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Items: 1 to 50 of 57

1.

Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.

Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, Gennarino VA, Wasco W, Schmahmann JD, Albers MW, Zoghbi HY, Tanzi RE.

Cell. 2019 Aug 22;178(5):1159-1175.e17. doi: 10.1016/j.cell.2019.07.043.

PMID:
31442405
2.

Calsenilin, a Presenilin Interactor, Regulates RhoA Signaling and Neurite Outgrowth.

Kim HJ, Lee WH, Kim MJ, Shin S, Jang B, Park JB, Wasco W, Buxbaum JD, Kim YS, Choi EK.

Int J Mol Sci. 2018 Apr 13;19(4). pii: E1196. doi: 10.3390/ijms19041196.

3.

Editorial overview: Molecular & genetic basis of disease.

Bonini NM, Lee EB, Wasco W, Roses AD.

Curr Opin Genet Dev. 2017 Jun;44:iv-vi. doi: 10.1016/j.gde.2017.04.003. Epub 2017 May 2. No abstract available.

PMID:
28473186
4.

Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography.

Li A, Ahsen OO, Liu JJ, Du C, McKee ML, Yang Y, Wasco W, Newton-Cheh CH, O'Donnell CJ, Fujimoto JG, Zhou C, Tanzi RE.

Hum Mol Genet. 2013 Sep 15;22(18):3798-806. doi: 10.1093/hmg/ddt230. Epub 2013 May 21.

5.

Calsenilin regulates presenilin 1/γ-secretase-mediated N-cadherin ε-cleavage and β-catenin signaling.

Jang C, Choi JK, Na YJ, Jang B, Wasco W, Buxbaum JD, Kim YS, Choi EK.

FASEB J. 2011 Dec;25(12):4174-83. doi: 10.1096/fj.11-185926. Epub 2011 Aug 18.

PMID:
21852538
6.

Deficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideum.

Myre MA, Lumsden AL, Thompson MN, Wasco W, MacDonald ME, Gusella JF.

PLoS Genet. 2011 Apr;7(4):e1002052. doi: 10.1371/journal.pgen.1002052. Epub 2011 Apr 28.

7.

Calsenilin is degraded by the ubiquitin-proteasome pathway.

Jang C, Choi JK, Kim E, Park ES, Wasco W, Buxbaum JD, Kim YS, Choi EK.

Biochem Biophys Res Commun. 2011 Feb 11;405(2):180-5. doi: 10.1016/j.bbrc.2010.12.137. Epub 2011 Jan 7.

PMID:
21216226
8.

Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.

Myre MA, Washicosky K, Moir RD, Tesco G, Tanzi RE, Wasco W.

Cell Signal. 2009 Apr;21(4):567-76. doi: 10.1016/j.cellsig.2008.12.008. Epub 2008 Dec 25.

9.

Type 4 OFF cone bipolar cells of the mouse retina express calsenilin and contact cones as well as rods.

Haverkamp S, Specht D, Majumdar S, Zaidi NF, Brandstätter JH, Wasco W, Wässle H, Tom Dieck S.

J Comp Neurol. 2008 Mar 1;507(1):1087-101.

PMID:
18095322
10.

The APP family of proteins: similarities and differences.

Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ.

Biochem Soc Trans. 2007 Apr;35(Pt 2):416-20.

PMID:
17371289
11.

Calsenilin interacts with transcriptional co-repressor C-terminal binding protein(s).

Zaidi NF, Kuplast KG, Washicosky KJ, Kajiwara Y, Buxbaum JD, Wasco W.

J Neurochem. 2006 Aug;98(4):1290-301. Epub 2006 Jun 19.

12.

Expression of calsenilin in neurons and astrocytes in the Alzheimer's disease brain.

Jin JK, Choi JK, Wasco W, Buxbaum JD, Kozlowski PB, Carp RI, Kim YS, Choi EK.

Neuroreport. 2005 Apr 4;16(5):451-5.

PMID:
15770150
13.

Intracellular calcium modulates the nuclear translocation of calsenilin.

Zaidi NF, Thomson EE, Choi EK, Buxbaum JD, Wasco W.

J Neurochem. 2004 May;89(3):593-601.

14.

Altered Abeta formation and long-term potentiation in a calsenilin knock-out.

Lilliehook C, Bozdagi O, Yao J, Gomez-Ramirez M, Zaidi NF, Wasco W, Gandy S, Santucci AC, Haroutunian V, Huntley GW, Buxbaum JD.

J Neurosci. 2003 Oct 8;23(27):9097-106.

15.

Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3.

Choi EK, Miller JS, Zaidi NF, Salih E, Buxbaum JD, Wasco W.

Mol Cell Neurosci. 2003 Jul;23(3):495-506.

PMID:
12837631
16.

gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.

Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ.

Biochemistry. 2003 Jun 10;42(22):6664-73.

PMID:
12779321
17.

Biochemical and immunocytochemical characterization of calsenilin in mouse brain.

Zaidi NF, Berezovska O, Choi EK, Miller JS, Chan H, Lilliehook C, Hyman BT, Buxbaum JD, Wasco W.

Neuroscience. 2002;114(1):247-63.

PMID:
12207970
18.

Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling.

Lilliehook C, Chan S, Choi EK, Zaidi NF, Wasco W, Mattson MP, Buxbaum JD.

Mol Cell Neurosci. 2002 Apr;19(4):552-9.

PMID:
11988022
19.

Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments.

Tekirian TL, Merriam DE, Marshansky V, Miller J, Crowley AC, Chan H, Ausiello D, Brown D, Buxbaum JD, Xia W, Wasco W.

Brain Res Mol Brain Res. 2001 Nov 30;96(1-2):14-20.

PMID:
11731004
20.

Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3.

Osawa M, Tong KI, Lilliehook C, Wasco W, Buxbaum JD, Cheng HY, Penninger JM, Ikura M, Ames JB.

J Biol Chem. 2001 Nov 2;276(44):41005-13. Epub 2001 Sep 4.

21.

Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2.

Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, Wasco W.

J Biol Chem. 2001 Jun 1;276(22):19197-204. Epub 2001 Mar 9.

22.

Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease.

Buxbaum JD, Lilliehook C, Chan JY, Go RC, Bassett SS, Tanzi RE, Wasco W, Blacker D.

Neurosci Lett. 2000 Nov 24;294(3):135-8.

PMID:
11072133
23.

Calsenilin reverses presenilin-mediated enhancement of calcium signaling.

Leissring MA, Yamasaki TR, Wasco W, Buxbaum JD, Parker I, LaFerla FM.

Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8590-3.

24.

Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment.

Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W.

Nat Med. 1998 Oct;4(10):1177-81.

PMID:
9771752
25.
26.

A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes.

Gómez-Isla T, Wasco W, Pettingell WP, Gurubhagavatula S, Schmidt SD, Jondro PD, McNamara M, Rodes LA, DiBlasi T, Growdon WB, Seubert P, Schenk D, Growdon JH, Hyman BT, Tanzi RE.

Ann Neurol. 1997 Jun;41(6):809-13.

PMID:
9189043
27.

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells.

Kim TW, Pettingell WH, Hallmark OG, Moir RD, Wasco W, Tanzi RE.

J Biol Chem. 1997 Apr 25;272(17):11006-10.

28.

Phosphorylation of Alzheimer beta-amyloid precursor-like proteins.

Suzuki T, Ando K, Isohara T, Oishi M, Lim GS, Satoh Y, Wasco W, Tanzi RE, Nairn AC, Greengard P, Gandy SE, Kirino Y.

Biochemistry. 1997 Apr 15;36(15):4643-9.

PMID:
9109675
29.

Developmental regulation of presenilin mRNA expression parallels notch expression.

Berezovska O, Xia MQ, Page K, Wasco W, Tanzi RE, Hyman BT.

J Neuropathol Exp Neurol. 1997 Jan;56(1):40-4.

PMID:
8990127
30.

Quantification of APP and APLP2 mRNA in APOE genotyped Alzheimer's disease brains.

Johnston JA, Norgren S, Ravid R, Wasco W, Winblad B, Lannfelt L, Cowburn RF.

Brain Res Mol Brain Res. 1996 Dec 31;43(1-2):85-95.

PMID:
9037522
31.

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation.

Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacanà E, Sunderland T, Zhao B, Kusiak JW, Wasco W, D'Adamio L.

Science. 1996 Dec 6;274(5293):1710-3.

PMID:
8939861
32.

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.

Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S.

Nat Med. 1996 Aug;2(8):864-70.

PMID:
8705854
33.

The gene defects responsible for familial Alzheimer's disease.

Tanzi RE, Kovacs DM, Kim TW, Moir RD, Guenette SY, Wasco W.

Neurobiol Dis. 1996;3(3):159-68. Review.

PMID:
8980016
34.

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

Kovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W.

Nat Med. 1996 Feb;2(2):224-9.

PMID:
8574969
35.

The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene.

Kovacs DM, Wasco W, Witherby J, Felsenstein KM, Brunel F, Roeder RG, Tanzi RE.

Hum Mol Genet. 1995 Sep;4(9):1527-33.

PMID:
8541835
36.

Familial Alzheimer's chromosome 14 mutations.

Wasco W, Pettingell WP, Jondro PD, Schmidt SD, Gurubhagavatula S, Rodes L, DiBlasi T, Romano DM, Guenette SY, Kovacs DM, et al.

Nat Med. 1995 Sep;1(9):848. No abstract available.

PMID:
7585193
37.

Candidate gene for the chromosome 1 familial Alzheimer's disease locus.

Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu CE, Jondro PD, Schmidt SD, Wang K, et al.

Science. 1995 Aug 18;269(5226):973-7.

PMID:
7638622
38.

A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media.

Webster MT, Groome N, Francis PT, Pearce BR, Sherriff FE, Thinakaran G, Felsenstein KM, Wasco W, Tanzi RE, Bowen DM.

Biochem J. 1995 Aug 15;310 ( Pt 1):95-9.

39.

Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density.

Kim TW, Wu K, Xu JL, McAuliffe G, Tanzi RE, Wasco W, Black IB.

Brain Res Mol Brain Res. 1995 Aug;32(1):36-44.

PMID:
7494461
40.

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH.

Nature. 1995 Jun 29;375(6534):754-60.

PMID:
7596406
41.

The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily.

Bush AI, Pettingell WH Jr, de Paradis M, Tanzi RE, Wasco W.

J Biol Chem. 1994 Oct 28;269(43):26618-21.

42.

Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex.

Ali G, Wasco W, Cai X, Szabo P, Sheu KF, Cooper AJ, Gaston SM, Gusella JF, Tanzi RE, Blass JP.

Somat Cell Mol Genet. 1994 Mar;20(2):99-105.

PMID:
8009371
43.

Genetic studies of Alzheimer's disease: lessons learned and future imperatives.

Tanzi RE, Bush AI, Wasco W.

Neurobiol Aging. 1994;15 Suppl 2:S145-8. Review. No abstract available.

PMID:
7700440
44.

The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene.

Tanzi RE, Petrukhin K, Chernov I, Pellequer JL, Wasco W, Ross B, Romano DM, Parano E, Pavone L, Brzustowicz LM, et al.

Nat Genet. 1993 Dec;5(4):344-50.

PMID:
8298641
45.

Search for the genes responsible for familial Alzheimer's disease.

Wasco W, Peppercorn J, Tanzi RE.

Ann N Y Acad Sci. 1993 Sep 24;695:203-8. Review.

PMID:
8239284
46.

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor.

Wasco W, Gurubhagavatula S, Paradis MD, Romano DM, Sisodia SS, Hyman BT, Neve RL, Tanzi RE.

Nat Genet. 1993 Sep;5(1):95-100.

PMID:
8220435
47.

The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19.

Wasco W, Brook JD, Tanzi RE.

Genomics. 1993 Jan;15(1):237-9. No abstract available.

PMID:
8432545
48.

Genetic heterogeneity of gene defects responsible for familial Alzheimer disease.

Tanzi R, Gaston S, Bush A, Romano D, Pettingell W, Peppercorn J, Paradis M, Gurubhagavatula S, Jenkins B, Wasco W.

Genetica. 1993;91(1-3):255-63. Review.

PMID:
8125274
49.

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

Wasco W, Bupp K, Magendantz M, Gusella JF, Tanzi RE, Solomon F.

Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10758-62.

50.

Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.

Tanzi RE, Vaula G, Romano DM, Mortilla M, Huang TL, Tupler RG, Wasco W, Hyman BT, Haines JL, Jenkins BJ, et al.

Am J Hum Genet. 1992 Aug;51(2):273-82.

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