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Items: 30

1.

Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer.

de Bruin EC, Cowell C, Warne PH, Jiang M, Saunders RE, Melnick MA, Gettinger S, Walther Z, Wurtz A, Heynen GJ, Heideman DA, Gómez-Román J, García-Castaño A, Gong Y, Ladanyi M, Varmus H, Bernards R, Smit EF, Politi K, Downward J.

Cancer Discov. 2014 May;4(5):606-19. doi: 10.1158/2159-8290.CD-13-0741. Epub 2014 Feb 17.

2.

PI3K pathway dependencies in endometrioid endometrial cancer cell lines.

Weigelt B, Warne PH, Lambros MB, Reis-Filho JS, Downward J.

Clin Cancer Res. 2013 Jul 1;19(13):3533-44. doi: 10.1158/1078-0432.CCR-12-3815. Epub 2013 May 14.

3.

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies.

Steckel M, Molina-Arcas M, Weigelt B, Marani M, Warne PH, Kuznetsov H, Kelly G, Saunders B, Howell M, Downward J, Hancock DC.

Cell Res. 2012 Aug;22(8):1227-45. doi: 10.1038/cr.2012.82. Epub 2012 May 22.

4.

PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs.

Weigelt B, Warne PH, Downward J.

Oncogene. 2011 Jul 21;30(29):3222-33. doi: 10.1038/onc.2011.42. Epub 2011 Feb 28.

PMID:
21358673
5.

Rictor is a novel target of p70 S6 kinase-1.

Treins C, Warne PH, Magnuson MA, Pende M, Downward J.

Oncogene. 2010 Feb 18;29(7):1003-16. doi: 10.1038/onc.2009.401. Epub 2009 Nov 23.

PMID:
19935711
6.

Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.

Swanton C, Marani M, Pardo O, Warne PH, Kelly G, Sahai E, Elustondo F, Chang J, Temple J, Ahmed AA, Brenton JD, Downward J, Nicke B.

Cancer Cell. 2007 Jun;11(6):498-512.

7.

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.

Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J.

Cell. 2007 Jun 1;129(5):957-68.

8.

Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.

Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, Hancock DC.

Mol Cell. 2005 Dec 9;20(5):673-85.

9.

CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness.

Michl P, Ramjaun AR, Pardo OE, Warne PH, Wagner M, Poulsom R, D'Arrigo C, Ryder K, Menke A, Gress T, Downward J.

Cancer Cell. 2005 Jun;7(6):521-32.

10.
11.

Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells.

Pardo OE, Lesay A, Arcaro A, Lopes R, Ng BL, Warne PH, McNeish IA, Tetley TD, Lemoine NR, Mehmet H, Seckl MJ, Downward J.

Mol Cell Biol. 2003 Nov;23(21):7600-10. Erratum in: Mol Cell Biol. 2004 Aug;24(15):6887.

13.

Murine Ksr interacts with MEK and inhibits Ras-induced transformation.

Denouel-Galy A, Douville EM, Warne PH, Papin C, Laugier D, Calothy G, Downward J, Eychène A.

Curr Biol. 1998 Jan 1;8(1):46-55.

14.

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway.

Khwaja A, Rodriguez-Viciana P, Wennström S, Warne PH, Downward J.

EMBO J. 1997 May 15;16(10):2783-93.

15.

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras.

Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J.

Cell. 1997 May 2;89(3):457-67.

16.

P110delta, a novel phosphoinositide 3-kinase in leukocytes.

Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD.

Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4330-5.

17.

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways.

Marte BM, Rodriguez-Viciana P, Wennström S, Warne PH, Downward J.

Curr Biol. 1997 Jan 1;7(1):63-70. Erratum in: Curr Biol 1997 Mar 1;7(3):197.

18.

Networks of interaction of p120cbl and p130cas with Crk and Grb2 adaptor proteins.

Khwaja A, Hallberg B, Warne PH, Downward J.

Oncogene. 1996 Jun 20;12(12):2491-8.

PMID:
8700507
19.

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J.

EMBO J. 1996 May 15;15(10):2442-51.

20.

Phosphatidylinositol 3' kinase: one of the effectors of Ras.

Rodriguez-Viciana P, Marte BM, Warne PH, Downward J.

Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29;351(1336):225-31; discussion 231-2. Review.

PMID:
8650270
21.

Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos.

Buday L, Warne PH, Downward J.

Oncogene. 1995 Oct 5;11(7):1327-31.

PMID:
7478553
22.
23.

Phosphatidylinositol-3-OH kinase as a direct target of Ras.

Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J.

Nature. 1994 Aug 18;370(6490):527-32.

PMID:
8052307
24.

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro.

Warne PH, Viciana PR, Downward J.

Nature. 1993 Jul 22;364(6435):352-5.

PMID:
8332195
25.

The growth factor IL-2 activates p21ras proteins in normal human T lymphocytes.

Graves JD, Downward J, Izquierdo-Pastor M, Rayter S, Warne PH, Cantrell DA.

J Immunol. 1992 Apr 15;148(8):2417-22.

PMID:
1532814
26.

Stimulation of p21ras upon T-cell activation.

Downward J, Graves JD, Warne PH, Rayter S, Cantrell DA.

Nature. 1990 Aug 23;346(6286):719-23.

PMID:
2201921
27.
28.

Placental-type alkaline phosphatase in cervical neoplasia.

McLaughlin PJ, Warne PH, Hutchinson GE, Johnson PM, Tucker DF.

Br J Cancer. 1987 Feb;55(2):197-201.

30.

Adoptive T cell immunotherapy of MSV-induced tumours in nude mice. Part I. Biology of tumour regression and recurrence.

Tucker DF, Knight RA, Warne PH.

Clin Exp Metastasis. 1983 Jul-Sep;1(3):261-73.

PMID:
6100803

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