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Lumacaftor/ Ivacaftor improves exercise tolerance in patients with Cystic Fibrosis and severe airflow obstruction.

Wark PAB, Cookson K, Thiruchelvam T, Brannan J, Dorahy DJ.

BMC Pulm Med. 2019 Jun 17;19(1):106. doi: 10.1186/s12890-019-0866-y.


IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis.

Starkey MR, Plank MW, Casolari P, Papi A, Pavlidis S, Guo Y, Cameron GJM, Haw TJ, Tam A, Obiedat M, Donovan C, Hansbro NG, Nguyen DH, Nair PM, Kim RY, Horvat JC, Kaiko GE, Durum SK, Wark PA, Sin DD, Caramori G, Adcock IM, Foster PS, Hansbro PM.

Eur Respir J. 2019 Jun 13. pii: 1800174. doi: 10.1183/13993003.00174-2018. [Epub ahead of print]


Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3 inflammasome.

Liu G, Mateer SW, Hsu A, Goggins BJ, Tay H, Mathe A, Fan K, Neal R, Bruce J, Burns G, Minahan K, Maltby S, Fricker M, Foster PS, Wark PAB, Hansbro PM, Keely S.

Mucosal Immunol. 2019 Apr 11. doi: 10.1038/s41385-019-0163-3. [Epub ahead of print]


A systematic review of reviews identifying UK validated dietary assessment tools for inclusion on an interactive guided website for researchers:

Hooson Jzh J, Hutchinson Jyh J, Warthon-Medina M, Hancock N, Greathead K, Knowles B, Vargas-Garcia E, Gibson LE, Bush LA, Margetts B, Robinson S, Ness A, Alwan NA, Wark PA, Roe M, Finglas P, Steer T, Page P, Johnson L, Roberts K, Amoutzopoulos B, Burley VJ, Greenwood DC, Cade JE.

Crit Rev Food Sci Nutr. 2019 Mar 18:1-25. doi: 10.1080/10408398.2019.1566207. [Epub ahead of print]


Treatable traits: a new paradigm for 21st century management of chronic airway diseases: Treatable Traits Down Under International Workshop report.

McDonald VM, Fingleton J, Agusti A, Hiles SA, Clark VL, Holland AE, Marks GB, Bardin PP, Beasley R, Pavord ID, Wark PAB, Gibson PG; participants of the Treatable Traits Down Under International Workshop; Treatable Traits Down Under International Workshop participants:.

Eur Respir J. 2019 May 9;53(5). pii: 1802058. doi: 10.1183/13993003.02058-2018. Print 2019 May. Review.


Protocol for a systematic review and qualitative synthesis of information quality frameworks in eHealth.

Fadahunsi KP, Akinlua JT, O'Connor S, Wark PA, Gallagher J, Carroll C, Majeed A, O'Donoghue J.

BMJ Open. 2019 Mar 5;9(3):e024722. doi: 10.1136/bmjopen-2018-024722.


Estimating blood pressure trends and the nocturnal dip from photoplethysmography.

Radha M, de Groot K, Rajani N, Wong CCP, Kobold N, Vos V, Fonseca P, Mastellos N, Wark PA, Velthoven N, Haakma R, Aarts RM.

Physiol Meas. 2019 Feb 26;40(2):025006. doi: 10.1088/1361-6579/ab030e.


Hypersegmented airway neutrophils and its association with reduced lung function in adults with obstructive airway disease: an exploratory study.

Lokwani R, Wark PAB, Baines KJ, Barker D, Simpson JL.

BMJ Open. 2019 Jan 28;9(1):e024330. doi: 10.1136/bmjopen-2018-024330.


Mechanisms and Management of Asthma Exacerbations.

Ramsahai JM, Hansbro PM, Wark PAB.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):423-432. doi: 10.1164/rccm.201810-1931CI.


Appropriate use of oral corticosteroids for severe asthma.

Ramsahai JM, Wark PA.

Med J Aust. 2018 Jul 16;209(S2):S18-S21.


Measuring Engagement in eHealth and mHealth Behavior Change Interventions: Viewpoint of Methodologies.

Short CE, DeSmet A, Woods C, Williams SL, Maher C, Middelweerd A, Müller AM, Wark PA, Vandelanotte C, Poppe L, Hingle MD, Crutzen R.

J Med Internet Res. 2018 Nov 16;20(11):e292. doi: 10.2196/jmir.9397.


Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease.

Donovan C, Starkey MR, Kim RY, Rana BMJ, Barlow JL, Jones B, Haw TJ, Mono Nair P, Budden K, Cameron GJM, Horvat JC, Wark PA, Foster PS, McKenzie ANJ, Hansbro PM.

J Leukoc Biol. 2019 Jan;105(1):143-150. doi: 10.1002/JLB.3AB0518-178R. Epub 2018 Sep 27.


Treatable traits can be identified in a severe asthma registry and predict future exacerbations.

McDonald VM, Hiles SA, Godbout K, Harvey ES, Marks GB, Hew M, Peters M, Bardin PG, Reynolds PN, Upham JW, Baraket M, Bhikoo Z, Bowden J, Brockway B, Chung LP, Cochrane B, Foxley G, Garrett J, Jayaram L, Jenkins C, Katelaris C, Katsoulotos G, Koh MS, Kritikos V, Lambert M, Langton D, Lara Rivero A, Middleton PG, Nanguzgambo A, Radhakrishna N, Reddel H, Rimmer J, Southcott AM, Sutherland M, Thien F, Wark PAB, Yang IA, Yap E, Gibson PG.

Respirology. 2019 Jan;24(1):37-47. doi: 10.1111/resp.13389. Epub 2018 Sep 19.


Validity of an online 24-h recall tool (myfood24) for dietary assessment in population studies: comparison with biomarkers and standard interviews.

Wark PA, Hardie LJ, Frost GS, Alwan NA, Carter M, Elliott P, Ford HE, Hancock N, Morris MA, Mulla UZ, Noorwali EA, Petropoulou K, Murphy D, Potter GDM, Riboli E, Greenwood DC, Cade JE.

BMC Med. 2018 Aug 9;16(1):136. doi: 10.1186/s12916-018-1113-8.


Influenza A virus infection dysregulates the expression of microRNA-22 and its targets; CD147 and HDAC4, in epithelium of asthmatics.

Moheimani F, Koops J, Williams T, Reid AT, Hansbro PM, Wark PA, Knight DA.

Respir Res. 2018 Aug 2;19(1):145. doi: 10.1186/s12931-018-0851-7.


Apps and wearables for monitoring physical activity and sedentary behaviour: A qualitative systematic review protocol on barriers and facilitators.

Wilde LJ, Ward G, Sewell L, Müller AM, Wark PA.

Digit Health. 2018 May 16;4:2055207618776454. doi: 10.1177/2055207618776454. eCollection 2018 Jan-Dec.


Effects of fruit and vegetable consumption on inflammatory biomarkers and immune cell populations: a systematic literature review and meta-analysis.

Hosseini B, Berthon BS, Saedisomeolia A, Starkey MR, Collison A, Wark PAB, Wood LG.

Am J Clin Nutr. 2018 Jul 1;108(1):136-155. doi: 10.1093/ajcn/nqy082.


Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations.

Singanayagam A, Glanville N, Girkin JL, Ching YM, Marcellini A, Porter JD, Toussaint M, Walton RP, Finney LJ, Aniscenko J, Zhu J, Trujillo-Torralbo MB, Calderazzo MA, Grainge C, Loo SL, Veerati PC, Pathinayake PS, Nichol KS, Reid AT, James PL, Solari R, Wark PAB, Knight DA, Moffatt MF, Cookson WO, Edwards MR, Mallia P, Bartlett NW, Johnston SL.

Nat Commun. 2018 Jun 8;9(1):2229. doi: 10.1038/s41467-018-04574-1.


Trends in asthma self-management skills and inhaled corticosteroid use during pregnancy and postpartum from 2004 to 2017.

Robijn AL, Jensen ME, Gibson PG, Powell H, Giles WB, Clifton VL, Mattes J, Peek MJ, Barrett HL, Seeho SK, Callaway LK, Abbott A, Attia J, Wark PA, Murphy VE.

J Asthma. 2019 Jun;56(6):594-602. doi: 10.1080/02770903.2018.1471709. Epub 2018 Jun 8.


Working while unwell: Workplace impairment in people with severe asthma.

Hiles SA, Harvey ES, McDonald VM, Peters M, Bardin P, Reynolds PN, Upham JW, Baraket M, Bhikoo Z, Bowden J, Brockway B, Chung LP, Cochrane B, Foxley G, Garrett J, Hew M, Jayaram L, Jenkins C, Katelaris C, Katsoulotos G, Koh MS, Kritikos V, Lambert M, Langton D, Lara Rivero A, Marks GB, Middleton PG, Nanguzgambo A, Radhakrishna N, Reddel H, Rimmer J, Southcott AM, Sutherland M, Thien F, Wark PAB, Yang IA, Yap E, Gibson PG.

Clin Exp Allergy. 2018 Jun;48(6):650-662. doi: 10.1111/cea.13153. Epub 2018 May 17.


Physical Activity, Sedentary Behavior, and Diet-Related eHealth and mHealth Research: Bibliometric Analysis.

Müller AM, Maher CA, Vandelanotte C, Hingle M, Middelweerd A, Lopez ML, DeSmet A, Short CE, Nathan N, Hutchesson MJ, Poppe L, Woods CB, Williams SL, Wark PA.

J Med Internet Res. 2018 Apr 18;20(4):e122. doi: 10.2196/jmir.8954. Review.


Developments in cystic fibrosis personalised epithelial assays: Science and patient perspectives.

Kaiko GE, Wark PAB.

J Cyst Fibros. 2018 May;17(3):289-291. doi: 10.1016/j.jcf.2018.03.012. Epub 2018 Apr 13. No abstract available.


Understanding the Unfolded Protein Response in the Pathogenesis of Asthma.

Pathinayake PS, Hsu AC, Waters DW, Hansbro PM, Wood LG, Wark PAB.

Front Immunol. 2018 Feb 6;9:175. doi: 10.3389/fimmu.2018.00175. eCollection 2018. Review.


Respiratory Viruses and Asthma.

Wark PAB, Ramsahai JM, Pathinayake P, Malik B, Bartlett NW.

Semin Respir Crit Care Med. 2018 Feb;39(1):45-55. doi: 10.1055/s-0037-1617412. Epub 2018 Feb 10. Review.


Pathophysiology of severe asthma: We've only just started.

King GG, James A, Harkness L, Wark PAB.

Respirology. 2018 Mar;23(3):262-271. doi: 10.1111/resp.13251. Epub 2018 Jan 9. Review.


Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches.

Reid AT, Veerati PC, Gosens R, Bartlett NW, Wark PA, Grainge CL, Stick SM, Kicic A, Moheimani F, Hansbro PM, Knight DA.

Pharmacol Ther. 2018 May;185:155-169. doi: 10.1016/j.pharmthera.2017.12.009. Epub 2017 Dec 27. Review.


Impaired Th1 responses in patients with acute exacerbations of COPD are improved with PD-1 blockade.

Tan DBA, Teo TH, Setiawan AM, Ong NE, Zimmermann M, Hsu AC, Wark PAB, Moodley YP.

Clin Immunol. 2018 Mar;188:64-66. doi: 10.1016/j.clim.2017.12.007. Epub 2017 Dec 20. No abstract available.


DIET@NET: Best Practice Guidelines for dietary assessment in health research.

Cade JE, Warthon-Medina M, Albar S, Alwan NA, Ness A, Roe M, Wark PA, Greathead K, Burley VJ, Finglas P, Johnson L, Page P, Roberts K, Steer T, Hooson J, Greenwood DC, Robinson S; DIET@NET consortium.

BMC Med. 2017 Nov 15;15(1):202. doi: 10.1186/s12916-017-0962-x.


Treatment burden, clinical outcomes, and comorbidities in COPD: an examination of the utility of medication regimen complexity index in COPD.

Negewo NA, Gibson PG, Wark PA, Simpson JL, McDonald VM.

Int J Chron Obstruct Pulmon Dis. 2017 Oct 6;12:2929-2942. doi: 10.2147/COPD.S136256. eCollection 2017.


Regulation of xanthine dehydrogensase gene expression and uric acid production in human airway epithelial cells.

Huff RD, Hsu AC, Nichol KS, Jones B, Knight DA, Wark PAB, Hansbro PM, Hirota JA.

PLoS One. 2017 Sep 1;12(9):e0184260. doi: 10.1371/journal.pone.0184260. eCollection 2017.


Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c.

Liu G, Cooley MA, Nair PM, Donovan C, Hsu AC, Jarnicki AG, Haw TJ, Hansbro NG, Ge Q, Brown AC, Tay H, Foster PS, Wark PA, Horvat JC, Bourke JE, Grainge CL, Argraves WS, Oliver BG, Knight DA, Burgess JK, Hansbro PM.

J Pathol. 2017 Dec;243(4):510-523. doi: 10.1002/path.4979.


MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD.

Hsu AC, Dua K, Starkey MR, Haw TJ, Nair PM, Nichol K, Zammit N, Grey ST, Baines KJ, Foster PS, Hansbro PM, Wark PA.

JCI Insight. 2017 Apr 6;2(7):e90443. doi: 10.1172/jci.insight.90443.


The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Sawada N, Wark PA, Merritt MA, Tsugane S, Ward HA, Rinaldi S, Weiderpass E, Dartois L, His M, Boutron-Ruault MC, Turzanski-Fortner R, Kaaks R, Overvad K, Redondo ML, Travier N, Molina-Portillo E, Dorronsoro M, Cirera L, Ardanaz E, Perez-Cornago A, Trichopoulou A, Lagiou P, Valanou E, Masala G, Pala V, Hm Peeters P, T van der Schouw Y, Melander O, Manjer J, da Silva M, Skeie G, Tjønneland A, Olsen A, J Gunter M, Riboli E, J Cross A.

PLoS One. 2017 Mar 3;12(3):e0173117. doi: 10.1371/journal.pone.0173117. eCollection 2017.


Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.

Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, Mayall JR, Ali MK, Starkey MR, Hansbro NG, Hirota JA, Wood LG, Simpson JL, Knight DA, Wark PA, Gibson PG, O'Neill LAJ, Cooper MA, Horvat JC, Hansbro PM.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297. doi: 10.1164/rccm.201609-1830OC.


Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.

Kedzierski L, Tate MD, Hsu AC, Kolesnik TB, Linossi EM, Dagley L, Dong Z, Freeman S, Infusini G, Starkey MR, Bird NL, Chatfield SM, Babon JJ, Huntington N, Belz G, Webb A, Wark PA, Nicola NA, Xu J, Kedzierska K, Hansbro PM, Nicholson SE.

Elife. 2017 Feb 14;6. pii: e20444. doi: 10.7554/eLife.20444.


Measured Adiposity in Relation to Head and Neck Cancer Risk in the European Prospective Investigation into Cancer and Nutrition.

Ward HA, Wark PA, Muller DC, Steffen A, Johansson M, Norat T, Gunter MJ, Overvad K, Dahm CC, Halkjær J, Tjønneland A, Boutron-Ruault MC, Fagherazzi G, Mesrine S, Brennan P, Freisling H, Li K, Kaaks R, Trichopoulou A, Lagiou P, Panico S, Grioni S, Tumino R, Vineis P, Palli D, Peeters PHM, Bueno-de-Mesquita HB, Weiderpass E, Agudo A, Quirós JR, Larrañaga N, Ardanaz E, Huerta JM, Sánchez MJ, Laurell G, Johansson I, Westin U, Wallström P, Bradbury KE, Wareham NJ, Khaw KT, Pearson C, Boeing H, Riboli E.

Cancer Epidemiol Biomarkers Prev. 2017 Jun;26(6):895-904. doi: 10.1158/1055-9965.EPI-16-0886. Epub 2017 Feb 9.


Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort.

Molina-Montes E, Sánchez MJ, Buckland G, Bueno-de-Mesquita HB, Weiderpass E, Amiano P, Wark PA, Kühn T, Katzke V, Huerta JM, Ardanaz E, Quirós JR, Affret A, His M, Boutron-Ruault MC, Peeters PH, Ye W, Sund M, Boeing H, Iqbal K, Ohlsson B, Sonestedt E, Tjønneland A, Petersen KE, Travis RC, Skeie G, Agnoli C, Panico S, Palli D, Tumino R, Sacerdote C, Freisling H, Huybrechts I, Overvad K, Trichopoulou A, Bamia C, Vasilopoulou E, Wareham N, Khaw KT, Cross AJ, Ward HA, Riboli E, Duell EJ.

Br J Cancer. 2017 Mar 14;116(6):811-820. doi: 10.1038/bjc.2017.14. Epub 2017 Feb 7.


Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2015: the Influenza Complications Alert Network.

Cheng AC, Holmes M, Dwyer DE, Irving LB, Korman TM, Senenayake S, Macartney KK, Blyth CC, Brown S, Waterer G, Hewer R, Friedman ND, Wark PA, Simpson G, Upham J, Bowler SD, Lessing A, Kotsimbos T, Kelly PM.

Commun Dis Intell Q Rep. 2016 Dec 24;40(4):E521-E526.


Long-term efficacy and safety of α1 proteinase inhibitor treatment for emphysema caused by severe α1 antitrypsin deficiency: an open-label extension trial (RAPID-OLE).

McElvaney NG, Burdon J, Holmes M, Glanville A, Wark PA, Thompson PJ, Hernandez P, Chlumsky J, Teschler H, Ficker JH, Seersholm N, Altraja A, Mäkitaro R, Chorostowska-Wynimko J, Sanak M, Stoicescu PI, Piitulainen E, Vit O, Wencker M, Tortorici MA, Fries M, Edelman JM, Chapman KR; RAPID Extension Trial Group.

Lancet Respir Med. 2017 Jan;5(1):51-60. doi: 10.1016/S2213-2600(16)30430-1. Epub 2016 Dec 2. Erratum in: Lancet Respir Med. 2017 Feb;5(2):e13.


Severe asthma: Current management, targeted therapies and future directions-A roundtable report.

McDonald VM, Maltby S, Reddel HK, King GG, Wark PA, Smith L, Upham JW, James AL, Marks GB, Gibson PG.

Respirology. 2017 Jan;22(1):53-60. doi: 10.1111/resp.12957. Epub 2016 Nov 30. Review.


Use of biologics to treat acute exacerbations and manage disease in asthma, COPD and IPF.

Murray LA, Grainge C, Wark PA, Knight DA.

Pharmacol Ther. 2017 Jan;169:1-12. doi: 10.1016/j.pharmthera.2016.11.003. Epub 2016 Nov 24. Review.


The genetic and epigenetic landscapes of the epithelium in asthma.

Moheimani F, Hsu AC, Reid AT, Williams T, Kicic A, Stick SM, Hansbro PM, Wark PA, Knight DA.

Respir Res. 2016 Sep 22;17(1):119. Review.


Recent advances in understanding and managing asthma.

Loo SL, Wark PA.

F1000Res. 2016 Aug 23;5. pii: F1000 Faculty Rev-2052. doi: 10.12688/f1000research.9236.1. eCollection 2016. Review.


Fiber intake modulates the association of alcohol intake with breast cancer.

Romieu I, Ferrari P, Chajès V, de Batlle J, Biessy C, Scoccianti C, Dossus L, Christine Boutron M, Bastide N, Overvad K, Olsen A, Tjønneland A, Kaaks R, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Sieri S, Tumino R, Vineis P, Panico S, Bueno-de-Mesquita HB, Gils CH, Peeters PH, Lund E, Skeie G, Weiderpass E, Ramón Quirós J, Chirlaque MD, Ardanaz E, Sánchez MJ, Duell EJ, Amiano Etxezarreta P, Borgquist S, Hallmans G, Johansson I, Maria Nilsson L, Khaw KT, Wareham N, Key TJ, Travis RC, Murphy N, Wark PA, Riboli E.

Int J Cancer. 2017 Jan 15;140(2):316-321. doi: 10.1002/ijc.30415.


Development of a New Branded UK Food Composition Database for an Online Dietary Assessment Tool.

Carter MC, Hancock N, Albar SA, Brown H, Greenwood DC, Hardie LJ, Frost GS, Wark PA, Cade JE.

Nutrients. 2016 Aug 5;8(8). pii: E480. doi: 10.3390/nu8080480.


Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Navarrete-Muñoz EM, Wark PA, Romaguera D, Bhoo-Pathy N, Michaud D, Molina-Montes E, Tjønneland A, Olsen A, Overvad K, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke VA, Kühn T, Steffen A, Trichopoulou A, Klinaki E, Papatesta EM, Masala G, Krogh V, Tumino R, Naccarati A, Mattiello A, Peeters PH, Rylander C, Parr CL, Skeie G, Weiderpass E, Quirós JR, Duell EJ, Dorronsoro M, Huerta JM, Ardanaz E, Wareham N, Khaw KT, Travis RC, Key T, Stepien M, Freisling H, Riboli E, Bueno-de-Mesquita HB.

Am J Clin Nutr. 2016 Sep;104(3):760-8. doi: 10.3945/ajcn.116.130963. Epub 2016 Aug 10.


Truck drivers' perceptions on wearable devices and health promotion: a qualitative study.

Greenfield R, Busink E, Wong CP, Riboli-Sasco E, Greenfield G, Majeed A, Car J, Wark PA.

BMC Public Health. 2016 Jul 30;16:677. doi: 10.1186/s12889-016-3323-3.


Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD.

Negewo NA, McDonald VM, Baines KJ, Wark PA, Simpson JL, Jones PW, Gibson PG.

Int J Chron Obstruct Pulmon Dis. 2016 Jul 1;11:1495-504. doi: 10.2147/COPD.S100338. eCollection 2016.


MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

Conickx G, Mestdagh P, Avila Cobos F, Verhamme FM, Maes T, Vanaudenaerde BM, Seys LJ, Lahousse L, Kim RY, Hsu AC, Wark PA, Hansbro PM, Joos GF, Vandesompele J, Bracke KR, Brusselle GG.

Am J Respir Crit Care Med. 2017 Jan 1;195(1):43-56. doi: 10.1164/rccm.201506-1182OC.


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