):36-42. doi: 10.1016/j.ab.2012.09.001. Epub 2012 Sep 19.

PMID:
23000003
19.

pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast.

Murakami C, Delaney JR, Chou A, Carr D, Schleit J, Sutphin GL, An EH, Castanza AS, Fletcher M, Goswami S, Higgins S, Holmberg M, Hui J, Jelic M, Jeong KS, Kim JR, Klum S, Liao E, Lin MS, Lo W, Miller H, Moller R, Peng ZJ, Pollard T, Pradeep P, Pruett D, Rai D, Ros V, Schuster A, Singh M, Spector BL, Vander Wende H, Wang AM, Wasko BM, Olsen B, Kaeberlein M.

Cell Cycle. 2012 Aug 15;11(16):3087-96. doi: 10.4161/cc.21465. Epub 2012 Aug 8.

20.

Yeast as a model to understand the interaction between genotype and the response to calorie restriction.

Schleit J, Wasko BM, Kaeberlein M.

FEBS Lett. 2012 Aug 31;586(18):2868-73. doi: 10.1016/j.febslet.2012.07.038. Epub 2012 Jul 22. Review.

21.

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro.

Wasko BM, Smits JP, Shull LW, Wiemer DF, Hohl RJ.

J Lipid Res. 2011 Nov;52(11):1957-64. doi: 10.1194/jlr.M016089. Epub 2011 Sep 8.

22.

Bisphosphonates induce autophagy by depleting geranylgeranyl diphosphate.

Wasko BM, Dudakovic A, Hohl RJ.

J Pharmacol Exp Ther. 2011 May;337(2):540-6. doi: 10.1124/jpet.110.175521. Epub 2011 Feb 18.

PMID:
21335425
23.

Synthesis and biological evaluation of a series of aromatic bisphosphonates.

Barney RJ, Wasko BM, Dudakovic A, Hohl RJ, Wiemer DF.

Bioorg Med Chem. 2010 Oct 15;18(20):7212-20. doi: 10.1016/j.bmc.2010.08.036. Epub 2010 Aug 19.

PMID:
20832326
24.

Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae.

Wasko BM, Holland CL, Resnick MA, Lewis LK.

DNA Repair (Amst). 2009 Feb 1;8(2):162-9. doi: 10.1016/j.dnarep.2008.09.010. Epub 2008 Nov 18.

25.

Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation.

Wiemer AJ, Yu JS, Shull LW, Barney RJ, Wasko BM, Lamb KM, Hohl RJ, Wiemer DF.

Bioorg Med Chem. 2008 Apr 1;16(7):3652-60. doi: 10.1016/j.bmc.2008.02.016. Epub 2008 Feb 8.

PMID:
18308574

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