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Items: 1 to 50 of 95

1.

A protein chimera strategy supports production of a model "difficult-to-express" recombinant target.

Hussain H, Fisher DI, Roth RG, Mark Abbott W, Carballo-Amador MA, Warwicker J, Dickson AJ.

FEBS Lett. 2018 Jun 22. doi: 10.1002/1873-3468.13170. [Epub ahead of print]

PMID:
29933498
2.

Interfacial Adsorption of Monoclonal Antibody COE-3 at the Solid/Water Interface.

Pan F, Li Z, Leyshon T, Rouse D, Li R, Smith C, Campana M, Webster JRP, Bishop SM, Narwal R, van der Walle CF, Warwicker J, Lu JR.

ACS Appl Mater Interfaces. 2018 Jan 10;10(1):1306-1316. doi: 10.1021/acsami.7b13332. Epub 2017 Dec 19.

PMID:
29215260
3.

Features of reactive cysteines discovered through computation: from kinase inhibition to enrichment around protein degrons.

Fowler NJ, Blanford CF, de Visser SP, Warwicker J.

Sci Rep. 2017 Nov 27;7(1):16338. doi: 10.1038/s41598-017-15997-z.

4.

Protein-protein interactions in paralogues: Electrostatics modulates specificity on a conserved steric scaffold.

Ivanov SM, Cawley A, Huber RG, Bond PJ, Warwicker J.

PLoS One. 2017 Oct 10;12(10):e0185928. doi: 10.1371/journal.pone.0185928. eCollection 2017.

5.
6.

Erratum to: Charged residues next to transmembrane regions revisited: "Positive-inside rule" is complemented by the "negative inside depletion/outside enrichment rule".

Baker JA, Wong WC, Eisenhaber B, Warwicker J, Eisenhaber F.

BMC Biol. 2017 Aug 18;15(1):72. doi: 10.1186/s12915-017-0410-6. No abstract available.

7.

Prediction of Reduction Potentials of Copper Proteins with Continuum Electrostatics and Density Functional Theory.

Fowler NJ, Blanford CF, Warwicker J, de Visser SP.

Chemistry. 2017 Nov 2;23(61):15436-15445. doi: 10.1002/chem.201702901. Epub 2017 Sep 21.

8.

Charged residues next to transmembrane regions revisited: "Positive-inside rule" is complemented by the "negative inside depletion/outside enrichment rule".

Baker JA, Wong WC, Eisenhaber B, Warwicker J, Eisenhaber F.

BMC Biol. 2017 Jul 24;15(1):66. doi: 10.1186/s12915-017-0404-4. Erratum in: BMC Biol. 2017 Aug 18;15(1):72.

9.

Neutron Reflection Study of Surface Adsorption of Fc, Fab, and the Whole mAb.

Li Z, Li R, Smith C, Pan F, Campana M, Webster JRP, van der Walle CF, Uddin S, Bishop SM, Narwal R, Warwicker J, Lu JR.

ACS Appl Mater Interfaces. 2017 Jul 12;9(27):23202-23211. doi: 10.1021/acsami.7b06131. Epub 2017 Jun 27.

PMID:
28613817
10.

Protein-Sol: a web tool for predicting protein solubility from sequence.

Hebditch M, Carballo-Amador MA, Charonis S, Curtis R, Warwicker J.

Bioinformatics. 2017 Oct 1;33(19):3098-3100. doi: 10.1093/bioinformatics/btx345.

11.

The effect of charge mutations on the stability and aggregation of a human single chain Fv fragment.

Austerberry JI, Dajani R, Panova S, Roberts D, Golovanov AP, Pluen A, van der Walle CF, Uddin S, Warwicker J, Derrick JP, Curtis R.

Eur J Pharm Biopharm. 2017 Jun;115:18-30. doi: 10.1016/j.ejpb.2017.01.019. Epub 2017 Feb 1.

PMID:
28161552
12.

Proofreading of substrate structure by the Twin-Arginine Translocase is highly dependent on substrate conformational flexibility but surprisingly tolerant of surface charge and hydrophobicity changes.

Jones AS, Austerberry JI, Dajani R, Warwicker J, Curtis R, Derrick JP, Robinson C.

Biochim Biophys Acta. 2016 Dec;1863(12):3116-3124. doi: 10.1016/j.bbamcr.2016.09.006. Epub 2016 Sep 13.

13.

Energetics and Dynamics Across the Bcl-2-Regulated Apoptotic Pathway Reveal Distinct Evolutionary Determinants of Specificity and Affinity.

Ivanov SM, Huber RG, Warwicker J, Bond PJ.

Structure. 2016 Nov 1;24(11):2024-2033. doi: 10.1016/j.str.2016.09.006. Epub 2016 Oct 20.

14.

Polyunsaturated fatty acids inhibit Kv1.4 by interacting with positively charged extracellular pore residues.

Farag NE, Jeong D, Claydon T, Warwicker J, Boyett MR.

Am J Physiol Cell Physiol. 2016 Aug 1;311(2):C255-68. doi: 10.1152/ajpcell.00277.2015. Epub 2016 Jun 8.

15.

Energetic Calculations to Decipher pH-Dependent Oligomerization and Domain Swapping of Proteins.

Shingate P, Warwicker J, Sowdhamini R.

PLoS One. 2015 Jun 4;10(6):e0127716. doi: 10.1371/journal.pone.0127716. eCollection 2015.

16.

Computational Tools for Interpreting Ion Channel pH-Dependence.

Sazanavets I, Warwicker J.

PLoS One. 2015 Apr 27;10(4):e0125293. doi: 10.1371/journal.pone.0125293. eCollection 2015.

17.

Breaking and restoring the hydrophobic core of a centromere-binding protein.

Saeed S, Jowitt TA, Warwicker J, Hayes F.

J Biol Chem. 2015 Apr 3;290(14):9273-83. doi: 10.1074/jbc.M115.638148. Epub 2015 Feb 23.

18.

Deciphering complex patterns of class-I HLA-peptide cross-reactivity via hierarchical grouping.

Mukherjee S, Warwicker J, Chandra N.

Immunol Cell Biol. 2015 Jul;93(6):522-32. doi: 10.1038/icb.2015.3. Epub 2015 Feb 24.

PMID:
25708537
19.

Pathophysiologic Changes in Extracellular pH Modulate Parathyroid Calcium-Sensing Receptor Activity and Secretion via a Histidine-Independent Mechanism.

Campion KL, McCormick WD, Warwicker J, Khayat ME, Atkinson-Dell R, Steward MC, Delbridge LW, Mun HC, Conigrave AD, Ward DT.

J Am Soc Nephrol. 2015 Sep;26(9):2163-71. doi: 10.1681/ASN.2014070653. Epub 2015 Jan 2.

20.

Specific ion and buffer effects on protein-protein interactions of a monoclonal antibody.

Roberts D, Keeling R, Tracka M, van der Walle CF, Uddin S, Warwicker J, Curtis R.

Mol Pharm. 2015 Jan 5;12(1):179-93. doi: 10.1021/mp500533c. Epub 2014 Dec 2.

PMID:
25389571
21.

Structure and mechanism of the bifunctional CinA enzyme from Thermus thermophilus.

Karuppiah V, Thistlethwaite A, Dajani R, Warwicker J, Derrick JP.

J Biol Chem. 2014 Nov 28;289(48):33187-97. doi: 10.1074/jbc.M114.608448. Epub 2014 Oct 13.

22.

The role of electrostatics in protein-protein interactions of a monoclonal antibody.

Roberts D, Keeling R, Tracka M, van der Walle CF, Uddin S, Warwicker J, Curtis R.

Mol Pharm. 2014 Jul 7;11(7):2475-89. doi: 10.1021/mp5002334. Epub 2014 Jun 18.

PMID:
24892385
23.

The Use of Antibodies in Small-Molecule Drug Discovery.

Marsden CJ, Eckersley S, Hebditch M, Kvist AJ, Milner R, Mitchell D, Warwicker J, Marley AE.

J Biomol Screen. 2014 Jul;19(6):829-38. doi: 10.1177/1087057114527770. Epub 2014 Apr 2. Review.

PMID:
24695620
24.

Lysine and arginine content of proteins: computational analysis suggests a new tool for solubility design.

Warwicker J, Charonis S, Curtis RA.

Mol Pharm. 2014 Jan 6;11(1):294-303. doi: 10.1021/mp4004749. Epub 2013 Nov 27.

25.

Soluble expression of proteins correlates with a lack of positively-charged surface.

Chan P, Curtis RA, Warwicker J.

Sci Rep. 2013 Nov 26;3:3333. doi: 10.1038/srep03333.

26.

Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex.

Watson HR, Wunderley L, Andreou T, Warwicker J, High S.

Biochem J. 2013 Dec 1;456(2):297-309. doi: 10.1042/BJ20130100.

27.

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities.

Barkauskaite E, Brassington A, Tan ES, Warwicker J, Dunstan MS, Banos B, Lafite P, Ahel M, Mitchison TJ, Ahel I, Leys D.

Nat Commun. 2013;4:2164. doi: 10.1038/ncomms3164.

28.

The association of BAG6 with SGTA and tail-anchored proteins.

Leznicki P, Roebuck QP, Wunderley L, Clancy A, Krysztofinska EM, Isaacson RL, Warwicker J, Schwappach B, High S.

PLoS One. 2013;8(3):e59590. doi: 10.1371/journal.pone.0059590. Epub 2013 Mar 22.

29.

The transcriptional regulator CprK detects chlorination by combining direct and indirect readout mechanisms.

Kemp LR, Dunstan MS, Fisher K, Warwicker J, Leys D.

Philos Trans R Soc Lond B Biol Sci. 2013 Mar 11;368(1616):20120323. doi: 10.1098/rstb.2012.0323. Print 2013 Apr 19.

30.

Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast and ovarian tumours.

Milner R, Wombwell H, Eckersley S, Barnes D, Warwicker J, Van Dorp E, Rowlinson R, Dearden S, Hughes G, Harbron C, Wellings B, Hodgson D, Womack C, Gray N, Lau A, O'Connor MJ, Marsden C, Kvist AJ.

Virchows Arch. 2013 Mar;462(3):269-79. doi: 10.1007/s00428-012-1368-y. Epub 2013 Jan 25. Erratum in: Virchows Arch. 2013 May;462(5):601. Rowlinson, Rachel [added].

PMID:
23354597
31.

Positional editing of transmembrane domains during ion channel assembly.

Öjemalm K, Watson HR, Roboti P, Cross BC, Warwicker J, von Heijne G, High S.

J Cell Sci. 2013 Jan 15;126(Pt 2):464-72. doi: 10.1242/jcs.111773. Epub 2012 Dec 10.

32.
33.

Temperature-dependent study reveals that dynamics of hydrophobic residues plays an important functional role in the mitochondrial Tim9-Tim10 complex.

Ivanova E, Pang J, Jowitt TA, Yan G, Warwicker J, Sutcliffe MJ, Lu H.

Proteins. 2012 Feb;80(2):602-15. doi: 10.1002/prot.23224. Epub 2011 Nov 17.

PMID:
22095685
34.

Progress in the prediction of pKa values in proteins.

Alexov E, Mehler EL, Baker N, Baptista AM, Huang Y, Milletti F, Nielsen JE, Farrell D, Carstensen T, Olsson MH, Shen JK, Warwicker J, Williams S, Word JM.

Proteins. 2011 Dec;79(12):3260-75. doi: 10.1002/prot.23189. Epub 2011 Oct 15. Review.

35.

pKa predictions with a coupled finite difference Poisson-Boltzmann and Debye-Hückel method.

Warwicker J.

Proteins. 2011 Dec;79(12):3374-80. doi: 10.1002/prot.23078. Epub 2011 Jun 9.

PMID:
21661058
36.

A biochemical analysis of the constraints of tail-anchored protein biogenesis.

Leznicki P, Warwicker J, High S.

Biochem J. 2011 Jun 15;436(3):719-27. doi: 10.1042/BJ20101737.

37.

Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E.

Tait S, Dutta K, Cowburn D, Warwicker J, Doig AJ, McCarthy JE.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17627-32. doi: 10.1073/pnas.1008242107. Epub 2010 Sep 28.

38.

SitesIdentify: a protein functional site prediction tool.

Bray T, Chan P, Bougouffa S, Greaves R, Doig AJ, Warwicker J.

BMC Bioinformatics. 2009 Nov 18;10:379. doi: 10.1186/1471-2105-10-379.

39.

Evidence for the adaptation of protein pH-dependence to subcellular pH.

Chan P, Warwicker J.

BMC Biol. 2009 Oct 22;7:69. doi: 10.1186/1741-7007-7-69.

40.

Stability and solubility of proteins from extremophiles.

Greaves RB, Warwicker J.

Biochem Biophys Res Commun. 2009 Mar 13;380(3):581-5. doi: 10.1016/j.bbrc.2009.01.145. Epub 2009 Jan 29.

PMID:
19285004
41.

Sequence and structural features of enzymes and their active sites by EC class.

Bray T, Doig AJ, Warwicker J.

J Mol Biol. 2009 Mar 13;386(5):1423-36. doi: 10.1016/j.jmb.2008.11.057. Epub 2008 Dec 10.

PMID:
19100748
42.
43.

Charge environments around phosphorylation sites in proteins.

Kitchen J, Saunders RE, Warwicker J.

BMC Struct Biol. 2008 Mar 25;8:19. doi: 10.1186/1472-6807-8-19.

44.

Design of stability at extreme alkaline pH in streptococcal protein G.

Palmer B, Angus K, Taylor L, Warwicker J, Derrick JP.

J Biotechnol. 2008 Apr 30;134(3-4):222-30. doi: 10.1016/j.jbiotec.2007.12.009. Epub 2008 Jan 16.

PMID:
18304667
45.
46.

Modelling the pH-dependent properties of Kv1 potassium channels.

Liu B, Westhead DR, Boyett MR, Warwicker J.

J Mol Biol. 2007 Apr 27;368(2):328-35. Epub 2007 Feb 22.

PMID:
17359997
47.

The CXXC motif at the N terminus of an alpha-helical peptide.

Iqbalsyah TM, Moutevelis E, Warwicker J, Errington N, Doig AJ.

Protein Sci. 2006 Aug;15(8):1945-50.

48.

Subcellular pH and predicted pH-dependent features of proteins.

Chan P, Lovrić J, Warwicker J.

Proteomics. 2006 Jun;6(12):3494-501.

PMID:
16705750
49.

Simulation of non-specific protein-mRNA interactions.

Magee J, Warwicker J.

Nucleic Acids Res. 2005 Nov 27;33(21):6694-9. Print 2005.

50.

Anomalies in the ionic properties of serum albumin.

Salaman MR, Warwicker J.

Proteins. 2005 Nov 15;61(3):468-72.

PMID:
16161108

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