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Items: 1 to 50 of 194

1.

Voltage-Independent SK-Channel Dysfunction Causes Neuronal Hyperexcitability in the Hippocampus of Fmr1 Knock-Out Mice.

Deng PY, Carlin D, Oh YM, Myrick LK, Warren ST, Cavalli V, Klyachko VA.

J Neurosci. 2019 Jan 2;39(1):28-43. doi: 10.1523/JNEUROSCI.1593-18.2018. Epub 2018 Nov 2.

PMID:
30389838
2.

Case-control meta-analysis of blood DNA methylation and autism spectrum disorder.

Andrews SV, Sheppard B, Windham GC, Schieve LA, Schendel DE, Croen LA, Chopra P, Alisch RS, Newschaffer CJ, Warren ST, Feinberg AP, Fallin MD, Ladd-Acosta C.

Mol Autism. 2018 Jun 28;9:40. doi: 10.1186/s13229-018-0224-6. eCollection 2018.

3.

Reply to Plüss et al.: The strength of PEMapper/PECaller lies in unbiased calling using large sample sizes.

Johnston HR, Chopra P, Wingo TS, Patel V, Epstein MP, Mulle JG, Warren ST, Zwick ME, Cutler DJ.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8323. doi: 10.1073/pnas.1714535114. Epub 2017 Sep 15. No abstract available.

4.

The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons.

Bienkowski RS, Banerjee A, Rounds JC, Rha J, Omotade OF, Gross C, Morris KJ, Leung SW, Pak C, Jones SK, Santoro MR, Warren ST, Zheng JQ, Bassell GJ, Corbett AH, Moberg KH.

Cell Rep. 2017 Aug 8;20(6):1372-1384. doi: 10.1016/j.celrep.2017.07.038.

5.

PEMapper and PECaller provide a simplified approach to whole-genome sequencing.

Johnston HR, Chopra P, Wingo TS, Patel V; International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome, Epstein MP, Mulle JG, Warren ST, Zwick ME, Cutler DJ.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1923-E1932. doi: 10.1073/pnas.1618065114. Epub 2017 Feb 21.

6.

Unraveling the genetic architecture of copy number variants associated with schizophrenia and other neuropsychiatric disorders.

Rutkowski TP, Schroeder JP, Gafford GM, Warren ST, Weinshenker D, Caspary T, Mulle JG.

J Neurosci Res. 2017 May;95(5):1144-1160. doi: 10.1002/jnr.23970. Epub 2016 Nov 8. Review.

7.

Reactivation of FMR1 by CRISPR/Cas9-Mediated Deletion of the Expanded CGG-Repeat of the Fragile X Chromosome.

Xie N, Gong H, Suhl JA, Chopra P, Wang T, Warren ST.

PLoS One. 2016 Oct 21;11(10):e0165499. doi: 10.1371/journal.pone.0165499. eCollection 2016.

8.

Identification of consensus binding sites clarifies FMRP binding determinants.

Anderson BR, Chopra P, Suhl JA, Warren ST, Bassell GJ.

Nucleic Acids Res. 2016 Aug 19;44(14):6649-59. doi: 10.1093/nar/gkw593. Epub 2016 Jul 4.

9.

A catalog of hemizygous variation in 127 22q11 deletion patients.

Hestand MS, Nowakowska BA, Vergaelen E, Van Houdt J, Dehaspe L, Suhl JA, Del-Favero J, Mortier G, Zackai E, Swillen A, Devriendt K, Gur RE, McDonald-McGinn DM, Warren ST, Emanuel BS, Vermeesch JR.

Hum Genome Var. 2016 Jan 14;3:15065. doi: 10.1038/hgv.2015.65. eCollection 2016.

10.

Single-Nucleotide Mutations in FMR1 Reveal Novel Functions and Regulatory Mechanisms of the Fragile X Syndrome Protein FMRP.

Suhl JA, Warren ST.

J Exp Neurosci. 2015 Dec 8;9(Suppl 2):35-41. doi: 10.4137/JEN.S25524. eCollection 2015. Review.

11.

A 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR.

Suhl JA, Muddashetty RS, Anderson BR, Ifrim MF, Visootsak J, Bassell GJ, Warren ST.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6553-61. doi: 10.1073/pnas.1514260112. Epub 2015 Nov 9.

12.

Genome-wide association study of schizophrenia in Ashkenazi Jews.

Goes FS, McGrath J, Avramopoulos D, Wolyniec P, Pirooznia M, Ruczinski I, Nestadt G, Kenny EE, Vacic V, Peters I, Lencz T, Darvasi A, Mulle JG, Warren ST, Pulver AE.

Am J Med Genet B Neuropsychiatr Genet. 2015 Dec;168(8):649-59. doi: 10.1002/ajmg.b.32349. Epub 2015 Jul 21.

PMID:
26198764
13.

Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures.

Myrick LK, Deng PY, Hashimoto H, Oh YM, Cho Y, Poidevin MJ, Suhl JA, Visootsak J, Cavalli V, Jin P, Cheng X, Warren ST, Klyachko VA.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):949-56. doi: 10.1073/pnas.1423094112. Epub 2015 Jan 5.

14.

Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain.

Myrick LK, Hashimoto H, Cheng X, Warren ST.

Hum Mol Genet. 2015 Mar 15;24(6):1733-40. doi: 10.1093/hmg/ddu586. Epub 2014 Nov 20.

15.

Analysis of FMRP mRNA target datasets reveals highly associated mRNAs mediated by G-quadruplex structures formed via clustered WGGA sequences.

Suhl JA, Chopra P, Anderson BR, Bassell GJ, Warren ST.

Hum Mol Genet. 2014 Oct 15;23(20):5479-91. doi: 10.1093/hmg/ddu272. Epub 2014 May 29.

16.

A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response.

Alpatov R, Lesch BJ, Nakamoto-Kinoshita M, Blanco A, Chen S, Stützer A, Armache KJ, Simon MD, Xu C, Ali M, Murn J, Prisic S, Kutateladze TG, Vakoc CR, Min J, Kingston RE, Fischle W, Warren ST, Page DC, Shi Y.

Cell. 2014 May 8;157(4):869-81. doi: 10.1016/j.cell.2014.03.040.

17.

Coordination of engineered factors with TET1/2 promotes early-stage epigenetic modification during somatic cell reprogramming.

Zhu G, Li Y, Zhu F, Wang T, Jin W, Mu W, Lin W, Tan W, Li W, Street RC, Peng S, Zhang J, Feng Y, Warren ST, Sun Q, Jin P, Chen D.

Stem Cell Reports. 2014 Feb 27;2(3):253-61. doi: 10.1016/j.stemcr.2014.01.012. eCollection 2014 Mar 11.

18.

Comparing the Future Concerns of Early Wave Baby Boomers With the Concerns of Young-Old Adults.

Adams-Price CE, Turner JJ, Warren ST.

J Appl Gerontol. 2015 Sep;34(6):691-711. doi: 10.1177/0733464813493135. Epub 2013 Jul 19.

PMID:
24652891
19.

Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice.

Chopra P, Papale LA, White AT, Hatch A, Brown RM, Garthwaite MA, Roseboom PH, Golos TG, Warren ST, Alisch RS.

BMC Genomics. 2014 Feb 13;15:131. doi: 10.1186/1471-2164-15-131.

20.

Robust regression analysis of copy number variation data based on a univariate score.

Satten GA, Allen AS, Ikeda M, Mulle JG, Warren ST.

PLoS One. 2014 Feb 7;9(2):e86272. doi: 10.1371/journal.pone.0086272. eCollection 2014.

21.

Fragile X syndrome due to a missense mutation.

Myrick LK, Nakamoto-Kinoshita M, Lindor NM, Kirmani S, Cheng X, Warren ST.

Eur J Hum Genet. 2014 Oct;22(10):1185-9. doi: 10.1038/ejhg.2013.311. Epub 2014 Jan 22.

22.

Toward pluripotency by reprogramming: mechanisms and application.

Wang T, Warren ST, Jin P.

Protein Cell. 2013 Nov;4(11):820-32. Review.

23.

Reciprocal duplication of the Williams-Beuren syndrome deletion on chromosome 7q11.23 is associated with schizophrenia.

Mulle JG, Pulver AE, McGrath JA, Wolyniec PS, Dodd AF, Cutler DJ, Sebat J, Malhotra D, Nestadt G, Conrad DF, Hurles M, Barnes CP, Ikeda M, Iwata N, Levinson DF, Gejman PV, Sanders AR, Duan J, Mitchell AA, Peter I, Sklar P, O'Dushlaine CT, Grozeva D, O'Donovan MC, Owen MJ, Hultman CM, Kähler AK, Sullivan PF; Molecular Genetics of Schizophrenia Consortium, Kirov G, Warren ST.

Biol Psychiatry. 2014 Mar 1;75(5):371-7. doi: 10.1016/j.biopsych.2013.05.040. Epub 2013 Jul 17.

24.

Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency.

Wang T, Wu H, Li Y, Szulwach KE, Lin L, Li X, Chen IP, Goldlust IS, Chamberlain SJ, Dodd A, Gong H, Ananiev G, Han JW, Yoon YS, Rudd MK, Yu M, Song CX, He C, Chang Q, Warren ST, Jin P.

Nat Cell Biol. 2013 Jun;15(6):700-11. doi: 10.1038/ncb2748. Epub 2013 May 19.

25.

The unstable repeats--three evolving faces of neurological disease.

Nelson DL, Orr HT, Warren ST.

Neuron. 2013 Mar 6;77(5):825-43. doi: 10.1016/j.neuron.2013.02.022. Review.

26.

Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1 locus.

Alisch RS, Wang T, Chopra P, Visootsak J, Conneely KN, Warren ST.

BMC Med Genet. 2013 Jan 29;14:18. doi: 10.1186/1471-2350-14-18.

27.

Hemizygous mutations in SNAP29 unmask autosomal recessive conditions and contribute to atypical findings in patients with 22q11.2DS.

McDonald-McGinn DM, Fahiminiya S, Revil T, Nowakowska BA, Suhl J, Bailey A, Mlynarski E, Lynch DR, Yan AC, Bilaniuk LT, Sullivan KE, Warren ST, Emanuel BS, Vermeesch JR, Zackai EH, Jerome-Majewska LA.

J Med Genet. 2013 Feb;50(2):80-90. doi: 10.1136/jmedgenet-2012-101320. Epub 2012 Dec 11.

28.

Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum.

Wang T, Pan Q, Lin L, Szulwach KE, Song CX, He C, Wu H, Warren ST, Jin P, Duan R, Li X.

Hum Mol Genet. 2012 Dec 15;21(26):5500-10. doi: 10.1093/hmg/dds394. Epub 2012 Oct 5.

29.

Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen.

Henderson C, Wijetunge L, Kinoshita MN, Shumway M, Hammond RS, Postma FR, Brynczka C, Rush R, Thomas A, Paylor R, Warren ST, Vanderklish PW, Kind PC, Carpenter RL, Bear MF, Healy AM.

Sci Transl Med. 2012 Sep 19;4(152):152ra128.

30.

The human genome: a diamond in the rough.

Emanuel BS, Warren ST, Garber KB.

Curr Opin Genet Dev. 2012 Jun;22(3):189-90. doi: 10.1016/j.gde.2012.04.005. Epub 2012 May 18. No abstract available.

PMID:
22608825
31.

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.

Kenny EE, Pe'er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant SR, Bressman S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, Marder K, McGovern DP, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH, Peter I.

PLoS Genet. 2012;8(3):e1002559. doi: 10.1371/journal.pgen.1002559. Epub 2012 Mar 8.

32.

New perspectives on the biology of fragile X syndrome.

Wang T, Bray SM, Warren ST.

Curr Opin Genet Dev. 2012 Jun;22(3):256-63. doi: 10.1016/j.gde.2012.02.002. Epub 2012 Feb 28. Review.

33.

Genomic tics in tourette syndrome.

Mulle JG, Warren ST.

Biol Psychiatry. 2012 Mar 1;71(5):390-1. doi: 10.1016/j.biopsych.2011.12.017. No abstract available.

PMID:
22310325
34.

Age-associated DNA methylation in pediatric populations.

Alisch RS, Barwick BG, Chopra P, Myrick LK, Satten GA, Conneely KN, Warren ST.

Genome Res. 2012 Apr;22(4):623-32. doi: 10.1101/gr.125187.111. Epub 2012 Feb 1.

35.

Relative burden of large CNVs on a range of neurodevelopmental phenotypes.

Girirajan S, Brkanac Z, Coe BP, Baker C, Vives L, Vu TH, Shafer N, Bernier R, Ferrero GB, Silengo M, Warren ST, Moreno CS, Fichera M, Romano C, Raskind WH, Eichler EE.

PLoS Genet. 2011 Nov;7(11):e1002334. doi: 10.1371/journal.pgen.1002334. Epub 2011 Nov 10.

36.

Local RNA translation at the synapse and in disease.

Liu-Yesucevitz L, Bassell GJ, Gitler AD, Hart AC, Klann E, Richter JD, Warren ST, Wolozin B.

J Neurosci. 2011 Nov 9;31(45):16086-93. doi: 10.1523/JNEUROSCI.4105-11.2011. Review.

37.

Molecular mechanisms of fragile X syndrome: a twenty-year perspective.

Santoro MR, Bray SM, Warren ST.

Annu Rev Pathol. 2012;7:219-45. doi: 10.1146/annurev-pathol-011811-132457. Epub 2011 Oct 10. Review.

PMID:
22017584
38.

An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabilities.

Kaminsky EB, Kaul V, Paschall J, Church DM, Bunke B, Kunig D, Moreno-De-Luca D, Moreno-De-Luca A, Mulle JG, Warren ST, Richard G, Compton JG, Fuller AE, Gliem TJ, Huang S, Collinson MN, Beal SJ, Ackley T, Pickering DL, Golden DM, Aston E, Whitby H, Shetty S, Rossi MR, Rudd MK, South ST, Brothman AR, Sanger WG, Iyer RK, Crolla JA, Thorland EC, Aradhya S, Ledbetter DH, Martin CL.

Genet Med. 2011 Sep;13(9):777-84. doi: 10.1097/GIM.0b013e31822c79f9.

39.

Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling.

Muddashetty RS, Nalavadi VC, Gross C, Yao X, Xing L, Laur O, Warren ST, Bassell GJ.

Mol Cell. 2011 Jun 10;42(5):673-88. doi: 10.1016/j.molcel.2011.05.006.

40.

Deletion 17q12 is a recurrent copy number variant that confers high risk of autism and schizophrenia.

Moreno-De-Luca D; SGENE Consortium, Mulle JG; Simons Simplex Collection Genetics Consortium, Kaminsky EB, Sanders SJ; GeneSTAR, Myers SM, Adam MP, Pakula AT, Eisenhauer NJ, Uhas K, Weik L, Guy L, Care ME, Morel CF, Boni C, Salbert BA, Chandrareddy A, Demmer LA, Chow EW, Surti U, Aradhya S, Pickering DL, Golden DM, Sanger WG, Aston E, Brothman AR, Gliem TJ, Thorland EC, Ackley T, Iyer R, Huang S, Barber JC, Crolla JA, Warren ST, Martin CL, Ledbetter DH.

Am J Hum Genet. 2010 Nov 12;87(5):618-30. doi: 10.1016/j.ajhg.2010.10.004. Epub 2010 Nov 4. Erratum in: Am J Hum Genet. 2011 Jan 7;88(1):121.

41.

Neurogenetics: advancing the "next-generation" of brain research.

Zoghbi HY, Warren ST.

Neuron. 2010 Oct 21;68(2):165-73. doi: 10.1016/j.neuron.2010.10.015.

42.

Identification of novel FMR1 variants by massively parallel sequencing in developmentally delayed males.

Collins SC, Bray SM, Suhl JA, Cutler DJ, Coffee B, Zwick ME, Warren ST.

Am J Med Genet A. 2010 Oct;152A(10):2512-20. doi: 10.1002/ajmg.a.33626.

43.

Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population.

Bray SM, Mulle JG, Dodd AF, Pulver AE, Wooding S, Warren ST.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16222-7. doi: 10.1073/pnas.1004381107. Epub 2010 Aug 26.

44.

Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome.

Gross C, Nakamoto M, Yao X, Chan CB, Yim SY, Ye K, Warren ST, Bassell GJ.

J Neurosci. 2010 Aug 11;30(32):10624-38. doi: 10.1523/JNEUROSCI.0402-10.2010.

45.

Microdeletions of 3q29 confer high risk for schizophrenia.

Mulle JG, Dodd AF, McGrath JA, Wolyniec PS, Mitchell AA, Shetty AC, Sobreira NL, Valle D, Rudd MK, Satten G, Cutler DJ, Pulver AE, Warren ST.

Am J Hum Genet. 2010 Aug 13;87(2):229-36. doi: 10.1016/j.ajhg.2010.07.013.

46.

Empirical evaluation of oligonucleotide probe selection for DNA microarrays.

Mulle JG, Patel VC, Warren ST, Hegde MR, Cutler DJ, Zwick ME.

PLoS One. 2010 Mar 29;5(3):e9921. doi: 10.1371/journal.pone.0009921.

47.

Array-based FMR1 sequencing and deletion analysis in patients with a fragile X syndrome-like phenotype.

Collins SC, Coffee B, Benke PJ, Berry-Kravis E, Gilbert F, Oostra B, Halley D, Zwick ME, Cutler DJ, Warren ST.

PLoS One. 2010 Mar 5;5(3):e9476. doi: 10.1371/journal.pone.0009476.

48.

Incidence of fragile X syndrome by newborn screening for methylated FMR1 DNA.

Coffee B, Keith K, Albizua I, Malone T, Mowrey J, Sherman SL, Warren ST.

Am J Hum Genet. 2009 Oct;85(4):503-14. doi: 10.1016/j.ajhg.2009.09.007.

49.

Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants.

Arlt MF, Mulle JG, Schaibley VM, Ragland RL, Durkin SG, Warren ST, Glover TW.

Am J Hum Genet. 2009 Mar;84(3):339-50. doi: 10.1016/j.ajhg.2009.01.024. Epub 2009 Feb 19.

50.

Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function.

Bassell GJ, Warren ST.

Neuron. 2008 Oct 23;60(2):201-14. doi: 10.1016/j.neuron.2008.10.004. Review.

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