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Aerosol delivery of dry powder synthetic lung surfactant to surfactant-deficient rabbits and preterm lambs on non-invasive respiratory support.

Walther FJ, Gupta M, Lipp MM, Chan H, Krzewick J, Gordon LM, Waring AJ.

Gates Open Res. 2019 Mar 14;3:6. doi: 10.12688/gatesopenres.12899.2. eCollection 2019.


Beyond electrostatics: Antimicrobial peptide selectivity and the influence of cholesterol-mediated fluidity and lipid chain length on protegrin-1 activity.

Henderson JM, Iyengar NS, Lam KLH, Maldonado E, Suwatthee T, Roy I, Waring AJ, Lee KYC.

Biochim Biophys Acta Biomembr. 2019 Oct 1;1861(10):182977. doi: 10.1016/j.bbamem.2019.04.011. Epub 2019 May 8.


Position of lipidation influences anticancer activity of Smac analogs.

Micewicz ED, Nguyen C, Micewicz A, Waring AJ, McBride WH, Ruchala P.

Bioorg Med Chem Lett. 2019 Jul 1;29(13):1628-1635. doi: 10.1016/j.bmcl.2019.04.041. Epub 2019 Apr 26.


Advances in synthetic lung surfactant protein technology.

Walther FJ, Gordon LM, Waring AJ.

Expert Rev Respir Med. 2019 Jun;13(6):499-501. doi: 10.1080/17476348.2019.1589372. Epub 2019 Mar 6. No abstract available.


Insights into the structure and molecular topography of the fatty acylated domain of synaptotagmin-1.

Ruchala P, Waring AJ, Cilluffo M, Whitelegge JP, Gundersen CB.

Biochim Biophys Acta Biomembr. 2019 Mar 1;1861(3):677-684. doi: 10.1016/j.bbamem.2018.12.019. Epub 2019 Jan 4.


A sulfur-free peptide mimic of surfactant protein B (B-YL) exhibits high in vitro and in vivo surface activities.

Walther FJ, Gupta M, Gordon LM, Waring AJ.

Version 2. Gates Open Res. 2018 Jul 10 [revised 2018 Jan 1];2:13. doi: 10.12688/gatesopenres.12799.2. eCollection 2018.


Oligomeric Structure and Three-Dimensional Fold of the HIV gp41 Membrane-Proximal External Region and Transmembrane Domain in Phospholipid Bilayers.

Kwon B, Lee M, Waring AJ, Hong M.

J Am Chem Soc. 2018 Jul 5;140(26):8246-8259. doi: 10.1021/jacs.8b04010. Epub 2018 Jun 22.


A Combination of the Aerosolized PPAR-γ Agonist Pioglitazone and a Synthetic Surfactant Protein B Peptide Mimic Prevents Hyperoxia-Induced Neonatal Lung Injury in Rats.

Sakurai R, Lee C, Shen H, Waring AJ, Walther FJ, Rehan VK.

Neonatology. 2018;113(4):296-304. doi: 10.1159/000486188. Epub 2018 Feb 9.


Design of Surfactant Protein B Peptide Mimics Based on the Saposin Fold for Synthetic Lung Surfactants.

Walther FJ, Gordon LM, Waring AJ.

Biomed Hub. 2016 Sep-Dec;1(3). pii: 451076. doi: 10.1159/000451076. Epub 2016 Nov 16.


Antimicrobial Peptides Share a Common Interaction Driven by Membrane Line Tension Reduction.

Henderson JM, Waring AJ, Separovic F, Lee KYC.

Biophys J. 2016 Nov 15;111(10):2176-2189. doi: 10.1016/j.bpj.2016.10.003.


Stability of an amphipathic helix-hairpin surfactant peptide in liposomes.

Waring AJ, Gupta M, Gordon LM, Fujii G, Walther FJ.

Biochim Biophys Acta. 2016 Dec;1858(12):3113-3119. doi: 10.1016/j.bbamem.2016.09.014. Epub 2016 Sep 21.


Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation.

Micewicz ED, Sharma S, Waring AJ, Luong HT, McBride WH, Ruchala P.

Int J Pept Res Ther. 2016 Mar 1;22(1):67-81. Epub 2015 Aug 19.


Combined effect of synthetic protein, Mini-B, and cholesterol on a model lung surfactant mixture at the air-water interface.

Chakraborty A, Hui E, Waring AJ, Dhar P.

Biochim Biophys Acta. 2016 Apr;1858(4):904-12. doi: 10.1016/j.bbamem.2016.01.008. Epub 2016 Jan 15.


The GraS Sensor in Staphylococcus aureus Mediates Resistance to Host Defense Peptides Differing in Mechanisms of Action.

Chaili S, Cheung AL, Bayer AS, Xiong YQ, Waring AJ, Memmi G, Donegan N, Yang SJ, Yeaman MR.

Infect Immun. 2015 Nov 23;84(2):459-66. doi: 10.1128/IAI.01030-15. Print 2016 Feb.


Lipid-conjugated Smac analogues.

Micewicz ED, Ratikan JA, Waring AJ, Whitelegge JP, McBride WH, Ruchala P.

Bioorg Med Chem Lett. 2015 Oct 15;25(20):4419-27. doi: 10.1016/j.bmcl.2015.09.017. Epub 2015 Sep 8.


Viral fusion protein transmembrane domain adopts β-strand structure to facilitate membrane topological changes for virus-cell fusion.

Yao H, Lee MW, Waring AJ, Wong GC, Hong M.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):10926-31. doi: 10.1073/pnas.1501430112. Epub 2015 Aug 17.


Small lipidated anti-obesity compounds derived from neuromedin U.

Micewicz ED, Bahattab OS, Willars GB, Waring AJ, Navab M, Whitelegge JP, McBride WH, Ruchala P.

Eur J Med Chem. 2015 Aug 28;101:616-26. doi: 10.1016/j.ejmech.2015.07.020. Epub 2015 Jul 14.


Synthetic lung surfactant reduces alveolar-capillary protein leakage in surfactant-deficient rabbits.

Gupta R, Hernández-Juviel JM, Waring AJ, Walther FJ.

Exp Lung Res. 2015 Jun;41(5):293-9. doi: 10.3109/01902148.2015.1024354.


Site-specific mutation of the sensor kinase GraS in Staphylococcus aureus alters the adaptive response to distinct cationic antimicrobial peptides.

Cheung AL, Bayer AS, Yeaman MR, Xiong YQ, Waring AJ, Memmi G, Donegan N, Chaili S, Yang SJ.

Infect Immun. 2014 Dec;82(12):5336-45. doi: 10.1128/IAI.02480-14. Epub 2014 Oct 6.


Surfactant protein C peptides with salt-bridges ("ion-locks") promote high surfactant activities by mimicking the α-helix and membrane topography of the native protein.

Walther FJ, Waring AJ, Hernández-Juviel JM, Ruchala P, Wang Z, Notter RH, Gordon LM.

PeerJ. 2014 Jul 15;2:e485. doi: 10.7717/peerj.485. eCollection 2014.


Aerosol delivery of synthetic lung surfactant.

Walther FJ, Hernández-Juviel JM, Waring AJ.

PeerJ. 2014 May 27;2:e403. doi: 10.7717/peerj.403. eCollection 2014.


Synthetic surfactant containing SP-B and SP-C mimics is superior to single-peptide formulations in rabbits with chemical acute lung injury.

Walther FJ, Hernández-Juviel JM, Gordon LM, Waring AJ.

PeerJ. 2014 May 22;2:e393. doi: 10.7717/peerj.393. eCollection 2014.


Novel dimeric Smac analogs as prospective anticancer agents.

Micewicz ED, Luong HT, Jung CL, Waring AJ, McBride WH, Ruchala P.

Bioorg Med Chem Lett. 2014 Mar 15;24(6):1452-7. doi: 10.1016/j.bmcl.2014.02.024. Epub 2014 Feb 18.


CotH3 mediates fungal invasion of host cells during mucormycosis.

Gebremariam T, Liu M, Luo G, Bruno V, Phan QT, Waring AJ, Edwards JE Jr, Filler SG, Yeaman MR, Ibrahim AS.

J Clin Invest. 2014 Jan;124(1):237-50. doi: 10.1172/JCI71349. Epub 2013 Dec 20.


A 2H solid-state NMR study of lipid clustering by cationic antimicrobial and cell-penetrating peptides in model bacterial membranes.

Kwon B, Waring AJ, Hong M.

Biophys J. 2013 Nov 19;105(10):2333-42. doi: 10.1016/j.bpj.2013.08.020.


Role of the N-terminal seven residues of surfactant protein B (SP-B).

Sharifahmadian M, Sarker M, Palleboina D, Waring AJ, Walther FJ, Morrow MR, Booth V.

PLoS One. 2013 Sep 2;8(9):e72821. doi: 10.1371/journal.pone.0072821. eCollection 2013.


A compensatory mutation provides resistance to disparate HIV fusion inhibitor peptides and enhances membrane fusion.

Wood MP, Cole AL, Ruchala P, Waring AJ, Rohan LC, Marx P, Tarwater PM, Gupta P, Cole AM.

PLoS One. 2013;8(2):e55478. doi: 10.1371/journal.pone.0055478. Epub 2013 Feb 5.


Effects of the lung surfactant protein B construct Mini-B on lipid bilayer order and topography.

Palleboina D, Waring AJ, Notter RH, Booth V, Morrow M.

Eur Biophys J. 2012 Sep;41(9):755-67. doi: 10.1007/s00249-012-0850-4. Epub 2012 Aug 19.


Synthesis and activity of a novel diether phosphonoglycerol in phospholipase-resistant synthetic lipid:peptide lung surfactants().

Schwan AL, Singh SP, Davy JA, Waring AJ, Gordon LM, Walther FJ, Wang Z, Notter RH.

Medchemcomm. 2011 Dec 1;2(12):1167-1173. Epub 2011 Oct 19.


Visualizing the analogy between competitive adsorption and colloid stability to restore lung surfactant function.

Shieh IC, Waring AJ, Zasadzinski JA.

Biophys J. 2012 Feb 22;102(4):777-86. doi: 10.1016/j.bpj.2012.01.014. Epub 2012 Feb 21.


Orientation and depth of surfactant protein B C-terminal helix in lung surfactant bilayers.

Bertani P, Vidovic V, Yang TC, Rendell J, Gordon LM, Waring AJ, Bechinger B, Booth V.

Biochim Biophys Acta. 2012 May;1818(5):1165-72. doi: 10.1016/j.bbamem.2012.01.001. Epub 2012 Jan 9.


Lipid-protein interactions alter line tensions and domain size distributions in lung surfactant monolayers.

Dhar P, Eck E, Israelachvili JN, Lee DW, Min Y, Ramachandran A, Waring AJ, Zasadzinski JA.

Biophys J. 2012 Jan 4;102(1):56-65. doi: 10.1016/j.bpj.2011.11.4007. Epub 2012 Jan 3.


KL₄ peptide induces reversible collapse structures on multiple length scales in model lung surfactant.

Holten-Andersen N, Michael Henderson J, Walther FJ, Waring AJ, Ruchala P, Notter RH, Lee KY.

Biophys J. 2011 Dec 21;101(12):2957-65. doi: 10.1016/j.bpj.2011.10.050. Epub 2011 Dec 20.


Mechanism of structural transformations induced by antimicrobial peptides in lipid membranes.

Lam KL, Wang H, Siaw TA, Chapman MR, Waring AJ, Kindt JT, Lee KY.

Biochim Biophys Acta. 2012 Feb;1818(2):194-204. doi: 10.1016/j.bbamem.2011.11.002. Epub 2011 Nov 9.


Context mediates antimicrobial efficacy of kinocidin congener peptide RP-1.

Yount NY, Cohen SE, Kupferwasser D, Waring AJ, Ruchala P, Sharma S, Wasserman K, Jung CL, Yeaman MR.

PLoS One. 2011;6(11):e26727. doi: 10.1371/journal.pone.0026727. Epub 2011 Nov 4.


Characterization of the retrocyclin analogue RC-101 as a preventative of Staphylococcus aureus nasal colonization.

Lamers RP, Eade CR, Waring AJ, Cole AL, Cole AM.

Antimicrob Agents Chemother. 2011 Nov;55(11):5338-46. doi: 10.1128/AAC.00619-11. Epub 2011 Aug 8.


Grifonin-1: a small HIV-1 entry inhibitor derived from the algal lectin, Griffithsin.

Micewicz ED, Cole AL, Jung CL, Luong H, Phillips ML, Pratikhya P, Sharma S, Waring AJ, Cole AM, Ruchala P.

PLoS One. 2010 Dec 16;5(12):e14360. doi: 10.1371/journal.pone.0014360.


The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques.

Cole AM, Patton DL, Rohan LC, Cole AL, Cosgrove-Sweeney Y, Rogers NA, Ratner D, Sassi AB, Lackman-Smith C, Tarwater P, Ramratnam B, Ruchala P, Lehrer RI, Waring AJ, Gupta P.

PLoS One. 2010 Nov 29;5(11):e15111. doi: 10.1371/journal.pone.0015111.


A ToF-SIMS study of the lateral organization of lipids and proteins in pulmonary surfactant systems.

Keating E, Waring AJ, Walther FJ, Possmayer F, Veldhuizen RA, Petersen NO.

Biochim Biophys Acta. 2011 Mar;1808(3):614-21. doi: 10.1016/j.bbamem.2010.11.015. Epub 2010 Nov 24.


Oxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipids.

Ruchala P, Navab M, Jung CL, Hama-Levy S, Micewicz ED, Luong H, Reyles JE, Sharma S, Waring AJ, Fogelman AM, Lehrer RI.

PLoS One. 2010 Apr 14;5(4):e10181. doi: 10.1371/journal.pone.0010181.


Synthetic surfactant based on analogues of SP-B and SP-C is superior to single-peptide surfactants in ventilated premature rabbits.

Almlén A, Walther FJ, Waring AJ, Robertson B, Johansson J, Curstedt T.

Neonatology. 2010 Jun;98(1):91-9. doi: 10.1159/000276980. Epub 2010 Jan 21.


Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs.

Walther FJ, Waring AJ, Hernandez-Juviel JM, Gordon LM, Wang Z, Jung CL, Ruchala P, Clark AP, Smith WM, Sharma S, Notter RH.

PLoS One. 2010 Jan 13;5(1):e8672. doi: 10.1371/journal.pone.0008672.


Functional importance of the NH2-terminal insertion sequence of lung surfactant protein B.

Frey SL, Pocivavsek L, Waring AJ, Walther FJ, Hernandez-Juviel JM, Ruchala P, Lee KY.

Am J Physiol Lung Cell Mol Physiol. 2010 Mar;298(3):L335-47. doi: 10.1152/ajplung.00190.2009. Epub 2009 Dec 18.


Structure of chemokine-derived antimicrobial Peptide interleukin-8alpha and interaction with detergent micelles and oriented lipid bilayers.

Bourbigot S, Fardy L, Waring AJ, Yeaman MR, Booth V.

Biochemistry. 2009 Nov 10;48(44):10509-21. doi: 10.1021/bi901311p.


Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine.

Yount NY, Kupferwasser D, Spisni A, Dutz SM, Ramjan ZH, Sharma S, Waring AJ, Yeaman MR.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-7. doi: 10.1073/pnas.0904465106. Epub 2009 Aug 13.


Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins.

Lehrer RI, Jung G, Ruchala P, Wang W, Micewicz ED, Waring AJ, Gillespie EJ, Bradley KA, Ratner AJ, Rest RF, Lu W.

Infect Immun. 2009 Sep;77(9):4028-40. doi: 10.1128/IAI.00232-09. Epub 2009 Jul 6.


Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D.

Doss M, White MR, Tecle T, Gantz D, Crouch EC, Jung G, Ruchala P, Waring AJ, Lehrer RI, Hartshorn KL.

J Immunol. 2009 Jun 15;182(12):7878-87. doi: 10.4049/jimmunol.0804049.

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