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Hypoxia Modulates Platelet Purinergic Signalling Pathways.

Paterson GG, Young JM, Willson JA, Graham CJ, Dru RC, Lee EW, Torpey GS, Walmsley SR, Chan MV, Warner TD, Baillie JK, Thompson AAR.

Thromb Haemost. 2020 Feb;120(2):253-261. doi: 10.1055/s-0039-3400305. Epub 2019 Dec 13.


Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox.

Mitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR, Kirkby NS.

Circ Res. 2019 Oct 11;125(9):847-854. doi: 10.1161/CIRCRESAHA.119.314927. Epub 2019 Sep 12.


Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage.

Vulliamy P, Gillespie S, Armstrong PC, Allan HE, Warner TD, Brohi K.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17444-17449. doi: 10.1073/pnas.1904978116. Epub 2019 Aug 12.


Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2.

Lucotti S, Cerutti C, Soyer M, Gil-Bernabé AM, Gomes AL, Allen PD, Smart S, Markelc B, Watson K, Armstrong PC, Mitchell JA, Warner TD, Ridley AJ, Muschel RJ.

J Clin Invest. 2019 Mar 25;129(5):1845-1862. doi: 10.1172/JCI121985. eCollection 2019 Mar 25.


Cut to the Quick: The Consequences of Youth Violent Victimization for the Timing of Dating Debut and First Union Formation.

Warner TD, Warner DF, Kuhl DC.

Am Sociol Rev. 2017 Dec;82(6):1241-1271. doi: 10.1177/0003122417734353. Epub 2017 Oct 12.


Inhibition of profibrotic microRNA-21 affects platelets and their releasate.

Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M, Moreau T, Barallobre-Barreiro J, Lynch M, Yin X, Schulte C, Baig F, Pechlaner R, Langley SR, Zampetaki A, Santer P, Weger M, Plasenzotti R, Schosserer M, Grillari J, Kiechl S, Willeit J, Shah AM, Ghevaert C, Warner TD, Fernández-Hernando C, Suárez Y, Mayr M.

JCI Insight. 2018 Nov 2;3(21). pii: 123335. doi: 10.1172/jci.insight.123335.


Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy.

Knowles RB, Warner TD.

Pharmacol Ther. 2019 Jan;193:83-90. doi: 10.1016/j.pharmthera.2018.08.004. Epub 2018 Aug 4. Review.


Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment".

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD.

Circ Res. 2018 May 11;122(10):e84-e85. doi: 10.1161/CIRCRESAHA.118.312976. No abstract available.


Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry.

Chan MV, Leadbeater PD, Watson SP, Warner TD.

Platelets. 2018 Nov;29(7):686-689. doi: 10.1080/09537104.2018.1466388. Epub 2018 May 1.


96-well plate-based aggregometry.

Chan MV, Armstrong PC, Warner TD.

Platelets. 2018 Nov;29(7):650-655. doi: 10.1080/09537104.2018.1445838. Epub 2018 Mar 15. Review.


Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond).

Crescente M, Menke L, Chan MV, Armstrong PC, Warner TD.

Br J Pharmacol. 2019 Apr;176(8):988-999. doi: 10.1111/bph.14196. Epub 2018 Apr 19. Review.


Mental Health Effects of Stress over the Life Span of Refugees.

Hollifield M, Warner TD, Krakow B, Westermeyer J.

J Clin Med. 2018 Feb 6;7(2). pii: E25. doi: 10.3390/jcm7020025.


Broad Consent for Research on Biospecimens: The Views of Actual Donors at Four U.S. Medical Centers.

Warner TD, Weil CJ, Andry C, Degenholtz HB, Parker L, Carithers LJ, Feige M, Wendler D, Pentz RD.

J Empir Res Hum Res Ethics. 2018 Apr;13(2):115-124. doi: 10.1177/1556264617751204. Epub 2018 Feb 1.


Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD.

Circ Res. 2018 Feb 16;122(4):555-559. doi: 10.1161/CIRCRESAHA.117.312144. Epub 2018 Jan 3.


Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levels.

Lundberg Slingsby MH, Gliemann L, Thrane M, Rytter N, Egelund J, Chan MV, Armstrong PC, Warner TD, Hellsten Y.

Acta Physiol (Oxf). 2018 May;223(1):e13028. doi: 10.1111/apha.13028. Epub 2018 Jan 19.


Adolescent Sexual Risk Taking: The Distribution of Youth Behaviors and Perceived Peer Attitudes Across Neighborhood Contexts.

Warner TD.

J Adolesc Health. 2018 Feb;62(2):226-233. doi: 10.1016/j.jadohealth.2017.09.007. Epub 2017 Dec 6.


Inhibition of platelet aggregation ex vivo is repressed in apolipoprotein E deficient mice.

Carrier É, Houde M, Grandbois M, Bkaily G, Warner TD, D'Orléans-Juste P.

Can J Physiol Pharmacol. 2017 Aug;95(8):954-960. doi: 10.1139/cjpp-2017-0314. Epub 2017 Jul 13.


Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets.

Unsworth AJ, Bye AP, Tannetta DS, Desborough MJR, Kriek N, Sage T, Allan HE, Crescente M, Yaqoob P, Warner TD, Jones CI, Gibbins JM.

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1482-1493. doi: 10.1161/ATVBAHA.117.309135. Epub 2017 Jun 15.


Platelet reactivity influences clot structure as assessed by fractal analysis of viscoelastic properties.

Knowles RB, Lawrence MJ, Ferreira PM, Hayman MA, D'Silva LA, Stanford SN, Sabra A, Tucker AT, Hawkins KM, Williams PR, Warner TD, Evans PA.

Platelets. 2018 Mar;29(2):162-170. doi: 10.1080/09537104.2017.1306039. Epub 2017 May 15.


Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies.

Armstrong PC, Hoefer T, Knowles RB, Tucker AT, Hayman MA, Ferreira PM, Chan MV, Warner TD.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):949-956. doi: 10.1161/ATVBAHA.116.308763. Epub 2017 Mar 9.


Why Neighborhoods (and How We Study Them) Matter for Adolescent Development.

Warner TD, Settersten RA Jr.

Adv Child Dev Behav. 2017;52:105-152. doi: 10.1016/bs.acdb.2016.10.003. Epub 2016 Dec 28. Review.


Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing.

Ahmetaj-Shala B, Tesfai A, Constantinou C, Leszczynski R, Chan MV, Gashaw H, Galaris G, Mazi S, Warner TD, Kirkby NS, Mitchell JA.

Biochem Biophys Res Commun. 2017 Mar 18;484(4):762-766. doi: 10.1016/j.bbrc.2017.01.161. Epub 2017 Jan 31.


ISTH Advanced Training Course on platelet bleeding disorders: How should they be investigated?St. Anne's College, Oxford, 6-9th September 2016.

Watson SP, Daly ME, Harrison P, Lowe GC, Paterson A, Rivera J, Warner TD, Morgan NV.

Platelets. 2016 Dec;27(8):719-721. Epub 2016 Nov 14. No abstract available.


Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.

Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD.

FASEB J. 2016 Dec;30(12):4256-4266. Epub 2016 Sep 15.


Knowledge and Awareness of Sickle Cell Trait Among Young African American Adults.

Harrison SE, Walcott CM, Warner TD.

West J Nurs Res. 2017 Sep;39(9):1222-1239. doi: 10.1177/0193945916665089. Epub 2016 Aug 22.


Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid.

Hinz C, Aldrovandi M, Uhlson C, Marnett LJ, Longhurst HJ, Warner TD, Alam S, Slatter DA, Lauder SN, Allen-Redpath K, Collins PW, Murphy RC, Thomas CP, O'Donnell VB.

J Biol Chem. 2016 Jun 24;291(26):13448-64. doi: 10.1074/jbc.M115.700609. Epub 2016 Apr 22.


The Geography of Normative Climates: An Application to Adolescent Substance Use.

Thrash CR, Warner TD.

J Youth Adolesc. 2016 Aug;45(8):1587-603. doi: 10.1007/s10964-016-0444-z. Epub 2016 Feb 22.


Expression of the PlA2 allele of glycoprotein IIIa and its impact on platelet function.

Floyd CN, Ferro A, Warner TD.

JRSM Cardiovasc Dis. 2015 Nov 3;4:2048004015610252. doi: 10.1177/2048004015610252. eCollection 2015 Jan-Dec.


The importance of endothelium-derived mediators to the efficacy of dual anti-platelet therapy.

Warner TD, Armstrong PC, Chan MV, Knowles RB.

Expert Rev Hematol. 2016 Mar;9(3):223-5. doi: 10.1586/17474086.2016.1140035. No abstract available.


Rural providers' access to online resources: a randomized controlled trial.

Eldredge JD, Hall LJ, McElfresh KR, Warner TD, Stromberg TL, Trost J, Jelinek DA.

J Med Libr Assoc. 2016 Jan;104(1):33-41. doi: 10.3163/1536-5050.104.1.005.


Association of MicroRNAs and YRNAs With Platelet Function.

Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton AC, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley SR, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey RF, Mayr M.

Circ Res. 2016 Feb 5;118(3):420-432. doi: 10.1161/CIRCRESAHA.114.305663. Epub 2015 Dec 8.


Adolescent Survival Expectations: Variations by Race, Ethnicity, and Nativity.

Warner TD, Swisher RR.

J Health Soc Behav. 2015 Dec;56(4):478-94. doi: 10.1177/0022146515611730. Epub 2015 Nov 17.


P2Y12 receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation.

Chan MV, Knowles RB, Lundberg MH, Tucker AT, Mohamed NA, Kirkby NS, Armstrong PC, Mitchell JA, Warner TD.

Br J Clin Pharmacol. 2016 Apr;81(4):621-33. doi: 10.1111/bcp.12826. Epub 2016 Feb 10.


Reply to letter regarding article, "evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs".

Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie LS, Armstrong PC, Nüsing RM, Tomlinson JA, Warner TD, Leiper J, Mitchell JA.

Circulation. 2015 Oct 27;132(17):e213-4. doi: 10.1161/CIRCULATIONAHA.115.017260. No abstract available.


Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy.

Hoefer T, Armstrong PC, Finsterbusch M, Chan MV, Kirkby NS, Warner TD.

Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2122-33. doi: 10.1161/ATVBAHA.115.306219. Epub 2015 Aug 13.


Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction.

Armstrong PC, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S, Warner TD.

Blood. 2015 Sep 3;126(10):e11-8. doi: 10.1182/blood-2015-01-621656. Epub 2015 Jul 27.


Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

Kirkby NS, Reed DM, Edin ML, Rauzi F, Mataragka S, Vojnovic I, Bishop-Bailey D, Milne GL, Longhurst H, Zeldin DC, Mitchell JA, Warner TD.

FASEB J. 2015 Nov;29(11):4568-78. doi: 10.1096/fj.15-275065. Epub 2015 Jul 16.


Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation.

Rull G, Mohd-Zain ZN, Shiel J, Lundberg MH, Collier DJ, Johnston A, Warner TD, Corder R.

Vascul Pharmacol. 2015 Aug;71:70-8. doi: 10.1016/j.vph.2015.02.010. Epub 2015 Apr 11.


Association of Atmospheric Particulate Matter and Ozone with Gestational Diabetes Mellitus.

Hu H, Ha S, Henderson BH, Warner TD, Roth J, Kan H, Xu X.

Environ Health Perspect. 2015 Sep;123(9):853-9. doi: 10.1289/ehp.1408456. Epub 2015 Mar 20.


Executive function and cortical thickness in youths prenatally exposed to cocaine, alcohol and tobacco.

Gautam P, Warner TD, Kan EC, Sowell ER.

Dev Cogn Neurosci. 2015 Dec;16:155-165. doi: 10.1016/j.dcn.2015.01.010. Epub 2015 Feb 2.


Prostaglandin E1 potentiates the effects of P2Y12 blockade on ADP-mediated platelet aggregation in vitro: Insights using short thromboelastography.

Khanna V, Armstrong PC, Warner TD, Curzen N.

Platelets. 2015;26(7):689-92. doi: 10.3109/09537104.2014.1001832. Epub 2015 Mar 3.


Protocol for a human in vivo model of acute cigarette smoke inhalation challenge in smokers with COPD: monitoring the nasal and systemic immune response using a network biology approach.

Ross CL, Galloway-Phillipps N, Armstrong PC, Mitchell JA, Warner TD, Brearley C, Ito M, Tunstall T, Elkin S, Kon OM, Hansel TT, Paul-Clark MJ.

BMJ Open. 2015 Jan 28;5(1):e005750. doi: 10.1136/bmjopen-2014-005750.


Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs.

Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie L, Armstrong PC, Nüsing RM, Tomlinson JA, Warner TD, Leiper J, Mitchell JA.

Circulation. 2015 Feb 17;131(7):633-42. doi: 10.1161/CIRCULATIONAHA.114.011591. Epub 2014 Dec 9.


It's not your mother's marijuana: effects on maternal-fetal health and the developing child.

Warner TD, Roussos-Ross D, Behnke M.

Clin Perinatol. 2014 Dec;41(4):877-94. doi: 10.1016/j.clp.2014.08.009. Epub 2014 Sep 27. Review.


Experiences of Pediatric Patients With Sickle Cell Disease in Rural Emergency Departments.

Alston KJ, Valrie CR, Walcott C, Warner TD, Fuh B.

J Pediatr Hematol Oncol. 2015 Apr;37(3):195-9. doi: 10.1097/MPH.0000000000000284.


The effect of direct and indirect exposure to violence on youth survival expectations.

Warner TD, Swisher RR.

J Adolesc Health. 2014 Dec;55(6):817-22. doi: 10.1016/j.jadohealth.2014.06.019. Epub 2014 Sep 6.


COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks.

Kirkby NS, Lundberg MH, Wright WR, Warner TD, Paul-Clark MJ, Mitchell JA.

PLoS One. 2014 Jun 2;9(6):e98165. doi: 10.1371/journal.pone.0098165. eCollection 2014.


Along the way to developing a theory of the program: a re-examination of the conceptual framework as an organizing strategy.

Helitzer DL, Sussman AL, Hoffman RM, Getrich CM, Warner TD, Rhyne RL.

Eval Program Plann. 2014 Aug;45:157-63. doi: 10.1016/j.evalprogplan.2014.04.005. Epub 2014 Apr 30.


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