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In vitro efficacies, ADME, and pharmacokinetic properties of phenoxazine derivatives active against Mycobacterium tuberculosis.

Tanner L, Evans JC, Seldon R, Jordaan A, Warner DF, Haynes RK, Parkinson CJ, Wiesner L.

Antimicrob Agents Chemother. 2019 Aug 19. pii: AAC.01010-19. doi: 10.1128/AAC.01010-19. [Epub ahead of print]


Harnessing Biological Insight to Accelerate Tuberculosis Drug Discovery.

de Wet TJ, Warner DF, Mizrahi V.

Acc Chem Res. 2019 Aug 20;52(8):2340-2348. doi: 10.1021/acs.accounts.9b00275. Epub 2019 Jul 30.


Mycobacterium tuberculosis Metabolism.

Mashabela GT, de Wet TJ, Warner DF.

Microbiol Spectr. 2019 Jul;7(4). doi: 10.1128/microbiolspec.GPP3-0067-2019.


Semisynthetic Antimycobacterial C-3 Silicate and C-3/C-21 Ester Derivatives of Fusidic Acid: Pharmacological Evaluation and Stability Studies in Liver Microsomes, Rat Plasma, and Mycobacterium tuberculosis culture.

Njoroge M, Kaur G, Espinoza-Moraga M, Wasuna A, Dziwornu GA, Seldon R, Taylor D, Okombo J, Warner DF, Chibale K.

ACS Infect Dis. 2019 Sep 13;5(9):1634-1644. doi: 10.1021/acsinfecdis.9b00208. Epub 2019 Jul 29.


Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: Antimicrobial evaluation and mechanistic insights.

Baartzes N, Stringer T, Seldon R, Warner DF, Taylor D, Wittlin S, Chibale K, Smith GS.

Eur J Med Chem. 2019 Oct 15;180:121-133. doi: 10.1016/j.ejmech.2019.06.069. Epub 2019 Jun 26.


Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB.

Campaniço A, Carrasco MP, Njoroge M, Seldon R, Chibale K, Perdigão J, Portugal I, Warner DF, Moreira R, Lopes F.

ChemMedChem. 2019 Aug 20;14(16):1537-1546. doi: 10.1002/cmdc.201900289. Epub 2019 Jul 25.


Complex Multimorbidity and Breast Cancer Screening Among Midlife and Older Women: The Role of Perceived Need.

Warner DF, Koroukian SM, Schiltz NK, Smyth KA, Cooper GS, Owusu C, Stange KC, Berger NA.

Gerontologist. 2019 May 17;59(Suppl 1):S77-S87. doi: 10.1093/geront/gny180.


Synthesis and biological evaluation of 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones.

Olawode EO, Tandlich R, Prinsloo E, Isaacs M, Hoppe H, Seldon R, Warner DF, Steenkamp V, Kaye PT.

Bioorg Med Chem Lett. 2019 Jul 1;29(13):1572-1575. doi: 10.1016/j.bmcl.2019.05.001. Epub 2019 May 3.


New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum and Mycobacterium tuberculosis.

Beteck RM, Seldon R, Jordaan A, Warner DF, Hoppe HC, Laming D, Khanye SD.

Molecules. 2019 May 4;24(9). pii: E1740. doi: 10.3390/molecules24091740.


Detection, survival and infectious potential of Mycobacterium tuberculosis in the environment: a review of the evidence and epidemiological implications.

Martinez L, Verma R, Croda J, Horsburgh CR Jr, Walter KS, Degner N, Middelkoop K, Koch A, Hermans S, Warner DF, Wood R, Cobelens F, Andrews JR.

Eur Respir J. 2019 Jun 27;53(6). pii: 1802302. doi: 10.1183/13993003.02302-2018. Print 2019 Jun. Review.


Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives.

Cilliers P, Seldon R, Smit FJ, Aucamp J, Jordaan A, Warner DF, N'Da DD.

Chem Biol Drug Des. 2019 Aug;94(2):1518-1536. doi: 10.1111/cbdd.13534. Epub 2019 Jun 17.


Quinolone-isoniazid hybrids: synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation.

Beteck RM, Seldon R, Jordaan A, Warner DF, Hoppe HC, Laming D, Legoabe LJ, Khanye SD.

Medchemcomm. 2019 Jan 11;10(2):326-331. doi: 10.1039/c8md00480c. eCollection 2019 Feb 1.


Expanding the anti-TB arsenal.

Mizrahi V, Warner DF.

Science. 2019 Feb 1;363(6426):457-458. doi: 10.1126/science.aaw5224. No abstract available.


Cut to the Quick: The Consequences of Youth Violent Victimization for the Timing of Dating Debut and First Union Formation.

Warner TD, Warner DF, Kuhl DC.

Am Sociol Rev. 2017 Dec;82(6):1241-1271. doi: 10.1177/0003122417734353. Epub 2017 Oct 12.


Editorial overview: Tuberculosis, malaria and schistosomiasis; understanding resistance and development of new drugs.

Egan TJ, Warner DF.

Curr Opin Pharmacol. 2018 Oct;42:iv-vi. doi: 10.1016/j.coph.2018.09.002. Epub 2018 Sep 24. No abstract available.


Death of Mycobacterium tuberculosis by l-arginine starvation.

Mizrahi V, Warner DF.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9658-9660. doi: 10.1073/pnas.1813587115. Epub 2018 Sep 6. No abstract available.


Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological Activity.

Gumbo M, Beteck RM, Mandizvo T, Seldon R, Warner DF, Hoppe HC, Isaacs M, Laming D, Tam CC, Cheng LW, Liu N, Land KM, Khanye SD.

Molecules. 2018 Aug 15;23(8). pii: E2038. doi: 10.3390/molecules23082038.


Drug permeation and metabolism in Mycobacterium tuberculosis: Prioritising local exposure as essential criterion in new TB drug development.

Tanner L, Denti P, Wiesner L, Warner DF.

IUBMB Life. 2018 Sep;70(9):926-937. doi: 10.1002/iub.1866. Epub 2018 Jun 22. Review.


The Good, the Bad, and the Indifferent: Physical Disability, Social Role Configurations, and Changes in Loneliness Among Married and Unmarried Older Adults.

Warner DF, Adams SA, Anderson RK.

J Aging Health. 2019 Sep;31(8):1423-1453. doi: 10.1177/0898264318781129. Epub 2018 Jun 15.


2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

Murugesan D, Ray PC, Bayliss T, Prosser GA, Harrison JR, Green K, Soares de Melo C, Feng TS, Street LJ, Chibale K, Warner DF, Mizrahi V, Epemolu O, Scullion P, Ellis L, Riley J, Shishikura Y, Ferguson L, Osuna-Cabello M, Read KD, Green SR, Lamprecht DA, Finin PM, Steyn AJC, Ioerger TR, Sacchettini J, Rhee KY, Arora K, Barry CE 3rd, Wyatt PG, Boshoff HIM.

ACS Infect Dis. 2018 Jun 8;4(6):954-969. doi: 10.1021/acsinfecdis.7b00275. Epub 2018 Mar 26.


The Influence of Multimorbidity on Leading Causes of Death in Older Adults With Cognitive Impairment.

Schiltz NK, Warner DF, Sun J, Smyth KA, Gravenstein S, Stange KC, Koroukian SM.

J Aging Health. 2019 Jul;31(6):1025-1042. doi: 10.1177/0898264317751946. Epub 2018 Jan 18.


Older Adults Undergoing Total Hip or Knee Arthroplasty: Chronicling Changes in Their Multimorbidity Profile in the Last Two Decades.

Koroukian SM, Schiltz NK, Warner DF, Klika AK, Higuera-Rueda CA, Barsoum WK.

J Arthroplasty. 2018 Apr;33(4):976-982. doi: 10.1016/j.arth.2017.11.014. Epub 2017 Nov 13.


Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis.

Reiche MA, Warner DF, Mizrahi V.

Front Mol Biosci. 2017 Nov 14;4:75. doi: 10.3389/fmolb.2017.00075. eCollection 2017. Review.


Changes in Case-Mix and Health Outcomes of Medicare Fee-for-Service Beneficiaries and Managed Care Enrollees During the Years 1992-2011.

Koroukian SM, Basu J, Schiltz NK, Navale S, Bakaki PM, Warner DF, Dor A, Given CW, Stange KC.

Med Care. 2018 Jan;56(1):39-46. doi: 10.1097/MLR.0000000000000847.


Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.

Wilson CR, Gessner RK, Moosa A, Seldon R, Warner DF, Mizrahi V, Soares de Melo C, Simelane SB, Nchinda A, Abay E, Taylor D, Njoroge M, Brunschwig C, Lawrence N, Boshoff HIM, Barry CE 3rd, Sirgel FA, van Helden P, Harris CJ, Gordon R, Ghidelli-Disse S, Pflaumer H, Boesche M, Drewes G, Sanz O, Santos G, Rebollo-Lopez MJ, Urones B, Selenski C, Lafuente-Monasterio MJ, Axtman M, Lelièvre J, Ballell L, Mueller R, Street LJ, Ghorpade SR, Chibale K.

J Med Chem. 2017 Dec 28;60(24):10118-10134. doi: 10.1021/acs.jmedchem.7b01347. Epub 2017 Dec 7.


DNA Replication Fidelity in the Mycobacterium tuberculosis Complex.

Warner DF, Rock JM, Fortune SM, Mizrahi V.

Adv Exp Med Biol. 2017;1019:247-262. doi: 10.1007/978-3-319-64371-7_13. Review.


Multimorbidity: constellations of conditions across subgroups of midlife and older individuals, and related Medicare expenditures.

Koroukian SM, Schiltz NK, Warner DF, Sun J, Stange KC, Given CW, Dor A.

J Comorb. 2017 Apr 10;7(1):33-43. doi: 10.15256/joc.2017.7.91. eCollection 2017.


Versatility of 7-Substituted Coumarin Molecules as Antimycobacterial Agents, Neuronal Enzyme Inhibitors and Neuroprotective Agents.

Kapp E, Visser H, Sampson SL, Malan SF, Streicher EM, Foka GB, Warner DF, Omoruyi SI, Enogieru AB, Ekpo OE, Zindo FT, Joubert J.

Molecules. 2017 Sep 30;22(10). pii: E1644. doi: 10.3390/molecules22101644.


Proteomic comparison of three clinical diarrhoeagenic drug-resistant Escherichia coli isolates grown on CHROMagar™STEC media.

Kalule JB, Fortuin S, Calder B, Robberts L, Keddy KH, Nel AJM, Garnett S, Nicol M, Warner DF, Soares NC, Blackburn JM.

J Proteomics. 2018 May 30;180:25-35. doi: 10.1016/j.jprot.2017.09.003. Epub 2017 Sep 5.


Increasing Burden of Complex Multimorbidity Across Gradients of Cognitive Impairment.

Koroukian SM, Schiltz NK, Warner DF, Stange KC, Smyth KA.

Am J Alzheimers Dis Other Demen. 2017 Nov;32(7):408-417. doi: 10.1177/1533317517726388. Epub 2017 Sep 5.


Susceptibility of Mycobacterium tuberculosis Cytochrome bd Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome c.

Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V, Warner DF.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01338-17. doi: 10.1128/AAC.01338-17. Print 2017 Oct.


Antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes.

Stringer T, Seldon R, Liu N, Warner DF, Tam C, Cheng LW, Land KM, Smith PJ, Chibale K, Smith GS.

Dalton Trans. 2017 Aug 14;46(30):9875-9885. doi: 10.1039/c7dt01952a. Epub 2017 Jul 17.


Complex multimorbidity and health outcomes in older adult cancer survivors.

Warner DF, Schiltz NK, Stange KC, Given CW, Owusu C, Berger NA, Koroukian SM.

Fam Med Community Health. 2017 Jul;5(2):129-138. doi: 10.15212/FMCH.2017.0127.


The Influence of HIV on the Evolution of Mycobacterium tuberculosis.

Koch AS, Brites D, Stucki D, Evans JC, Seldon R, Heekes A, Mulder N, Nicol M, Oni T, Mizrahi V, Warner DF, Parkhill J, Gagneux S, Martin DP, Wilkinson RJ.

Mol Biol Evol. 2017 Jul 1;34(7):1654-1668. doi: 10.1093/molbev/msx107.


DNA Replication in Mycobacterium tuberculosis.

Ditse Z, Lamers MH, Warner DF.

Microbiol Spectr. 2017 Mar;5(2). doi: 10.1128/microbiolspec.TBTB2-0027-2016. Review.


Social determinants, multimorbidity, and patterns of end-of-life care in older adults dying from cancer.

Koroukian SM, Schiltz NK, Warner DF, Given CW, Schluchter M, Owusu C, Berger NA.

J Geriatr Oncol. 2017 Mar;8(2):117-124. doi: 10.1016/j.jgo.2016.10.001. Epub 2016 Oct 28.


Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.

Singh V, Dhar N, Pató J, Kolly GS, Korduláková J, Forbak M, Evans JC, Székely R, Rybniker J, Palčeková Z, Zemanová J, Santi I, Signorino-Gelo F, Rodrigues L, Vocat A, Covarrubias AS, Rengifo MG, Johnsson K, Mowbray S, Buechler J, Delorme V, Brodin P, Knott GW, Aínsa JA, Warner DF, Kéri G, Mikušová K, McKinney JD, Cole ST, Mizrahi V, Hartkoorn RC.

Mol Microbiol. 2017 Jan;103(1):13-25. doi: 10.1111/mmi.13535. Epub 2016 Oct 29.


Identifying Specific Combinations of Multimorbidity that Contribute to Health Care Resource Utilization: An Analytic Approach.

Schiltz NK, Warner DF, Sun J, Bakaki PM, Dor A, Given CW, Stange KC, Koroukian SM.

Med Care. 2017 Mar;55(3):276-284. doi: 10.1097/MLR.0000000000000660.


Design, Synthesis, and Evaluation of Novel Hybrid Efflux Pump Inhibitors for Use against Mycobacterium tuberculosis.

Kumar M, Singh K, Naran K, Hamzabegovic F, Hoft DF, Warner DF, Ruminski P, Abate G, Chibale K.

ACS Infect Dis. 2016 Oct 14;2(10):714-725. Epub 2016 Sep 6.


The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.

Singh V, Donini S, Pacitto A, Sala C, Hartkoorn RC, Dhar N, Keri G, Ascher DB, Mondésert G, Vocat A, Lupien A, Sommer R, Vermet H, Lagrange S, Buechler J, Warner DF, McKinney JD, Pato J, Cole ST, Blundell TL, Rizzi M, Mizrahi V.

ACS Infect Dis. 2017 Jan 13;3(1):5-17. doi: 10.1021/acsinfecdis.6b00102. Epub 2016 Sep 8.


Genome-Wide Transposon Mutagenesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.

Majumdar G, Mbau R, Singh V, Warner DF, Dragset MS, Mukherjee R.

Methods Mol Biol. 2017;1498:321-335.


Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery.

Naran K, Moosa A, Barry CE 3rd, Boshoff HI, Mizrahi V, Warner DF.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6748-6757. doi: 10.1128/AAC.01178-16. Print 2016 Nov.


Physical Disability and Increased Loneliness among Married Older Adults: The Role of Changing Social Relations.

Warner DF, Adams SA.

Soc Ment Health. 2016 Jul;6(2):106-128. doi: 10.1177/2156869315616257. Epub 2015 Nov 25.


Defining a diagnostic gene signature for tuberculosis.

Warner DF.

Lancet Respir Med. 2016 Mar;4(3):170-1. doi: 10.1016/S2213-2600(16)00063-1. Epub 2016 Feb 20. No abstract available.


Combinations of Chronic Conditions, Functional Limitations, and Geriatric Syndromes that Predict Health Outcomes.

Koroukian SM, Schiltz N, Warner DF, Sun J, Bakaki PM, Smyth KA, Stange KC, Given CW.

J Gen Intern Med. 2016 Jun;31(6):630-7. doi: 10.1007/s11606-016-3590-9. Epub 2016 Feb 22.


Real-Time Investigation of Tuberculosis Transmission: Developing the Respiratory Aerosol Sampling Chamber (RASC).

Wood R, Morrow C, Barry CE 3rd, Bryden WA, Call CJ, Hickey AJ, Rodes CE, Scriba TJ, Blackburn J, Issarow C, Mulder N, Woodward J, Moosa A, Singh V, Mizrahi V, Warner DF.

PLoS One. 2016 Jan 25;11(1):e0146658. doi: 10.1371/journal.pone.0146658. eCollection 2016.


Functional status in older women diagnosed with pelvic organ prolapse.

Sanses TV, Schiltz NK, Couri BM, Mahajan ST, Richter HE, Warner DF, Guralnik J, Koroukian SM.

Am J Obstet Gynecol. 2016 May;214(5):613.e1-7. doi: 10.1016/j.ajog.2015.11.038. Epub 2015 Dec 15.


Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration.

van der Westhuyzen R, Winks S, Wilson CR, Boyle GA, Gessner RK, Soares de Melo C, Taylor D, de Kock C, Njoroge M, Brunschwig C, Lawrence N, Rao SP, Sirgel F, van Helden P, Seldon R, Moosa A, Warner DF, Arista L, Manjunatha UH, Smith PW, Street LJ, Chibale K.

J Med Chem. 2015 Dec 10;58(23):9371-81. doi: 10.1021/acs.jmedchem.5b01542. Epub 2015 Nov 20.


Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization.

Soares de Melo C, Feng TS, van der Westhuyzen R, Gessner RK, Street LJ, Morgans GL, Warner DF, Moosa A, Naran K, Lawrence N, Boshoff HI, Barry CE 3rd, Harris CJ, Gordon R, Chibale K.

Bioorg Med Chem. 2015 Nov 15;23(22):7240-50. doi: 10.1016/j.bmc.2015.10.021. Epub 2015 Oct 22. Erratum in: Bioorg Med Chem. 2016 Jan 15;24(2):314. Candice, Soares de Melo [corrected to Soares de Melo, Candice].


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