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Items: 1 to 50 of 152


Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systems.

Li A, Nelson SR, Rahmanseresht S, Braet F, Cornachione AS, Previs SB, O'Leary TS, McNamara JW, Rassier DE, Sadayappan S, Previs MJ, Warshaw DM.

Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21882-21892. doi: 10.1073/pnas.1910549116. Epub 2019 Oct 7.


Myosin Va transport of liposomes in three-dimensional actin networks is modulated by actin filament density, position, and polarity.

Lombardo AT, Nelson SR, Kennedy GG, Trybus KM, Walcott S, Warshaw DM.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8326-8335. doi: 10.1073/pnas.1901176116. Epub 2019 Apr 9.


Revealing the mechanism of how cardiac myosin-binding protein C N-terminal fragments sensitize thin filaments for myosin binding.

Inchingolo AV, Previs SB, Previs MJ, Warshaw DM, Kad NM.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6828-6835. doi: 10.1073/pnas.1816480116. Epub 2019 Mar 15.


Single molecule glycosylase studies with engineered 8-oxoguanine DNA damage sites show functional defects of a MUTYH polyposis variant.

Nelson SR, Kathe SD, Hilzinger TS, Averill AM, Warshaw DM, Wallace SS, Lee AJ.

Nucleic Acids Res. 2019 Apr 8;47(6):3058-3071. doi: 10.1093/nar/gkz045.


Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii.

Powell CJ, Ramaswamy R, Kelsen A, Hamelin DJ, Warshaw DM, Bosch J, Burke JE, Ward GE, Boulanger MJ.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10548-E10555. doi: 10.1073/pnas.1811167115. Epub 2018 Oct 22.


Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function.

Papadaki M, Holewinski RJ, Previs SB, Martin TG, Stachowski MJ, Li A, Blair CA, Moravec CS, Van Eyk JE, Campbell KS, Warshaw DM, Kirk JA.

JCI Insight. 2018 Oct 18;3(20). pii: 121264. doi: 10.1172/jci.insight.121264.


Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca2+-dependent manner.

Lin BL, Li A, Mun JY, Previs MJ, Previs SB, Campbell SG, Dos Remedios CG, Tombe PP, Craig R, Warshaw DM, Sadayappan S.

Sci Rep. 2018 Feb 8;8(1):2604. doi: 10.1038/s41598-018-21053-1.


Prior exposure to nutritive and artificial sweeteners differentially alters the magnitude and persistence of sucrose-conditioned flavor preferences in BALB/c and C57BL/6 inbred mouse strains.

LaMagna S, Olsson K, Warshaw D, Fazilov G, Iskhakov B, Buras A, Bodnar RJ.

Nutr Neurosci. 2019 Oct;22(10):706-717. doi: 10.1080/1028415X.2018.1436216. Epub 2018 Feb 7.


Dissecting the molecular assembly of the Toxoplasma gondii MyoA motility complex.

Powell CJ, Jenkins ML, Parker ML, Ramaswamy R, Kelsen A, Warshaw DM, Ward GE, Burke JE, Boulanger MJ.

J Biol Chem. 2017 Nov 24;292(47):19469-19477. doi: 10.1074/jbc.M117.809632. Epub 2017 Sep 25.


Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro.

Lombardo AT, Nelson SR, Ali MY, Kennedy GG, Trybus KM, Walcott S, Warshaw DM.

Nat Commun. 2017 Jun 1;8:15692. doi: 10.1038/ncomms15692.


Acquisition and expression of fat-conditioned flavor preferences are differentially affected by NMDA receptor antagonism in BALB/c and SWR mice.

Kraft TT, Huang D, LaMagna S, Warshaw D, Natanova E, Sclafani A, Bodnar RJ.

Eur J Pharmacol. 2017 Mar 15;799:26-32. doi: 10.1016/j.ejphar.2017.01.034. Epub 2017 Jan 26.


Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion.

Whitelaw JA, Latorre-Barragan F, Gras S, Pall GS, Leung JM, Heaslip A, Egarter S, Andenmatten N, Nelson SR, Warshaw DM, Ward GE, Meissner M.

BMC Biol. 2017 Jan 18;15(1):1. doi: 10.1186/s12915-016-0343-5.


Cargo Transport by Two Coupled Myosin Va Motors on Actin Filaments and Bundles.

Ali MY, Vilfan A, Trybus KM, Warshaw DM.

Biophys J. 2016 Nov 15;111(10):2228-2240. doi: 10.1016/j.bpj.2016.09.046.


Tropomyosin isoforms bias actin track selection by vertebrate myosin Va.

Sckolnick M, Krementsova EB, Warshaw DM, Trybus KM.

Mol Biol Cell. 2016 Oct 1;27(19):2889-97. doi: 10.1091/mbc.E15-09-0641. Epub 2016 Aug 17.


"C.R.E.A.T.E."-ing Unique Primary-Source Research Paper Assignments for a Pleasure and Pain Course Teaching Neuroscientific Principles in a Large General Education Undergraduate Course.

Bodnar RJ, Rotella FM, Loiacono I, Coke T, Olsson K, Barrientos A, Blachorsky L, Warshaw D, Buras A, Sanchez CM, Azad R, Stellar JR.

J Undergrad Neurosci Educ. 2016 Apr 15;14(2):A104-10. eCollection 2016 Spring.


NMDA receptor antagonism differentially reduces acquisition and expression of sucrose- and fructose-conditioned flavor preferences in BALB/c and SWR mice.

Kraft TT, Huang D, Lolier M, Warshaw D, LaMagna S, Natanova E, Sclafani A, Bodnar RJ.

Pharmacol Biochem Behav. 2016 Sep;148:76-83. doi: 10.1016/j.pbb.2016.06.007. Epub 2016 Jun 16.


Dense granule trafficking in Toxoplasma gondii requires a unique class 27 myosin and actin filaments.

Heaslip AT, Nelson SR, Warshaw DM.

Mol Biol Cell. 2016 Jul 1;27(13):2080-9. doi: 10.1091/mbc.E15-12-0824. Epub 2016 May 4.


HEART DISEASE. Throttling back the heart's molecular motor.

Warshaw DM.

Science. 2016 Feb 5;351(6273):556-7. doi: 10.1126/science.aaf1636. No abstract available.


Phosphorylation and calcium antagonistically tune myosin-binding protein C's structure and function.

Previs MJ, Mun JY, Michalek AJ, Previs SB, Gulick J, Robbins J, Warshaw DM, Craig R.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3239-44. doi: 10.1073/pnas.1522236113. Epub 2016 Feb 23.


Flexural Stiffness of Myosin Va Subdomains as Measured from Tethered Particle Motion.

Michalek AJ, Kennedy GG, Warshaw DM, Ali MY.

J Biophys. 2015;2015:465693. doi: 10.1155/2015/465693. Epub 2015 Nov 30.


BALB/c and SWR inbred mice differ in post-oral fructose appetition as revealed by sugar versus non-nutritive sweetener tests.

Kraft TT, Huang D, Lolier M, Warshaw D, LaMagna S, Natanova E, Sclafani A, Bodnar RJ.

Physiol Behav. 2016 Jan 1;153:64-9. doi: 10.1016/j.physbeh.2015.10.020. Epub 2015 Oct 17.


Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling.

Previs MJ, Prosser BL, Mun JY, Previs SB, Gulick J, Lee K, Robbins J, Craig R, Lederer WJ, Warshaw DM.

Sci Adv. 2015;1(1). pii: e1400205.


Dopamine D1 and opioid receptor antagonist-induced reductions of fructose and saccharin intake in BALB/c and SWR inbred mice.

Kraft TT, Huang D, Natanova E, Lolier M, Yakubov Y, La Magna S, Warshaw D, Sclafani A, Bodnar RJ.

Pharmacol Biochem Behav. 2015 Apr;131:13-8. doi: 10.1016/j.pbb.2015.01.010. Epub 2015 Jan 24.


Cytoskeletal dependence of insulin granule movement dynamics in INS-1 beta-cells in response to glucose.

Heaslip AT, Nelson SR, Lombardo AT, Beck Previs S, Armstrong J, Warshaw DM.

PLoS One. 2014 Oct 13;9(10):e109082. doi: 10.1371/journal.pone.0109082. eCollection 2014.


Motor coupling through lipid membranes enhances transport velocities for ensembles of myosin Va.

Nelson SR, Trybus KM, Warshaw DM.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3986-95. doi: 10.1073/pnas.1406535111. Epub 2014 Sep 8.


Biofilm formation protects Escherichia coli against killing by Caenorhabditis elegans and Myxococcus xanthus.

DePas WH, Syed AK, Sifuentes M, Lee JS, Warshaw D, Saggar V, Csankovszki G, Boles BR, Chapman MR.

Appl Environ Microbiol. 2014 Nov;80(22):7079-87. doi: 10.1128/AEM.02464-14. Epub 2014 Sep 5.


Myosin VI must dimerize and deploy its unusual lever arm in order to perform its cellular roles.

Mukherjea M, Ali MY, Kikuti C, Safer D, Yang Z, Sirkia H, Ropars V, Houdusse A, Warshaw DM, Sweeney HL.

Cell Rep. 2014 Sep 11;8(5):1522-32. doi: 10.1016/j.celrep.2014.07.041. Epub 2014 Aug 21.


Two glycosylase families diffusively scan DNA using a wedge residue to probe for and identify oxidatively damaged bases.

Nelson SR, Dunn AR, Kathe SD, Warshaw DM, Wallace SS.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2091-9. doi: 10.1073/pnas.1400386111. Epub 2014 May 5.


Insights into the glycosylase search for damage from single-molecule fluorescence microscopy.

Lee AJ, Warshaw DM, Wallace SS.

DNA Repair (Amst). 2014 Aug;20:23-31. doi: 10.1016/j.dnarep.2014.01.007. Epub 2014 Feb 20. Review.


Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism.

Mun JY, Previs MJ, Yu HY, Gulick J, Tobacman LS, Beck Previs S, Robbins J, Warshaw DM, Craig R.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2170-5. doi: 10.1073/pnas.1316001111. Epub 2014 Jan 29.


Molecular modulation of actomyosin function by cardiac myosin-binding protein C.

Previs MJ, Michalek AJ, Warshaw DM.

Pflugers Arch. 2014 Mar;466(3):439-44. doi: 10.1007/s00424-013-1433-7. Epub 2014 Jan 10. Review.


More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va.

Sckolnick M, Krementsova EB, Warshaw DM, Trybus KM.

J Biol Chem. 2013 Oct 11;288(41):29313-22. doi: 10.1074/jbc.M113.476929. Epub 2013 Aug 26.


Phosphorylation modulates the mechanical stability of the cardiac myosin-binding protein C motif.

Michalek AJ, Howarth JW, Gulick J, Previs MJ, Robbins J, Rosevear PR, Warshaw DM.

Biophys J. 2013 Jan 22;104(2):442-52. doi: 10.1016/j.bpj.2012.12.021.


Myosin VI has a one track mind versus myosin Va when moving on actin bundles or at an intersection.

Ali MY, Previs SB, Trybus KM, Sweeney HL, Warshaw DM.

Traffic. 2013 Jan;14(1):70-81. doi: 10.1111/tra.12017. Epub 2012 Oct 30.


A branched kinetic scheme describes the mechanochemical coupling of Myosin Va processivity in response to substrate.

Zhang C, Ali MY, Warshaw DM, Kad NM.

Biophys J. 2012 Aug 22;103(4):728-37. doi: 10.1016/j.bpj.2012.07.033.


Mechanical coupling between myosin molecules causes differences between ensemble and single-molecule measurements.

Walcott S, Warshaw DM, Debold EP.

Biophys J. 2012 Aug 8;103(3):501-10. doi: 10.1016/j.bpj.2012.06.031.


Molecular mechanics of cardiac myosin-binding protein C in native thick filaments.

Previs MJ, Beck Previs S, Gulick J, Robbins J, Warshaw DM.

Science. 2012 Sep 7;337(6099):1215-8. doi: 10.1126/science.1223602. Epub 2012 Aug 23.


Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor.

Moore JR, Leinwand L, Warshaw DM.

Circ Res. 2012 Jul 20;111(3):375-85. doi: 10.1161/CIRCRESAHA.110.223842. Review.


The extent of cardiac myosin binding protein-C phosphorylation modulates actomyosin function in a graded manner.

Weith AE, Previs MJ, Hoeprich GJ, Previs SB, Gulick J, Robbins J, Warshaw DM.

J Muscle Res Cell Motil. 2012 Dec;33(6):449-59. doi: 10.1007/s10974-012-9312-y. Epub 2012 Jul 3.


Tilting and twirling as myosin V steps along actin filaments as detected by fluorescence polarization.

Warshaw DM.

J Gen Physiol. 2012 Feb;139(2):97-100. doi: 10.1085/jgp.201210769. No abstract available.


Full-length myosin Va exhibits altered gating during processive movement on actin.

Armstrong JM, Krementsova E, Michalek AJ, Heaslip AT, Nelson SR, Trybus KM, Warshaw DM.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):E218-24. doi: 10.1073/pnas.1109709109. Epub 2012 Jan 6.


Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain.

Weith A, Sadayappan S, Gulick J, Previs MJ, Vanburen P, Robbins J, Warshaw DM.

J Mol Cell Cardiol. 2012 Jan;52(1):219-27. doi: 10.1016/j.yjmcc.2011.09.019. Epub 2011 Sep 25.


Quantum dot labeling strategies to characterize single-molecular motors.

Nelson SR, Ali MY, Warshaw DM.

Methods Mol Biol. 2011;778:111-21. doi: 10.1007/978-1-61779-261-8_8.


Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport.

Ali MY, Kennedy GG, Safer D, Trybus KM, Sweeney HL, Warshaw DM.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E535-41. doi: 10.1073/pnas.1104298108. Epub 2011 Aug 1.


Single Qdot-labeled glycosylase molecules use a wedge amino acid to probe for lesions while scanning along DNA.

Dunn AR, Kad NM, Nelson SR, Warshaw DM, Wallace SS.

Nucleic Acids Res. 2011 Sep 1;39(17):7487-98. doi: 10.1093/nar/gkr459. Epub 2011 Jun 11.


Simultaneous observation of tail and head movements of myosin V during processive motion.

Lu H, Kennedy GG, Warshaw DM, Trybus KM.

J Biol Chem. 2010 Dec 31;285(53):42068-74. doi: 10.1074/jbc.M110.180265. Epub 2010 Oct 25.


Modeling smooth muscle myosin's two heads: long-lived enzymatic roles and phosphorylation-dependent equilibria.

Walcott S, Warshaw DM.

Biophys J. 2010 Aug 9;99(4):1129-38. doi: 10.1016/j.bpj.2010.06.018.


Collaborative dynamic DNA scanning by nucleotide excision repair proteins investigated by single- molecule imaging of quantum-dot-labeled proteins.

Kad NM, Wang H, Kennedy GG, Warshaw DM, Van Houten B.

Mol Cell. 2010 Mar 12;37(5):702-13. doi: 10.1016/j.molcel.2010.02.003.


A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity.

Heaslip AT, Leung JM, Carey KL, Catti F, Warshaw DM, Westwood NJ, Ballif BA, Ward GE.

PLoS Pathog. 2010 Jan 15;6(1):e1000720. doi: 10.1371/journal.ppat.1000720.


Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro.

Debold EP, Saber W, Cheema Y, Bookwalter CS, Trybus KM, Warshaw DM, Vanburen P.

J Mol Cell Cardiol. 2010 Feb;48(2):286-92. doi: 10.1016/j.yjmcc.2009.09.014. Epub 2009 Sep 30.

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